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1. 发明申请

US20060258670A1 New phenylpyridylpiperazine compounds 失效
标题翻译：新苯基吡啶基哌嗪化合物
公开(公告)号：US20060258670A1
公开(公告)日：2006-11-16
申请号：US11432250
申请日：2006-05-11
申请人： Patrice Desos , Alexis Cordi , Pierre Lestage
发明人： Patrice Desos , Alexis Cordi , Pierre Lestage
IPC分类号： A61K31/496 , C07D403/04
CPC分类号： C07D213/74
摘要： A compound selected from those of formula (I): wherein: X represents a C(O) or SO2 group, R1 represents an aryl group or a group NR3R4 wherein R3 and R4 are as defined in the description, R2 represents an alkyl, (C3-C8)cycloalkyl or (C3-C8)cycloalkyl-(C1-C6)alkyl group, its isomers, and addition salts thereof, and medicinal products containing the same which are useful in treating conditions treatable by antagonists of type H3 central histamine receptors.
摘要翻译：选自式（I）的化合物的化合物：其中：X表示C（O）或SO 2 H 2基团，R 1表示芳基或NR 其中R 3和R 4如在说明书中所定义，R 2，R 3，R 3，R 4，（C 1 -C 3 -C 8）环烷基或（C 3 -C 8 -C 8）环烷基或（C 3 -C 3 -C 8）烷基，环烷基 - （C 1 -C 6 -C 6）烷基，其异构体及其加成盐，以及含有它们的药物，可用于治疗由拮抗剂治疗的病症 H 3型中枢组胺受体。

2. 发明授权

US06486143B2 6-amino- or 6-hydrazino-sulphonyl-3-quinolynyl-phosphonic acid compounds 失效
标题翻译： 6-氨基或6-肼基磺酰基-3-喹啉基 - 膦酸化合物
公开(公告)号：US06486143B2
公开(公告)日：2002-11-26
申请号：US09784632
申请日：2001-02-15
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： A61K31675
CPC分类号： C07F9/60
摘要： The invention relates to a compound of formula (I): wherein: R1 represents halogen or a group CF3, R2 represents hydrogen or alkyl or cycloalkyl, R3 is as defined in the description, R4 and R5 represent hydrogen or alkyl, cycloalkyl, aryl or arylalkyl a group Medicaments.
摘要翻译：本发明涉及式（I）化合物：其中：R 1表示卤素或基团CF 3，R 2表示氢或烷基或环烷基，R 3如说明书中所定义，R 4和R 5表示氢或烷基，环烷基，芳基或芳基烷基一个基团。

3. 发明授权

US5670493A Aminophenylphosphonic acid compounds 失效
标题翻译：氨基苯膦酸化合物
公开(公告)号：US5670493A
公开(公告)日：1997-09-23
申请号：US684469
申请日：1996-07-19
申请人： Alex Cordi , Patrice Desos , Angela D. Morris , Ghanem Atassi
发明人： Alex Cordi , Patrice Desos , Angela D. Morris , Ghanem Atassi
IPC分类号： A61K31/66 , A61K31/665 , A61K31/67 , A61K31/675 , A61P27/02 , A61P35/00 , C07F9/38 , C07F9/40 , C07F9/572 , C07F9/655 , C07F9/6553
CPC分类号： C07F9/655345 , C07F9/3834 , C07F9/3882 , C07F9/4021 , C07F9/5728 , C07F9/65515
摘要： A compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2, which may be identical or different, represent hydrogen or halogen, or alkyl, alkoxy, nitro or trihalomethyl, X represents CO, SO.sub.2 or CH.sub.2, A.sub.1 represents any one of the groups as defined in the description, A.sub.2 represents --(CH.sub.2).sub.n or --CH.dbd.CH--, R.sub.3, R.sub.4, which may be identical or different, represent hydrogen or alkyl, its isomers as well as its addition salts with a pharmaceutically acceptable base and medicinal product containing the same are useful as angiogenesis inhibitors.
摘要翻译：式（I）化合物：其中：R 1，R 2可以相同或不同，表示氢或卤素，或烷基，烷氧基，硝基或三卤甲基，X表示CO，SO 2或CH 2， A1表示说明书中定义的任何一个基团，A 2表示 - （CH 2）n或-CH = CH-，R 3，R 4可以相同或不同，表示氢或烷基，其异构体及其加成与药学上可接受的碱的盐和含有它们的药物可用作血管发生抑制剂。

4. 发明申请

US20070249594A1 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US20070249594A1
公开(公告)日：2007-10-25
申请号：US11823439
申请日：2007-06-27
申请人： Patrice Desos , Alex Cordi , Pierre Lestage
发明人： Patrice Desos , Alex Cordi , Pierre Lestage
IPC分类号： A61K31/549 , A61K31/554 , C07D279/16 , C07D285/22
CPC分类号： C07D513/04
摘要： Compounds of formula (I): wherein: R1 represents hydrogen, a halogen or alkyl, R1a represents hydrogen or alkyl, R2 represents hydrogen, a halogen or hydroxy, A represents NR4, R3 represents hydrogen, alkyl or cycloalkyl, R4 represents hydrogen or alkyl, X is as defined in the description, their isomers, and also addition salts thereof. Medicinal products containing the same which are useful in treating disorders of the AMPA system.
摘要翻译：式（I）的化合物：其中：R 1表示氢，卤素或烷基，R 1a表示氢或烷基，R 2表示氢，卤素或羟基，A表示NR 4，R 3表示氢，烷基或环烷基，R 4表示氢或烷基，X 如说明书中所定义，它们的异构体及其加成盐。含有该药物的药物可用于治疗AMPA系统的病症。

5. 发明授权

US07262190B2 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US07262190B2
公开(公告)日：2007-08-28
申请号：US11297260
申请日：2005-12-08
申请人： Patrice Desos , Alexis Cordi , Pierre Lestage , Laurence Danober
发明人： Patrice Desos , Alexis Cordi , Pierre Lestage , Laurence Danober
IPC分类号： C07D513/04 , C07D285/26 , A61K31/542 , A61P25/24
CPC分类号： C07D513/04
摘要： The invention relates to compounds of formula (I): wherein: R1 represents hydrogen, alkyl or cycloalkyl, R2 represents hydrogen, halogen or hydroxy, A represents CR3R4 or NR3 wherein R3 and R4 are as defined in the description, Y represents an alkylene chain as described in the description, X represents NR5R6, S(O)nR7, OR8, C(O)R9, amidino or a heterocycle, their isomers, and addition salts thereof; and medicinal products containing the same which are useful in the prevention or treatment of diseases associated with AMPA flux.
摘要翻译：本发明涉及式（I）的化合物：其中：R 1表示氢，烷基或环烷基，R 2表示氢，卤素或羟基，A表示CR

6. 发明授权

US07250411B2 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US07250411B2
公开(公告)日：2007-07-31
申请号：US10499082
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： C07D285/22 , A61K31/5415 , A61P25/24
CPC分类号： C07D285/24 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl,their isomers and also their addition salts with a pharmaceutically acceptable acid or base.Medicaments.
摘要翻译：式（I）化合物：其中：R 1表示羟基或RCO-O-，R 2表示氢，卤素，羟基或R'CO-O，R， R'可以相同或不同，表示直链或支链（C 1 -C 6 -C 6）烷基，其任选被直链或支链的芳基（C 2 任选被芳基，直链或支链（C 1 -C 6 -C 6）全卤代烷基取代的（C 1 -C 6 - 金刚烷基，芳基或杂芳基，R 3表示直链或支链（C 1 -C 3）烷基的氢， C 1 -C 6烷基或（C 3 -C 7 -C 7）环烷基，A表示CR 4 R 7， R 5或NR 4，R 4表示氢或直链或支链（C 1 -C 6 - /它们的异构体，以及它们与药学上可接受的酸或碱的加成盐。药剂

7. 发明申请

US20050014744A1 Benzothiazine and benzothiadiazine compounds 失效
标题翻译：苯并噻嗪和苯并噻二嗪化合物
公开(公告)号：US20050014744A1
公开(公告)日：2005-01-20
申请号：US10499082
申请日：2002-12-20
申请人： Alex Cordi , Patrice Desos , Pierre Lestage
发明人： Alex Cordi , Patrice Desos , Pierre Lestage
IPC分类号： A61K31/5415 , A61K31/549 , A61P9/10 , A61P25/08 , A61P25/14 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P43/00 , C07B61/00 , C07D279/02 , C07D285/24 , C07D279/16 , C07D285/22
CPC分类号： C07D285/24 , C07D279/02
摘要： Compounds of formula (I): wherein: R1 represents hydroxy or RCO—O—, R2 represents hydrogen, halogen, hydroxy or R′CO—O, R, R′, which may be identical or different, represent linear or branched (C1-C6)alkyl optionally substituted by aryl, linear or branched (C2-C6)alkenyl optionally substituted by aryl, linear or branched (C1-C6)perhaloalkyl, (C3-C7)cycloalkyl, adamantyl, aryl or heteroaryl, R3 represents hydrogen, linear or branched (C1-C6)alkyl or (C3-C7)cycloalkyl, A represents CR4R5 or NR4, R4 represents hydrogen or linear or branched (C1-C6)alkyl, their isomers and also their addition salts with a pharmaceutically acceptable acid or base. Medicaments.
摘要翻译：式（I）化合物：其中：R 1表示羟基或RCO-O-，R 2表示氢，卤素，羟基或R'CO-O，R，R'可以相同或不同，表示直链或支链任选被芳基，直链或支链（C1-C6）全卤代烷基，（C3-C7）环烷基，金刚烷基，芳基或杂芳基取代的直链或支链（C2-C6）烯基取代的-C6-烷基，R3代表氢，直链或支链（C1-C6）烷基或（C3-C7）环烷基，A表示CR4R5或NR4，R4表示氢或直链或支链（C1-C6）烷基，它们的异构体，以及它们与药学上可接受的酸的加成盐或基础。药剂

8. 发明授权

US5646132A 2(1H)-quinolone compounds 失效
标题翻译： 2（1H） - 喹诺酮化合物
公开(公告)号：US5646132A
公开(公告)日：1997-07-08
申请号：US499946
申请日：1995-07-10
申请人： Alex Cordi , Patrice Desos , Jean Lepagnol
发明人： Alex Cordi , Patrice Desos , Jean Lepagnol
IPC分类号： A61K31/675 , A61P25/00 , A61P25/08 , A61P25/18 , A61P25/28 , A61P43/00 , C07F9/576 , C07F9/60
CPC分类号： C07F9/5765 , C07F9/60
摘要： Compound of formula (I): ##STR1## in which: R.sub.1, R.sub.2 and R.sub.3, which are identical or different, represent hydrogen or halogen or alkyl, nitro, cyano or aminosulfonyl, or alternatively, when two of them are located on adjacent carbons, form, with the carbon atoms to which they are attached, (C.sub.3 -C.sub.7) cycloalkyl ring or substituted or unsubstituted benzene ring,R.sub.4 represents hydrogen, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or a group ##STR2## in which R.sub.6 and R.sub.7, which are identical or different, represent hydrogen or substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl,R.sub.5 represents hydrogen, hydroxyl, linear or branched (C.sub.1 -C.sub.6) alkoxy, phenoxy, mercapto, linear or branched (C.sub.1 -C.sub.6) alkylthio, substituted or unsubstituted, linear or branched (C.sub.1 -C.sub.6) alkyl, substituted or unsubstituted phenyl or substituted or unsubstituted amino, or a group ##STR3## in which R.sub.6 and R.sub.7 are as defined above, their isomers as well as their addition salts with a pharmaceutically acceptable acid or base, and medicinal product containing the same are useful as inhibitor of the pathological phenomena associated with hyperactivation of the excitating amino acid-dependant pathways of neurotransmission.
摘要翻译：式（I）化合物：其中：R 1，R 2和R 3相同或不同，表示氢或卤素或烷基，硝基，氰基或氨基磺酰基，或者当其中两个位于（C 3 -C 7）环烷基环或取代或未取代的苯环，R 4表示氢，直链或支链（C 1 -C 6）烷基，取代或未取代的苯基或取代或未取代的苯基基团其中R6和R7相同或不同，表示氢或取代或未取代的直链或支链（C1-C6）烷基，R5表示氢，羟基，直链或支链（C1-C6）烷氧基，苯氧基（C1-C6）烷基，取代或未取代的直链或支链（C1-C6）烷基，取代或未取代的苯基或取代或未取代的氨基，或其中R6和R7为它们的异构体以及它们与药物的加成盐可接受的酸或碱，以及含有它们的药物可用作与神经传递的兴奋性氨基酸依赖性途径的高活化相关的病理现象的抑制剂。

9. 发明授权

US07494995B2 Phenylpyridylpiperazine compounds 失效
标题翻译：苯基吡啶基哌嗪化合物
公开(公告)号：US07494995B2
公开(公告)日：2009-02-24
申请号：US11432787
申请日：2006-05-11
申请人： Patrice Desos , Alexis Cordi , Pierre Lestage
发明人： Patrice Desos , Alexis Cordi , Pierre Lestage
IPC分类号： A61K31/4418 , C07D213/72 , C07D213/74
CPC分类号： C07D213/74
摘要： A compound selected from those of formula (I): wherein: R1 represents an NR3SO2R4 group wherein: R3 represents a hydrogen atom or an alkyl group, R4 represents an alkyl group, aryl group or NR5R6 group, R2 represents an alkyl, cycloalkyl or cycloalkylalkyl group, and medicinal products containing the same which are useful in treating conditions treatable by antagonists of type H3 central histamine receptors.
摘要翻译：选自式（I）的化合物：其中：R1表示NR3SO2R4基团，其中：R3表示氢原子或烷基，R4表示烷基，芳基或NR5R6基团，R2表示烷基，环烷基或环烷基烷基组和含有该组合物的药物，可用于治疗由H3型中枢组胺受体的拮抗剂治疗的病症。

10. 发明授权

US07494994B2 Phenylpyridylpiperazine compounds 失效
标题翻译：苯基吡啶基哌嗪化合物
公开(公告)号：US07494994B2
公开(公告)日：2009-02-24
申请号：US11432250
申请日：2006-05-11
申请人： Patrice Desos , Alexis Cordi , Pierre Lestage
发明人： Patrice Desos , Alexis Cordi , Pierre Lestage
IPC分类号： A61K31/4418 , C07D213/72 , C07D213/74
CPC分类号： C07D213/74
摘要： A compound selected from those of formula (I): wherein: X represents a C(O) or SO2 group, R1 represents an aryl group or a group NR3R4 wherein R3 and R4 are as defined in the description, R2 represents an alkyl, (C3-C8)cycloalkyl or (C3-C8)cycloalkyl-(C1-C6)alkyl group, its isomers, and addition salts thereof, and medicinal products containing the same which are useful in treating conditions treatable by antagonists of type H3 central histamine receptors.
摘要翻译：选自式（I）的化合物：其中：X表示C（O）或SO 2基团，R 1表示芳基或NR 3 R 4，其中R 3和R 4如说明书中所定义，R 2表示烷基（ C 3 -C 8）环烷基或（C 3 -C 8）环烷基 - （C 1 -C 6）烷基，其异构体及其加成盐，以及含有它们的药物，可用于治疗由H3型中枢组胺受体。

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