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1. 发明授权

US09181313B2 Treatment and prevention of malaria 有权
标题翻译：治疗和预防疟疾
公开(公告)号：US09181313B2
公开(公告)日：2015-11-10
申请号：US13823979
申请日：2012-02-24
申请人： Alexander Douglas , Simon Draper , Adrian Hill , Andrew Williams , Joseph Illingworth
发明人： Alexander Douglas , Simon Draper , Adrian Hill , Andrew Williams , Joseph Illingworth
IPC分类号： C07K14/445 , A61K39/39 , A61K39/015 , C07K16/20 , C12N15/115 , A61K39/00
CPC分类号： A61K39/015 , A61K39/39 , A61K2039/507 , A61K2039/5256 , A61K2039/53 , C07K14/445 , C07K16/205 , C07K2317/76 , C12N7/00 , C12N15/115 , C12N15/86 , C12N2310/16 , C12N2710/10341 , C12N2710/10371 , C12N2710/24141 , C12N2710/24171 , Y02A50/412
摘要： There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising a Reticulocyte-binding protein Homologue 5 (PfRH5) antigen having at least 90% identity with SEQ ID NO: 1, or a fragment thereof; or which comprise a viral vector that expresses PfRH5 antigen having at least 90% identity with SEQ ID NO: 2, or a fragment thereof.
摘要翻译：提供的抗原，编码抗原的载体，以及针对抗原的抗体和其它结合化合物及其在预防或治疗疟疾中的用途。特别地，提供了包含与SEQ ID NO：1具有至少90％同一性的网织红细胞结合蛋白同源物5（PfRH5）抗原或其片段的组合物; 或其包含表达与SEQ ID NO：2具有至少90％同一性的PfRH5抗原或其片段的病毒载体。

2. 发明申请

US20130183332A1 Treatment and Prevention of Malaria 有权
标题翻译：治疗和预防疟疾
公开(公告)号：US20130183332A1
公开(公告)日：2013-07-18
申请号：US13823979
申请日：2012-02-24
申请人： Alexander Douglas , Simon Draper , Adrian Hill , Andrew Williams , Joseph Illingworth
发明人： Alexander Douglas , Simon Draper , Adrian Hill , Andrew Williams , Joseph Illingworth
IPC分类号： C07K14/445 , A61K39/39 , A61K39/015
CPC分类号： A61K39/015 , A61K39/39 , A61K2039/507 , A61K2039/5256 , A61K2039/53 , C07K14/445 , C07K16/205 , C07K2317/76 , C12N7/00 , C12N15/115 , C12N15/86 , C12N2310/16 , C12N2710/10341 , C12N2710/10371 , C12N2710/24141 , C12N2710/24171 , Y02A50/412
摘要： There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising a Reticulocyte-binding protein Homologue 5 (PfRH5) antigen having at least 90% identity with SEQ ID NO: 1, or a fragment thereof; or which comprise a viral vector that expresses PfRH5 antigen having at least 90% identity with SEQ ID NO: 2, or a fragment thereof.
摘要翻译：提供的抗原，编码抗原的载体，以及针对抗原的抗体和其它结合化合物及其在预防或治疗疟疾中的用途。特别地，提供了包含与SEQ ID NO：1具有至少90％同一性的网织红细胞结合蛋白同源物5（PfRH5）抗原或其片段的组合物; 或其包含表达与SEQ ID NO：2具有至少90％同一性的PfRH5抗原或其片段的病毒载体。

3. 发明授权

US08280263B2 Multi-feed detection and control system 有权
标题翻译：多进料检测和控制系统
公开(公告)号：US08280263B2
公开(公告)日：2012-10-02
申请号：US13017081
申请日：2011-01-31
申请人： Nicholas Baxter , Andrew Hill , Andrew Ashwood , Nicholas Gates , Robert Sanders , Andrew Williams
发明人： Nicholas Baxter , Andrew Hill , Andrew Ashwood , Nicholas Gates , Robert Sanders , Andrew Williams
IPC分类号： G03G15/10
CPC分类号： G03G15/6511 , B41J11/0095 , B41J13/0018 , B65H5/062 , B65H7/12 , B65H2220/09 , B65H2301/44514 , B65H2404/14 , B65H2404/632 , B65H2511/524 , B65H2513/41 , G03G2215/00396 , G03G2215/004 , B65H2220/01 , B65H2220/02 , B65H2220/11
摘要： A paper feed system for use in a printing apparatus that detects multi-feeds and separates all sheets while allowing a single sheet to continue into the machine includes a nip with a drive roller for feeding sheets. A reversible pressure roller downstream of the drive roller is connected to a motor, but idles in the direction of the paper feed in normal operation. When a multi-feed is detected, the motor is turned ON and the reversible pressure roll actuated by a controller. The reversible pressure roller has more friction with the sheet in its contact than the friction between sheets. This drives the sheet in contact backwards. This sheet can be diverted to a separate paper path using a gate mechanism and, if desired, fed back into the feed path.
摘要翻译：用于在允许单张纸继续进入机器的同时检测多次进给和分离所有片材的打印设备中的进纸系统包括具有用于进给纸张的驱动辊的辊隙。驱动辊下游的可逆压力辊连接到电动机，但在正常操作中在供纸方向空转。当检测到多进给时，马达被打开，可逆压力辊由控制器启动。可逆压力辊与片材在接触时的摩擦力大于片材之间的摩擦力。这会使纸张向后移动。可以使用门机构将该片材转移到单独的纸路径，并且如果需要，将其反馈到进给路径中。

4. 发明申请

US20120195667A1 MULTI-FEED DETECTION AND CONTROL SYSTEM 有权
标题翻译：多进制检测和控制系统
公开(公告)号：US20120195667A1
公开(公告)日：2012-08-02
申请号：US13017081
申请日：2011-01-31
申请人： Nicholas Baxter , Andrew Hill , Andrew Ashwood , Nicholas Gates , Robert Sanders , Andrew Williams
发明人： Nicholas Baxter , Andrew Hill , Andrew Ashwood , Nicholas Gates , Robert Sanders , Andrew Williams
IPC分类号： G03G15/00
CPC分类号： G03G15/6511 , B41J11/0095 , B41J13/0018 , B65H5/062 , B65H7/12 , B65H2220/09 , B65H2301/44514 , B65H2404/14 , B65H2404/632 , B65H2511/524 , B65H2513/41 , G03G2215/00396 , G03G2215/004 , B65H2220/01 , B65H2220/02 , B65H2220/11
摘要： A paper feed system for use in a printing apparatus that detects multi-feeds and separates all sheets while allowing a single sheet to continue into the machine includes a nip with a drive roller for feeding sheets. A reversible pressure roller downstream of the drive roller is connected to a motor, but idles in the direction of the paper feed in normal operation. When a multi-feed is detected, the motor is turned ON and the reversible pressure roll actuated by a controller. The reversible pressure roller has more friction with the sheet in its contact than the friction between sheets. This drives the sheet in contact backwards. This sheet can be diverted to a separate paper path using a gate mechanism and, if desired, fed back into the feed path.
摘要翻译：用于在允许单张纸继续进入机器的同时检测多次进给和分离所有片材的打印设备中的进纸系统包括具有用于进给纸张的驱动辊的辊隙。驱动辊下游的可逆压力辊连接到电动机，但在正常操作中在供纸方向空转。当检测到多进给时，马达被打开，可逆压力辊由控制器启动。可逆压力辊与片材在接触时的摩擦力大于片材之间的摩擦力。这会使纸张向后移动。可以使用门机构将该片材转移到单独的纸路径，并且如果需要，将其反馈到进给路径中。

5. 发明授权

US07285072B2 Vehicle control system 有权
标题翻译：车辆控制系统
公开(公告)号：US07285072B2
公开(公告)日：2007-10-23
申请号：US11124774
申请日：2005-05-09
申请人： Andrew Williams
发明人： Andrew Williams
IPC分类号： B60W10/04
CPC分类号： F16H61/66 , B60W2510/0638 , B60W2520/10 , B60W2710/0644 , B60W2720/10 , B60Y2200/22 , B60Y2200/221 , Y10T477/675 , Y10T477/676
摘要： A control system for a vehicle, the vehicle including an engine, a variable transmission for varying the transmission ratio between an output member of the engine and a ground engaging drive apparatus, the control system including at least one control apparatus which is operative to provide inputs to a controller, the controller being responsive to inputs from the control apparatus when the control system is operating in a first operating mode, to provide output signals to vary the engine speed, and when the control system is operating in a second operating mode, to provide output signals to vary the transmission ratio without changing the engine speed, and a mode selector control whereby an operator may select the first or second operating mode.
摘要翻译：一种用于车辆的控制系统，所述车辆包括发动机，用于改变所述发动机的输出构件和地面接合驱动装置之间的传动比的可变传动装置，所述控制系统包括至少一个控制装置，所述控制装置可操作以提供输入控制器响应于当控制系统在第一操作模式下操作时来自控制装置的输入，以提供输出信号以改变发动机速度，并且当控制系统在第二操作模式下操作时，提供输出信号以改变传动比而不改变发动机转速;以及模式选择器控制，由此操作者可以选择第一或第二操作模式。

6. 发明申请

US20070080207A1 AUTOMATED CHECK CASHING AND LOAN PROCESSING ATM SYSTEM AND METHODOLOGY 失效
标题翻译：自动检查货币兑换和贷款处理ATM系统和方法
公开(公告)号：US20070080207A1
公开(公告)日：2007-04-12
申请号：US11465462
申请日：2006-08-18
申请人： Andrew Williams
发明人： Andrew Williams
IPC分类号： G07F19/00 , G06Q40/00
CPC分类号： G06Q40/12 , G06Q10/02 , G06Q20/042 , G06Q20/10 , G06Q20/102 , G06Q40/00 , G06Q40/02 , G06Q40/025
摘要： Automated methods for processing a cash advance and/or a check cashing transaction using an ATM entail obtaining identification information for a user; producing an image of each side of an original check for the transaction; accessing a database of financial transactions to determine if the transaction has an unacceptable risk; voiding the original check and returning the voided check to the user; producing a cash (debit) card and corresponding account for a principal amount for the user; and communicating the image of each side of the original check to a settlement service provider via a communications network on a maturity date.
摘要翻译：使用ATM处理现金提前和/或支票兑现交易的自动化方法需要获得用户的识别信息; 产生交易的原始支票的每一面的图像; 访问金融交易数据库以确定交易是否具有不可接受的风险; 使原始检查无效，并向用户返回无效检查; 生成现金（借方）卡和用户本金的相应账户; 并且在到期日通过通信网络将原始支票的每一侧的图像传送给结算服务提供商。

7. 发明申请

US20060115840A1 In situ dilution of external controls for use in microarrays 失效
标题翻译：用于微阵列的外部对照的原位稀释
公开(公告)号：US20060115840A1
公开(公告)日：2006-06-01
申请号：US11253987
申请日：2005-10-18
申请人： Sherri Boucher , Craig Parfett , Carole Yauk , Andrew Williams , George Douglas , Gu Zhou
发明人： Sherri Boucher , Craig Parfett , Carole Yauk , Andrew Williams , George Douglas , Gu Zhou
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6837 , C12Q2545/113 , C12Q2527/143 , C12Q2527/137 , C12Q2565/507
摘要： An array in which an external control feature for normalization has been designed and tested for its ability to mimic the range of observed expression levels for a test set of oligos. The external control probes span a series of concentrations. They are spatially randomized across a grid of an array. The series of concentrations is duplicated in a given grid. The individual grid layout and number of control and external normalization features per grid have been designed to cope with sources of both systematic error and spatial variation.
摘要翻译：其中已经设计并测试了用于归一化的外部控制特征的能力，以模拟寡核苷酸测试集观察到的表达水平的范围。外部控制探针跨越一系列浓度。它们通过阵列的网格在空间上随机化。一系列浓度在给定的网格中重复。每个电网的单独电网布局和控制和外部归一化特征的数量已被设计为应对系统误差和空间变化的来源。

8. 发明授权

US5434154A Antimigraine 4-pyrimidinyl and pyridinyl derivatives of indol-3yl-alkylpiperazines 失效
标题翻译：吲哚-3-基 - 烷基哌嗪的抗偏头痛4-嘧啶基和吡啶基衍生物
公开(公告)号：US5434154A
公开(公告)日：1995-07-18
申请号：US233545
申请日：1994-04-26
申请人： David W. Smith , Joseph P. Yevich , Andrew Williams , Edward H. Ruediger , Keith D. Combrink , Bradley C. Pearce
发明人： David W. Smith , Joseph P. Yevich , Andrew Williams , Edward H. Ruediger , Keith D. Combrink , Bradley C. Pearce
IPC分类号： A61K31/495 , A61K31/40 , A61K31/44 , A61K31/505 , A61K31/506 , A61P25/04 , A61P25/06 , C07D209/10 , C07D213/65 , C07D239/36 , C07D241/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D403/06
CPC分类号： C07D401/12 , C07D403/12
摘要： A series of novel alkoxypyridin-4-yl and alkoxypyrimidin-4-yl derivatives of indol-3-ylalkylpiperazines of Formula I are intended to be useful agents ##STR1## for alleviation of vascular headache on the basis of their potent affinity and agonist activity at 5-HT1D binding sites.
摘要翻译：式I的吲哚-3-基烷基哌嗪的一系列新的烷氧基吡啶-4-基和烷氧基嘧啶-4-基衍生物是基于它们在5-HT1D结合位点上的有效亲和力和激动剂活性而成为有用的试剂。

9. 发明申请

US20130283639A1 DEVICE FOR RAPIDLY SECURING AND OBSCURING FOOTWEAR LACES 审中-公开
标题翻译：快速安全和装备足球鞋的设备
公开(公告)号：US20130283639A1
公开(公告)日：2013-10-31
申请号：US13627115
申请日：2012-09-26
申请人： Andrew Williams , Peter Christoper Foster
发明人： Andrew Williams , Peter Christoper Foster
IPC分类号： A43C7/00
CPC分类号： A43C7/00 , A43B1/0081 , A43C7/02 , A43C11/1493
摘要： A device for rapidly securing and obscuring footwear laces includes a strap having a cinching device such as a cord lock; a plurality of tubular lace restraints along the length of the strap; and a means for connecting one end of the strap to the other, so as to secure the device around a wearer's ankle with the laces obscured beneath. Laces travel the majority of the length of the strap, and can stay engaged with the laces even when footwear is not being worn. A user can insert foot into footwear, tighten laces by pulling on ends, cinch laces in tightened position by engaging cinching device, wrap strap with laces around ankle, and secure in place around ankle or ankle of footwear.
摘要翻译：用于快速固定和遮蔽鞋带的装置包括具有收紧装置（例如绳索）的带子; 沿着带的长度的多个管状花边约束; 以及用于将带的一端连接到另一端的装置，以便将装置固定在佩戴者的脚踝周围，鞋带在下方隐藏。鞋带旅行大部分长度的表带，即使没有穿鞋子，也可以与鞋带保持接触。用户可以将脚插入鞋类，通过拉动端部来收紧鞋带，通过接合收紧装置收紧紧固的位置，将绑带与鞋带缠绕在脚踝周围，并固定在脚踝或脚踝附近。

10. 发明申请

US20120306147A1 DUAL NIP MULTI-FEED DETECTION AND CONTROL SYSTEM 有权
标题翻译：双核多进制检测和控制系统
公开(公告)号：US20120306147A1
公开(公告)日：2012-12-06
申请号：US13585879
申请日：2012-08-15
申请人： Nicholas Baxter , Andrew Hill , Andrew Ashwood , Nicholas Gates , Robert Sanders , Andrew Williams
发明人： Nicholas Baxter , Andrew Hill , Andrew Ashwood , Nicholas Gates , Robert Sanders , Andrew Williams
IPC分类号： B65H7/02 , B65H5/06
CPC分类号： G03G15/6511 , B41J11/0095 , B41J13/0018 , B65H5/062 , B65H7/12 , B65H2220/09 , B65H2301/44514 , B65H2404/14 , B65H2404/632 , B65H2511/524 , B65H2513/41 , G03G2215/00396 , G03G2215/004 , B65H2220/01 , B65H2220/02 , B65H2220/11
摘要： A paper feed system for use in a printing apparatus that detects multi-feeds and separates all sheets while allowing a single sheet to continue into the machine includes a nip with a drive roller for feeding sheets. A reversible pressure roller downstream of the drive roller is connected to a motor, but idles in the direction of the paper feed in normal operation. When a multi-feed is detected, the motor is turned ON and the reversible pressure roll actuated by a controller. The reversible pressure roller has more friction with the sheet in its contact than the friction between sheets. This drives the sheet in contact backwards.
摘要翻译：用于在允许单张纸继续进入机器的同时检测多次进给和分离所有片材的打印设备中的进纸系统包括具有用于进给纸张的驱动辊的辊隙。驱动辊下游的可逆压力辊连接到电动机，但在正常操作中在供纸方向空转。当检测到多进给时，马达被打开，可逆压力辊由控制器启动。可逆压力辊与片材在接触时的摩擦力大于片材之间的摩擦力。这会使纸张向后移动。

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