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    • 5. 发明授权
    • Method and kit for supplying a fluid to a subcutaneous placement site
    • 用于向皮下放置位置供应流体的方法和试剂盒
    • US06254586B1
    • 2001-07-03
    • US09395530
    • 1999-09-14
    • Alfred E. MannJohn J. MastrototaroClifford W. Hague
    • Alfred E. MannJohn J. MastrototaroClifford W. Hague
    • A61M3100
    • A61B5/14865A61B5/415A61B5/418A61B5/6849A61M2005/1726
    • There is provided a method of supplying a fluid to a placement site. For instance, a sensor set is first mounted onto a skin of a user, and a placement site is contacted with the sensor set. The sensor set includes a base to secure the sensor set to the skin of the user; a cannula coupled to and extending from the base; an insertion device operatively coupled to the sensor set and the cannula to facilitate insertion of the cannula to contact the placement site; an externally extending conduit; and a sensor. The cannula has at least one lumen with an end for fluid communication with the placement site, and also has at least one port formed near another end of the lumen opposite the end for fluid communication. The conduit is in fluid communication with the at least one port of the cannula. The sensor has a sensor portion exposed by the at least one port in the at least one lumen of the cannula to determine a body characteristic of the user at the placement site. After the sensor set is mounted on the user's skin, a fluid is introduced through the externally extending conduit and the lumen to the placement site. Kits for carrying out the inventive methods are also provided.
    • 提供了将流体供应到放置位置的方法。 例如,传感器组首先安装在用户的皮肤上,并且放置位置与传感器组接触。 所述传感器组包括用于将所述传感器组固定到使用者皮肤的基座; 耦合到所述基座并从所述基座延伸的插管; 插入装置,其可操作地耦合到所述传感器组和所述插管,以便于套管插入以与所述放置位置接触; 外部延伸导管; 和传感器。 插管具有至少一个具有端部的内腔,用于与放置位置流体连通,并且还具有至少一个端口,其形成在与端部相对的端部的另一端附近,用于流体连通。 导管与套管的至少一个端口流体连通。 传感器具有通过插管的至少一个内腔中的至少一个端口暴露的传感器部分,以确定放置位置处的使用者的身体特征。 将传感器组安装在用户的皮肤上后,将流体通过外部延伸的管道和内腔引入到放置位置。 还提供了用于实施本发明方法的试剂盒。
    • 7. 发明授权
    • Neural stimulator with percutaneous connectivity
    • 具有经皮连接的神经刺激器
    • US08655455B2
    • 2014-02-18
    • US13500731
    • 2010-09-30
    • Alfred E. MannTom Xiaohai He
    • Alfred E. MannTom Xiaohai He
    • A61N1/00
    • A61N1/0539A61M39/0247A61M2039/0261A61M2039/0267A61N1/0536A61N1/36017A61N1/36128
    • An implantable neurostimulation system includes both implantable and external components. Electrical connectivity between the external and implanted components is achieved through a plurality of feedthrough pins located within an insulative wall of a percutaneous port embedded in the skin. The percutaneous port has the general shape and appearance of a small thimble, embedded in the skin with its open end facing outwardly from the skin surface, and with its closed end located below the skin surface, thereby forming a cavity or dimple in the skin. Various plugs or cartridges can be removably inserted into the cavity of the percutaneous port, in various orientations, to facilitate appropriate connectivity between the external and implanted components of the system through selected ones of the feedthrough pins. A mesh edging secured around the periphery wall of the port promotes tissue ingrowth and vascularization, thereby forming a percutaneous seal around the port that prevents infection.
    • 植入式神经刺激系统包括可植入和外部组件。 外部和植入部件之间的电连接通过位于皮肤内的经皮端口的绝缘壁内的多个穿通针来实现。 经皮端口具有嵌入皮肤中的小套管的一般形状和外观,其开口端从皮肤表面向外,并且其封闭端位于皮肤表面下方,从而在皮肤中形成空腔或凹坑。 可以以各种取向将各种插头或药筒可移除地插入到经皮端口的空腔中,以通过选定的馈通针来促进系统的外部部件和植入部件之间的适当连接。 围绕端口的周围壁固定的网状边缘促进组织向内生长和血管形成,从而在端口周围形成防止感染的经皮密封。