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1. 发明授权

US5866576A Epoxide-containing compounds 失效
标题翻译：含环氧化物的化合物
公开(公告)号：US5866576A
公开(公告)日：1999-02-02
申请号：US778563
申请日：1997-01-03
申请人： Gail Underiner , J. Peter Klein , John Michnick , Alistair Leigh , Anil Kumar
发明人： Gail Underiner , J. Peter Klein , John Michnick , Alistair Leigh , Anil Kumar
IPC分类号： C07D303/36 , C07D405/06 , C07D473/10 , A61K31/505 , C07D239/02
CPC分类号： C07D405/06 , C07D303/36 , C07D473/10
摘要： Disclosed are enantiomers, diastereomers, salts, solvates, hydrates and mixtures thereof, of formula I: ##STR1## The core moiety is a monocyclic ring structure having five to six ring atoms and two nitrogen atoms at the 1 and 3 positions, n is an integer from 4 to 16, R.sub.1 and R.sub.2 are hydrogen, halogen or C.sub.1-12 alkyl or alkenyl, and (CH.sub.2).sub.n may be optionally substituted by a hydroxyl, halogen, oxygen, a C.sub.1-4 alkyl group or a dimethylamino group. The compounds and pharmaceutical composition thereof are useful in methods for treating an individual having a disease or treatment-induced toxicity mediated through a second messenger.
摘要翻译：公开了式I的对映异构体，非对映异构体，盐，溶剂化物，水合物及其混合物：核心部分是在1和3位具有5至6个环原子和2个氮原子的单环环结构，n为 4至16的整数，R 1和R 2是氢，卤素或C 1-12烷基或链烯基，和（CH 2）n可任选被羟基，卤素，氧，C 1-4烷基或二甲基氨基取代。化合物及其药物组合物可用于治疗患有通过第二信使介导的疾病或治疗诱导的毒性的个体的方法。

2. 发明授权

US5521315A Olefin substituted long chain compounds 失效
标题翻译：烯烃取代的长链化合物
公开(公告)号：US5521315A
公开(公告)日：1996-05-28
申请号：US59697
申请日：1993-05-10
申请人： Gail Underiner , David Porubek , J. Peter Klein , Elisa Eiseman , Alistair Leigh , Anil Kumar , John Michnick
发明人： Gail Underiner , David Porubek , J. Peter Klein , Elisa Eiseman , Alistair Leigh , Anil Kumar , John Michnick
IPC分类号： C07D239/54 , A61K31/015 , A61K31/047 , A61K31/195 , A61K31/40 , A61K31/403 , A61K31/4035 , A61K31/505 , A61K31/52 , A61K31/522 , A61P1/00 , A61P1/02 , A61P1/16 , A61P3/00 , A61P3/08 , A61P3/10 , A61P11/00 , A61P13/02 , A61P15/00 , A61P19/10 , A61P25/28 , A61P29/00 , A61P37/00 , A61P43/00 , C07C13/08 , C07C13/16 , C07C15/40 , C07C49/20 , C07C49/647 , C07D209/48 , C07D473/06 , C07D211/88 , C07D239/80
CPC分类号： C07D473/06
摘要： There is disclosed an olefin-substituted compound having the formula:R--(core moiety),wherein R is a straignt chain hydrocarbon having at least one double bond and a carbon chain length of from about 6 to about 18 carbon atoms, wherein multiple double bonds are separated from each other by at least three carbon atoms, wherein the closest double bond to the core moiety is at least five carbon atoms from the core moiety, and wherein the hydrocarbon chain may be substituted by a hydroxyl, halo, keto or dimethylanimo group and/or interrupted by an oxygen atom and salts thereof and pharmaceutical compositions thereof.
摘要翻译：公开了具有下式的烯烃取代的化合物：R-（核心部分），其中R是具有至少一个双键且碳链长度为约6至约18个碳原子的直链烃，其中多个双键彼此分开至少三个碳原子，其中与核心部分最接近的双键是至少五个来自核心部分的碳原子，并且其中烃链可以被羟基，卤素，酮基或二甲基亚胺基取代组和/或被氧原子及其盐和其药物组合物中断。

3. 发明授权

US6121270A Epoxide-containing compounds 失效
标题翻译：含环氧化物的化合物
公开(公告)号：US6121270A
公开(公告)日：2000-09-19
申请号：US98473
申请日：1998-06-17
申请人： Gail Underiner , J. Peter Klein , John Michnick , Alistair Leigh , Anil Kumar
发明人： Gail Underiner , J. Peter Klein , John Michnick , Alistair Leigh , Anil Kumar
IPC分类号： C07D303/36 , C07D405/06 , C07D473/10 , A61K31/52 , C07D473/04
CPC分类号： C07D405/06 , C07D303/36 , C07D473/10
摘要： Disclosed are enantiomers diastereomers, salts, solvates, hydrates and mixtures thereof, of formula I: ##STR1## The core moiety is non-cyclic or at least one five- to seven-membered ring, n is an integer from about 4 to about 16, R.sub.1 and R.sub.2 are hydrogen, halogen or C.sub.1-12 alkyl or alkenyl, and (CH.sub.2).sub.n may be substituted by a hydroxyl, halogen, oxygen, a (C.sub.1-4) alkyl group or a dimethylamino group. The compounds and pharmaceutical composition thereof are useful in methods for treating an individual having a disease or treatment-induced toxicity, mediated by second messenger activity.
摘要翻译：公开了式I的对映体非对映异构体，盐，溶剂合物，水合物及其混合物：核心部分是非环状或至少一个五至七元环，n是约4至约16的整数，R 1和 R2是氢，卤素或C1-12烷基或烯基，（CH2）n可以被羟基，卤素，氧，（C1-4）烷基或二甲氨基取代。所述化合物及其药物组合物可用于治疗由第二信使活性介导的具有疾病或治疗诱导的毒性的个体的方法。

4. 发明授权

US5670506A Halogen, isothiocyanate or azide substituted xanthines 失效
标题翻译：卤素，异硫氰酸酯或叠氮取代黄嘌呤
公开(公告)号：US5670506A
公开(公告)日：1997-09-23
申请号：US42946
申请日：1993-04-05
申请人： Alistair Leigh , John Michnick , Anil Kumar , Gail Underiner
发明人： Alistair Leigh , John Michnick , Anil Kumar , Gail Underiner
IPC分类号： C07D209/48 , C07D239/54 , C07D239/96 , C07D473/10 , A61K31/52 , C07D473/00
CPC分类号： C07D209/48 , C07D239/54 , C07D239/96 , C07D473/10
摘要： There is disclosed a compound having the formula: ##STR1## wherein n is an integer from 5 to 9, wherein the core moiety is a heterocylic moiety wherein C.sub.a, C.sub.b, and C.sub.c are an R or S enantiomer or racemic mixture and the C.sub.a, C.sub.b, and C.sub.c carbon atoms are bonded together by a single bond, double bond, ether or ester linkages, wherein R.sub.1, R.sub.2 and R.sub.3 are independently halo, hydroxy, hydrogen, keto, isothiocyano, azide or haloacetoxy with the proviso that at least one of R.sub.1, R.sub.2 or R.sub.3 must be a halo, isothiocyano, azide or haloacetoxy group, wherein R.sub.4 is hydrogen, C.sub.1-6 alkyl, C.sub.1-6 alkenyl, cyclo C.sub.4-6 alkyl, or phenyl, and wherein halo refers to fluoro, chloro, bromo and iodo and salts thereof and pharmaceutical compositions thereof.
摘要翻译：公开了具有下式的化合物：其中n是5至9的整数，其中核心部分是杂环部分，其中Ca，Cb和Cc是R或S对映异构体或外消旋混合物，Ca， Cb和Cc碳原子通过单键，双键，醚或酯键键合在一起，其中R 1，R 2和R 3独立地是卤素，羟基，氢，酮基，异硫氰基，叠氮基或卤代乙酰氧基，条件是至少一个的R 1，R 2或R 3必须是卤素，异硫氰基，叠氮化物或卤代乙酰氧基，其中R 4是氢，C 1-6烷基，C 1-6烯基，环C 4-6烷基或苯基，其中卤素是指氟，氯，溴和碘及其盐及其药物组合物。

5. 发明授权

US09206155B2 Chiral 1-(4-methylphenylmethyl)-5-OXO-{N-[3-T-butoxycarbonyl-aminomethyl)]-piperidin-1-yl-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion 有权
标题翻译：手性1-（4-甲基苯基甲基）-5-氧代-N- {N- [3-叔丁氧基羰基 - 氨基甲基）] - 哌啶-1-基 - 吡咯烷-2-甲酰胺作为胶原诱导的血小板活化和粘附抑制剂
公开(公告)号：US09206155B2
公开(公告)日：2015-12-08
申请号：US13995336
申请日：2012-01-12
申请人： Dinesh Kumar Dikshit , Madhu Dikshit , Tanveer Irshad Siddiqui , Anil Kumar , Rabi Sankar Bhatta , Girish Kumar Jain , Manoj Kumar Barthwal , Ankita Misra , Vivek Khanna , Prem Prakash , Manish Jain , Vishal Singh , Varsha Gupta , Anil Kumar Dwivedi
发明人： Dinesh Kumar Dikshit , Madhu Dikshit , Tanveer Irshad Siddiqui , Anil Kumar , Rabi Sankar Bhatta , Girish Kumar Jain , Manoj Kumar Barthwal , Ankita Misra , Vivek Khanna , Prem Prakash , Manish Jain , Vishal Singh , Varsha Gupta , Anil Kumar Dwivedi
IPC分类号： C07D401/06 , C07B53/00
CPC分类号： A61K31/454 , C07B53/00 , C07D401/06
摘要： Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-1-(4-methyl-phenylmethyl)-5-oxo-(3S)—{N-[(3-t-butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)—{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p methylphenylmethyl)lpyroglutamate in good chiral purity.
摘要翻译：手性1-（4-甲基苯基甲基）-5-氧代 - {N - [（3-叔丁氧基羰基 - 氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-甲酰胺作为胶原诱导的血小板活化和粘附抑制剂本发明提供手性（2S）-1-（4-甲基 - 苯基甲基）-5-氧代 - （3S） - {N - [（3-叔丁氧基羰基氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-酮（2S）-1-（4-甲基苯基甲基）-5-氧代 - （3R） - {N - [（3-叔丁氧基羰基氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-酮分别为式6和7的甲酰胺。本发明还涉及这些部分作为通过胶原受体介导的胶原诱导的血小板粘附和聚集的抑制剂的用途。本发明提供了一种制备式6和7的手性羧酰胺的方法，该方法在N-烷基化过程中有利于避免在α-羧酸中心的任何外消旋化。在低温下使用试剂LiHMDS以提供良好的手性纯度的N-（p甲基苯基甲基）l吡咯烷酸甲酯。

6. 发明申请

US20130338193A1 CHIRAL 1-(4-METHYLPHENYLMETHYL)-5-OXO--PYRROLIDINE-2-CARBOXAMIDES AS INHIBITORS OF COLLAGEN INDUCED PLATELET ACTIVATION AND ADHESION 有权
标题翻译： CHIRAL 1-（4-甲基苯基甲基）-5-氧代 - 吡咯烷-2-羧酸酰胺作为胶原诱导的板激活和粘附的抑制剂
公开(公告)号：US20130338193A1
公开(公告)日：2013-12-19
申请号：US13995336
申请日：2012-01-12
申请人： Dinesh Kumar Dikshit , Madhu Dikshit , Tanveer Irshad Siddiqui , Anil Kumar , Rabi Sankar Bhata , Girish Kumar Jain , Manoj Kumar Barthwal , Ankita Misra , Vivek Khanna , Prem Prakash , Manish Jain , Vishal Singh , Varsha Gupta , Anil Kumar Dwivedi
发明人： Dinesh Kumar Dikshit , Madhu Dikshit , Tanveer Irshad Siddiqui , Anil Kumar , Rabi Sankar Bhata , Girish Kumar Jain , Manoj Kumar Barthwal , Ankita Misra , Vivek Khanna , Prem Prakash , Manish Jain , Vishal Singh , Varsha Gupta , Anil Kumar Dwivedi
IPC分类号： C07D401/06
CPC分类号： A61K31/454 , C07B53/00 , C07D401/06
摘要： Chiral 1-(4-methylphenylmethyl)-5-oxo-{N-[(3-t-butoxycarbonyl-aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamides as inhibitors of collagen induced platelet activation and adhesion The present invention provides chiral (2S)-1-(4-methyl-phenylmethyl)-5-oxo-(3S)-{N-[(3-t butoxycarbonyl aminomethyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide, and (2S)-1-(4-methylphenylmethyl)-5-oxo-(3R)-{N-[(3-t-butoxycarbonyl amino methyl)]-piperidin-1-yl}-pyrrolidine-2-carboxamide of formula 6 and 7 respectively. The present invention also relates to use of these moieties as inhibitors of collagen induced platelet adhesion and aggregation mediated through collagen receptors. The present invention provides a process for preparation of chiral carboxamides of formula 6 and 7 using the process which has advantage to avoid any racemization at the a-carboxylic center, during N-alkylation. The reagent LiHMDS is used at low temperatures to furnish methyl N-(p methylphenylmethyl)lpyroglutamate in good chiral purity.
摘要翻译：手性1-（4-甲基苯基甲基）-5-氧代 - {N - [（3-叔丁氧基羰基 - 氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-甲酰胺作为胶原诱导的血小板活化和粘附抑制剂本发明提供手性（2S）-1-（4-甲基 - 苯基甲基）-5-氧代 - （3S） - {N - [（3-叔丁氧基羰基氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-酮（2S）-1-（4-甲基苯基甲基）-5-氧代 - （3R） - {N - [（3-叔丁氧基羰基氨基甲基）] - 哌啶-1-基} - 吡咯烷-2-甲酰胺分别为式6和7。本发明还涉及这些部分作为通过胶原受体介导的胶原诱导的血小板粘附和聚集的抑制剂的用途。本发明提供了一种制备式6和7的手性羧酰胺的方法，该方法在N-烷基化过程中有利于避免在α-羧酸中心的任何外消旋化。在低温下使用试剂LiHMDS以提供良好的手性纯度的N-（p甲基苯基甲基）l吡咯烷酸甲酯。

7. 发明授权

US09475901B2 Photoalignment materials having improved adhesion 有权
标题翻译：具有改善粘附性的光对准材料
公开(公告)号：US09475901B2
公开(公告)日：2016-10-25
申请号：US12959467
申请日：2010-12-03
申请人： Gobinda Saha , Anil Kumar
发明人： Gobinda Saha , Anil Kumar
IPC分类号： C09K19/00 , C08F220/30 , C08F220/62 , C09K19/56 , G02B1/04 , C08F220/36
CPC分类号： C08F222/20 , C08F220/30 , C08F220/62 , C08F2220/301 , C08F2220/303 , C08F2220/305 , C08F2220/365 , C09K19/56 , G02B1/04 , G02F1/1337 , G02F1/133788 , Y10T428/1005 , Y10T428/1014 , Y10T428/31931 , C08L33/10 , C08L101/12 , C08F220/34 , C08F2220/343 , C08F230/08 , C08F2220/281
摘要： The present disclosure provides for new photoalignment (co)polymer materials which demonstrate improved adhesion to a substrate. The (co)polymeric structure includes at least one photochemically active chromophore and at least one adhesion promoter group. Articles of manufacture, optical elements, ophthalmic elements and liquid crystal cells which include at least one photoalignment layer made from the photoalignment (co)polymer materials and methods for formation are also disclosed.
摘要翻译：本公开提供了新的光取向（共）聚合物材料，其表现出对基材的改善的粘附性。（共）聚合物结构包括至少一种光化学活性发色团和至少一个粘合促进剂基团。还公开了包括由光取向（共）聚合物材料和形成方法制成的至少一个光取向层的制造物，光学元件，眼用元件和液晶单元。

8. 发明授权

US09425859B2 Interference mitigation for broadband over power line 有权
标题翻译：电力线宽带干扰减轻
公开(公告)号：US09425859B2
公开(公告)日：2016-08-23
申请号：US12911625
申请日：2010-10-25
申请人： Timothy M. Mitchell , Anil Kumar , Roger C. Vondoenhoff , Matthias Beck
发明人： Timothy M. Mitchell , Anil Kumar , Roger C. Vondoenhoff , Matthias Beck
IPC分类号： H04L5/16 , H04B3/54
CPC分类号： H04B3/546 , H04B2203/5445
摘要： Systems and methods to exchange data between a vehicle and a remote computer system, are disclosed. In one embodiment, a system to exchange data between a vehicle and a remote computer system comprises at least one power line adapted to couple to the vehicle, a local area network, a modem coupled to the local area network and the at least one power line, and a power line interference server comprising logic to allocate communication channels within a specified frequency range on the power line. Other embodiments may be described.
摘要翻译：公开了在车辆和远程计算机系统之间交换数据的系统和方法。在一个实施例中，在车辆和远程计算机系统之间交换数据的系统包括适于耦合到车辆的至少一个电力线，局域网，耦合到局域网的调制解调器和至少一个电力线以及电力线干扰服务器，其包括用于在电力线上的指定频率范围内分配通信信道的逻辑。可以描述其他实施例。

9. 发明申请

US20150002688A1 AUTOMATED CAMERA ADJUSTMENT 审中-公开
标题翻译：自动相机调整
公开(公告)号：US20150002688A1
公开(公告)日：2015-01-01
申请号：US13928262
申请日：2013-06-26
申请人： James A. Baldwin , Richard S. Bell , Anil Kumar
发明人： James A. Baldwin , Richard S. Bell , Anil Kumar
IPC分类号： H04N5/232
CPC分类号： H04N5/23203 , H04N5/23296 , H04N5/77
摘要： In embodiments, apparatuses, methods and storage media are described that are associated with controlling production of images on a camera. In embodiments, a device with a camera, such as a content consumption device, may determine a current orientation of the camera and may adjust production of images from the camera to account for the orientation. The device may determine the orientation based on physical data, such as data from an accelerometer, compass, and/or gyroscope. the device may also determine the orientation from image data. The device may adjust production of images by either before capture, such as by physically adjusting the orientation of the camera, or after capture, such as by panning, tilting, and/or zooming captured images. Other embodiments may be described and claimed.
摘要翻译：在实施例中，描述与控制相机上的图像的生成相关联的装置，方法和存储介质。在实施例中，具有诸如内容消费设备的照相机的设备可以确定照相机的当前方向，并且可以调整来自相机的图像的生成以解决方向。设备可以基于诸如来自加速度计，罗盘和/或陀螺仪的数据的物理数据来确定取向。该装置还可以确定来自图像数据的取向。该装置可以在拍摄之前通过例如通过物理地调整相机的方向，或者在拍摄之后，例如通过平移，倾斜和/或缩放拍摄的图像来调整图像的产生。可以描述和要求保护其他实施例。

10. 发明授权

US08920928B2 Photochromic compounds and compositions 有权
标题翻译：光致变色化合物和组合物
公开(公告)号：US08920928B2
公开(公告)日：2014-12-30
申请号：US13325285
申请日：2011-12-14
申请人： Meng He , Darrin R. Dabideen , Sujit Mondal , Xiao-Man Dai , Ruisong Xu , Wenjing Xiao , Massimiliano Tomasulo , Huayun Yu , Anu Chopra , Anil Kumar
发明人： Meng He , Darrin R. Dabideen , Sujit Mondal , Xiao-Man Dai , Ruisong Xu , Wenjing Xiao , Massimiliano Tomasulo , Huayun Yu , Anu Chopra , Anil Kumar
IPC分类号： G02B1/04 , G02C7/02 , G02C7/10 , G02C7/14 , C07D311/92 , C07D311/94
CPC分类号： C07D311/94 , C07D311/92 , G02B1/04 , G02C7/02 , G02C7/102 , G02C7/14 , Y10T428/31504 , Y10T428/31551 , Y10T428/31663 , Y10T428/31935
摘要： Described herein are compounds generally comprising an indeno[2′,3′:3,4]naptho[1,2-b]pyran structure. Such compounds may be useful for their photochromic properties, and be used in certain photochromic compositions. Such compositions may further comprise other photochromic compositions and/or materials. Additionally, such compounds and/or compositions may be suitable for preparing certain photochromic articles.
摘要翻译：本文描述的是通常包含茚并[2'，3'：3,4]萘酚[1,2-b]吡喃结构的化合物。这些化合物可用于其光致变色性质，并可用于某些光致变色组合物中。这样的组合物还可以包含其它光致变色组合物和/或材料。另外，这样的化合物和/或组合物可适用于制备某些光致变色制品。

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