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1. 发明授权

US06903233B2 Process for producing optically active 3-halogenocarboxylic acid ester and 3-azidocarboxylic acid ester 失效
标题翻译：光学活性3-卤代羧酸酯和3-叠氮基羧酸酯的制备方法
公开(公告)号：US06903233B2
公开(公告)日：2005-06-07
申请号：US10383866
申请日：2003-03-10
申请人： Akira Amano , Daisuke Igarashi , Takashi Miura
发明人： Akira Amano , Daisuke Igarashi , Takashi Miura
IPC分类号： C07C67/307 , C07C227/32 , C07C247/12 , C07C205/00 , C07C69/62 , C07C229/00 , C07C247/04 , C09K19/52
CPC分类号： C07C247/12 , C07C67/307 , C07C227/32 , C07C69/63
摘要： A process for producing an optically active 3-azide-carboxylic acid ester by reacting an optically active 3-hydroxycarboxylic acid ester and a thionyl halide in the presence of a basic substance in an organic solvent to produce an optically active 3-halogenocarboxylic acid ester which is then reacted with an azide salt represented by the formula: MN3 (wherein M is an alkaline metal) in water or a mixture of water and a water soluble organic solvent.
摘要翻译：一种光学活性3-叠氮化物 - 羧酸酯的制备方法，该方法是通过使光学活性的3-羟基羧酸酯和亚硫酰卤在碱性物质的存在下在有机溶剂中反应制备光学活性的3-卤代羧酸酯，然后与水或水和水溶性有机溶剂的混合物中的下式表示的叠氮化物盐（其中M是碱金属）反应。

2. 发明授权

US07754889B2 Optically active transition metal-diamine compound and process for producing optically active alcohol with the same 有权
标题翻译：光活性过渡金属 - 二胺化合物及其制备光学活性醇的方法
公开(公告)号：US07754889B2
公开(公告)日：2010-07-13
申请号：US10594744
申请日：2005-03-28
申请人： Akira Amano , Daisuke Igarashi , Noboru Sayo
发明人： Akira Amano , Daisuke Igarashi , Noboru Sayo
IPC分类号： C07F15/00
CPC分类号： C07C211/49 , B01J31/0222 , B01J31/1805 , B01J31/4015 , B01J31/4038 , B01J2231/643 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/827 , B01J2531/96 , C07B2200/07 , C07C29/143 , C07C211/27 , C07C311/18 , C07F15/0053 , C07F15/0073 , C07F15/008 , Y02P20/584 , C07C33/22
摘要： The present invention provides a water-soluble transition metal-diamine complex which can be easily separated from reaction products through liquid separation, etc. and is recycleable; an optically active diamine compound constituting the ligand of the complex; and a catalyst for asymmetric synthesis which comprises these. The present invention relates to a water-soluble optically active transition metal-diamine complex represented by the formula (2): [wherein R1 and R2 each represents hydrogen, a hydrocarbon group, —SO2R13 (wherein R13 is a hydrocarbon group, substituted amino, etc.), etc.; R3 to R12 each represents hydrogen, a hydrocarbon group, alkoxy, substituted amino, etc.; M represents a transition metal; X represents halogen; L represents a ligand; and * indicates an asymmetric carbon atom; provided that at least one of R3 to R7 and R8 to R12 is substituted amino], a catalyst for asymmetric synthesis containing the complex, and a process for producing an optically active alcohol, which comprises using the catalyst to asymmetrically reduce a ketone.
摘要翻译：本发明提供一种水溶性过渡金属 - 二胺络合物，其可以通过液体分离等容易地从反应产物中分离出来并且是可再循环的; 构成络合物配体的光学活性二胺化合物; 和包含这些的不对称合成催化剂。本发明涉及由式（2）表示的水溶性光学活性过渡金属 - 二胺络合物：其中R1和R2各自表示氢，烃基，-SO2R13（其中R13为烃基，取代氨基，等等） R3至R12各自表示氢，烃基，烷氧基，取代的氨基等; M表示过渡金属; X表示卤素; L表示配体; 和*表示不对称碳原子; 条件是R 3至R 7和R 8至R 12中的至少一个为取代的氨基]，含有络合物的不对称合成催化剂，以及制备光学活性醇的方法，其包括使用该催化剂不对称还原酮。

3. 发明申请

US20070149831A1 Optically active transition metal-diamine compound and process for producing optically active alcohol with the same 有权
标题翻译：光活性过渡金属 - 二胺化合物及其制备光学活性醇的方法
公开(公告)号：US20070149831A1
公开(公告)日：2007-06-28
申请号：US10594744
申请日：2005-03-28
申请人： Akira Amano , Daisuke Igarashi , Noboru Sayo
发明人： Akira Amano , Daisuke Igarashi , Noboru Sayo
IPC分类号： C07C29/14 , C07F15/00
CPC分类号： C07C211/49 , B01J31/0222 , B01J31/1805 , B01J31/4015 , B01J31/4038 , B01J2231/643 , B01J2531/0266 , B01J2531/821 , B01J2531/822 , B01J2531/827 , B01J2531/96 , C07B2200/07 , C07C29/143 , C07C211/27 , C07C311/18 , C07F15/0053 , C07F15/0073 , C07F15/008 , Y02P20/584 , C07C33/22
摘要： The present invention provides a water-soluble transition metal-diamine complex which can be easily separated from reaction products through liquid separation, etc. and is recycleable; an optically active diamine compound constituting the ligand of the complex; and a catalyst for asymmetric synthesis which comprises these. The present invention relates to a water-soluble optically active transition metal-diamine complex represented by the formula (2): [wherein R1 and R2 each represents hydrogen, a hydrocarbon group, —SO2R13 (wherein R13 is a hydrocarbon group, substituted amino, etc.), etc.; R3 to R12 each represents hydrogen, a hydrocarbon group, alkoxy, substituted amino, etc.; M represents a transition metal; X represents halogen; L represents a ligand; and * indicates an asymmetric carbon atom; provided that at least one of R3 to R7 and R8 to R12 is substituted amino], a catalyst for asymmetric synthesis containing the complex, and a process for producing an optically active alcohol, which comprises using the catalyst to asymmetrically reduce a ketone.
摘要翻译：本发明提供一种水溶性过渡金属 - 二胺络合物，其可以通过液体分离等容易地从反应产物中分离出来并且是可再循环的; 构成络合物配体的光学活性二胺化合物; 和包含这些的不对称合成催化剂。本发明涉及由式（2）表示的水溶性光学活性过渡金属 - 二胺络合物：其中R 1和R 2各自表示氢，烃基，-SO 2 R 13（其中R 13是烃基，取代的氨基等）等; R 12至R 12各自表示氢，烃基，烷氧基，取代的氨基等; M表示过渡金属; X表示卤素; L表示配体; 和*表示不对称碳原子; 条件是R 3至R 7和R 8至R 12中的至少一个为取代的氨基]，含有络合物的不对称合成催化剂，以及制备光学活性醇的方法，其包括使用该催化剂不对称地还原酮。

4. 发明申请

US20070060772A1 Phosphines, transition metal complexes containing the same as the ligand, and process for production of optically active carboxylic acids 有权
公开(公告)号：US20070060772A1
公开(公告)日：2007-03-15
申请号：US11540166
申请日：2006-09-29
申请人： Akira Amano , Daisuke Igarashi , Noboru Sayo
发明人： Akira Amano , Daisuke Igarashi , Noboru Sayo
IPC分类号： C07B53/00 , C07F15/00
CPC分类号： C07F9/5027 , C07B2200/07 , C07C51/36 , C07F9/65517 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008 , C07F15/045 , C07C53/128
摘要： [PROBLEMS] To provide a method by which desired optically active carboxylic acids may be prepared from a carboxylic acid having a carbon-carbon double bond through asymmetric hydrogenation with a catalyst consisting of a transition metal complex containing a water-soluble ligand and which permits easy separation of the used catalyst from the product by liquid-liquid separation alone and enables the recovery of an expensive transition metal and the reuse of the catalyst. [MEANS FOR SOLVING PROBLEMS] Phosphines represented by the general formula (1): wherein X1 is oxygen or methylene; X2 is methylene, ethylene, trimethylene, 1,2-dimethylethylene, isopropylidene, or difluoromethylene; A is a Group IA alkali metal of the periodic table, hydrogen, or an ammonium ion; and a, b, c and d are each an integer of 0 or 1, with the proviso that the cases wherein the sum of a, b, c, and d is 0 are excepted.

5. 发明授权

US07294601B2 Phosphines, transition metal complexes containing the same as the ligand, and process for production of optically active carboxylic acids 有权
标题翻译：含有与配体相同的膦，过渡金属配合物，以及光学活性羧酸的制造方法
公开(公告)号：US07294601B2
公开(公告)日：2007-11-13
申请号：US11540166
申请日：2006-09-29
申请人： Akira Amano , Daisuke Igarashi , Noboru Sayo
发明人： Akira Amano , Daisuke Igarashi , Noboru Sayo
IPC分类号： B01J31/00
CPC分类号： C07F9/5027 , C07B2200/07 , C07C51/36 , C07F9/65517 , C07F15/004 , C07F15/0053 , C07F15/0066 , C07F15/008 , C07F15/045 , C07C53/128
摘要： [PROBLEMS] To provide a method by which desired optically active carboxylic acids may be prepared from a carboxylic acid having a carbon-carbon double bond through asymmetric hydrogenation with a catalyst consisting of a transition metal complex containing a water-soluble ligand and which permits easy separation of the used catalyst from the product by liquid-liquid separation alone and enables the recovery of an expensive transition metal and the reuse of the catalyst.[MEANS FOR SOLVING PROBLEMS] Phosphines represented by the general formula (1): wherein X1 is oxygen or methylene; X2 is methylene, ethylene, trimethylene, 1,2-dimethylethylene, isopropylidene, or difluoromethylene; A is a Group IA alkali metal of the periodic table, hydrogen, or an ammonium ion; and a, b, c and d are each an integer of 0 or 1, with the proviso that the cases wherein the sum of a, b, c, and d is 0 are excepted.
摘要翻译： [问题]提供一种通过不对称氢化由具有碳 - 碳双键的羧酸制备所需光学活性羧酸的方法，该催化剂由含有水溶性配体的过渡金属配合物组成的催化剂制备，并且容易通过液 - 液分离将所用催化剂与产物分离，并且能够回收昂贵的过渡金属和催化剂的再利用。解决问题的手段由通式（1）表示的膦：其中X 1是氧或亚甲基; X 2是亚甲基，亚乙基，三亚甲基，1,2-二甲基乙烯，异亚丙基或二氟亚甲基; A是周期表的IA族碱金属，氢或铵离子; 并且a，b，c和d各自为0或1的整数，条件是除了a，b，c和d之和的情况。

6. 发明申请

US20060211882A1 Method for producing optically active carboxylic acid 审中-公开
标题翻译：光学活性羧酸的制备方法
公开(公告)号：US20060211882A1
公开(公告)日：2006-09-21
申请号：US10550564
申请日：2004-03-26
申请人： Akira Amano , Daisuke Igarashi , Noboru Sayo
发明人： Akira Amano , Daisuke Igarashi , Noboru Sayo
IPC分类号： C07C51/36
CPC分类号： C07C51/36 , C07B2200/07 , C07C53/128
摘要： A method for producing a desired optically active carboxylic acid with a high optical purity, wherein a complex catalyst used can be recovered and reused as an aqueous solution. The method contains the step of subjecting an &agr;,&bgr; -unsaturated carboxylic acid in water or a mixed solvent of water and a water-insoluble organic solvent in the presence of a sulfonated BINAP—Ru complex represented by the formula [3]: [RuX(arene){(SO?3#191M)?2#191-BINAP}]X [3]wherein X represents a chlorine atom, a bromine atom or an iodine atom, arene represents a benzene or an alkyl-substituted benzene, M represents an alkaline metal atom, and BINAP represents 2,2′-bis(diphenylphosphine)-1,1′-binaphthyl to an asymmetric hydrogenation. The sulfonated BINAP—Ru complex can be recycled.
摘要翻译：一种制备具有高光学纯度的所需光学活性羧酸的方法，其中可以回收使用的复合催化剂并将其再次用作水溶液。该方法包括在由式[3]表示的磺化BINAP-Ru络合物的存在下使α，β-不饱和羧酸在水或水和水不溶性有机溶剂的混合溶剂中进行的步骤：[RuX （芳烃）{（SO 3＃191M）2＃191-BINAP}] X [3]其中X表示氯原子，溴原子或碘原子，芳烃表示苯或烷基取代的苯，M 代表碱金属原子，BINAP代表2,2'-双（二苯基膦）-1,1'-联萘与不对称氢化反应。磺化的BINAP-Ru络合物可以回收利用。

7. 发明授权

US06407293B1 Process for producing 3-1-menthoxypropane-1,2-diol 有权
标题翻译：制备3-1-薄荷氧基丙-1,2-二醇的方法
公开(公告)号：US06407293B1
公开(公告)日：2002-06-18
申请号：US09962122
申请日：2001-09-26
申请人： Akira Amano , Teruyoshi Akiyama , Takashi Miura , Toshimitsu Hagiwara
发明人： Akira Amano , Teruyoshi Akiyama , Takashi Miura , Toshimitsu Hagiwara
IPC分类号： C07C3512
CPC分类号： C07C43/196 , C07C41/03
摘要： A process for producing highly pure 3-1-menthoxypropane-1,2-diol safely and efficiently, and an intermediate to be used in the process. 3-1-menthoxypropane-1,2-diol represented by the chemical formula (IV) is produced by adding 1-menthol to a 1,2-epoxy-3-halogenopropane represented by the following general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid to produce a novel 1-halogeno-3-1-menthoxypropan-2-ol represented by the following general formula (II), then, epoxidating it with a base in the presence of a phase transfer catalyst to produce a 1,2-epoxy-3-1-menthoxypropane represented by the chemical formula (III), and further hydrolyzing it.
摘要翻译：安全有效地生产高纯度3-1-薄荷氧基丙二醇-1,2-二醇的方法，以及该方法中使用的中间体。由化学式（IV）表示的3-1-薄荷氧基丙烷-1,2-二醇通过将1-薄荷醇加入到由下列通式（I）表示的1,2-环氧-3-氯代丙烷中（其中X表示卤素原子）在有机溶剂中在路易斯酸存在下反应，得到由以下通式（II）表示的新型1-卤代-3-三氟甲氧基丙-2-醇，然后用碱进行环氧化存在相转移催化剂以制备由化学式（III）表示的1,2-环氧-3-丁氧基丙烷，并进一步水解。

8. 发明授权

US06515188B2 Method for producing 3-l-menthoxypropane-1,2-diol 有权
公开(公告)号：US06515188B2
公开(公告)日：2003-02-04
申请号：US10115096
申请日：2002-04-04
申请人： Akira Amano , Teruyoshi Akiyama , Takashi Miura , Toshimitsu Hagiwara
发明人： Akira Amano , Teruyoshi Akiyama , Takashi Miura , Toshimitsu Hagiwara
IPC分类号： C07C523
CPC分类号： C07C41/26 , C07B2200/07 , C07C41/03 , C07C41/42 , C07C67/11 , C07C2601/14 , C07C69/16 , C07C69/08 , C07C43/196
摘要： A method for safely and efficiently producing high purity 3-l-menthoxypropane-1,2-diol and intermediates to be used in the method. As shown in the following reaction formula, 3-l-menthoxypropane-1,2-diol represented by the chemical formula (IV) is produced by adding l-menthol to a 1,2-epoxy-3-halogenopropane represented by the general formula (I) (wherein X represents a halogen atom) in an organic solvent in the presence of a Lewis acid, thereby producing a 1-halogeno-3-l-menthoxypropan-2-ol represented by the general formula (II), allowing the first intermediate to react with an alkali metal salt of an aliphatic carboxylic acid having from 1 to 5 carbon atoms to produce a 1-acyloxy-2-substituted-3-l-menthoxypropane represented by the general formula (III) and then hydrolyzing the second intermediate.

9. 发明授权

US07837461B2 Microlens transcription molding roller and manufacturing method thereof 有权
标题翻译：微透镜转录成型辊及其制造方法
公开(公告)号：US07837461B2
公开(公告)日：2010-11-23
申请号：US12115743
申请日：2008-05-06
申请人： Akira Amano , Sumihisa Kondo
发明人： Akira Amano , Sumihisa Kondo
IPC分类号： B29C59/04 , B23C3/04
CPC分类号： B29D11/00365 , B29C59/04 , Y10S425/808 , Y10T409/303752 , Y10T409/30868 , Y10T428/24331
摘要： A microlens transcription molding roller used for transcription-molding a plurality of microlenses on a sheet includes a plurality of microlens molding surfaces arrayed on an outer circumference of the roller along one spiral around an axis of the roller at a constant interval.
摘要翻译：用于在片材上转印成型多个微透镜的微透镜转印模制辊包括以恒定间隔围绕辊的轴线沿着一个螺旋排列在辊的外圆周上的多个微透镜模制表面。

10. 发明授权

US6084138A (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-ol, process for preparing the same, and use thereof 失效
标题翻译：（E） - （R）-2-烷基-4-（2,2,3-三甲基环戊-3-烯-1-基）-2-丁烯-1-醇，其制备方法及其用途
公开(公告)号：US6084138A
公开(公告)日：2000-07-04
申请号：US108745
申请日：1998-07-01
申请人： Takashi Aida , Makoto Harada , Takeshi Yamamoto , Hisao Iwai , Akira Amano , Tetsuro Yamasaki
发明人： Takashi Aida , Makoto Harada , Takeshi Yamamoto , Hisao Iwai , Akira Amano , Tetsuro Yamasaki
IPC分类号： B01J31/24 , C07B61/00 , C07C29/141 , C07C33/12 , C11B9/00 , C07C35/06
CPC分类号： C07C29/141 , C07C33/12 , C11B9/003 , C07B2200/07 , C07B2200/09 , C07C2101/10
摘要： An (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-ol represented by formula (I): ##STR1## wherein R represents an alkyl group having 1 to 3 carbon atoms, and a process for preparing the same comprising hydrogenating a corresponding (E)-(R)-2-alkyl-4-(2,2,3-trimethylcyclopent-3-en-1-yl)-2-buten-1-al in the presence of a ruthenium-phosphine complex as a catalyst, a base comprising an alkali metal or an alkaline earth metal, and an amine. The compound (I) has an excellent sandalwood oil odor.
摘要翻译：由式（I）表示的（E） - （R）-2-烷基-4-（2,2,3-三甲基环戊-3-烯-1-基）-2-丁烯-1-醇：其中R表示具有1至3个碳原子的烷基，及其制备方法包括将相应的（E） - （R）-2-烷基-4-（2,2,3-三甲基环戊-3-烯-1-基）吡啶-2-基）-2-丁烯-1 -Al，在作为催化剂的钌 - 膦配合物的存在下，包含碱金属或碱土金属的碱和胺。化合物（I）具有优异的檀香油气味。

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