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1. 发明授权

US06635635B2 Benzothiadiazine compounds 失效
标题翻译：苯并噻二嗪化合物
公开(公告)号：US06635635B2
公开(公告)日：2003-10-21
申请号：US09916479
申请日：2001-07-27
申请人： Alex Cordi , Patrice Desos , François Lefoulon , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , François Lefoulon , Pierre Lestage
IPC分类号： C07D51304
CPC分类号： C07D513/04
摘要： Compound of formula (I): wherein: R1 represents hydroxy, RCO—O— or RCO—NRa—, R2 represents hydrogen, halogen, or hydroxy, R′CO—O or R′CO—NR′a—, R and R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, Ra and R′a, which may be identical or different, represent hydrogen or linear or branched (C1-C6)alkyl, linear or branched (C1-C6)perhaloalkyl, linear or branched (C1-C6)acyl, aryl or heteroaryl, its isomer and addition salts thereof with a pharmaceutically acceptable acid or base and medicinal products containing the same are useful as AMPA modulators.
摘要翻译：式（I）化合物：其中：R1代表羟基，RCO-O-或RCO-NRa-，R2代表氢，卤素或羟基，R'CO-O或R'CO-NR'a-，R和R （C 1 -C 6）烷基，任选被芳基，直链或支链（C 1 -C 6）全卤代烷基取代的直链或支链（C 1 -C 6）烷基，任选被芳基，直链或支链（C 2 -C 6） -C 7）环烷基，金刚烷基，芳基或杂芳基，R a和R a可以相同或不同，表示氢或直链或支链（C1-C6）烷基，直链或支链（C1-C6）全卤代烷基，直链或支链（C 1 -C 6）酰基，芳基或杂芳基，其异构体和其药学上可接受的酸或碱的加成盐和含有它们的药物可用作AMPA调节剂。

2. 发明授权

US06486143B2 6-amino- or 6-hydrazino-sulphonyl-3-quinolynyl-phosphonic acid compounds 失效
标题翻译： 6-氨基或6-肼基磺酰基-3-喹啉基 - 膦酸化合物
公开(公告)号：US06486143B2
公开(公告)日：2002-11-26
申请号：US09784632
申请日：2001-02-15
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： A61K31675
CPC分类号： C07F9/60
摘要： The invention relates to a compound of formula (I): wherein: R1 represents halogen or a group CF3, R2 represents hydrogen or alkyl or cycloalkyl, R3 is as defined in the description, R4 and R5 represent hydrogen or alkyl, cycloalkyl, aryl or arylalkyl a group Medicaments.
摘要翻译：本发明涉及式（I）化合物：其中：R 1表示卤素或基团CF 3，R 2表示氢或烷基或环烷基，R 3如说明书中所定义，R 4和R 5表示氢或烷基，环烷基，芳基或芳基烷基一个基团。

3. 发明授权

US07423034B2 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US07423034B2
公开(公告)日：2008-09-09
申请号：US11823439
申请日：2007-06-27
申请人： Patrice Desos , Alex Cordi , Pierre Lestage
发明人： Patrice Desos , Alex Cordi , Pierre Lestage
IPC分类号： C07D285/22 , A61K31/5415 , A61P25/24
CPC分类号： C07D513/04
摘要： Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, X is as defined in the description, their isomers, and also addition salts thereof. Medicinal products containing the same which are useful in treating disorders of the AMPA system.
摘要翻译：式（I）的化合物：其中：R 1表示氢，卤素或烷基，R 1a表示氢或烷基，R 2表示氢，卤素或羟基，A表示NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，X 如说明书中所定义，它们的异构体及其加成盐。含有该药物的药物可用于治疗AMPA系统的病症。

4. 发明申请

US20070249594A1 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US20070249594A1
公开(公告)日：2007-10-25
申请号：US11823439
申请日：2007-06-27
申请人： Patrice Desos , Alex Cordi , Pierre Lestage
发明人： Patrice Desos , Alex Cordi , Pierre Lestage
IPC分类号： A61K31/549 , A61K31/554 , C07D279/16 , C07D285/22
CPC分类号： C07D513/04
摘要： Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, X is as defined in the description, their isomers, and also addition salts thereof. Medicinal products containing the same which are useful in treating disorders of the AMPA system.
摘要翻译：式（I）的化合物：其中：R 1表示氢，卤素或烷基，R 1a表示氢或烷基，R 2表示氢，卤素或羟基，A表示NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，X 如说明书中所定义，它们的异构体及其加成盐。含有该药物的药物可用于治疗AMPA系统的病症。

5. 发明授权

US07250411B2 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US07250411B2
公开(公告)日：2007-07-31
申请号：US10499082
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： C07D285/22 , A61K31/5415 , A61P25/24
CPC分类号： C07D285/24 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl,their isomers and also their addition salts with a pharmaceutically acceptable acid or base.Medicaments.
摘要翻译：式（I）化合物：其中：R 1表示羟基或RCO-O-，R 2表示氢，卤素，羟基或R'CO-O，R， R'可以相同或不同，表示直链或支链（C 1 -C 6 -C 6）烷基，其任选被直链或支链的芳基（C 2 任选被芳基，直链或支链（C 1 -C 6 -C 6）全卤代烷基取代的（C 1 -C 6 - 金刚烷基，芳基或杂芳基，R 3表示直链或支链（C 1 -C 3）烷基的氢， C 1 -C 6烷基或（C 3 -C 7 -C 7）环烷基，A表示CR 4 R 7， R 5或NR 4，R 4表示氢或直链或支链（C 1 -C 6 - /它们的异构体，以及它们与药学上可接受的酸或碱的加成盐。药剂

6. 发明申请

US20050014744A1 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US20050014744A1
公开(公告)日：2005-01-20
申请号：US10499082
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： A61K31/5415 , A61K31/549 , A61P9/10 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07B61/00 , C07D279/02 , C07D285/24 , C07D279/16 , C07D285/22
CPC分类号： C07D285/24 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl, their isomers and also their addition salts with a pharmaceutically acceptable acid or base. Medicaments.
摘要翻译：式（I）化合物：其中：R 1表示羟基或RCO-O-，R 2表示氢，卤素，羟基或R'CO-O，R，R'可以相同或不同，表示直链或支链任选被芳基，直链或支链（C1-C6）全卤代烷基，（C3-C7）环烷基，金刚烷基，芳基或杂芳基取代的直链或支链（C2-C6）烯基取代的-C6-烷基，R3代表氢，直链或支链（C1-C6）烷基或（C3-C7）环烷基，A表示CR4R5或NR4，R4表示氢或直链或支链（C1-C6）烷基，它们的异构体，以及它们与药学上可接受的酸的加成盐或基础。药剂

7. 发明授权

US07253162B2 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US07253162B2
公开(公告)日：2007-08-07
申请号：US10865184
申请日：2004-06-10
申请人： Patrice Desos , Alex Cordi , Pierre Lestage
发明人： Patrice Desos , Alex Cordi , Pierre Lestage
IPC分类号： C07D513/04 , A61K31/542 , A61P25/24
CPC分类号： C07D513/04
摘要： Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with the adjacent —CHR3—, forms the ring wherein m represents 1, 2 or 3, R5 represents hydrogen or a halogen, X is as defined in the description, their isomers, and also addition salts thereof.
摘要翻译：式（I）的化合物：其中：R 1表示氢，卤素或烷基，R 1a表示氢或烷基，R 2表示氢，卤素或羟基，A表示CR 4 R 5或NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，或A表示氮，并且与相邻的-CHR 3 - 一起形成环，其中m表示1,2或 3，R 5表示氢或卤素，X如说明书中所定义，它们的异构体及其加成盐。

8. 发明申请

US20050065146A1 Novel benzothiazine and benzothiadiazine derivatives, method for preparing same and pharmaceutical compositions containing same 失效
标题翻译：新的苯并噻嗪和苯并噻二嗪衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US20050065146A1
公开(公告)日：2005-03-24
申请号：US10499164
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： C07D285/24 , A61K31/549 , A61P25/00 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , C07D279/02 , C07D513/04 , C07D498/04
CPC分类号： C07D513/04 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents aryl or heteroaryl, R2 represents hydrogen, halogen or hydroxy, X represents oxygen or sulphur, Y represents oxygen, sulphur or NR wherein R represents hydrogen or alkyl, A represents CR4R5 or NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, or A represents nitrogen and, together with adjacent —CHR3—, forms the ring wherein m represents 1, 2 or 3, R5 represents hydrogen or halogen, their isomers and also their addition salts Medicaments.
摘要翻译：式（I）化合物：其中：R1表示芳基或杂芳基，R2表示氢，卤素或羟基，X表示氧或硫，Y表示氧，硫或NR，其中R表示氢或烷基，A表示CR4R5或NR4，R3 表示氢，烷基或环烷基，R 4表示氢或烷基，或A表示氮，并且与相邻的-CHR 3一起形成环，其中m表示1,2或3，R 5表示氢或卤素，它们的异构体及其加成盐药物。

9. 发明授权

US06596709B1 6-sulphanoyl-3-quinolylphosphonic acid compounds 失效
标题翻译： 6-氨磺酰基-3-喹啉基膦酸化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US06596709B1
公开(公告)日：2003-07-22
申请号：US10314509
申请日：2002-12-09
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： A61K31675
CPC分类号： C07F9/60 , Y10S514/878 , Y10S514/879 , Y10S514/907
摘要： The invention relates to a compound of formula (I): wherein: X represents chlorine or fluorine or CF3, R represents hydrogen or a group and methods for using the same.
摘要翻译：本发明涉及式（I）化合物：其中：X表示氯或氟或CF 3，R表示氢或一个基团，以及使用该化合物的方法。

10. 发明授权

US5776949A 2-(1H) quinolinone compounds 失效
标题翻译： 2-（1H）喹啉酮化合物
公开(公告)号：US5776949A
公开(公告)日：1998-07-07
申请号：US889920
申请日：1997-07-10
申请人： Alex Cordi , Patrice Desos , Jean Lepagnol , Philippe Morain , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Jean Lepagnol , Philippe Morain , Pierre Lestage
IPC分类号： A61K31/47 , A61P9/00 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07D215/36 , C07D401/04 , C07D471/04 , C07D521/00
CPC分类号： C07D231/12 , C07D215/36 , C07D233/56 , C07D249/08 , C07D401/04 , C07D471/04
摘要： A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, R.sub.3, which are identical or different, represent hydrogen, halogen, alkyl, nitro, cyano, aminosulfonyl, imidazolyl, or pyrrolyl, or alternatively, when two of them are situated on adjacent carbons, may form with the carbon atoms to which they are attached a benzene ring on C.sub.3 -C.sub.7 cyloalkyl R.sub.4 represents hydroxyl, alkoxy, phenoxy, or amino, their isomers as well as their addition salts with a pharmaceutically-acceptable base, and medicinal products containing the same which are useful as inhibitors of the the pathological phenomena linked to hyperactivation of the neurotransmission pathways by the excitatory amino acids.
摘要翻译：式（I）化合物：其中：R 1，R 2，R 3相同或不同，表示氢，卤素，烷基，硝基，氰基，氨基磺酰基，咪唑基或吡咯基，或者，当它们中的两个位于相邻的碳上时，可以与它们所连接的碳原子一起形成C3-C7环烷基上的苯环R4表示羟基，烷氧基，苯氧基或氨基，它们的异构体以及它们与药学上可接受的碱和含有它们的药物，其可用作与兴奋性氨基酸对神经传递途径的过度活化有关的病理现象的抑制剂。

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