专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5830053A Oesophagus sealing 失效
标题翻译：食管密封
公开(公告)号：US5830053A
公开(公告)日：1998-11-03
申请号：US765986
申请日：1997-01-02
申请人： Albert James Vick , Denis Brett , Harry Schulz , Paul Stapleton , Jeffrey Owen
发明人： Albert James Vick , Denis Brett , Harry Schulz , Paul Stapleton , Jeffrey Owen
IPC分类号： A22B5/14
CPC分类号： A22B5/14
摘要： An oesophagus seal for sealing the oesophagus in a slaughtered animal comprises a plug (10) for insertion into the oesophagus (40) and a retainer in the form of a clamp (20) which internally engages and clamps to tissues of the oesophagus (40) to resist disengagement of the plug. The plug (10) has an outer peripheral clamp surface (13) and the clamp (20) is in the form of a clamp ring (21) which clamps the internal mucosa (41) of the oesophagus (40) between the clamp ring (21) and the outside clamp surface (13). The plug (10) has a reduced diameter neck (15) and a conical ramped outer surface (16) leading to the clamp surface. The clamp ring (21) is initially located beyond the neck (15) and is advanceable so that tissues (41) surrounding and projecting into the neck portion (15), e.g. by application of a vacuum, will be pinched between the advancing clamp ring (21) and the surface (16) and, upon further advance of the clamp ring (21), the tissues (41) are pinched between the clamp ring (21) and the outer clamp surface (13). There is also provided an oesophagus sealing system comprising an applicator rod (30) having an end for mounting of the oesophagus seal, and having an associated actuator (35) which is selectively moveable axially to move the clamp (20) so as to engage and clamp the tissues (41) of the oesophagus (40) between the clamp (20) and the plug (10).
摘要翻译： PCT No.PCT / AU96 / 00287 Sec。 371日期1997年1月2日 102（e）日期1997年1月2日PCT提交1996年5月10日PCT公布。公开号WO96 / 35332 日期1996年11月14日食管密封用于在屠宰动物中密封食道包括用于插入食道（40）的塞子（10）和夹具（20）形式的保持器，其内部接合并夹紧到食道（40）抵抗插头的脱离。插头（10）具有外周夹持表面（13），并且夹具（20）是夹紧环（21）的形式，夹紧环（21）夹住食管（40）的内部粘膜（41） 21）和外侧夹紧面（13）。插头（10）具有缩径的颈部（15）和通向夹具表面的圆锥形倾斜的外表面（16）。夹紧环（21）最初位于颈部（15）之外并且可推进，使得围绕并伸入颈部部分（15）的组织（41）通过施加真空将被夹持在前进的夹紧环（21）和表面（16）之间，并且当夹紧环（21）进一步前进时，组织（41）被夹在夹紧环（21）和外夹具表面（13）。还提供了一种食管密封系统，其包括具有用于安装食管密封件的端部的施用器杆（30），并且具有相关联的致动器（35），该致动器可选择性地沿轴向移动以移动夹具（20）夹紧夹具（20）和插头（10）之间的食道（40）的组织（41）。

2. 发明授权

US08338476B2 Compositions and methods of sensitizing methicillin resistant Staphylococcus aureus to beta-lactam antibiotics 有权
标题翻译：使耐甲氧西林金黄色葡萄球菌对β-内酰胺抗生素敏感的组合物和方法
公开(公告)号：US08338476B2
公开(公告)日：2012-12-25
申请号：US12095960
申请日：2005-12-29
申请人： Paul Stapleton , Yukihiko Hara , Peter Taylor
发明人： Paul Stapleton , Yukihiko Hara , Peter Taylor
IPC分类号： A61K31/352 , A61K31/397 , A01N43/16 , A01N43/44 , A01N43/90
CPC分类号： A61K31/353 , A61K31/05 , A61K45/06 , A61K2300/00
摘要： Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.
摘要翻译：考虑的方法和组合物进一步增加致敏MRSA对各种抗生素药物的敏感性。最优选地，MRSA已经被乳糖化儿茶素（例如ECG）敏化，并且通过暴露于非半乳糖化儿茶素（例如EC），最优选相应的非乙酰化儿茶素来实现进一步的敏化。

3. 发明申请

US20100035979A1 Compositions and Methods of Sensitizing Methicillin Resistant Staphylococcus Aureus to Oxacillin 有权
标题翻译：将耐甲氧西林金黄色葡萄球菌对奥西西林敏化的组合物和方法
公开(公告)号：US20100035979A1
公开(公告)日：2010-02-11
申请号：US12095960
申请日：2005-12-29
申请人： Paul Stapleton , Yukihiko Hara , Peter Taylor
发明人： Paul Stapleton , Yukihiko Hara , Peter Taylor
IPC分类号： A61K31/352 , C12N1/20
CPC分类号： A61K31/353 , A61K31/05 , A61K45/06 , A61K2300/00
摘要： Contemplated methods and compositions further increase susceptibility of sensitized MRSA against various antibiotic drugs. Most preferably, the MRSA is already sensitized with a galloylated catechin (e.g., ECG), and further sensitization is achieved by exposure to a non-galloylated catechin (e.g., EC), and most preferably the corresponding non-galloylated catechin.
摘要翻译：考虑的方法和组合物进一步增加致敏MRSA对各种抗生素药物的敏感性。最优选地，MRSA已经被乳糖化儿茶素（例如ECG）敏化，并且通过暴露于非半乳糖化儿茶素（例如EC），最优选相应的非乙酰化儿茶素来实现进一步的敏化。

4. 发明申请

US20070021384A1 Compounds for use in the treatment of infection 失效
标题翻译：用于治疗感染的化合物
公开(公告)号：US20070021384A1
公开(公告)日：2007-01-25
申请号：US11455889
申请日：2006-06-20
申请人： James Anderson , Catherine Headley , Paul Stapleton , Peter Taylor
发明人： James Anderson , Catherine Headley , Paul Stapleton , Peter Taylor
IPC分类号： A61K31/695 , A61K31/353 , C07F7/02
CPC分类号： C07D311/62 , C07D311/60
摘要： There is provided a novel compound of the general formula I in which each of R8 to R10 is hydrogen, aryl, C1-6 alkyl, trialkylsilyl or acyl; R1 to R5 are individually selected from hydrogen, hydroxy, C1-6 alkoxy and acyloxy; R6 and R7 are H, C1-4 alkyl, trialkylsilyl or acyl; X is O or NR, and R is H or Me; in which any of the alkyl groups including alkyl groups in alkoxy, acyl and acyloxy groups may be substituted by aryl, C1-4 alkyl, C1-4 alkoxy, hydroxyl, trialkylsiloxy or acyloxy groups; with the proviso that R2 and R3 are not both OH when R4 is H or OH, R1 and R5 are both H, and X is O. The amide compounds (X is NR) are analogues of epigallocatechin gallate or epicatechin galate, with an amide bond in place of the natural ester bond, with resistance to hydrolysis by esterase enzymes. The ester compounds (X is O) have a different hydroxylation pattern on the B ring as compared to the natural products. The compounds may be used to modulate the resistance to β-lactam antibiotics of various infections, especially methicillin resistant Staphylococcus aureus (MRSA). Pharmaceutical compositions containing the novel compounds and combinations of the novel compounds and β-lactam antibiotics are described.
摘要翻译：提供了通式I的新化合物，其中R 8和R 10各自为氢，芳基，C 1-6烷基，烷基，三烷基甲硅烷基或酰基; R 1至R 5各自独立地选自氢，羟基，C 1-6烷氧基和酰氧基; R 6和R 7是H，C 1-4烷基，三烷基甲硅烷基或酰基; X是O或NR，R是H或Me; 其中包括烷氧基，酰基和酰氧基中的烷基的任何烷基可以被芳基，C 1-4烷基，C 1-4烷氧基，羟基三烷基甲硅烷氧基或酰氧基; 条件是当R 4为H或OH时，R 2和R 3不同时为OH，R 1为H >和R 5都是H，X是O.酰胺化合物（X是NR）是表没食子儿茶素没食子酸酯或表儿茶素加成酸酯的类似物，酰胺键代替天然酯键，与耐酯酶水解。与天然产物相比，酯化合物（X为O）在B环上具有不同的羟基化模式。该化合物可用于调节对各种感染的β-内酰胺抗生素的抗性，特别是耐甲氧西林金黄色葡萄球菌（MRSA）。描述了含有新化合物和新化合物和β-内酰胺抗生素的组合的药物组合物。

5. 发明申请

US20090082429A1 Antimicrobial Compositions and Methods of Use 审中-公开
标题翻译：抗微生物组合物和使用方法
公开(公告)号：US20090082429A1
公开(公告)日：2009-03-26
申请号：US12250202
申请日：2008-10-13
申请人： Paul Stapleton , Shinich Uesato , Peter W. Taylor , Yukihiko Hara
发明人： Paul Stapleton , Shinich Uesato , Peter W. Taylor , Yukihiko Hara
IPC分类号： A61K31/353 , A61P31/04
CPC分类号： A61K31/353 , G06Q50/22
摘要： A catechin is modified in at least one position (most preferably in the 3-position of the C-ring) to increase its lipophilicity. Contemplated catechins are demonstrated to have significantly improved antibacterial properties, likely due to catastrophic membrane damage.
摘要翻译：儿茶素在至少一个位置（最优选在C环的3-位）被修饰以增加其亲油性。被证明的儿茶素具有显着改善的抗菌性能，可能是由于灾难性的膜损伤。

6. 发明申请

US20070082944A1 Antimicrobial compositions and methods of use 审中-公开
标题翻译：抗微生物组合物和使用方法
公开(公告)号：US20070082944A1
公开(公告)日：2007-04-12
申请号：US10569526
申请日：2003-09-12
申请人： Paul Stapleton , Shinich Uesato , Peter Taylor , Yukihiko Hara
发明人： Paul Stapleton , Shinich Uesato , Peter Taylor , Yukihiko Hara
IPC分类号： A61K31/353 , G06Q50/00
CPC分类号： A61K31/353 , G06Q50/22
摘要： A catechin is modified in at least one position (most preferably in the 3-position of the C-ring) to increase its lipophilicity. Contemplated catechins are demonstrated to have significantly improved antibacterial properties, likely due to catastrophic membrane damage.
摘要翻译：儿茶素在至少一个位置（最优选在C环的3-位）被修饰以增加其亲油性。被证明的儿茶素具有显着改善的抗菌性能，可能是由于灾难性的膜损伤。

7. 发明授权

US6142861A Meat decontamination 失效
标题翻译：肉类去污
公开(公告)号：US6142861A
公开(公告)日：2000-11-07
申请号：US155563
申请日：1998-09-30
申请人： John Buhot , Paul Stapleton , Paul Green , Paul Anderson
发明人： John Buhot , Paul Stapleton , Paul Green , Paul Anderson
IPC分类号： A22C17/08 , A22B5/00 , A22B5/08
CPC分类号： A22B5/08
摘要： The invention relates to decontaminating meat by locating a body of meat (10) within a chamber (15), providing a volume (25) of decontaminating water (27) sufficient to fill the chamber (15) and immerse the body of meat; supplying the decontaminating water (27) at e.g. 80.degree. C. to the chamber at multiple inlet point (31-34) accompanied by substantial turbulence as it fills the chamber (15) and discharging the decontaminating water from the chamber (15) after the body of meat (10) has been decontaminated (e.g. after ten seconds). The volume of decontaminating water (27) is provided in an elevated vessel (26) connected to the chamber (15) through a supply passage (30) of relatively large flow area. The body of meat (10) is suspended from an overhead conveyor (11) and is conveyed into the chamber (15) through an entry opening and out of the chamber (15) through an exit opening, the body of meat (10) being paused in its movement by the conveyor (11) when it has entered the chamber (15) to enable the decontaminating operation to take place.
摘要翻译： PCT No.PCT / AU98 / 00053 Sec。 371日期：1998年9月30日 102（e）1998年9月30日PCT PCT 1998年1月30日PCT。公开号WO98 / 33390 日期1998年8月6日本发明涉及通过将肉体（10）定位在腔室（15）内来去污肉，提供足以填充腔室（15）的净化水（27）的体积（25）并将肉体; 以例如方式供应去污水（27）。 80℃，在多个入口点（31-34）处的腔室，伴随着充满腔室（15）的大量湍流，并且在肉体（10）已被净化之后从腔室（15）排出净化水（例如十秒钟后）。净化水（27）的体积设置在通过相对大的流动面积的供给通道（30）连接到室（15）的升高的容器（26）中。肉体（10）悬挂在架空输送机（11）上，通过入口通过出口开口输入腔室（15），肉体（10）为当输送机（11）进入腔室（15）时，其通过输送机（11）的运动暂停，以使得能够进行去污操作。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式