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1. 发明授权

US06632943B2 Process for production of optically active pyrroloazepine derivatives 失效
标题翻译：光学活性吡咯并氮衍生物的制备方法
公开(公告)号：US06632943B2
公开(公告)日：2003-10-14
申请号：US09913262
申请日：2001-08-10
申请人： Akira Mizuno , Kazuto Sekiuchi , Takushi Nagata , Teruo Muraishi
发明人： Akira Mizuno , Kazuto Sekiuchi , Takushi Nagata , Teruo Muraishi
IPC分类号： C07D48704
CPC分类号： C07D487/04
摘要： It is provided a method for preparing the pyrroloazepine derivatives, especially in optically active form useful as drugs, by low-priced and simple method and in industrial applicable scale, represented by the following formula (I): wherein Z represents optionally substituted phenyl group, which comprises; a process for the asymmetric reduction of ketone compound with metal hydride compound and alcohol compound in the presence of optically active cobalt complex catalyst, and a process for the purification of the resulting compound.
摘要翻译：本发明提供一种制备吡咯并氮衍生物的方法，特别是用作药物的光学活性形式，通过低价简便的方法和工业应用规模，由下式（I）表示：其中Z表示任意取代的苯基，其包括：在光学活性钴配合物催化剂存在下用金属氢化物化合物和醇化合物不对称还原酮化合物的方法，和一种纯化所得化合物的方法。 PTEXT>

2. 发明授权

US07892486B2 Method of sterilization and apparatus therefore 有权
标题翻译：因此灭菌方法和设备
公开(公告)号：US07892486B2
公开(公告)日：2011-02-22
申请号：US10594387
申请日：2005-03-29
申请人： Akira Mizuno , Hiroyuki Yuyama , Yoshinori Shirahara
发明人： Akira Mizuno , Hiroyuki Yuyama , Yoshinori Shirahara
IPC分类号： A61L2/20
CPC分类号： A61L2/208 , A61L2/14 , A61L2/202 , A61L2202/24
摘要： A harmless sterilization method and sterilization apparatus which provide adequate sterilization effects without residual gas. The method includes a sterilization step in which a chamber containing an object to be sterilized is depressurized; a hydrogen peroxide supply step in which hydrogen peroxide is supplied into the chamber; an ozone supply step in which ozone is supplied into the chamber; a sterilization step in which the hydrogen peroxide and ozone supplied inside the chamber are dispersed to sterilize the object to be sterilized; an exhaust step in which gas inside the chamber is exhausted; and a plasma generation step in which plasma is generated inside the chamber to break down hydrogen peroxide and ozone remaining near the object to be sterilized, and radicals which promote sterilization are generated.
摘要翻译：无残留气体提供充分杀菌效果的无害灭菌方法和杀菌装置。该方法包括灭菌步骤，其中包含待消毒物体的室被减压; 过氧化氢供给步骤，其中将过氧化氢供给到室中; 将臭氧供给到所述室内的臭氧供给步骤; 灭菌步骤，其中分散在室内的过氧化氢和臭氧被分散以消毒待消毒的物体; 废气步骤，其中室内的气体被耗尽; 以及等离子体产生步骤，其中在腔室内产生等离子体以分解残留在待消毒物体附近的过氧化氢和臭氧，并产生促进灭菌的自由基。

3. 发明授权

US07758675B2 Gas treatment device 失效
标题翻译：气体处理装置
公开(公告)号：US07758675B2
公开(公告)日：2010-07-20
申请号：US11587816
申请日：2005-04-13
申请人： Kenta Naito , Satoru Senbayashi , Yuichi Hamada , Akira Mizuno , Junichi Kasai , Yoshinobu Tamura
发明人： Kenta Naito , Satoru Senbayashi , Yuichi Hamada , Akira Mizuno , Junichi Kasai , Yoshinobu Tamura
IPC分类号： B03C3/15
CPC分类号： F01N3/01 , B01D53/32 , B01D2258/01 , B01D2259/818 , B03C3/36 , B03C3/45 , B03C2201/30 , F01N2240/20 , Y02T10/20 , Y10S55/38
摘要： Gas treatment equipment including a corona electrode and a dust-collection electrode facing the corona electrode, and forming corona discharge in gas passing between the corona electrode and the dust-collection electrode by applying a high voltage between them to collect components in the gas wherein a gas turbulence accelerator is located in the vicinity of the surface of the dust-collection electrode facing the corona electrode.
摘要翻译：气体处理设备包括电晕电极和面向电晕电极的集尘电极，并且通过在它们之间施加高电压而在电晕电极和集尘电极之间形成的气体中形成电晕放电，以收集气体中的成分，其中气体湍流加速器位于集尘电极的面对电晕电极的表面附近。

4. 发明授权

US07187098B2 Axial gap rotating electrical machine 有权
标题翻译：轴向间隙旋转电机
公开(公告)号：US07187098B2
公开(公告)日：2007-03-06
申请号：US11065176
申请日：2005-02-24
申请人： Masahiro Hasebe , Masami Ishikawa , Akira Mizuno
发明人： Masahiro Hasebe , Masami Ishikawa , Akira Mizuno
IPC分类号： H02K21/12
CPC分类号： H02K21/24 , H02K1/2793
摘要： An axial gap rotating electrical machine is provided with permanent magnets and cores in a rotor. The permanent magnets are oriented such that magnetization surfaces face in the circumferential direction of the rotor. The cores are arranged alternately with the permanent magnets in the circumferential direction of the rotor. The amount of magnetic flux on the outside in the radial direction of the rotor is made greater than the amount of magnetic flux on the inside in the radial direction of the rotor. As a result, the magnetic flux density at the rotor cores can be made substantially constant in the radial direction of the rotor and torque output with respect to the size of the permanent magnets is improved by preventing magnetic saturation of the cores.
摘要翻译：轴向间隙旋转电机在转子中设置永磁体和铁心。永磁体被定向为使得磁化表面在转子的圆周方向上面对。芯与转子的圆周方向上的永久磁铁交替排列。使转子的径向外侧的磁通量大于转子径向内侧的磁通量。结果，转子芯的磁通密度可以在转子的径向方向上基本上恒定，并且通过防止磁芯的磁饱和来改善相对于永磁体的尺寸的扭矩输出。

5. 发明申请

US20060197721A1 Flat type image display device 失效
标题翻译：平面型图像显示装置
公开(公告)号：US20060197721A1
公开(公告)日：2006-09-07
申请号：US10548717
申请日：2004-05-27
申请人： Akira Mizuno , Masayuki Esaki
发明人： Akira Mizuno , Masayuki Esaki
IPC分类号： G09G3/28
CPC分类号： H04N5/64 , H04N5/70 , Y10S345/901
摘要： A flat panel image display unit such as a plasma display device is provided having a structure of signal input terminals that is adaptable flexibly to a plurality of different kinds of video signals. The image display unit includes a flat display panel, a display drive circuit block, an input signal circuit block connected between the display drive circuit block and an external apparatus for outputting a video signal, and an enclosure for housing the above components. The input signal circuit block includes a plurality of different kinds of board blocks provided replaceably according to a plurality of different forms of signals. A casing member is placed inside the enclosure and is provided with an insertion opening for accepting insertion of any of the board blocks. A guide rail is for positioning the board block to a predetermined position. The plurality of guide rails are provided according to the board block of a smallest unit size.
摘要翻译：提供了诸如等离子体显示装置的平板图像显示单元，其具有可灵活地适应于多种不同种类的视频信号的信号输入端的结构。图像显示单元包括平面显示面板，显示驱动电路块，连接在显示驱动电路块和用于输出视频信号的外部设备之间的输入信号电路块，以及用于容纳上述组件的外壳。输入信号电路块包括根据多种不同形式的信号可替换地提供的多种不同种类的板块。外壳部件放置在外壳的内部，并且设置有用于接受任何板块的插入的插入开口。导轨用于将板块定位到预定位置。根据最小单位尺寸的板块提供多个导轨。

6. 发明申请

US20050179337A1 Axial gap electric rotary machine 审中-公开
标题翻译：轴向电动旋转机
公开(公告)号：US20050179337A1
公开(公告)日：2005-08-18
申请号：US10983894
申请日：2004-11-09
申请人： Masahiro Hasebe , Masami Ishikawa , Akira Mizuno , Yoji Takeda , Masayuki Sanada
发明人： Masahiro Hasebe , Masami Ishikawa , Akira Mizuno , Yoji Takeda , Masayuki Sanada
IPC分类号： H02K1/12 , H02K1/27 , H02K16/02 , H02K19/10 , H02K21/24 , H02K21/12 , H02K1/22 , H02K3/00
CPC分类号： H02K21/24 , H02K1/2793 , H02K19/103
摘要： An axial gap electric rotary machine includes a rotor and a stator which face each other with an axial gap therebetween. The rotor includes permanent magnets which are arranged with their magnetic poles spaced around the circumference of the rotor, with the magnetic poles of adjacent permanent magnets being opposite each other. The permanent magnets and rotor cores are alternately arranged around the circumference of the rotor. Consequently, north poles and south poles are alternately formed at a surface of the rotor facing the stator, and reluctance of a magnetic path which passes through a permanent magnet is larger than reluctance of a magnetic path which does not pass through the permanent magnet, whereby the functions of a reluctance type rotary machine and a permanent magnet synchronous machine are combined in a compact structure.
摘要翻译：轴向间隙电动旋转机械包括转子和定子，它们之间具有轴向间隙。转子包括永磁体，它们的磁极间隔绕转子的周边排列，相邻的永磁体的磁极彼此相对。永久磁铁和转子铁芯绕转子周围交替布置。因此，北极和南极交替地形成在面向定子的转子的表面，并且穿过永磁体的磁路的磁阻大于不通过永磁体的磁路的磁阻，由此磁阻式旋转机和永磁同步电机的功能结合在一起，结构紧凑。

7. 发明授权

US06838522B2 Propylene polymer compositions 失效
标题翻译：丙烯聚合物组合物
公开(公告)号：US06838522B2
公开(公告)日：2005-01-04
申请号：US09973902
申请日：2001-10-11
申请人： Mikio Hashimoto , Takasi Ueda , Masaaki Kawasaki , Satoru Moriya , Akira Mizuno , Daisuke Fukuoka , Junichi Imuta , Keiji Hirose , Junji Saito , Yoshihisa Kiso
发明人： Mikio Hashimoto , Takasi Ueda , Masaaki Kawasaki , Satoru Moriya , Akira Mizuno , Daisuke Fukuoka , Junichi Imuta , Keiji Hirose , Junji Saito , Yoshihisa Kiso
IPC分类号： C08F4/642 , C08L23/08 , C08L23/10 , C08L23/12 , C08L23/14 , C08L23/16 , C08L23/04
CPC分类号： C08L23/12 , C08L23/0815 , C08L23/10 , C08L23/142 , C08L23/16 , C08L2205/02 , C08L2314/06 , C08L2666/04
摘要： A propylene polymer composition comprising a propylene polymer prepared by using a zirconocene catalyst having two aryl-substituted indenyl group and having a melt flow rate (MFR) of 0.01 to 30 g/10 min and a second propylene polymer prepared by using a zirconocene catalyst having a melt flow rate (MFR) of 30 to 1,000 g/10 min and, if desired, a soft polymer, a ratio of the MFR of the second propylene polymer to the MFR of the second propylene polymer being not less than 30. These propylene polymer compositions are excellent in heat resistance, mechanical strength, tensile elongation at break, etc., and hence they can be favorably used for various structural materials such as those of automobile and electrical appliances, daily necessaries, various films and sheets.
摘要翻译：一种丙烯聚合物组合物，其包含通过使用具有两个芳基取代的茚基的熔体流动速率（MFR）为0.01至30g / 10min的二茂锆催化剂制备的丙烯聚合物，以及通过使用二茂锆催化剂制备的第二丙烯聚合物，所述二茂锆催化剂具有熔体流动速率（MFR）为30至1,000g / 10min，如果需要，软质聚合物，第二丙烯聚合物的MFR与第二丙烯聚合物的MFR之比不小于30.这些丙烯聚合物组合物的耐热性，机械强度，断裂伸长率等优异，因此可以有利地用于汽车，电器，日用品，各种膜，片等各种结构材料。

8. 发明授权

US06624314B2 Pyrrolothiazine and pyrrolothiazepine compounds having serotonin-2 receptor antagonistic and alpha-1-blocking action 失效
标题翻译：具有5-羟色胺受体拮抗作用和α-1-阻断作用的吡罗噻嗪和吡咯并噻吩类化合物
公开(公告)号：US06624314B2
公开(公告)日：2003-09-23
申请号：US09871655
申请日：2001-06-04
申请人： Akira Mizuno , Makoto Shibata , Tomoe Kamei , Harukazu Fukami , Norio Inomata
发明人： Akira Mizuno , Makoto Shibata , Tomoe Kamei , Harukazu Fukami , Norio Inomata
IPC分类号： C07D20736
CPC分类号： C07D513/04 , C07D207/36
摘要： A pyrrolesulfonamide derivative having the following formula (I): wherein the ring P represented by is a pyrrole ring having the following structure: wherein R represents alkyl, cycloalkyl, cycloalkylalkyl or aralkyl; the dashed line indicates the presence or absence of a bond; l stands for 0 or 1; A represents alkylene, alkenylene or alkynylene; and Y represents a group in which W represents CH, C═ or N; m stands for 0 or 1 when W is CH or N, or m stands for 1 when W is C═; B represents a specific divalent group; E1 and E2 each independently represents H or lower alkyl; and D represents an aromatic hydrocarbon group or heterocyclic group. The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is useful as a therapeutic for circulatory diseases such as ischemic heart diseases, cerebrovascular disturbances and peripheral circulatory disturbances.
摘要翻译：具有下式（I）的吡咯磺酰胺衍生物：其中由具有以下结构的吡咯环表示的环P：其中R表示烷基，环烷基，环烷基烷基或芳烷基; 虚线表示存在或不存在键; l代表0或1; A表示亚烷基，亚烯基或亚炔基; Y表示W表示CH，C =或N的基团; 当W为CH或N时，m代表0或1，当W为C =时，m代表1; B表示特定的二价基团; E1和E2各自独立地表示H或低级烷基; D表示芳族烃基或杂环基。化合物（I）具有强的5-羟色胺-2受体拮抗作用，毒性低，副作用小，作为循环系统疾病如缺血性心脏病，脑血管障碍和周围循环障碍的治疗有用。

9. 发明授权

US06187772B1 Pyrroloazepine compounds 失效
标题翻译：吡咯并氮化合物
公开(公告)号：US06187772B1
公开(公告)日：2001-02-13
申请号：US09147248
申请日：1998-11-12
申请人： Akira Mizuno , Makoto Shibata , Tomoe Kamei , Norio Inomata
发明人： Akira Mizuno , Makoto Shibata , Tomoe Kamei , Norio Inomata
IPC分类号： C07D48704
CPC分类号： C07D207/416 , C07D487/04
摘要： Disclosed are pyrroloazepine compounds and their salts. These pyrroloazepine compounds are represented by formula (I) wherein the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z2 is not present and Z1 is H but, when the bond is absent, Z1 and Z2 are both Hs; Z1 is H and Z2 is OH; Z1 and Z2 are both SR5s in which R5 is alkyl, aralkyl or aryl; or Z1 and Z2 are combined together to represent O, NOR6 in which R6 is H, alkyl, aralkyl or aryl, or C2-C3 alkylenedithio; R is H, alkyl, cycloalkyl, cycloalkyl alkyl or aralkyl; and the ring P is a specific pyrrole ring. These pyrroloazepine compounds and salts are effective as preventives or therapeutics for general circulatory diseases such as hypertension, heart failure, ischemic hear diseases, cerebrovascular disturbances and peripheral circulatory disturbances. Their production processes are also disclosed
摘要翻译：公开了吡咯并氮化合物及其盐。这些吡咯并氮化合物由式（I）表示，其中虚线表示存在或不存在键; 当存在键时，Z 2不存在且Z1为H，但不存在键时，Z 1和Z 2均为Hs; Z1是H，Z2是OH; Z 1和Z 2都是SR 5，其中R 5是烷基，芳烷基或芳基; 或Z 1和Z 2组合在一起以表示其中R 6为H，烷基，芳烷基或芳基或C 2 -C 3亚烷基二硫基的O，NOR 6; R为H，烷基，环烷基，环烷基烷基或芳烷基; 环P是特定的吡咯环。这些吡咯并氮化合物和盐可用作一般循环系统疾病如高血压，心力衰竭，缺血性听觉疾病，脑血管障碍和外周循环障碍的预防剂或治疗剂。他们的生产过程也被披露

10. 发明授权

US5962448A Pyrroloazepine derivatives 失效
标题翻译：吡咯并氮衍生物
公开(公告)号：US5962448A
公开(公告)日：1999-10-05
申请号：US875495
申请日：1997-08-21
申请人： Akira Mizuno , Makoto Shibata , Tomoe Iwamori , Tetsuo Shimamoto , Kyoko Nakanishi , Norio Inomata
发明人： Akira Mizuno , Makoto Shibata , Tomoe Iwamori , Tetsuo Shimamoto , Kyoko Nakanishi , Norio Inomata
IPC分类号： A61P7/00 , A61P9/00 , C07D207/34 , C07D487/04 , C07D495/20 , A61K31/55
CPC分类号： C07D487/04 , C07D207/34
摘要： A pyrroloazepine compound having the following formula (I): whereinthe ring P represented by ##STR1## is a pyrrole ring having the following structure: ##STR2## wherein R.sub.1 represents C.sub.1 -C.sub.8 alkyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.4 -C.sub.8 cycloalkyl-alkyl, C.sub.6 -C.sub.14 aryl or C.sub.7 -C.sub.22 aralkyl, which are optionally substituted; and R.sub.2 represents H or C.sub.1 -C.sub.8 alkyl, which is optionally substituted; the dashed line indicates the presence or absence of a bond; and, when the bond is present, Z.sub.2 is not present and Z.sub.1 represents H, but, when the bond is absent, Z.sub.1 and Z.sub.2 are both H; Z.sub.1 represents H and Z.sub.2 represents a group OR.sub.3, in which R.sub.3 represents H, C.sub.1 -C.sub.8 alkyl, or C.sub.7 -C.sub.22 aralkyl, which are optionally substituted; Z.sub.1 and Z.sub.2 both represent groups SR.sub.4, in which R.sub.4 represents C.sub.1 -C.sub.8 alkyl or C.sub.7 -C.sub.22 aralkyl, which are optionally substituted; or Z.sub.1 and Z.sub.2 are combined together to represent O, a group NOR.sub.5, in which R.sub.5 represents H, or C.sub.1 -C.sub.8 alkyl or C.sub.2 -C.sub.3 alkylenedithio, which are optionally substituted; A represents alkylene, alkenylene or alkynylene; and Y represents a group in which W is CH, C.dbd. or N, m is for 0 or 1, n is for 1, 2 or 3, G is O, S, C.dbd.O, sulfinyl, sulfonyl, alkylene, alkenylene or acetal; E.sub.1 and E.sub.2 is H or C.sub.1 -C.sub.8 alkyl; and D represents an aromatic hydrocarbon or an aromatic heterocyclic ring. The compound (I) has strong serotonin-2 receptor antagonistic action and low toxicity and less side effects, and is therapeutically useful in the treatment of circulatory diseases and/or conditions related thereto.
摘要翻译： PCT No.PCT / JP96 / 03522 Sec。 371日期1997年8月21日 102（e）日期1997年8月21日PCT提交1996年12月2日PCT公布。出版物WO97 / 20845 日期：1997年6月12日具有下式（I）的吡咯并氮吡啶化合物：其中由代表的环P是具有以下结构的吡咯环：其中R1表示C1-C8烷基，C3-C8环烷基，C4-C8环烷基 - 烷基，任选被取代的C 6 -C 14芳基或C 7 -C 22芳烷基; 并且R 2表示H或被任选取代的C 1 -C 8烷基; 虚线表示存在或不存在键; 当存在键时，Z 2不存在，Z1表示H，但不存在键时，Z 1和Z 2均为H; Z1表示H，Z2表示OR3，其中R3表示H，任选取代的C 1 -C 8烷基或C 7 -C 22芳烷基; Z 1和Z 2均表示SR 4，其中R 4表示任选取代的C 1 -C 8烷基或C 7 -C 22芳烷基; 或Z 1和Z 2组合在一起表示O，其中R 5表示H的基团NOR 5或任选被取代的C 1 -C 8烷基或C 2 -C 3亚烷基二硫基; A表示亚烷基，亚烯基或亚炔基; 并且Y表示W为CH，C =或N的基团，m为0或1，n为1,2或3，G为O，S，C = O，亚磺酰基，磺酰基，亚烷基，亚烯基或亚磺酰基乙缩醛 E1和E2是H或C1-C8烷基; D表示芳族烃或芳香族杂环。化合物（I）具有强的5-羟色胺-2受体拮抗作用和低毒性和较少的副作用，并且在治疗循环系统疾病和/或与之有关的病症中是治疗上有用的。

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