专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06312693B1 Antibodies against human CD40 有权
标题翻译：针对人CD40的抗体
公开(公告)号：US06312693B1
公开(公告)日：2001-11-06
申请号：US09247352
申请日：1999-02-10
申请人： Alejandro A. Aruffo , Diane Hollenbaugh , Anthony W. Siadak , Karen K. Berry , Linda Harris , Barbara A. Thorne , Jurgen Bajorath , William D. Huse , Herren Wu , Jeffry D. Watkins
发明人： Alejandro A. Aruffo , Diane Hollenbaugh , Anthony W. Siadak , Karen K. Berry , Linda Harris , Barbara A. Thorne , Jurgen Bajorath , William D. Huse , Herren Wu , Jeffry D. Watkins
IPC分类号： A61K39395
CPC分类号： C07K16/2878 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： The Applicants have discovered humanized anti-human CD40 antibodies which block the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens, collagen induced arthritis, and skin transplantation, and are also useful for their anti-inflammatory properties.
摘要翻译：申请人已经发现阻断gp39和CD40之间相互作用的人源化抗人CD40抗体。本发明的抗CD40抗体可有效调节针对T细胞依赖性抗原，胶原诱导的关节炎和皮肤移植的体液免疫应答，并且还可用于其抗炎性质。

2. 发明授权

US6051228A Antibodies against human CD40 失效
标题翻译：针对人CD40的抗体
公开(公告)号：US6051228A
公开(公告)日：2000-04-18
申请号：US26291
申请日：1998-02-19
申请人： Alejandro A. Aruffo , Diane Hollenbaugh , Anthony W. Siadak , Karen K. Berry , Linda Harris , Barbara A. Thorne , Jurgen Bajorath
发明人： Alejandro A. Aruffo , Diane Hollenbaugh , Anthony W. Siadak , Karen K. Berry , Linda Harris , Barbara A. Thorne , Jurgen Bajorath
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61P19/02 , A61P29/00 , A61P37/02 , A61P37/06 , A61P43/00 , C07K14/46 , C07K14/725 , C07K16/28 , C12N1/21 , C12N15/13
CPC分类号： C07K16/2878 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： The Applicants have discovered a novel antibody, more specifically a chimerized anti-human CD40 monoclonal antibody, which blocks the interaction between gp39 and CD40. The anti-CD40 antibodies of the present invention are effective in modulating humoral immune responses against T cell-dependent antigens, collagen induced arthritis, and skin transplantation, and are also useful for their anti-inflammatory properties.
摘要翻译：申请人已经发现了一种新的抗体，更具体地说是阻断gp39和CD40之间的相互作用的嵌合式抗人CD40单克隆抗体。本发明的抗CD40抗体可有效调节针对T细胞依赖性抗原，胶原诱导的关节炎和皮肤移植的体液免疫应答，并且还可用于其抗炎性质。

3. 发明授权

US06413514B1 Methods of using antibodies against human CD40 有权
标题翻译：使用针对人CD40的抗体的方法
公开(公告)号：US06413514B1
公开(公告)日：2002-07-02
申请号：US09466635
申请日：1999-12-17
申请人： Alejandro A. Aruffo , Diane Hollenbaugh , Anthony W. Siadak , Karen K. Berry , Linda Harris , Barbara A. Thorne , Jurgen Bajorath
发明人： Alejandro A. Aruffo , Diane Hollenbaugh , Anthony W. Siadak , Karen K. Berry , Linda Harris , Barbara A. Thorne , Jurgen Bajorath
IPC分类号： A61K39395
CPC分类号： C07K16/2878 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： A method for the treatment of T cell mediated disorders is described. The method involves administering to a subject a therapeutically effective amount of an anti-human CD40 antibody. Disease states suitable for treatment with this method include graft versus host disease and transplant rejection and auto immune disease such as type I diabetes, psoriasis, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, and myesthenia gravis.
摘要翻译：描述了治疗T细胞介导的病症的方法。该方法涉及向受试者施用治疗有效量的抗人CD40抗体。适合用这种方法治疗的疾病状态包括移植物抗宿主病和移植排斥反应以及自身免疫疾病如I型糖尿病，牛皮癣，多发性硬化，类风湿性关节炎，系统性红斑狼疮和重症肌无力。

4. 发明授权

US6114506A Composition and method for enhancing fibrinolysis 失效
公开(公告)号：US6114506A
公开(公告)日：2000-09-05
申请号：US933983
申请日：1997-09-19
申请人： Guy L. Reed , Linda Harris , Jurgen Bajorath , Gary Matsueda , Mei-Yin Hsu , Jiri Novotny
发明人： Guy L. Reed , Linda Harris , Jurgen Bajorath , Gary Matsueda , Mei-Yin Hsu , Jiri Novotny
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61P7/02 , A61P9/10 , A61P11/00 , C07K16/18 , C07K16/38 , C07K16/46 , C12N5/10 , C12N15/09 , C12N15/13 , C12P21/08 , C12R1/91 , G01N33/86 , C07K16/00
CPC分类号： G01N33/86 , A61K39/395 , A61K39/3955 , C07K16/38 , A61K2039/505 , A61K38/00 , C07K2317/24 , C07K2319/00
摘要： The present invention relates to a novel alpha-2-antiplasmin-binding molecules and treatment for pulmonary embolism, myocardial infarction, thrombosis or stroke in a patient which comprises administering an alpha-2-antiplasmin-binding molecule capable of preventing inhibition of plasmin by endogenous alpha-2-antiplasmin. The invention also relates to a treatment for pulmonary embolism, myocardial infarction, thrombosis or stroke in a patient comprising coadministrating an alpha-2-antiplasmin-binding molecule of the invention together with a thrombolytic agent.

5. 发明申请

US20130046242A1 Infusion tubing support clip 审中-公开
标题翻译：输液管支撑夹
公开(公告)号：US20130046242A1
公开(公告)日：2013-02-21
申请号：US13136877
申请日：2011-08-15
申请人： Linda Harris , Norward Harris
发明人： Linda Harris , Norward Harris
IPC分类号： A61M39/00
CPC分类号： A61M5/1418 , A61M2005/1586
摘要： One end of a length of fabric material is folded under and then over itself in forming a pair of loops, in one of which a ring is captured and through the other which an infusion tubing of a central venous catheter is captured, with the other end of the length of fabric material being coupled with a spring loaded clip securing the fabric material and infusion tubing to the clothing of a patient undergoing a medical infusion treatment.
摘要翻译：一长度的织物材料的一端折叠在其自身之上，然后在其上形成一对环，其中一个环被捕获，并且通过另一个环被捕获中心静脉导管的输注管，另一端将织物材料的长度与弹簧加载的夹子相结合，该夹子将织物材料和输注管固定到经历医用输液治疗的患者的衣服上。

6. 发明授权

US6060646A Tolerance of trichothecene mycotoxins in plants and animals through the modification of the peptidyl transferase gene 失效
标题翻译：通过修饰肽基转移酶基因，在植物和动物中耐受单端孢霉真菌毒素
公开(公告)号：US6060646A
公开(公告)日：2000-05-09
申请号：US909828
申请日：1997-08-12
申请人： Linda Harris , Steve Gleddie
发明人： Linda Harris , Steve Gleddie
IPC分类号： C07K14/415 , C12N15/29 , C12N15/65 , C12N15/82 , A01H1/00 , A01H5/00 , C07H21/04 , C12N15/00
CPC分类号： C12N15/8209 , C07K14/415 , C12N15/65 , C12N15/8242 , C12N15/8274 , C12N15/8282 , A01K2217/05
摘要： Fusarium graminearum is a plant pathogen, attacking a wide range of plant species including corn (ear and stalk rot), barley, and wheat (head blight). Fusarium epidemics result in millions of dollars of loses in crop revenues. Fusarium graminearum infection in the cereals reduces both grain yield and quality. Mycotoxins are produced by many fungal Fusarium species and thus the grain becomes contaminated with these mycotoxins, such as the trichothecenes. The major trichothecene produced by F. graminearum is deoxynivalenol (abbreviated as DON, also known as vomitoxin). Trichothecenes are potent protein synthesis inhibitors and are quite toxic to humans and livestock. A yeast gene has been identified which is resistant to the trichothecene, trichodermin. A corresponding plant gene has been prepared, which has been used to transform plants and would be suitable to transform animals. These transformed plants have an increased resistance to Fusarium infestation. Potentially, transformed animals could have an increased tolerance to the trichothecene mycotoxins.
摘要翻译：禾谷镰刀菌是一种植物病原体，攻击种类繁多的植物物种，包括玉米（耳朵和茎腐烂），大麦和小麦（头枯病）。镰刀菌流行导致作物收入损失数百万美元。禾谷镰刀菌感染谷物减少谷物产量和质量。真菌毒素是由许多真菌镰孢属物种产生的，因此谷物被这些霉菌毒素如单链孢霉素污染。由禾谷镰孢菌产生的主要单端孢霉烯是脱氧雪腐镰刀菌烯醇（简称DON，又称呕吐毒素）。 Trichothecenes是有力的蛋白质合成抑制剂，对人类和家畜有很大的毒性。已经鉴定出对单端孢霉烯（trichodhecene），trichodermin（耐药性）有抗性的酵母基因。已经制备了相应的植物基因，其已被用于转化植物并且适于转化动物。这些转化的植物对镰刀菌侵袭的抗性增加。潜在地，转化的动物可能具有增加对单端孢霉真菌毒素的耐受性。

7. 发明授权

US06939958B1 Regulatory region of a lipid transfer protein (LtpW1) from aleuron tissue of wheat 失效
标题翻译：来自小麦糊粉组织的脂质转移蛋白（LtpW1）的调节区
公开(公告)号：US06939958B1
公开(公告)日：2005-09-06
申请号：US10110637
申请日：2000-10-13
申请人： John Simmonds , Leslie Cass , Linda Harris , Sharon Allard , Kamal Malik , Teresa Martin-Heller , Dan Brown , Ming Hu , Brian Miki , Keqiang Wu
发明人： John Simmonds , Leslie Cass , Linda Harris , Sharon Allard , Kamal Malik , Teresa Martin-Heller , Dan Brown , Ming Hu , Brian Miki , Keqiang Wu
IPC分类号： C07K14/415 , C12N15/82 , C07H21/04
CPC分类号： C12N15/8234 , C07K14/415
摘要： This invention is directed to a regulatory region obtained from a wheat aleurone gene LtpW1. This regulatory region, truncated derivatives, mutations, or deletions of this regulatory region, can be used to express heterologous genes of interest within aleurone cells of a plant. Furthermore, this invention is directed to a truncated LtpW1 regulatory region that exhibits constitutive activity with both monocot and dicot plants. This invention is also directed to vectors comprising these regulatory regions operatively linked with a heterologous gene of interest, as well as plant cell cultures and transgenic plants comprising these vectors. A method for the preparation of a plant using the regulatory regions of this invention are also disclosed.
摘要翻译：本发明涉及从小麦糊粉基因LtpW1获得的调节区。该调节区域，该调节区的截短的衍生物，突变或缺失可用于在植物的糊粉母细胞内表达感兴趣的异源基因。此外，本发明涉及一种截短的LtpW1调节区，其表现出单子叶植物和双子叶植物的组成活性。本发明还涉及包含与感兴趣的异源基因可操作地连接的这些调节区的载体，以及包含这些载体的植物细胞培养物和转基因植物。还公开了使用本发明的调节区制备植物的方法。

8. 发明授权

US6013862A Wheat aleurone regulatory elements 失效
标题翻译：小麦糊粉调节元素
公开(公告)号：US6013862A
公开(公告)日：2000-01-11
申请号：US102046
申请日：1998-06-22
申请人： John Simmonds , Leslie Cass , Linda Harris , Sharon Allard
发明人： John Simmonds , Leslie Cass , Linda Harris , Sharon Allard
IPC分类号： C07K14/415 , C12N15/82 , A01H1/00 , C12N5/04 , C12N15/09
CPC分类号： C07K14/415 , C12N15/8234
摘要： This invention is directed to regulatory elements obtained from a wheat aleurone gene LtpW1. The regulatory element, analogs thereof, or truncated derivatives of this regulatory element, can be used to express heterologous genes of interest within the aleurone cells of a plant. This invention is also directed to vectors comprising these regulatory elements operatively linked with a heterologous gene of interest, as well as plant cell cultures and transgenic plants comprising these vectors. A method for the preparation of a plant using the regulatory elements of this invention are also disclosed. Furthermore, this invention is directed to a truncated LtpW1 regulatory element that exhibits constitutive activity within plants.
摘要翻译：本发明涉及从小麦糊粉基因LtpW1获得的调节元件。其调节元件，其类似物或该调节元件的截短的衍生物可用于在植物的糊粉体细胞内表达感兴趣的异源基因。本发明还涉及包含与感兴趣的异源基因操作性连接的这些调节元件的载体，以及包含这些载体的植物细胞培养物和转基因植物。还公开了使用本发明的调节元件制备植物的方法。此外，本发明涉及在植物中显示组成型活性的截短的LtpW1调节元件。

9. 发明授权

US06799331B2 Surgical gown with limited discrete sections of elastomeric materials 有权
标题翻译：具有弹性体材料有限分立部分的外科长袍
公开(公告)号：US06799331B2
公开(公告)日：2004-10-05
申请号：US10286388
申请日：2002-11-01
申请人： Henry L. Griesbach, III , Linda Harris
发明人： Henry L. Griesbach, III , Linda Harris
IPC分类号： A41B900
CPC分类号： A41D13/1209 , A41D2300/22
摘要： A protective garment, such as a surgical gown, includes areas subjected to tensile stretching forces when worn by a wearer. Such areas may correspond to back shoulder regions of the garment. Elastomeric patches are provided in at least one of the identified areas subjected to the tensile stretching forces, the elastomeric patches being generally surrounded by the remaining garment material.
摘要翻译：防护服，例如手术衣，包括穿着者穿着的拉伸拉伸力的区域。这样的区域可以对应于服装的后肩区域。在经受拉伸力的所识别的区域中的至少一个中提供弹性体贴片，弹性体贴片通常被剩余的服装材料包围。

10. 发明授权

US06671884B1 Method for defining areas of a protective garment subjected to stretching forces when worn by wearer 失效
标题翻译：用于限定佩戴者佩戴时受到拉伸力的防护服的区域的方法
公开(公告)号：US06671884B1
公开(公告)日：2004-01-06
申请号：US10286378
申请日：2002-11-01
申请人： Henry L. Griesbach, III , Linda Harris
发明人： Henry L. Griesbach, III , Linda Harris
IPC分类号： A41B900
CPC分类号： A41D13/1209 , A41D27/10
摘要： A method is provided for defining areas of a protective garment, such as a surgical gown, that are subjected to tensile stretching forces when worn by a wearer. Once identified, such areas may be substituted with elastomeric patches so that restrictive forces experienced by wearers of the garment are relieved.
摘要翻译：提供了一种用于限定穿戴者佩戴时受到拉伸力的保护性服装（例如手术衣）的区域的方法。一旦确定，这些区域可以用弹性体贴片代替，使得服装的佩戴者经历的限制力被释放。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式