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    • 10. 发明授权
    • Method of treating or preventing tissue deterioration, injury or damage due to periodontal disease or disease of oral mucosa, and/or downregulating NF-kappabeta or supressing NF-kappabeta-mediated actions
    • 治疗或预防由牙周病或口腔粘膜疾病引起的组织退化,损伤或损伤和/或下调NF-κB或抑制NF-κB介导的作用的方法
    • US08399412B2
    • 2013-03-19
    • US12444331
    • 2007-10-05
    • Gabriel SosneMichelle WheaterAllan L. Goldstein
    • Gabriel SosneMichelle WheaterAllan L. Goldstein
    • A61K38/17
    • A61K38/08A61K8/64A61K38/2292A61Q11/00
    • A method of treatment for treating, at least partly preventing, inhibiting or reducing tissue deterioration, injury or damage due to a periodontal disease or disease of oral mucosa, or for restoring tissue adversely affected by the disease, in a subject, and/or for downregulating NF-kappaB or suppressing NF-kappaB mediated action in a body, organ, tissue or cell, includes administering to a subject, body, organ, tissue or cell an effective amount of a composition including a peptide agent including at least one of Thymosin beta 4 (Tβ4), an isoform of Tβ4, an N-terminal fragment of Tβ4, a C-terminal fragment of Tβ4, Tβ4 sulfoxide, an LKKTET peptide or conservative variant thereof, an LKKTNT peptide or conservative variant thereof, a KLKKTET peptide or conservative variant thereof, an LKKTETQ peptide or conservative variant thereof, Tβ4ala, Tβ9, Tβ10, Tβ11, Tβ12, Tβ13, Tβ14, Tβ15, gelsolin, vitamin D binding protein (DBP), profilin, cofilin, depactin, DnaseI, vilin, fragmin, severin, capping protein, β-actinin, acumentin, an actin-sequestering peptide, an actin binding peptide, an actin-mobilizing peptide, an actin polymerization-modulating peptide, or a stimulating agent that stimulates production of an effective amount of the peptide agent in the subject, body, organ, tissue or cell.
    • 一种治疗方法,用于治疗,至少部分地预防,抑制或减少由于牙周疾病或口腔粘膜疾病引起的组织退化,损伤或损伤,或用于恢复患者受到不良影响的组织,和/或用于 在身体,器官,组织或细胞中下调NF-κB或抑制NF-κB介导的作用,包括向受试者,身体,器官,组织或细胞施用有效量的组合物,所述组合物包括包含至少一种胸腺素的肽试剂 β4(T&bgr; 4),T&bgr的同种型; 4,T&bgr的N末端片段; 4,T&bgr; 4,T&bgr; 4亚砜的C末端片段,LKKTET肽或其保守变体,LKKTNT 肽或其保守变体,KLKKTET肽或其保守变体,LKKTETQ肽或其保守变体,T&bgr; 4ala,T&bgr; 9,T&bgr; 10,T&bgr; 11,T&bgr; 12,T&bgr; 13,T&bgr; T&Bgr; 15,凝溶胶蛋白,维生素D结合蛋白(DBP),profilin,cof 肌动蛋白结合肽,肌动蛋白动员肽,肌动蛋白聚合调节肽或刺激剂,肌动蛋白结合肽,肌动蛋白动员肽,肌动蛋白聚合调节肽, 其刺激受试者,身体,器官,组织或细胞中有效量的肽试剂的产生。