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1. 发明申请

US20080160067A1 Novel soft chewable, tablet, and long-acting injectable veterinary antibiotic formulations 审中-公开
标题翻译：新型软咀嚼片，片剂和长效注射用兽药抗生素配方
公开(公告)号：US20080160067A1
公开(公告)日：2008-07-03
申请号：US11899282
申请日：2007-09-05
申请人： Albert Boeckh , Mark D. Soll , Monica Tejwani-Motwani , Robert P. Waranis , Fangjun Wu
发明人： Albert Boeckh , Mark D. Soll , Monica Tejwani-Motwani , Robert P. Waranis , Fangjun Wu
IPC分类号： A61K9/68 , A61K31/40
CPC分类号： A61K9/0056 , A61K9/0019 , A61K9/2013 , A61K9/2018 , A61K47/10
摘要： This document relates to formulations for combating bacterial infections in animals which provide for improved long-acting oral and injectable formulations for systemic delivery of antibiotics, which are designed to achieve high bioavailability.
摘要翻译：本文件涉及用于对抗动物细菌感染的制剂，其提供改进的用于系统递送抗生素的长效口服和可注射制剂，其被设计为实现高生物利用度。

2. 发明授权

US08362086B2 Long acting injectable formulations 有权
标题翻译：长效注射制剂
公开(公告)号：US08362086B2
公开(公告)日：2013-01-29
申请号：US11207980
申请日：2005-08-19
申请人： Mark D. Soll , Peter Hanson , Krishan Kumar , Monica Tejwani-Motwani
发明人： Mark D. Soll , Peter Hanson , Krishan Kumar , Monica Tejwani-Motwani
IPC分类号： A61K31/63 , A61K31/7048
CPC分类号： A61K31/00 , A61K9/0019 , A61K47/10 , A61K47/14 , A61K47/34 , A61K48/00
摘要： The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.
摘要翻译：本申请涉及用于对抗哺乳动物体内寄生虫和内寄生虫的长效注射剂（LAI）制剂。特别地，本发明提供了包含皮下挥发性溶剂，生物学上可接受的聚合物，生物活性剂和任选的一种或多种抗外寄生物或抗内分泌上可接受的添加剂或赋形剂的LAI制剂。令人惊奇的是，本发明的液体长效注射制剂通过具有长期稳定性能够解决与先前可注射制剂相关的问题，能够适应较小的针头直径并且实现控制哺乳动物中害虫的长效应。本发明的独特配方还允许抵抗已经变得对大环内酯类抗生素具有抗性的外寄生物和内寄生虫。

3. 发明申请

US20070042013A1 Long acting injectable formulations 有权
标题翻译：长效注射制剂
公开(公告)号：US20070042013A1
公开(公告)日：2007-02-22
申请号：US11207980
申请日：2005-08-19
申请人： Mark Soll , Peter Hanson , Krishan Kumar , Monica Tejwani-Motwani
发明人： Mark Soll , Peter Hanson , Krishan Kumar , Monica Tejwani-Motwani
IPC分类号： A01N43/04 , A01N25/00
CPC分类号： A61K31/00 , A61K9/0019 , A61K47/10 , A61K47/14 , A61K47/34 , A61K48/00
摘要： The application relates to long acting injectable (LAI) formulations for combating ectoparasites and endoparasites in mammals. In particular, this invention provides for a LAI formulation comprising a subcutaneously volatile solvent, a biologically acceptable polymer, a bioactive agents and optionally one or more anti-ectoparasitically or anti-endoparasitically acceptable additive or excipient. Surprisingly, the liquid long acting injectable formulations of the invention solve the problems associates with previous injectable formulations by having long term stability, being able to accommodate smaller needle diameters and achieving long acting effects in the control of pests in a mammal. The unique formulations of the invention also allow for combating ectoparasites and endoparasites which have become resistant to macrolide antibiotics.
摘要翻译：本申请涉及用于对抗哺乳动物体内寄生虫和内寄生虫的长效注射剂（LAI）制剂。特别地，本发明提供了包含皮下挥发性溶剂，生物学上可接受的聚合物，生物活性剂和任选的一种或多种抗外寄生物或抗内分泌上可接受的添加剂或赋形剂的LAI制剂。令人惊奇的是，本发明的液体长效注射制剂通过具有长期稳定性能够解决与先前可注射制剂相关的问题，能够适应较小的针头直径并且实现控制哺乳动物中害虫的长效应。本发明的独特配方还允许抵抗已经变得对大环内酯类抗生素具有抗性的外寄生物和内寄生虫。

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