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1. 发明授权

US5260363A Organopolysiloxane/olefin copolymers 失效
标题翻译：有机聚硅氧烷/烯烃共聚物
公开(公告)号：US5260363A
公开(公告)日：1993-11-09
申请号：US386213
申请日：1989-07-28
申请人： Akitaka Senuma , Toshiyuki Nagai , Kiroku Tsukada , Akio Hayashi , Isao Noda
发明人： Akitaka Senuma , Toshiyuki Nagai , Kiroku Tsukada , Akio Hayashi , Isao Noda
IPC分类号： B29C47/00 , C08F255/02 , C08F293/00 , C08G77/442 , C08L23/04 , C08L23/08 , C08L53/00 , C08L83/10 , C08L99/00 , H01B3/44 , H01B3/46 , C08K5/54
CPC分类号： C08F255/02 , C08F293/00 , C08G77/442 , C08L23/04 , C08L53/00 , H01B3/44 , H01B3/46 , Y10T428/31663 , Y10T428/31938
摘要： A composition comprising:(i) a crosslinkable thermoplastic resin;(ii) an aliphatic monomeric compound having two or more carbon to carbon double bonds;(iii) an organic peroxide crosslinking agent; and(iv) a linear organopolysiloxane/alpha-olefin copolymer having the following formula: ##STR1## wherein R is a saturated aliphatic or aromatic group and each R is alike or different;a is about 1 to about 1000; andb is about 5 to about 100The composition is useful as coating composition for an electrical conductor.
摘要翻译：一种组合物，其包含：（i）可交联热塑性树脂; （ii）具有两个或多个碳 - 碳双键的脂肪族单体化合物; （iii）有机过氧化物交联剂; 和（iv）具有下式的线性有机聚硅氧烷/α-烯烃共聚物：其中R是饱和脂族或芳族基团，每个R是相同或不同的; a约为1至约1000; 并且b为约5至约100。该组合物可用作电导体的涂料组合物。

2. 发明授权

US5037887A Crosslinkable composition 失效
标题翻译：可交联成分
公开(公告)号：US5037887A
公开(公告)日：1991-08-06
申请号：US386212
申请日：1989-07-28
申请人： Akitaka Senuma , Toshiyuki Nagai , Kiroku Tsukada , Akio Hayashi , Isao Noda
发明人： Akitaka Senuma , Toshiyuki Nagai , Kiroku Tsukada , Akio Hayashi , Isao Noda
IPC分类号： B29D7/00 , B29D23/00 , B29K96/00 , C08J5/18 , C08K5/14 , C08L23/02 , C08L23/04 , C08L47/00 , C08L53/00 , C08L83/07 , C08L83/10 , C08L83/14 , C08L87/00 , C08L101/00 , H01B3/46
CPC分类号： H01B3/46 , C08L101/00 , C08L23/02 , C08L83/10 , C08L83/14 , Y10T428/31663
摘要： A composition comprising:(i) a crosslinkable thermoplastic resin;(ii) an organic peroxide crosslinking agent; and(iii) a linear polyorganosiloxane having the following recurring unit: ##STR1## wherein R is a saturated aliphatic or aromatic group and each R can be alike or different;a is about 5 to about 100;b is about 1 to about 1000; and the polyorganosiloxane is terminated at the [CH.sub.2 ].sub.a end with --CH.dbd.CH.sub.2 or hydrogen and at the ##STR2## end with--[CH.sub.2 ].sub.a --CH.dbd.CH.sub.2 or hydrogen provided that at least one --CH.dbd.CH.sub.2 is present.
摘要翻译：一种组合物，其包含：（i）可交联热塑性树脂; （ii）有机过氧化物交联剂; 和（iii）具有以下重复单元的线性聚有机硅氧烷：其中R是饱和脂族或芳族基团，并且每个R可以相同或不同; a为约5至约100; b为约1至约1000; 并且聚有机硅氧烷在[CH 2] a端用-CH = CH 2或氢终止，并且在

3. 发明授权

US5143960A Modified ethylene copolymer 失效
标题翻译：改性乙烯共聚物
公开(公告)号：US5143960A
公开(公告)日：1992-09-01
申请号：US406287
申请日：1989-09-12
申请人： Akitaka Senuma , Toshiyuki Nagai , Kiroku Tsukada , Akio Hayashi
发明人： Akitaka Senuma , Toshiyuki Nagai , Kiroku Tsukada , Akio Hayashi
IPC分类号： C08J5/00 , C08F8/00 , C08F210/02 , C08F255/02 , C08K5/14 , C08K5/16 , C08L23/08
CPC分类号： C08F210/02 , C08F255/02 , Y10T428/1352 , Y10T428/23 , Y10T428/31721 , Y10T428/31938
摘要： A composition comprising (i) a copolymer of ethylene; one or more polar unsaturated alcohols, acids, or esters; and a N-substituted maleimide or (ii) a copolymer of ethylene and one or more polar unsaturated alcohols, acids, or esters grafted with an N-substituted maleimide.
摘要翻译：一种组合物，其包含（i）乙烯的共聚物; 一种或多种极性不饱和醇，酸或酯; 和N-取代马来酰亚胺或（ii）乙烯与一种或多种极性不饱和醇，酸或N-取代马来酰亚胺接枝的酯的共聚物。

4. 发明授权

US08269035B2 Process for production of radioactive-fluorine-labeled organic compound 有权
标题翻译：放射性氟标记有机化合物的制备方法
公开(公告)号：US08269035B2
公开(公告)日：2012-09-18
申请号：US12747726
申请日：2008-12-16
申请人： Fumie Kurosaki , Masahito Toyama , Akio Hayashi
发明人： Fumie Kurosaki , Masahito Toyama , Akio Hayashi
IPC分类号： C07C69/74
CPC分类号： C07B59/00 , C07B59/001 , C07B2200/05 , C07C269/06 , C07C2601/04 , Y02P20/55 , C07C271/24
摘要： A process for production of a radioactive fluorine-labeled organic compound is provided which can improve the yield of radioactive fluorination. Provided is a process in which a compound represented by the following formula (1): (wherein R1 is a straight or branched alkyl chain with 1-10 carbon atoms or an aromatic substituent, R2 is a straight or branched haloalkylsulfonic acid substituent with 1-10 carbon atoms, a straight or branched alkylsulfonic acid substituent with 1-10 carbon atoms, a fluorosulfonic acid substituent or an aromatic sulfonic acid substituent, and R3 is a protective group) is heated under stirring in an inert organic solvent in a presence of a phase transfer catalyst, 18F ions and potassium ions, so as to effect labeling with a radioactive fluorine, wherein the heating temperature is 40-90° C., and the concentration of the phase transfer catalyst in the inert organic solvent is 70 mmol/L or more. Preferably, the molar ratio of the phase transfer catalyst is 0.7 or more relative to the compound of the formula (1), and the concentration of the compound of the formula (1) in the inert organic solvent is 50 mmol/L or more.
摘要翻译：提供了可以提高放射性氟化产率的放射性氟标记的有机化合物的制造方法。本发明提供下述式（1）表示的化合物：其中，R 1为碳原子数为1〜10的直链或支链烷基或芳香族取代基的化合物，R2为直链或支链的卤代烷基磺酸取代基， 10个碳原子，具有1-10个碳原子的直链或支链烷基磺酸取代基，氟磺酸取代基或芳族磺酸取代基，并且R 3是保护基））在搅拌下在惰性有机溶剂中，在相转移催化剂，18F离子和钾离子，以便用放射性氟进行标记，其中加热温度为40-90℃，相转移催化剂在惰性有机溶剂中的浓度为70mmol / L 或者更多。相对于式（1）化合物，相转移催化剂的摩尔比优选为0.7以上，惰性有机溶剂中式（1）化合物的浓度为50mmol / L以上。

5. 发明申请

US20100119448A1 METHOD FOR PRODUCTION OF RADIATION DIAGNOSTIC IMAGING AGENT 有权
标题翻译：辐射诊断成像剂的生产方法
公开(公告)号：US20100119448A1
公开(公告)日：2010-05-13
申请号：US12526667
申请日：2008-02-12
申请人： Daisaku Nakamura , Soichi Nakamura , Masahito Toyama , Akio Hayashi
发明人： Daisaku Nakamura , Soichi Nakamura , Masahito Toyama , Akio Hayashi
IPC分类号： A61K51/04
CPC分类号： C07C229/48 , A61K9/0019 , A61K47/26 , A61K51/0402 , A61K51/0406 , C07B59/001 , C07B63/04 , C07B2200/05 , C07C2601/04
摘要： A method for producing a radioactive diagnostic imaging agent which contains a radioactive halogen-labeled amino acid compound as an effective ingredient and has a composition that can inhibit radiolysis of the effective ingredient, thereby further improving stability, is provided. Disclosed is a method for producing a radioactive diagnostic imaging agent, comprising a solution preparation step of preparing a solution containing a radioactive halogen-labeled amino acid compound, and a dilution step of diluting the solution containing the radioactive fluorine-labeled organic compound in order to adjust radioactive concentration thereof, which further comprises an acid addition step of adding an acid to the solution containing the radioactive fluorine-labeled organic compound, after the solution preparation step and before the dilution step, wherein the acid is added in the acid addition step in an amount sufficient to adjust the pH of the solution resulting from the dilution step to 2.0-5.9, for example, in an amount corresponding to 0.40-2.8 mmol per 1 L of the solution resulting from the dilution step.
摘要翻译：提供了含有放射性卤素标记的氨基酸化合物作为有效成分并具有能够抑制有效成分的放射线析出，从而进一步提高稳定性的组成的放射性诊断显像剂的制造方法。本发明公开了一种放射性诊断显像剂的制造方法，其特征在于，包括：制备含有放射性卤素标记的氨基酸化合物的溶液的溶液制备工序，以及稀释含有放射性氟标记的有机化合物的溶液的稀释步骤，调整其放射性浓度，其还包括在溶液制备步骤之后和稀释步骤之前在含有放射性氟标记的有机化合物的溶液中加入酸的酸添加步骤，其中在酸添加步骤中加入酸足以将由稀释步骤得到的溶液的pH调节至2.0-5.9的量，例如，相对于每1L由稀释步骤得到的溶液为0.40-2.8mmol的量。

6. 发明申请

US20100016626A1 PROCESS FOR PRODUCTION OF PRECURSOR COMPOUND FOR RADIOACTIVE HALOGEN-LABELED ORGANIC COMPOUND 有权
标题翻译：用于生产放射性标记有机化合物的前体化合物的方法
公开(公告)号：US20100016626A1
公开(公告)日：2010-01-21
申请号：US12448311
申请日：2007-12-17
申请人： Masahito Toyama , Akio Hayashi
发明人： Masahito Toyama , Akio Hayashi
IPC分类号： C07C69/74
CPC分类号： G21H5/02 , A61K51/0406 , C07B59/001 , C07B2200/09 , C07C303/28 , C07C303/44 , C07C2601/04 , Y02P20/55 , C07C309/73 , C07C309/65 , C07C309/66
摘要： A process is provided for producing a labeled precursor which is useful for production of a radioactive fluorine-labeled amino acid compound. In the reaction step for introducing a leaving group to a mixture of syn-form and anti-form of FACBC, a base is allowed to present in the reaction system to produce a syn-leaving group adduct, which is unreactive with the base and is highly stable, and an anti-leaving group adduct which can react with the base to form a water-soluble compound. By employing a purification method utilizing such a difference in solubility, the syn-leaving group adduct can be separated selectively. The base may be a linear- or branched-chain primary to tertiary alkylamine having 1 to 10 carbon atoms, a nitrogen-containing heterocyclic compound with 2 to 20 carbon atoms, and a nitrogen-containing hetero aromatic compound with 2 to 20 carbon atoms.
摘要翻译：提供了一种制备可用于制备放射性氟标记的氨基酸化合物的标记前体的方法。在用于将离去基团引入到FACBC的正构形式和抗体形式的混合物的反应步骤中，允许碱在反应体系中存在以产生与碱不反应的合成离去基团加合物，并且是高度稳定的抗离析基加合物，其可以与碱反应形成水溶性化合物。通过使用利用这种溶解度差异的纯化方法，可以选择性地分离出合成离去基加成物。碱可以是具有1-10个碳原子的直链或支链伯 - 叔烷基胺，具有2-20个碳原子的含氮杂环化合物和具有2-20个碳原子的含氮杂芳族化合物。

7. 发明申请

US20090226884A1 Method of Quantitative Analysis of Oxidized Protein, Labeling Reagents for Quantitative Analysis of Oxidized Protein and Labeling Reagent kit for Quantitative Analysis of Oxidized Protein 审中-公开
标题翻译：氧化蛋白定量分析方法，氧化蛋白定量分析标记试剂和氧化型蛋白质定量分析标记试剂盒
公开(公告)号：US20090226884A1
公开(公告)日：2009-09-10
申请号：US12225158
申请日：2007-03-20
申请人： Kazuo Tsujimoto , Akio Hayashi , Takaaki Kawai , Hiroyuki Matsumoto
发明人： Kazuo Tsujimoto , Akio Hayashi , Takaaki Kawai , Hiroyuki Matsumoto
IPC分类号： C12Q1/00 , G01N33/68
CPC分类号： G01N33/6842
摘要： Oxidized proteins, which have undergone oxidative modifications, are labeled with labeling reagents and quantified by mass spectrometry. In this process, a first labeling reagent, which is capable of reacting with the oxidized proteins, and a second labeling reagent, which has the same chemical structure as the first labeling reagent and in which at least part of the component atoms is substituted by an isotope of the atom concerned, are employed as the labeling reagents. The oxidized proteins labeled with the first labeling reagent and the oxidized proteins labeled with the second labeling reagent are mixed together and subjected to mass spectrometry, with mixing ratios varied. As the labeling reagents, are raised here 2,4-dinitrophenylhydrazine and 2,4-dinitrophenylhydrazine in which a carbon atom on the phenyl group has been substituted by a stable isotope (13C), for example.
摘要翻译：已经经过氧化修饰的氧化蛋白质用标记试剂标记并通过质谱法定量。在该方法中，能够与氧化蛋白反应的第一标记试剂和与第一标记试剂具有相同化学结构的第二标记试剂，其中至少部分成分原子被所用原子的同位素用作标记试剂。用第一标记试剂标记的氧化蛋白质和用第二标记试剂标记的氧化蛋白质混合在一起，进行质谱分析，混合比例变化。作为标记试剂，例如可以举出苯基中的碳原子被稳定的同位素（13C）代替的2,4-二硝基苯肼和2,4-二硝基苯肼。

8. 发明申请

US20080281121A1 Precursor Compound of Radioactive Halogen-Labeled Organic Compound 有权
标题翻译：放射性标记有机化合物的前体化合物
公开(公告)号：US20080281121A1
公开(公告)日：2008-11-13
申请号：US12085679
申请日：2006-11-28
申请人： Osamu Ito , Akio Hayashi , Fumie Kurosaki , Masahito Toyama , Toshiyuki Shinmura , Arinori Harano
发明人： Osamu Ito , Akio Hayashi , Fumie Kurosaki , Masahito Toyama , Toshiyuki Shinmura , Arinori Harano
IPC分类号： C07C69/74
CPC分类号： A61K51/0402 , A61K51/0406 , C07B59/00 , C07B2200/05 , C07C67/307 , C07C309/65 , C07C2601/04 , Y02P20/55
摘要： It is intended to provide a novel amino acid organic compound which can be used as a labeling precursor compound for radioactive halogen-labeled amino acid compounds including [18F]FACBC, and which prevents methanol from remaining in the radioactive halogen-labeled amino acid compounds produced therefrom. The novel amino acid organic compound is a compound represented by the following formula: wherein n is an integer of 0 or of 1 to 4; R1 is an ethyl, 1-propyl or isopropyl substituent; X is a halogen substituent or a group represented by —OR2; R2 is a straight-chain or branched-chain haloalkylsulfonic acid substituent with one to 10 carbon atoms, trialkylstannyl substituent with 3 to 12 carbon atoms, fluorosulfonic acid substituent or aromatic sulfonic acid substituent; and R3 is a protective group.
摘要翻译：旨在提供一种新的氨基酸有机化合物，其可用作用于放射性卤素标记的氨基酸化合物的标记前体化合物，包括[SUP 18 F] FACBC，并且其防止甲醇残留在由其制备的放射性卤素标记的氨基酸化合物。新型氨基酸有机化合物是下式表示的化合物：其中，n为0或1〜4的整数， R 1是乙基，1-丙基或异丙基取代基; X是卤素取代基或由-OR 2表示的基团。 R 2是具有1至10个碳原子的直链或支链卤代烷基磺酸取代基，具有3至12个碳原子的三烷基甲锡烷基取代基，氟代磺酸取代基或芳族磺酸取代基; R 3是保护基。

9. 发明申请

US20070256401A1 Drive operation device of walk-behind lawn mower 审中-公开
标题翻译：行走式割草机驱动作业装置
公开(公告)号：US20070256401A1
公开(公告)日：2007-11-08
申请号：US11790208
申请日：2007-04-24
申请人： Yoshihisa Hibi , Graeme Sidney Parris , Akio Hayashi
发明人： Yoshihisa Hibi , Graeme Sidney Parris , Akio Hayashi
IPC分类号： A01D75/28
CPC分类号： A01D34/824
摘要： A walk-behind lawn mower in a form that a handle arm is integrally provided toward an obliquely upper back in a rear of a machine, and a loop handle is provided at a rear end of the relevant handle arm with slightly tilting forward, and a driver performs drive operation while walking following the machine that travels by itself at a back of the machine, includes a throttle lever, the throttle lever being able to be drawn together with the handle by being operated by either of right and left hands grasping the handle, in addition, engine rotation frequency being able to be controlled using the amount of drawing, wherein the throttle lever is rotatably provided on the handle arm in an obliquely lower front or obliquely upper back of the handle.
摘要翻译：把手臂一体地设置在机器后部的斜上背部的形式的步行式割草机，并且在稍后向前倾斜的相关把手臂的后端设置有环把手，并且驾驶员在机器背后的机器行走时执行驾驶操作，包括节流杆，节气门杆能够通过由把手握住的左手和右手中的任一个操作而与手柄一起拉动此外，能够使用拉伸量来控制发动机转速，其中节流杆可旋转地设置在手柄的手柄的倾斜下前方或斜后方。

10. 发明授权

US06706260B1 Wound-covering preparation, wound-covering material, and method of wound healing 有权
标题翻译：伤口覆盖制剂，伤口覆盖材料和伤口愈合方法
公开(公告)号：US06706260B1
公开(公告)日：2004-03-16
申请号：US09743357
申请日：2001-01-05
申请人： Shinji Tanaka , Ken Suzuki , Kenshiro Shuto , Akio Hayashi , Nobuo Nakabayashi , Kazuhiko Ishihara
发明人： Shinji Tanaka , Ken Suzuki , Kenshiro Shuto , Akio Hayashi , Nobuo Nakabayashi , Kazuhiko Ishihara
IPC分类号： A61K3174
CPC分类号： C08F230/02 , A61L15/24 , A61L15/26 , A61L27/16 , C08F30/02 , C08L43/02 , C08F2220/1825 , C08F2222/108 , C08F2222/1013 , C08F2220/1858 , C08F2220/325 , C08L101/02
摘要： A wound-covering agent containing a polymer having a group represented by formula (I) (wherein R1, R2 and R3 are the same or different and each represents hydrogen atom or C1-4 alkyl, and m is an integer of 2 to 4); a wound-covering material containing the preparation; and a method of wound healing which comprises the step of covering the wound of a subject with the wound-covering material to protect the wound.
摘要翻译：含有具有式（I）表示的基团的聚合物的伤口覆盖剂（其中R 1，R 2和R 3相同或不同，各自表示氢原子或C 1-4烷基， m为2〜4的整数）; 含有该制剂的伤口覆盖材料; 以及伤口愈合方法，其包括用伤口覆盖材料覆盖受试者的伤口以保护伤口的步骤。

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