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1. 发明申请

US20120330092A1 DEVICE, SYSTEM, AND METHOD FOR MODULATING CARDIAC FUNCTION 审中-公开
标题翻译：用于调节心脏功能的装置，系统和方法
公开(公告)号：US20120330092A1
公开(公告)日：2012-12-27
申请号：US13525815
申请日：2012-06-18
申请人： Akira Shiose , Kiyotaka Fukamachi , Alex Massiello
发明人： Akira Shiose , Kiyotaka Fukamachi , Alex Massiello
IPC分类号： A61N1/362 , A61M1/10
CPC分类号： A61N1/056 , A61N2001/058
摘要： A therapy delivery device for modulating cardiac function in a subject includes a counterpulsation component, an endovascular lead, and at least one electrode that is physically coupled with the endovascular lead. Each of the counterpulsation component and the endovascular lead includes a proximal end and a distal end. The proximal end of the endovascular lead is physically connected to the distal end of the counterpulsation component.
摘要翻译：用于调节受试者心脏功能的治疗递送装置包括反搏组件，血管内引线和与血管内铅物理耦合的至少一个电极。每个反搏组件和血管内引线包括近端和远端。血管内引线的近端物理连接到反搏组件的远端。

2. 发明授权

US08983601B2 Extravascular neuromodulation to treat heart failure 有权
标题翻译：血管内神经调节治疗心力衰竭
公开(公告)号：US08983601B2
公开(公告)日：2015-03-17
申请号：US13405909
申请日：2012-02-27
申请人： Kiyotaka Fukamachi , Alex Massiello , Mariko Kobayashi , Ray Dessoffy , Eugene Jung , Shubhayu Basu
发明人： Kiyotaka Fukamachi , Alex Massiello , Mariko Kobayashi , Ray Dessoffy , Eugene Jung , Shubhayu Basu
IPC分类号： A61N1/00 , A61N1/36 , A61N1/362
CPC分类号： A61N1/36114 , A61N1/36139 , A61N1/3627
摘要： Treatment of heart failure in a patient by electrically modulating both the sympathetic and parasympathetic autonomic cardiac nerve fibers that innervate the patient's heart at an extravascular site in the pericardial space of the heart. The extravascular site is any suitable single location inside the chest cavity that carries both sympathetic and parasympathetic cardiac nerves such as the cardiac plexus or the pericardial transverse sinus or any two separate extravascular sites with one site carrying predominantly sympathetic cardiac nerves and the other site carrying predominantly parasympathetic cardiac nerves for electrically modulating the balance of autonomic cardiac nerve control. Physiologic inputs from a neuromodulation system's own sensors or from separate implanted or external cardiovascular hemodynamic sensor systems can be used for closed loop control over the balance of sympathetic and parasympathetic cardiac autonomic effects on the patient's cardiac function in real time response to chronic and transient physiologic needs.
摘要翻译：通过电动调节在心脏心包空间内的血管外位置支配患者心脏的交感神经和副交感神经自主神经纤维来治疗患者的心力衰竭。血管外部位是胸腔内任何合适的单一位置，其携带交感神经和副交感神经，如心脏神经丛或心包横向窦或任何两个分离的血管外部位，一个位点主要携带交感神经，另一个位点主要携带副交感神经，用于电调节自主神经控制的平衡。来自神经调节系统的自身传感器或来自分离的植入或外部心血管血液动力学传感器系统的生理输入可用于闭环控制对交感神经和副交感神经心脏自主影响对患者心脏功能的平衡，实时响应慢性和短暂的生理需求。

3. 发明申请

US20140172087A1 METHOD FOR PHYSIOLOGIC CONTROL OF A CONTINUOUS FLOW TOTAL ARTIFICIAL HEART 有权
标题翻译：连续流量人造心脏生理控制方法
公开(公告)号：US20140172087A1
公开(公告)日：2014-06-19
申请号：US14187615
申请日：2014-02-24
申请人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
发明人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
IPC分类号： A61M1/10 , F04D15/00
CPC分类号： A61M1/1001 , A61M1/1005 , A61M1/101 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M2205/3334 , F04D15/0066
摘要： A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter which is a function of electrical power delivered to the motor; (c) determining a flow rate through the first fluid circuit based on a second motor parameter which is a function of electrical power delivered to the motor; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit.
摘要翻译：提供了一种控制泵的方法，该泵包括耦合到转子的电动机，该转子在其相对端承载第一和第二叶轮。该方法包括：（a）使用电动机驱动转子，以使来自第一叶轮的流体通过第一流体回路，第二叶轮，第二流体回路循环到第一叶轮; （b）基于作为传送到电动机的电功率的函数的第一电动机参数来确定第一流体回路的电阻; （c）基于作为传送到所述电动机的电功率的函数的第二电动机参数来确定通过所述第一流体回路的流量; 以及（d）改变所述泵的至少一个操作参数，以便保持所述第一流体回路的流量和所述阻力之间的预定关系。

4. 发明授权

US08657874B2 Method for physiologic control of a continuous flow total artificial heart 有权
标题翻译：连续流总人造心脏生理控制方法
公开(公告)号：US08657874B2
公开(公告)日：2014-02-25
申请号：US12349658
申请日：2009-01-07
申请人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
发明人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
IPC分类号： A61M1/10
CPC分类号： A61M1/1001 , A61M1/1005 , A61M1/101 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M2205/3334 , F04D15/0066
摘要： A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter; (c) determining a flow rate through the first fluid circuit based on a second motor parameter; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit.
摘要翻译：提供了一种控制泵的方法，该泵包括耦合到转子的电动机，该转子在其相对端承载第一和第二叶轮。该方法包括：（a）使用电动机驱动转子，以使来自第一叶轮的流体通过第一流体回路，第二叶轮，第二流体回路循环到第一叶轮; （b）基于第一电动机参数确定第一流体回路的电阻; （c）基于第二电动机参数确定通过第一流体回路的流量; 以及（d）改变所述泵的至少一个操作参数，以便保持所述第一流体回路的流量和所述阻力之间的预定关系。

5. 发明授权

US09821098B2 Method for physiologic control of a continuous flow total artificial heart 有权
公开(公告)号：US09821098B2
公开(公告)日：2017-11-21
申请号：US14187615
申请日：2014-02-24
申请人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
发明人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
IPC分类号： A61M1/10 , F04D15/00 , A61M1/12
CPC分类号： A61M1/1001 , A61M1/1005 , A61M1/101 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M2205/3334 , F04D15/0066
摘要： A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter which is a function of electrical power delivered to the motor; (c) determining a flow rate through the first fluid circuit based on a second motor parameter which is a function of electrical power delivered to the motor; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit.

6. 发明申请

US20100174231A1 METHOD FOR PHYSIOLOGIC CONTROL OF A CONTINUOUS FLOW TOTAL ARTIFICIAL HEART 有权
标题翻译：连续流量人造心脏生理控制方法
公开(公告)号：US20100174231A1
公开(公告)日：2010-07-08
申请号：US12349658
申请日：2009-01-07
申请人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
发明人： David Horvath , Alex Massiello , Leonard A. R. Golding , Barry Kuban
IPC分类号： A61M31/00
CPC分类号： A61M1/1001 , A61M1/1005 , A61M1/101 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M2205/3334 , F04D15/0066
摘要： A method is provided of controlling a pump including a electrical motor coupled to a rotor which carries first and second impellers at opposite ends thereof. The method includes: (a) driving the rotor using the motor, so as to circulate fluid from the first impeller through a first fluid circuit, the second impeller, a second fluid circuit, and back to the first impeller; (b) determining a resistance of the first fluid circuit, based on a first motor parameter; (c) determining a flow rate through the first fluid circuit based on a second motor parameter; and (d) varying at least one operational parameter of the pump so as to maintain a predetermined relationship between the flow rate and the resistance of the first fluid circuit.
摘要翻译：提供了一种控制泵的方法，该泵包括耦合到转子的电动机，该转子在其相对端承载第一和第二叶轮。该方法包括：（a）使用电动机驱动转子，以使来自第一叶轮的流体通过第一流体回路，第二叶轮，第二流体回路循环到第一叶轮; （b）基于第一电动机参数确定第一流体回路的电阻; （c）基于第二电动机参数确定通过第一流体回路的流量; 以及（d）改变所述泵的至少一个操作参数，以便保持所述第一流体回路的流量和所述阻力之间的预定关系。

7. 发明授权

US08210829B2 Two-stage rotodynamic blood pump with axially movable rotor assembly for adjusting hydraulic performance characteristics 有权
标题翻译：具有轴向移动转子组件的两级旋转动力血泵用于调节液压性能特征
公开(公告)号：US08210829B2
公开(公告)日：2012-07-03
申请号：US12720953
申请日：2010-03-10
申请人： David Horvath , Leonard A. R. Golding , Alex Massiello
发明人： David Horvath , Leonard A. R. Golding , Alex Massiello
IPC分类号： F04D27/00 , F04D29/042 , F04D29/40 , A61M1/10
CPC分类号： F04D13/0633 , A61M1/1005 , A61M1/101 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M2205/3334 , F04D1/06 , F04D13/06 , F04D13/064 , F04D13/14 , F04D15/0033 , F04D29/042
摘要： A pump (10) includes a housing, a stator (20) supported in the housing, and a rotor assembly (30). The rotor assembly (30) includes a rotor (32) supported in the housing for rotation relative to the stator (20) about an axis (12). The rotor assembly (30) also includes a first impeller (34) operatively coupled to a first axial end of the rotor (32) for rotation with the rotor about the axis (12). The rotor assembly further includes a second impeller (36) operatively coupled to a second axial end of the rotor (32), opposite the first axial end, for rotation with the rotor about the axis (12). The rotor assembly (30) is movable along the axis (12) relative to the housing to adjust hydraulic performance characteristics of the pump (10).
摘要翻译：泵（10）包括壳体，支撑在壳体中的定子（20）和转子组件（30）。转子组件（30）包括支撑在壳体中以绕轴线（12）相对于定子（20）旋转的转子（32）。转子组件（30）还包括可操作地联接到转子（32）的第一轴向端部的第一叶轮（34），用于使转子围绕轴线（12）旋转。转子组件还包括可操作地联接到转子（32）的与第一轴向端相对的第二轴向端的第二叶轮（36），用于使转子绕轴线（12）旋转。转子组件（30）可相对于壳体沿着轴线（12）移动，以调节泵（10）的液压性能特性。

8. 发明申请

US20070253842A1 Two-stage rotodynamic blood pump 有权
标题翻译：两级旋转动力血泵
公开(公告)号：US20070253842A1
公开(公告)日：2007-11-01
申请号：US11789205
申请日：2007-04-24
申请人： David Horvath , Leonard A.R. Golding , Alex Massiello
发明人： David Horvath , Leonard A.R. Golding , Alex Massiello
IPC分类号： F04B17/00
CPC分类号： F04D1/06 , A61M1/1005 , A61M1/101 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/127 , A61M2205/3334 , F04D13/0633 , F04D13/064 , F04D29/042
摘要： A pump (10) includes a housing, a stator (20) supported in the housing, and a rotor assembly (30). The rotor assembly (30) includes a rotor (32) supported in the housing for rotation relative to the stator (20) about an axis (12). The rotor assembly (30) also includes a first impeller (34) operatively coupled to a first axial end of the rotor (32) for rotation with the rotor about the axis (12). The rotor assembly further includes a second impeller (36) operatively coupled to a second axial end of the rotor (32), opposite the first axial end, for rotation with the rotor about the axis (12). The rotor assembly (30) is movable along the axis (12) relative to the housing to adjust hydraulic performance characteristics of the pump (10).
摘要翻译：泵（10）包括壳体，支撑在壳体中的定子（20）和转子组件（30）。转子组件（30）包括支撑在壳体中以绕轴线（12）相对于定子（20）旋转的转子（32）。转子组件（30）还包括可操作地联接到转子（32）的第一轴向端部的第一叶轮（34），用于使转子围绕轴线（12）旋转。转子组件还包括可操作地联接到转子（32）的与第一轴向端相对的第二轴向端的第二叶轮（36），用于使转子绕轴线（12）旋转。转子组件（30）可相对于壳体沿着轴线（12）移动，以调节泵（10）的液压性能特性。

9. 发明授权

US09162019B2 Two-stage rotodynamic blood pump 有权
标题翻译：两级旋转动力血泵
公开(公告)号：US09162019B2
公开(公告)日：2015-10-20
申请号：US13540037
申请日：2012-07-02
申请人： David Horvath , Leonard A. R. Golding , Alex Massiello , Barry Kuban
发明人： David Horvath , Leonard A. R. Golding , Alex Massiello , Barry Kuban
IPC分类号： A61M1/10 , F04D1/06 , F04D13/06 , F04D13/14 , F04D15/00 , A61M1/12
CPC分类号： A61M1/1031 , A61M1/1005 , A61M1/101 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1029 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M2205/3334 , F04D1/06 , F04D13/06 , F04D13/064 , F04D13/14 , F04D15/0033
摘要： A pump includes a housing, a stator supported in the housing, and a rotor assembly including a rotor supported in the housing for rotation relative to the stator about an axis. The stator includes a stator core, a first lamination wound around an axial portion of the stator core, and a second lamination wound around a second axial portion of the stator core. The first and second laminations are spaced from each other along the length of the stator core. The rotor includes a rotor core, a first magnet assembly that extends around an axial portion of the rotor core, and a second magnet assembly that extends around a second axial portion of the rotor core. The first and second magnet assemblies are spaced from each other along the length of the rotor.
摘要翻译：泵包括壳体，支撑在壳体中的定子，以及转子组件，其包括支撑在壳体中的转子，用于相对于定子围绕轴线旋转。定子包括定子芯，围绕定子芯的轴向部分缠绕的第一层叠体，以及缠绕在定子芯的第二轴向部分上的第二层压体。第一和第二叠片沿着定子芯的长度彼此间隔开。转子包括转子芯，围绕转子芯的轴向部分延伸的第一磁体组件和围绕转子芯的第二轴向部分延伸的第二磁体组件。第一和第二磁体组件沿着转子的长度彼此间隔开。

10. 发明授权

US07704054B2 Two-stage rotodynamic blood pump 有权
标题翻译：两级旋转动力血泵
公开(公告)号：US07704054B2
公开(公告)日：2010-04-27
申请号：US11789205
申请日：2007-04-24
申请人： David Horvath , Leonard A. R. Golding , Alex Massiello
发明人： David Horvath , Leonard A. R. Golding , Alex Massiello
IPC分类号： F04B49/00 , F03B3/12 , F04B17/04 , A61M1/10
CPC分类号： F04D1/06 , A61M1/1005 , A61M1/101 , A61M1/1013 , A61M1/1015 , A61M1/1017 , A61M1/1031 , A61M1/1086 , A61M1/12 , A61M1/122 , A61M1/127 , A61M2205/3334 , F04D13/0633 , F04D13/064 , F04D29/042
摘要： A pump (10) includes a housing, a stator (20) supported in the housing, and a rotor assembly (30). The rotor assembly (30) includes a rotor (32) supported in the housing for rotation relative to the stator (20) about an axis (12). The rotor assembly (30) also includes a first impeller (34) operatively coupled to a first axial end of the rotor (32) for rotation with the rotor about the axis (12). The rotor assembly further includes a second impeller (36) operatively coupled to a second axial end of the rotor (32), opposite the first axial end, for rotation with the rotor about the axis (12). The rotor assembly (30) is movable along the axis (12) relative to the housing to adjust hydraulic performance characteristics of the pump (10).
摘要翻译：泵（10）包括壳体，支撑在壳体中的定子（20）和转子组件（30）。转子组件（30）包括支撑在壳体中以绕轴线（12）相对于定子（20）旋转的转子（32）。转子组件（30）还包括可操作地联接到转子（32）的第一轴向端部的第一叶轮（34），用于使转子围绕轴线（12）旋转。转子组件还包括可操作地联接到转子（32）的与第一轴向端相对的第二轴向端的第二叶轮（36），用于使转子绕轴线（12）旋转。转子组件（30）可相对于壳体沿着轴线（12）移动，以调节泵（10）的液压性能特性。

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