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1. 发明申请

US20110118348A1 Methods of stabilizing latanoprost in an aqueous solution 审中-公开
标题翻译：在水溶液中稳定拉坦前列素的方法
公开(公告)号：US20110118348A1
公开(公告)日：2011-05-19
申请号：US12930521
申请日：2011-01-10
申请人： Hiroyuki Asada , Akio Kimura
发明人： Hiroyuki Asada , Akio Kimura
IPC分类号： A61K31/216 , A61P27/02
CPC分类号： A61K47/183 , A61K9/0048 , A61K31/5575
摘要： A method of stabilizing latanoprost in an ophthalmic solution containing 0.005% (W/V) of latanoprost to be stored to be stored at room temperature (i) by adding 0.1 to 2% (W/V) of ε-aminocaproic acid to the solution or (ii) by adding 0.1 to 2% (W/V) of ε-aminocaproic acid and adjusting the pH of the solution to 5.0 to 6.25.
摘要翻译：在含有0.005％（W / V）的拉坦前列素的眼用溶液中稳定拉坦前列素的方法，待储存以在室温下储存（i），通过将0.1至2％（W / V）的氨基己酸加入到溶液或（ii）通过加入0.1至2％（W / V）的氨基己酸，并将溶液的pH调节至5.0至6.25。

2. 发明申请

US20100331407A1 Clear ophthalmic solution comprising latanoprost as active ingredient 有权
标题翻译：包含拉坦前列素作为活性成分的透明眼用溶液
公开(公告)号：US20100331407A1
公开(公告)日：2010-12-30
申请号：US12807045
申请日：2010-08-26
申请人： Hiroyuki Asada , Akio Kimura
发明人： Hiroyuki Asada , Akio Kimura
IPC分类号： A61K31/216 , A61P27/06
CPC分类号： A61K31/5575 , A61K9/0048 , A61K47/10 , A61K47/186 , A61K47/26 , A61K47/44 , Y10S514/912
摘要： A clear ophthalmic solution containing latanoprost having a concentration of 0.005% (W/V), 0.003 to 0.01% (W/V) benzalkonium chloride and at least one agent selected from the group consisting of glycerin, polyethylene glycol, propylene glycol and trehalose, wherein the agent is in a concentration to make the solution isotonic. A method of preventing white turbidity in an ophthalmic solution containing latanoprost having a concentration of 0.005% (W/V) and 0.003 to 0.01% (W/V) benzalkonium chloride, the method involving adding to the solution at least one agent selected from the group consisting of glycerin, polyethylene glycol, propylene glycol and trehalose, wherein the agent is in a concentration to make the solution isotonic.
摘要翻译：一种含有浓度为0.005％（W / V），0.003至0.01％（W / V）苯扎氯铵和至少一种选自甘油，聚乙二醇，丙二醇和海藻糖的药物的拉坦前列素的透明眼用溶液，其中所述试剂浓度为使所述溶液等渗。一种防止含有浓度为0.005％（W / V）和0.003〜0.01％（W / V）苯扎氯铵的拉坦前列素的眼用溶液中的白浊的方法，该方法包括向溶液中加入至少一种选自由甘油，聚乙二醇，丙二醇和海藻糖组成的组，其中所述试剂浓度为使溶液等渗。

3. 发明申请

US20080269353A1 Preventative Composition For Ophthalmic Use 审中-公开
标题翻译：眼科用途的预防组合物
公开(公告)号：US20080269353A1
公开(公告)日：2008-10-30
申请号：US11988613
申请日：2006-07-13
申请人： Koichi Takada , Akio Kimura , Mikiko Okemoto
发明人： Koichi Takada , Akio Kimura , Mikiko Okemoto
IPC分类号： A61K47/06 , A61K47/02
CPC分类号： A61K9/0048 , A61K47/10 , A61K47/183 , A61K47/22 , A61K47/26
摘要： An object of the present invention is to prevent the generation of chlorine dioxide in a liquid preparation for ophthalmic use containing a chlorite. A liquid preparation for ophthalmic use containing a preservative composition for ophthalmic use comprising a chlorite and at least one stabilizer selected from the following 1) to 7): 1) creatinine; 2) geraniol; 3) glucose; 4) tocopherol acetate; 5) oxyquinoline sulfate; 6) a sugar alcohol; and 7) a polyoxyethylene sorbitan fatty acid ester can prevent the generation of chlorine dioxide, and is therefore excellent in safety and exhibits a sustained preservative effect for a prolonged period of time.
摘要翻译：本发明的目的是防止在含有亚氯酸盐的眼用液剂中产生二氧化氯。一种用于眼用的液体制剂，其含有用于眼用的防腐剂组合物，其包含亚氯酸盐和至少一种选自以下1）至7）的稳定剂：1）肌酸酐; 2）香叶醇; 3）葡萄糖; 4）生育酚醋酸酯; 5）硫酸羟喹啉; 6）糖醇; 和7）聚氧乙烯脱水山梨醇脂肪酸酯可以防止二氧化氯的产生，因此安全性优异，并且在长时间内表现出持久的防腐效果。

4. 发明授权

US5929385A AC oxide superconductor wire and cable 失效
标题翻译： AC氧化物超导线和电缆
公开(公告)号：US5929385A
公开(公告)日：1999-07-27
申请号：US850184
申请日：1997-05-02
申请人： Masahiro Sugimoto , Akio Kimura , Masanao Mimura , Hideo Ishii , Shoichi Honjo , Yoshihiro Iwata
发明人： Masahiro Sugimoto , Akio Kimura , Masanao Mimura , Hideo Ishii , Shoichi Honjo , Yoshihiro Iwata
IPC分类号： H01L39/14 , H01B12/00
CPC分类号： H01L39/143
摘要： Disclosed is an AC oxide superconductor round wire including a metal matrix, and a plurality of superconductor filaments embedded in the metal matrix, wherein the superconductor filaments are twisted at a twist pitch L.sub.p satisfying the following relation.2L.sub.c1
摘要翻译：公开了一种包含金属基体的AC氧化物超导体圆线和嵌入在金属基体中的多根超导体丝，其中超导体长丝以满足以下关系的扭曲节距Lp扭曲.2Lc1

5. 发明授权

US5475930A Rotating and driving system for survey instrument 失效
标题翻译：测量仪表旋转驱动系统
公开(公告)号：US5475930A
公开(公告)日：1995-12-19
申请号：US266030
申请日：1994-06-27
申请人： Akio Kimura
发明人： Akio Kimura
IPC分类号： F16H1/16 , F16H57/021 , F16H57/022 , F16H57/12 , G01C1/02 , G01C5/00 , F16H15/00
CPC分类号： G01C1/02 , F16H1/16 , F16H57/12 , F16H2057/0213 , F16H2057/0221 , F16H2057/127 , F16H55/24 , Y10T74/19614 , Y10T74/19828
摘要： A rotating and driving system for a survey instrument, wherein a driven wheel is mounted on a shaft of a movable unit and a slide baseplate is disposed on the shaft so as to be movable in a direction perpendicular to the axis of the shaft. A gear, driven by a motor, is mounted on the slide baseplate in such a position that the gear can be engaged with the driven wheel when the slide baseplate is pushed in the proper direction. By providing engaging force between the driven wheel and the gear, backlash is suppressed, and positioning can be achieved at higher accuracy.
摘要翻译：一种用于测量仪器的旋转和驱动系统，其中从动轮安装在可移动单元的轴上，并且滑动基板设置在轴上，以便能够在垂直于轴的轴线的方向上移动。由电动机驱动的齿轮安装在滑动基座上，使得当滑动基板沿正确的方向被推动时，齿轮可与从动轮啮合。通过在从动轮和齿轮之间提供接合力，抑制了间隙，并且可以以更高的精度实现定位。

6. 发明授权

US5248531A Hemolysis depressant and plasticizer 失效
标题翻译：溶血抑制剂和增塑剂
公开(公告)号：US5248531A
公开(公告)日：1993-09-28
申请号：US769378
申请日：1991-10-01
申请人： Hirofumi Nagai , Yoshinori Kubota , Youko Tamura , Akio Kimura
发明人： Hirofumi Nagai , Yoshinori Kubota , Youko Tamura , Akio Kimura
IPC分类号： A01N1/02 , A61J1/00 , A61J1/05 , A61L31/04 , A61L33/00 , C08K5/103
CPC分类号： A61J1/10 , A01N1/021 , A01N1/0263 , A61L31/048 , A61L33/0041 , A61L33/0052 , C08K5/103 , Y10S514/822 , Y10T428/13 , Y10T428/1379
摘要： A hemolysis depressant and a plasticizer each comprising a triglyceride compound. Resin compositions for medical appliances, medical implements and blood preserving liquid using the triglyceride compound as a hemolysis depressant are capable of preventing the blood held in contact therewith from the phenomenon of hemolysis by the activity of the compound in protecting erythrocytes. Vinyl chloride type resin compositions for medical appliances and medical implement using the compound as a plasticizer are substantially deviced of toxicity and offers extremely high safety.
摘要翻译：一种溶血抑制剂和各自包含甘油三酯化合物的增塑剂。使用甘油三酯化合物作为溶血抑制剂的医疗用具，医疗器具和防血液的树脂组合物能够防止与保护红血球的化合物的活性相关的血液与血液保持接触的现象。使用该化合物作为增塑剂的用于医疗器具和医疗器械的氯乙烯型树脂组合物基本上具有毒性并提供极高的安全性。

7. 发明授权

US5067413A Apparatus for conveying travelable body 失效
标题翻译：用于运输行车的装置
公开(公告)号：US5067413A
公开(公告)日：1991-11-26
申请号：US474265
申请日：1990-02-01
申请人： Naoyuki Kiuchi , Masanori Fujimaru , Susumu Nakagawa , Eiji Taguchi , Masao Kasagi , Akio Kimura , Shinji Kawabe
发明人： Naoyuki Kiuchi , Masanori Fujimaru , Susumu Nakagawa , Eiji Taguchi , Masao Kasagi , Akio Kimura , Shinji Kawabe
IPC分类号： B61B13/12 , B65G35/00 , B65G35/06
CPC分类号： B65G35/06 , B61B13/127 , B65G35/00
摘要： The invention relates to a device for conveying travelable bodies which are provided no driving source, on a fixed path. A plurality of travelable bodies can travel on the fixed path while aligned substantially in close contact with each other. Traveling power is transmitted to one of a plurality of travelable bodies which is positioned on at least one end of the alignment. The traveling power drives the travelable body with frictional force while pressing one side surface of the travelable body, and is transmitted to the travelable body while backing up the other side surface of the travelable body. A device to transmit traveling power is arranged on only a part of the fixed path.
摘要翻译：本发明涉及一种用于输送在固定路径上没有设置驱动源的行驶体的装置。多个行走体可以在基本上彼此紧密接触的同时在固定路径上行进。移动功率被传送到位于对准的至少一端的多个可行车体中的一个。行驶动力以摩擦力驱动行驶体，同时按压行驶体的一个侧面，并且在支撑行驶体的另一侧表面的同时传递到行驶体。传输行驶动力的装置仅设置在固定路径的一部分上。

8. 发明授权

US5057872A Developer supplying device for supplying approximately constant amounts of developer 失效
标题翻译：显影剂供应装置，用于供应大约恒定量的显影剂
公开(公告)号：US5057872A
公开(公告)日：1991-10-15
申请号：US530962
申请日：1990-05-30
申请人： Hiromitsu Saijo , Shunji Yamamoto , Akio Kimura
发明人： Hiromitsu Saijo , Shunji Yamamoto , Akio Kimura
IPC分类号： G03G15/08
CPC分类号： G03G15/0886 , G03G15/0868 , G03G15/0877 , G03G2215/0665 , G03G2215/0675 , G03G2215/0685 , Y10S222/01
摘要： A developer supplying device includes: a substantially cylindrical developer container having on its peripheral surface a spiral groove, and being rotatable to transport a developer therein by the groove; a supplying element in a form of an opening provided at the peripheral surface of the container to supply the developer therethrough; and a regulating device provided in the container, regulating an amount of the developer supplied from the supplying element, and being so formed to reduce a sectional area between the regulating device and an inner surface of the container in the vicinity of the supplying element. The supplying device can have a container-supporting device having a guide device for guiding the developer supplied by the supplying element; and a supplying element-covering device provided at the peripheral surface of the container, and being opened to uncover the supplying element when the latter confronts the guide device for supplying the developer. The supplying device also can have a ball-like stirring device included in and movable within the container in accordance with rotation thereof to stir the developer. The supplying device further can have a holding device capable of being inserted thereinto the container and having the guide device; a transporting device for transporting the developer supplied through the guide device for development; a drive device for rotating the container; and a connecting device provided at one side of the container for rotation of the container within the holding device by the drive device.
摘要翻译：显影剂供应装置包括：基本上圆柱形的显影剂容器，在其外周表面上具有螺旋形凹槽，并且可旋转以通过凹槽将显影剂输送到其中; 设置在容器的外周表面处的开口形式的供应元件，以通过其提供显影剂; 以及设置在容器中的调节装置，调节从供给元件供给的显影剂的量，并且被形成为减小调节装置与供应元件附近的容器的内表面之间的截面积。供给装置可以具有容器支撑装置，其具有用于引导由供给元件供给的显影剂的引导装置; 以及设置在容器的周边表面的供给元件覆盖装置，当供应元件面对用于供应显影剂的引导装置时，打开以露出供给元件。供应装置还可以具有球状搅拌装置，其包括在容器内并可根据其旋转而移动以搅拌显影剂。供给装置还可以具有能够插入到容器中并具有引导装置的保持装置; 用于运送通过引导装置供应的显影剂用于显影的运送装置; 用于旋转容器的驱动装置; 以及设置在容器的一侧的连接装置，用于通过驱动装置使容器在保持装置内旋转。

9. 发明授权

US4794128A Porous film 失效
标题翻译：多孔薄膜
公开(公告)号：US4794128A
公开(公告)日：1988-12-27
申请号：US54856
申请日：1987-05-27
申请人： Heihachiro Kawaguchi , Hidenori Shirai , Akio Kimura
发明人： Heihachiro Kawaguchi , Hidenori Shirai , Akio Kimura
IPC分类号： B29C55/04 , A61L15/22 , B29K23/00 , B29K105/04 , B29L7/00 , C08J5/18 , C08J9/00 , C08K5/10 , C08L23/02 , C08L67/00 , C08L77/00
CPC分类号： C08J5/18 , A61L15/225 , C08J2323/02
摘要： A porous film comprises a polyolefin resin, a filler and a polyester obtained from a polybasic acid, a polyhydric alcohol and a monobasic acid having 14 to 22 carbon atoms and/or a monohydric alcohol having 12 to 22 carbon atoms or a polyester obtained from a polybasic acid and a monohydric alcohol, the film being obtained by melting and moulding and then stretching. It has a good permeability to moisture and impermeability to liquid, and is useful for a sanitary napkin.
摘要翻译：多孔膜包括聚烯烃树脂，填料和由多元酸，多元醇和具有14-22个碳原子的一元酸和/或具有12-22个碳原子的一元醇获得的聚酯或由多元酸和一元醇，该膜通过熔融和模塑然后拉伸获得。它对水分具有良好的渗透性和对液体的不渗透性，并且对于卫生巾是有用的。

10. 发明授权

US4604488A Cyclohexanol derivatives and fragrance compositions containing the same 失效
标题翻译：环己醇衍生物和含有它们的香料组合物
公开(公告)号：US4604488A
公开(公告)日：1986-08-05
申请号：US563972
申请日：1983-12-21
申请人： Yoshiaki Fujikura , Yasushi Kajihara , Naotake Takaishi , Yoshiaki Inamoto , Akio Kimura , Motoki Nakajima , Norioki Miyamoto
发明人： Yoshiaki Fujikura , Yasushi Kajihara , Naotake Takaishi , Yoshiaki Inamoto , Akio Kimura , Motoki Nakajima , Norioki Miyamoto
IPC分类号： A61K8/33 , A61Q13/00 , B01J23/00 , B01J25/00 , B01J27/00 , B01J31/00 , C07B61/00 , C07C27/00 , C07C29/17 , C07C35/21 , C07C37/16 , C07C41/00 , C07C41/30 , C07C43/196 , C07C43/21 , C07C67/00 , C11B9/00 , C11D9/44 , C07C35/22
CPC分类号： C07C35/21 , C07C29/19 , C07C37/14 , C11B9/0046 , C07C2102/42
摘要： Fragrant cyclohexanol derivatives are produced by condensing 2-ethylidene-5-norbornene with a phenol compound, in the presence of a Friedel-Crafts catalyst; and hydrogenating the condensation product in the presence of a metal catalyst.The compounds so produced have a green-floral odor and are advantageously used in soaps, detergents, shampoos, hair rinse, cosmetics, colognes and perfumes.
摘要翻译：在Friedel-Crafts催化剂存在下，将2-亚乙基-5-降冰片烯与酚化合物缩合制备芳香环己醇衍生物; 并在金属催化剂的存在下氢化缩合产物。如此生产的化合物具有绿花香味，并且有利地用于肥皂，洗涤剂，洗发剂，洗发剂，化妆品，古龙水和香水中。

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