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1. 发明授权

US06979816B2 Multi-source ion funnel 有权
标题翻译：多源离子漏斗
公开(公告)号：US06979816B2
公开(公告)日：2005-12-27
申请号：US10400356
申请日：2003-03-25
申请人： Keqi Tang , Mikhail B. Belov , Aleksey V. Tolmachev , Harold R. Udseth , Richard D. Smith
发明人： Keqi Tang , Mikhail B. Belov , Aleksey V. Tolmachev , Harold R. Udseth , Richard D. Smith
IPC分类号： H01J49/06 , H01J49/42 , H01J49/04
CPC分类号： H01J49/066 , H01J49/107 , H01J49/165
摘要： A method for introducing ions generated in a region of relatively high pressure into a region of relatively low pressure by providing at least two electrospray ion sources, providing at least two capillary inlets configured to direct ions generated by the electrospray sources into and through each of the capillary inlets, providing at least two sets of primary elements having apertures, each set of elements having a receiving end and an emitting end, the primary sets of elements configured to receive a ions from the capillary inlets at the receiving ends, and providing a secondary set of elements having apertures having a receiving end and an emitting end, the secondary set of elements configured to receive said ions from the emitting end of the primary sets of elements and emit said ions from said emitting end of the secondary set of elements. The method may further include the step of providing at least one jet disturber positioned within at least one of the sets of primary elements, providing a voltage, such as a dc voltage, in the jet disturber, thereby adjusting the transmission of ions through at least one of the sets of primary elements.
摘要翻译：一种通过提供至少两个电喷雾离子源将相对较高压力区域产生的离子引入至少两个电喷雾离子源的方法，提供至少两个毛细管入口，其构造成将由电喷雾源产生的离子引入和穿过每个毛细管入口，提供具有孔的至少两组主要元件，每组元件具有接收端和发射端，所述主要元件组被配置为在接收端处从毛细管入口接收离子，并且提供次级具有孔的一组元件具有接收端和发射端，所述次级元件被配置为从所述主要元件组的发射端接收所述离子，并从所述次级元件组的所述发射端发射所述离子。该方法还可以包括提供位于主要元件组中的至少一个中的至少一个喷射干燥器的步骤，在喷射干燥器中提供诸如直流电压的电压，从而通过至少调节离子的透过率其中一个主要元素。

2. 发明授权

US07351964B2 Ion funnel with extended mass range and reduced conductance limit aperture 失效
标题翻译：离子漏斗具有扩展的质量范围和减小的电导限制孔径
公开(公告)号：US07351964B2
公开(公告)日：2008-04-01
申请号：US11251528
申请日：2005-09-30
申请人： Aleksey V. Tolmachev , Richard D. Smith
发明人： Aleksey V. Tolmachev , Richard D. Smith
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/067 , H01J49/066
摘要： An improved ion funnel design is disclosed that decreases the axial RF (parasite) fields at the ion funnel exit. This is achieved by addition of one or more compensation electrodes after the conductance limit electrode. Various RF voltage profiles may be applied to the various electrodes minimizing the parasite axial potential wells. The smallest RF aperture that serves as the conductance limiting electrode is further reduced over standard designs. Overall, the ion funnel improves transmission ranges of both low m/z and high m/z ions, reducing RF activation of ions and decreasing the gas load to subsequent differential pumping stages.
摘要翻译：公开了一种改进的离子漏斗设计，其减少了离子漏斗出口处的轴向RF（寄生）场。这是通过在电导限制电极之后添加一个或多个补偿电极来实现的。各种RF电压分布可以被施加到使寄生虫轴向势阱最小化的各种电极。用作电导限制电极的最小RF孔径比标准设计进一步降低。总的来说，离子漏斗改善了低m / z和高m / z离子的透射范围，减少了离子的RF激发，并将气体负载降低到随后的差动泵送阶段。

3. 发明授权

US07499807B1 Methods for recalibration of mass spectrometry data 失效
标题翻译：重新校准质谱数据的方法
公开(公告)号：US07499807B1
公开(公告)日：2009-03-03
申请号：US11524028
申请日：2006-09-19
申请人： Aleksey V. Tolmachev , Richard D. Smith
发明人： Aleksey V. Tolmachev , Richard D. Smith
IPC分类号： G06F3/00
CPC分类号： H01J49/0009
摘要： Disclosed are methods for recalibrating mass spectrometry data that provide improvement in both mass accuracy and precision by adjusting for experimental variance in parameters that have a substantial impact on mass measurement accuracy. Optimal coefficients are determined using correlated pairs of mass values compiled by matching sets of measured and putative mass values that minimize overall effective mass error and mass error spread. Coefficients are subsequently used to correct mass values for peaks detected in the measured dataset, providing recalibration thereof. Sub-ppm mass measurement accuracy has been demonstrated on a complex fungal proteome after recalibration, providing improved confidence for peptide identifications.
摘要翻译：公开了重新校准质谱数据的方法，其通过调整对质量测量精度具有实质性影响的参数的实验方差来提高质量精度和精度。使用通过匹配集合的测量和推定质量值编译的相关质量值对来确定最优系数，从而使总体有效质量误差和质量误差扩展最小化。随后使用系数来校正在测量数据集中检测到的峰的质量值，从而提供其重新校准。在重新校准后，在复杂的真菌蛋白质组上已经证明了亚ppm质量测量精度，为肽鉴定提供了改进的置信度。

4. 发明申请

US20090048797A1 METHODS FOR RECALIBRATION OF MASS SPECTROMETRY DATA 失效
标题翻译：用于测量质谱数据的方法
公开(公告)号：US20090048797A1
公开(公告)日：2009-02-19
申请号：US11524028
申请日：2006-09-19
申请人： Aleksey V. Tolmachev , Richard D. Smith
发明人： Aleksey V. Tolmachev , Richard D. Smith
IPC分类号： G06F19/00
CPC分类号： H01J49/0009
摘要： Disclosed are methods for recalibrating mass spectrometry data that provide improvement in both mass accuracy and precision by adjusting for experimental variance in parameters that have a substantial impact on mass measurement accuracy. Optimal coefficients are determined using correlated pairs of mass values compiled by matching sets of measured and putative mass values that minimize overall effective mass error and mass error spread. Coefficients are subsequently used to correct mass values for peaks detected in the measured dataset, providing recalibration thereof. Sub-ppm mass measurement accuracy has been demonstrated on a complex fungal proteome after recalibration, providing improved confidence for peptide identifications.
摘要翻译：公开了重新校准质谱数据的方法，其通过调整对质量测量精度具有实质性影响的参数的实验方差来提高质量精度和精度。使用通过匹配集合的测量和推定质量值编译的相关质量值对来确定最优系数，从而使总体有效质量误差和质量误差扩展最小化。随后使用系数来校正在测量数据集中检测到的峰的质量值，从而提供其重新校准。在重新校准后，在复杂的真菌蛋白质组上已经证明了亚ppm质量测量精度，为肽鉴定提供了改进的置信度。

5. 发明申请

US20080054178A1 ION FUNNEL WITH EXTENDED MASS RANGE AND REDUCED CONDUCTANCE LIMIT APERTURE 失效
标题翻译：具有扩展质量范围和减少导线限制光圈的离子风机
公开(公告)号：US20080054178A1
公开(公告)日：2008-03-06
申请号：US11251528
申请日：2005-09-30
申请人： Aleksey V. Tolmachev , Richard D. Smith
发明人： Aleksey V. Tolmachev , Richard D. Smith
IPC分类号： H01J49/42
CPC分类号： H01J49/067 , H01J49/066
摘要： An improved ion funnel design is disclosed that decreases the axial RF (parasite) fields at the ion funnel exit. This is achieved by addition of one or more compensation electrodes after the conductance limit electrode. Various RF voltage profiles may be applied to the various electrodes minimizing the parasite axial potential wells. The smallest RF aperture that serves as the conductance limiting electrode is further reduced over standard designs. Overall, the ion funnel improves transmission ranges of both low m/z and high m/z ions, reducing RF activation of ions and decreasing the gas load to subsequent differential pumping stages.
摘要翻译：公开了一种改进的离子漏斗设计，其减少了离子漏斗出口处的轴向RF（寄生）场。这是通过在电导限制电极之后添加一个或多个补偿电极来实现的。各种RF电压分布可以被施加到使寄生虫轴向势阱最小化的各种电极。用作电导限制电极的最小RF孔径比标准设计进一步降低。总的来说，离子漏斗改善了低m / z和高m / z离子的透射范围，减少了离子的RF激发，并将气体负载降低到随后的差动泵送阶段。

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