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1. 发明授权

US5034308A Method for processing silver halide photosensitive material including the replenishing of washing water containing a chelating agent and a controlled amount of calcium and magnesium compounds 失效
标题翻译：用于处理卤化银感光材料的方法，包括补充含有螯合剂的洗涤水和受控量的钙和镁化合物
公开(公告)号：US5034308A
公开(公告)日：1991-07-23
申请号：US086790
申请日：1987-08-19
申请人： Akira Abe , Yoshihiro Fujita , Toshio Koshimizu , Kazuhiro Aikawa
发明人： Akira Abe , Yoshihiro Fujita , Toshio Koshimizu , Kazuhiro Aikawa
IPC分类号： G03C11/00 , G03C7/30 , G03C7/44
CPC分类号： G03C7/44 , G03C7/3046
摘要： A method for processing silver halide photosensitive materials comprising developing an exposed silver halide photosensitive material, fixing the developed photosensitive material and then washing it with a washing water, the washing water used in the water washing process being replenished in an amount of 2 to 50 times the volume of liquid carried over by the photosensitive material from a bath preceding the water washing bath per unit area thereof, the amount of calcium and magnesium compounds present in the water washing bath being reduced to not more than 5 mg/l, respectively, on the basis of elemental calcium and magnesium and the washing water containing at least one chelating agent having a stability constant of a chelate, which is formed between the chelating agent and calcium or magnesium, of at least 6 is herein disclosed. The method makes it possible to suppress the increase in turbidity due to the proliferation of bacteria and molds in washing bath even when the processing is continuously conducted while substantially saving the amount of washing water and further provides an excellent processed photosensitive materials.
摘要翻译：一种用于处理卤化银感光材料的方法，包括曝光的卤化银感光材料的显影，固定显影的感光材料，然后用洗涤水清洗，水洗过程中使用的洗涤水的量为2至50倍由感光材料从洗涤浴之前的浴中每单位面积的液体所携带的液体的体积，洗涤水中存在的钙和镁化合物的量分别减少到不超过5mg / l，本文公开了元素钙和镁的基础以及含有至少一种螯合剂的至少一种螯合剂的洗涤水，螯合剂在螯合剂和钙或镁之间形成至少为6。该方法即使在连续进行处理的同时可以抑制由于洗涤槽中的细菌和霉菌的增殖引起的浊度的增加，同时基本上节省了洗涤水的量并进一步提供了优良的加工感光材料。

2. 发明授权

US07473415B2 Near infrared fluorescent contrast agent and method for fluorescence imaging 失效
标题翻译：近红外荧光造影剂及荧光成像方法
公开(公告)号：US07473415B2
公开(公告)日：2009-01-06
申请号：US10506819
申请日：2003-03-07
申请人： Masayuki Kawakami , Hiroshi Kitaguchi , Kai Licha , Christin Perlitz , Hiroaki Eguchi , Natsuko Tsuda , Kazuhiro Aikawa
发明人： Masayuki Kawakami , Hiroshi Kitaguchi , Kai Licha , Christin Perlitz , Hiroaki Eguchi , Natsuko Tsuda , Kazuhiro Aikawa
IPC分类号： A61K51/00 , A61M36/14
CPC分类号： A61K49/0032 , A61K49/0052
摘要： A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R7, and R8 represent a C1-C10 alkyl group or the like; R3, R4, R5, R6, R9, R10, R11, and R12 represent a hydrogen atom, a C1-C6 alkyl group, an aryl group or the like; X1 and X2 represent a C1-C15 alkyl group or an aryl group and X1 and X2 in total have 0 to 4 carboxyl groups; m1, m2, and m3 represents 0 or 1; L1 to L7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.
摘要翻译： 1.一种近红外荧光造影剂，其特征在于，在生物体组织中的透过性优异，能够对肿瘤和/或血管进行特异性成像，其特征在于，含有式（I）表示的化合物或其药学上可接受的盐，其中R1，R2，R7，并且R 8表示C 1 -C 10烷基等; R3，R4，R5，R6，R9，R10，R11和R12表示氢原子，C1-C6烷基，芳基等; X1和X2表示C1-C15烷基或芳基，X1和X2总共具有0至4个羧基; m1，m2，m3表示0或1; L1至L7独立地表示次甲基; M表示氢原子，金属或季铵盐; n表示中和电荷所需的1〜7的整数。

3. 发明授权

US07101532B2 Liposome containing hydrophobic iodine compound 有权
标题翻译：含有疏水性碘化合物的脂质体
公开(公告)号：US07101532B2
公开(公告)日：2006-09-05
申请号：US10258801
申请日：2001-04-26
申请人： Kazuhiro Aikawa , Hiroshi Kitaguchi
发明人： Kazuhiro Aikawa , Hiroshi Kitaguchi
IPC分类号： A61K49/04
CPC分类号： A61K9/127 , A61K49/0438 , A61K49/0466
摘要： A liposome containing a hydrophobic iodine compound such as a 1,3,5-triiodobenzene derivative having at least one substituent containing 18 or more carbon atoms as a membrane component, and an X-ray contrast medium containing the liposome for use in radiography of a vascular disease and the like.
摘要翻译：含有疏水性碘化合物的脂质体，例如具有至少一个含有18个或更多个碳原子的取代基的1,3,5-三碘苯衍生物作为膜组分，以及含有用于放射线照相术的脂质体的X射线造影剂血管疾病等。

4. 发明授权

US06815455B1 Benzimidazole compounds and drugs containing the same 失效
标题翻译：苯并咪唑化合物和含有相同的药物
公开(公告)号：US06815455B1
公开(公告)日：2004-11-09
申请号：US10019249
申请日：2002-06-05
申请人： Kozo Aoki , Kazuhiro Aikawa , Masayuki Kawakami , Yongzhe Yan
发明人： Kozo Aoki , Kazuhiro Aikawa , Masayuki Kawakami , Yongzhe Yan
IPC分类号： A61K31454
CPC分类号： C07D401/12
摘要： A benzimidazole compound or a salt thereof which has an inhibitory action of foaming of macrophages and is useful as an active ingredient of a medicament for preventive and/or therapeutic treatment of arteriosclerosis, which is represented by the formula (I): wherein R1 represents a hydrogen atom, a halogen atom, a lower alkyl group, or a lower alkoxy group; R2 represents a hydrogen atom, an alkyl group, or an acyl group; R3 represents a functional group on the ring; A represents O or CH2 or CH that forms a double bond with an adjacent carbon atom; L represents a C4-C8 alkylene group or an ethyleneoxy linking group represented by (CH2CH2O)nCH2CH2 wherein n represents 1 or 2; X represents O, S or methylene group; and m represents 0 or 1.

5. 发明授权

US06787561B1 Benzimidazole compounds 失效
标题翻译：苯并咪唑化合物
公开(公告)号：US06787561B1
公开(公告)日：2004-09-07
申请号：US10019668
申请日：2002-06-05
申请人： Kozo Aoki , Kazuhiro Aikawa , Masayuki Kawakami , Yongzhe Yan
发明人： Kozo Aoki , Kazuhiro Aikawa , Masayuki Kawakami , Yongzhe Yan
IPC分类号： A61K314439
CPC分类号： C07D401/12 , C07D235/28 , C07D403/12 , C07D413/12 , C07D417/12
摘要： A benzimidazole compound or a salt thereof which has an inhibitory action of forming of macrophages and is useful as an active ingredient of an orally available medicament for preventive and/or therapeutic treatment of arteriosclerosis, which is represented by the formula (I): wherein, R1 represents one or more functional groups on the benzene ring selected from the group consisting of hydrogen atom, a halogen atom, a lower alkyl group and a lower alkoxy group; R2 represents hydrogen atom, an alkyl group or an acyl group; L represents a C4-C8 alkylene group or an ethyleneoxy linking group represented as (CH2CH2O)nCH2CH2 wherein n represents 1 or 2; X represents O or NH; Y represents S or a single bond; and Q represents a 5- or 6-membered heterocyclic group which may have a functional group on the ring.
摘要翻译：具有抑制巨噬细胞形成作用的苯并咪唑化合物或其盐，可用作由式（I）表示的用于预防和/或治疗动脉硬化的口服药物的活性成分：其中， R 1表示选自氢原子，卤素原子，低级烷基和低级烷氧基的苯环上的一个或多个官能团; R 2表示氢原子，烷基或酰基; L表示作为（CH 2 CH 2 O）n CH 2 CH 2表示的C 4 -C 8亚烷基或亚乙氧基连接基，其中n表示1或2; X表示O或NH; Y表示S或单键; Q表示在环上可具有官能团的5或6元杂环基。

6. 发明申请

US20090130022A1 MRI CONTRAST MEDIUM CONTAINING LIPOSOMES 审中-公开
标题翻译： MRI对比中药含有脂质体
公开(公告)号：US20090130022A1
公开(公告)日：2009-05-21
申请号：US11916391
申请日：2006-06-06
申请人： Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
发明人： Junji Nishigaki , Hiroyuki Hirai , Masayoshi Kojima , Kazuhiro Aikawa
IPC分类号： A61B5/055 , A61K9/127
CPC分类号： A61K49/1812
摘要： A liposome containing a phosphatidylcholine and a phosphatidylserine in combination as membrane components at a phosphatidylcholine:phosphatidylserine molar ratio of 3:1 to 1:2, and said liposome containing superparamagnetic particles having a mean particle size not less than 1 nm and not more than 50 nm. A means for selectively accumulating an MRI contrast medium in a lesion of a vascular disease caused by abnormal proliferation of vascular smooth muscle cells such as arteriosclerosis and restenosis after PTCA is provided.
摘要翻译：含有磷脂酰胆碱和磷脂酰丝氨酸的磷脂酰丝氨酸组合为磷脂酰胆碱的膜组分：磷脂酰丝氨酸摩尔比为3:1至1:2，所述脂质体含有平均粒度不小于1nm且不大于50的超顺磁性颗粒 nm。用于选择性地累积由血管平滑肌细胞的异常增殖引起的血管疾病的病变中的MRI造影剂的手段，所述血管病变由PTCA提供之后的动脉硬化和再狭窄引起。

7. 发明授权

US07264790B2 1,3-glyceride compound having two iodophenyl groups 失效
标题翻译：具有两个碘苯基的1,3-甘油酯化合物
公开(公告)号：US07264790B2
公开(公告)日：2007-09-04
申请号：US10487319
申请日：2002-08-22
申请人： Kazunobu Takahashi , Hiroshi Kitaguchi , Kazuhiro Aikawa
发明人： Kazunobu Takahashi , Hiroshi Kitaguchi , Kazuhiro Aikawa
IPC分类号： A61K49/00 , C07C53/00 , C07C57/00 , C07C59/00 , C08G63/48 , A61K49/04
CPC分类号： C07C233/83 , A61K49/0433 , A61K49/0466 , C07C69/66 , C07C69/712 , C07C69/736 , C07C233/18 , C07C237/20 , C07C323/52
摘要： A compound represented by the following general formula (I) or a salt thereof: wherein Ar1 and Ar2 independently represent a substituted or unsubstituted aryl group having at least one iodine atom as a substituent; L1 and L2 independently represent a divalent bridging group of which main chain consists of 7 or more atoms at least one of which is a heteroatom; and X represents —CH(OH)— or —CO—, which is suitable for an iodine-containing contrast medium containing liposomes.
摘要翻译：由以下通式（I）表示的化合物或其盐：其中Ar 1和Ar 2独立地表示具有至少一个碘原子的取代或未取代的芳基作为取代基; L 1和L 2独立地表示二价桥连基团，其主链由7个或更多个原子组成，其中至少一个是杂原子; X表示-CH（OH） - 或-CO-，适用于含有脂质体的含碘造影剂。

8. 发明申请

US20050226815A1 Near infrared fluorescent contrast agent and method for fluorescence imaging 失效
标题翻译：近红外荧光造影剂及荧光成像方法
公开(公告)号：US20050226815A1
公开(公告)日：2005-10-13
申请号：US10506819
申请日：2003-03-07
申请人： Masayuki Kawakami , Hiroshi Kitaguchi , Kai Licha , Christin Perlitz , Hiroaki Eguchi , Natsuko Tsuda , Kazuhiro Aikawa
发明人： Masayuki Kawakami , Hiroshi Kitaguchi , Kai Licha , Christin Perlitz , Hiroaki Eguchi , Natsuko Tsuda , Kazuhiro Aikawa
IPC分类号： C07D409/14 , A61B1/00 , A61B3/10 , A61B3/14 , A61K49/00 , C07D209/14 , C07D209/60 , G01N21/64 , A61B10/00 , A61B5/00 , A61B8/00
CPC分类号： A61K49/0032 , A61K49/0052
摘要： A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R7, and R8 represent a C1-C10 alkyl group or the like; R3, R4, R5, R6, R9, R10, R11, and R12 represent a hydrogen atom, a C1-C6 alkyl group, an aryl group or the like; X1 and X2 represent a C1-C15 alkyl group or an aryl group and X1 and X2 in total have 0 to 4 carboxyl groups; m1, m2, and m3 represents 0 or 1; L1 to L7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.
摘要翻译：一种近红外荧光造影剂，其在生物体组织中的渗透性优异，能够进行肿瘤和/或血管的特异性成像，其包含式（I）表示的化合物或其药学上可接受的盐，其中R 1， R 2，R 7，R 8和R 8表示C 1 -C 3烷基， 10烷基等; R 3，R 4，R 5，R 6，R 9， R 10，R 11和R 12代表氢原子，C 1 -C 12烷基， 6个烷基，芳基等; X 1和X 2代表C 1 -C 15烷基或芳基，X ^{1和X 2共有0至4个羧基; m 1，m 2，m 3，O 3表示0或1; L 1至L 7独立地表示次甲基; M表示氢原子，金属或季铵盐; n表示中和电荷所需的1〜7的整数。}

9. 发明授权

US5962493A 2-mercaptobenzimidazole derivatives and antihyperlipemic agent or antiarteriosclerotic agent containing the same 失效
标题翻译： 2-巯基苯并咪唑衍生物和抗高脂血症药或含有其的抗动脉硬化剂
公开(公告)号：US5962493A
公开(公告)日：1999-10-05
申请号：US975638
申请日：1997-11-21
申请人： Kozo Aoki , Kazuhiro Aikawa
发明人： Kozo Aoki , Kazuhiro Aikawa
IPC分类号： A61K31/415 , A61K31/4184 , C07D235/28
CPC分类号： A61K31/4184 , C07D235/28 , Y10S514/824
摘要： 2-Mercaptobenzimidazole derivatives represented by the following formulae, analogs and salts thereof are disclosed: ##STR1## These 2-mercaptobenzimidazole derivatives are useful as a medicine such as an antihyperlipemic agent or antiarteriosclerotic agent and also useful as an additive for silver halide photosensitive materials, liquid crystals and the like.
摘要翻译：公开了由下式表示的2-巯基苯并咪唑衍生物，其类似物和盐：这些2-巯基苯并咪唑衍生物可用作抗高血脂药或抗动脉硬化药物等药物，也可用作卤化银感光材料，液晶和类似。

10. 发明授权

US4923790A Silver halide photographic material 失效
公开(公告)号：US4923790A
公开(公告)日：1990-05-08
申请号：US247565
申请日：1988-09-22
申请人： Hirohiko Kato , Keiji Mihayashi , Kazuhiro Aikawa
发明人： Hirohiko Kato , Keiji Mihayashi , Kazuhiro Aikawa
IPC分类号： G03C1/37 , G03C7/26
CPC分类号： G03C1/37
摘要： A silver halide photographic material composed of a support having thereon at least one light-sensitive silver halide emulsion layer, wherein the material contains the combination of (i) at least one compound represented by formula (I) and (ii) and at least one compound represented by formulae (II) and/or (III): ##STR1## wherein R.sub.1 represents hydrogen, an alkyl group, an aryl group or an aralkyl group; X represents a halogen atom, a nitro group, a hydroxyl group, a cyano group, a lower alkyl group, a lower alkoxy group, --COR.sub.2, ##STR2## or --SO.sub.3 M; R.sub.2 represents hydrogen, --OM, a lower alkyl group, an aryl group, an aralkyl group, a lower alkoxy group, an aryloxy group, an aralkyloxy group or ##STR3## R.sub.3 and R.sub.4 each represents hydrogen, a lower alkyl group, an aryl group, an aralkyl group, --COR.sub.7 or --SO.sub.2 R.sub.7 ; R.sub.5 and R.sub.6 each represents hydrogen, a lower alkyl group, an aryl group or an aralkyl group; R.sub.7 represents a lower alkyl group, an aryl group or an aralkyl group, M represents hydrogen, an alkali metal atom or atoms necessary for forming a monovalent cation, m represents 0 or an integer of 1 to 4, n represents 0 or an integer of 1 to 4, and Z represents an atomic group necessary for forming a thiazolyl ring; ##STR4## where in R.sub.8 represents a lower alkylene group, X is the same as X in formula (I), p represents 0 or 1, and q represents 0 or an integer of 1 to 5; ##STR5## wherein R.sub.9 represents hydrogen, an alkyl group, an alkenyl group, an aralkyl group, an aryl group, a heterocyclic group, ##STR6## R.sub.10 and R.sub.11 each represents hydrogen, an alkyl group, an aryl group, a cyano group, a heterocyclic group, an alkylthio group, an arylthio group, an alkylsulfonyloxy group or an alkylsulfonyl group; R.sub.10 and R.sub.11 may be linked to form an aromatic ring; and R.sub.12 and R.sub.13 each represents hydrogen, an alkyl group, an aryl group or an aralkyl group. The material has superior antifungal and antibacterial properties.

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