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1. 发明授权

US4065459A Process for the preparation of thieno(3,2-c) pyridine and derivatives thereof 失效
标题翻译：噻吩并（3,2-c）吡啶及其衍生物的制备方法
公开(公告)号：US4065459A
公开(公告)日：1977-12-27
申请号：US655966
申请日：1976-02-06
申请人： Alan Heymes , Jean-Pierre Maffrand
发明人： Alan Heymes , Jean-Pierre Maffrand
IPC分类号： C07D513/04 , A61K20060101 , A61K31/425 , A61K31/545 , A61K31/546 , A61P31/04 , C07D20060101 , C07D495/04 , C07D501/00 , C07D501/04 , C07D501/20 , C07D501/22 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/56 , C07D501/60 , C07D519/06 , C07D283/00
CPC分类号： C07D495/04 , C07D501/20
摘要： This invention relates to a process for the preparation of compounds having the formula: ##STR1## in which R.sub.1 is H or lower alkyl and R.sub.2 is H or lower alkyl, or phenyl or benzyl optionally substituted with at least one halogen or a lower alkyl, lower alkoxy, trifluoromethyl or nitro group.According to this method, a compound of the formula: ##STR2## in which R.sub.1 and R.sub.2 are as defined above and R.sub.3 is H or optionally substituted alkyl or benzyl, is reacted with a derivative Hal--SO.sub.2 --R (III) in which Hal is halogen and R is optionally substituted alkyl, aryl or aralkyl, to give a derivative of the formula: ##STR3## in which the various symbols have the above-defined meanings, and the sulfonated derivative of the formula (IV) is heated in the presence of an acid, to give the compound of the formula (I).
摘要翻译：本发明涉及一种制备具有下式的化合物的方法：其中R 1为H或低级烷基且R 2为H或低级烷基，或任选被至少一个卤素取代的苯基或苄基，低级烷基，低级烷氧基，三氟甲基或硝基。

2. 发明授权

US06806282B2 Branched substituted amino derivatives of 3-amino-1-phenyl-1h-[1,2,4]triazol, methods for producing them and pharmaceutical compositions containing them 有权
标题翻译： 3-氨基-1-苯基-1h- [1,2,4]三唑的支链取代氨基衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US06806282B2
公开(公告)日：2004-10-19
申请号：US10149499
申请日：2002-06-12
申请人： Michel Geslin , Danielle Gully , Jean-Pierre Maffrand , Pierre Roger
发明人： Michel Geslin , Danielle Gully , Jean-Pierre Maffrand , Pierre Roger
IPC分类号： A61K314196
CPC分类号： C07D249/14
摘要： The present invention relates to novel branched substituted amino derivatives of 3-amino-1-phenyl-1H-[1,2,4]triazole, processes for their preparation and pharmaceutical compositions comprising them.
摘要翻译：本发明涉及3-氨基-1-苯基-1H- [1,2,4]三唑的新的支链取代氨基衍生物，其制备方法和包含它们的药物组合物。

3. 发明授权

US5798353A Polysubstituted 3-acylamino-5-phenyl-1,4-benzodiazepin-2-one derivatives, process for their preparation and the pharmaceutical compositions containing them 失效
标题翻译：多取代的3-酰基氨基-5-苯基-1,4-苯并二氮杂-2-酮衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5798353A
公开(公告)日：1998-08-25
申请号：US975003
申请日：1997-11-20
申请人： Alain Badorc , Pierre Despeyroux , Daniele Gully , Paul De Cointet , Daniel Frehel , Jean-Pierre Maffrand
发明人： Alain Badorc , Pierre Despeyroux , Daniele Gully , Paul De Cointet , Daniel Frehel , Jean-Pierre Maffrand
IPC分类号： C12N9/99 , A61K31/55 , A61K31/551 , A61P1/00 , A61P3/04 , A61P25/18 , A61P25/28 , A61P43/00 , C07D243/24 , C07D243/30 , C07D401/12 , C07D403/12 , C07K5/068 , C07K14/575 , C07K14/655 , C07K14/705
CPC分类号： C07D403/12 , C07D243/24
摘要： The invention relates to the compounds of formula (I) ##STR1## in which R.sub.I, R.sub.II, X.sub.1, X.sub.2, X.sub.3 and X.sub.4 are as defined in claim 1.
摘要翻译：本发明涉及其中RI，RII，X1，X2，X3和X4如权利要求1中所定义的式（I）化合物。

4. 发明授权

US4713373A Xylan sulfates of low molecular weight, process for their preparation and medicaments containing them 失效
标题翻译：低分子量的木聚糖硫酸盐，其制备方法和含有它们的药物
公开(公告)号：US4713373A
公开(公告)日：1987-12-15
申请号：US793657
申请日：1985-10-31
申请人： Alain Bayol , Francis Blanc , Jacqueline Lansen , Jean-Pierre Maffrand , Jean-Marie Pereillo
发明人： Alain Bayol , Francis Blanc , Jacqueline Lansen , Jean-Pierre Maffrand , Jean-Marie Pereillo
IPC分类号： C08B37/00 , A61K31/715 , A61P3/06 , A61P7/02 , C08B37/14 , A61K31/725
CPC分类号： C08B37/0057 , Y10S514/822
摘要： The present invention relates to novel xylan sulfates of average molecular weight comprised between 2000 and 5000 Daltons.The invention also relates to their process of preparation by fractionation and their use in therapeutics as orally active antithrombotic and hypolipaemic agents.
摘要翻译：本发明涉及平均分子量为2000-5000道尔顿的新型木聚糖硫酸盐。本发明还涉及其通过分级制备方法及其在治疗中的用途，作为口服活性抗血栓形成和降血脂药。

5. 发明授权

US4321266A 5-o-Cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-C] pyridine 失效
标题翻译： 5'-氰基苄基-4,5,6,7-四氢噻吩并[3,2-C]吡啶
公开(公告)号：US4321266A
公开(公告)日：1982-03-23
申请号：US193907
申请日：1980-10-06
申请人： Armand Amselem , Fernand Eloy , Jean-Pierre Maffrand
发明人： Armand Amselem , Fernand Eloy , Jean-Pierre Maffrand
IPC分类号： C07D495/04 , A61K31/395
CPC分类号： C07D495/04 , Y10S514/822
摘要： The free base, 5-o-cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine, a method for the preparation thereof, therapeutic compositions having blood-platelet aggregation inhibiting activity, therapeutic dosage units of the compositions, and a method for the treatment of warm-blooded animals to inhibit blood platelet aggregation, are described.
摘要翻译：游离碱5-邻氨基苄基-4,5,6,7-四氢噻吩并[3,2-c]吡啶，其制备方法，具有血小板聚集抑制活性的治疗组合物，治疗剂量单位为描述了用于治疗温血动物以抑制血小板聚集的组合物和方法。

6. 发明授权

US4119719A Piperazine compounds 失效
标题翻译：哌嗪化合物
公开(公告)号：US4119719A
公开(公告)日：1978-10-10
申请号：US833291
申请日：1977-09-14
申请人： Jean-Pierre Maffrand , Jean-Marie Pereillo
发明人： Jean-Pierre Maffrand , Jean-Marie Pereillo
IPC分类号： C07D295/13 , A61K31/495 , A61K31/535
CPC分类号： C07D295/13
摘要： Piperazine compound of formula ##STR1## wherein R.sub. 1 is halogen, lower alkyl, lower alkoxy or trifluoromethyl, R.sub.2 and R.sub.3 form, together with the nitrogen atom to which they are attached a saturated heterocycle having n cyclic atoms, n being 4-8, have analgesic activity.
摘要翻译：其中R 1是卤素，低级烷基，低级烷氧基或三氟甲基，R 2和R 3与它们连接的具有n个环原子的饱和杂环的氮原子一起形成，其中n为4-8，具有止痛活性。

7. 发明授权

US4496568A Antiinflammatory thieno [2,3-c]pyridine derivatives 失效
标题翻译：抗炎噻吩并[2,3-c]吡啶衍生物
公开(公告)号：US4496568A
公开(公告)日：1985-01-29
申请号：US487355
申请日：1983-04-25
申请人： Jean-Pierre Maffrand , Daniel Frehel
发明人： Jean-Pierre Maffrand , Daniel Frehel
IPC分类号： C07D513/02 , A61K31/435 , A61K31/4365 , A61P29/00 , C07D495/04 , A61K31/44
CPC分类号： C07D495/04
摘要： This invention relates to a process for the preparation of antiinflammatory thieno [2,3-c]- and [3,2-c]pyridines having respectively the following formulae: ##STR1## in which R.sub.1 and R.sub.2, which may be the same or different, represent each a hydrogen atom or an alkyl group, and their pharmaceutically acceptable acid addition salts, comprising:(a) condensing a compound of the following formulae (VII) or (VIII), respectively, ##STR2## with a sulfonyl chloride having the formula ClSO.sub.2 R.sub.3, in which R.sub.3 is a lower alkyl radical or a phenyl radical optionally substituted with a halogen atom or a lower alkyl group, within a two-phase solvent system and in the presence of sodium carbonate;(b) oxidizing in a solvent medium the resulting alcohols having respectively the following formula (V) or (VI): ##STR3## (c) treating the resulting ketones, having the following formula (III) or (IV): ##STR4## with a basic agent having the formula RO.sup.- M.sup.+ in which R is a branched- or straight-chain aliphatic alkyl radical and M.sup.+ is an alkali metal cation, within an alcohol solvent having the formula ROH, and at the reflux temperature of the reaction mixture, to give the compounds of the formula (I) or (II), respectively.
摘要翻译：本发明涉及分别具有以下分子式的抗炎噻吩并[2,3-c] - 和[3,2-c]吡啶的制备方法：其中R 1和R 2可以相同或不同，不同的，各自表示氢原子或烷基，以及它们的药学上可接受的酸加成盐，其包括：（a）分别将下式（VII）或（VIII）的化合物与具有其中R3是低级烷基或任选被卤素原子或低级烷基取代的苯基的式ClSO 2 R 3在两相溶剂体系内和在碳酸钠存在下; （b）在溶剂介质中氧化分别具有下式（Ⅴ）或（Ⅵ）的所得醇：（Ⅵ）（Ⅵ）（c）处理所得酮，具有下式（III ）或（IV）：其中R是支链或直链脂族烷基，M +是碱金属阳离子，具有式RO-M +的碱性试剂，（IV）在具有式ROH的醇溶剂中，并在反应混合物的回流温度下分别得到式（I）或（II）的化合物。

8. 发明授权

US4400384A 5-o-Cyanobenzyl-4,5,6,7-tetrahydrothieno [3,2-c] pyridine methanesulfonate and other novel salts thereof 失效
标题翻译： 5'-氰基苄基-4,5,6,7-四氢噻吩并[3,2-c]吡啶甲磺酸盐及其它新的盐
公开(公告)号：US4400384A
公开(公告)日：1983-08-23
申请号：US193906
申请日：1980-10-06
申请人： Armand Amselem , Fernand Eloy , Jean-Pierre Maffrand
发明人： Armand Amselem , Fernand Eloy , Jean-Pierre Maffrand
IPC分类号： C07D495/04 , C07D513/04 , A61K31/44
CPC分类号： C07D495/04 , Y10S514/821
摘要： The invention concerns novel 5-o-cyanobenzyl-4, 5, 6, 7-tetrahydrothieno-[3,2-c] pyridine acid addition salts having inhibitory action against blood platelet aggregation without anti-inflammatory activity, and the compositions and methods of use therefor.
摘要翻译：本发明涉及对没有抗炎活性的血小板聚集具有抑制作用的新的5-邻氰基苄基-4,5,6,7-四氢噻吩并[3,2-c]吡啶酸加成盐，以及其组合物和方法用于此。

9. 发明授权

US4107437A 2,3-Dihydrobenzofurans 失效
标题翻译： 2,3-二氢苯并呋喃
公开(公告)号：US4107437A
公开(公告)日：1978-08-15
申请号：US792504
申请日：1977-05-02
申请人： Jean-Pierre Maffrand , Jean-Marie Pereillo
发明人： Jean-Pierre Maffrand , Jean-Marie Pereillo
IPC分类号： A61K31/34 , A61K31/343 , A61K31/40 , A61K31/495 , A61K31/535 , A61P9/06 , A61P25/20 , C07D307/80 , C07D405/12
CPC分类号： C07D307/80 , Y10S514/821
摘要： 2,3-Dihydrobenzofuran of formula: ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, a lower alkyl or lower phenylalkyl or form, together with the nitrogen atom to which they are attached, a 4 to 8-membered saturated heterocyclic ring having 3 to 7 cyclic carbon atoms, a 4 to 8-membered saturated heterocyclic ring having 2 to 6 cyclic carbon atoms and two heteroatoms one of which is said nitrogen atom and the other is an oxygen atom, a sulphur atom or another nitrogen atom, said other nitrogen atom being optionally substituted by a phenyl, halophenyl, trifluromethylphenyl, lower alkylphenyl or lower alkoxyphenyl; n is 2 or 3, and the salts thereof.
摘要翻译： 2,3-二氢苯并呋喃，其结构式如下：其中R 1和R 2各自独立地为低级烷基或低级苯基烷基或与其连接的氮原子一起形成4至8元饱和的具有3至7个环状碳原子的杂环，具有2至6个环状碳原子的4至8元饱和杂环和2个杂原子，其中一个为所述氮原子，另一个为氧原子，硫原子或其它氮所述其它氮原子任选被苯基，卤代苯基，三氟甲基苯基，低级烷基苯基或低级烷氧基苯基取代; n为2或3，及其盐。

10. 发明授权

US4104390A Thieno [2,3-c] and [3,2-c] pyridines 失效
标题翻译：噻吩并[b 2,3-c {9 {0和{8,2-c {9 {
公开(公告)号：US4104390A
公开(公告)日：1978-08-01
申请号：US808694
申请日：1977-06-21
申请人： Gerard Ferrand , Daniel Frehel , Jean-Pierre Maffrand
发明人： Gerard Ferrand , Daniel Frehel , Jean-Pierre Maffrand
IPC分类号： A61K31/435 , A61K31/4365 , A61P7/02 , A61P29/00 , C07D333/20 , C07D333/36 , C07D495/04 , C07D513/04 , A61K31/38
CPC分类号： C07D495/04 , C07D333/20
摘要： This invention relates to pyridine derivatives of the formulae: ##STR1## in which R.sup.1 is hydrogen, lower alkyl, aralkyl optionally substituted on the aromatic nucleus with at least a halogen atom or a hydroxy, nitro, amino, cyano, carboxy, alkoxycarbonyl, lower alkyl, lower alkoxy or trifluoromethyl group; R.sup.2 is hydrogen or lower alkyl; and R.sup.3 is hydrogen or at least a substituent selected from a halogen atom, a hydroxy, lower alkyl and lower alkoxy group, and their pharmaceutically acceptable inorganic or organic acid addition salts.Said compounds have particularly an anti-inflammatory and blood-platelet aggregation inhibiting activity.
摘要翻译：本发明涉及以下结构式的吡啶衍生物：其中R 1为氢，低级烷基，任选在芳核上被至少具有卤素原子取代的芳烷基或羟基，硝基，氨基，氰基，羧基，烷氧基羰基，低级烷基，低级烷氧基或三氟甲基; R2是氢或低级烷基; 和R3是氢或至少一个选自卤素原子，羟基，低级烷基和低级烷氧基的取代基，以及它们的药学上可接受的无机酸或有机酸加成盐。

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