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1. 发明授权

US06279413B1 Articulated robot 失效
标题翻译：铰接式机器人
公开(公告)号：US06279413B1
公开(公告)日：2001-08-28
申请号：US09434160
申请日：1999-11-04
申请人： Akihiro Terada , Toshinari Tamura , Hisashi Ogawa , Takahiro Hase
发明人： Akihiro Terada , Toshinari Tamura , Hisashi Ogawa , Takahiro Hase
IPC分类号： B25J1800
CPC分类号： B25J19/0029 , Y10S414/13 , Y10S414/131 , Y10T74/20311 , Y10T74/20317 , Y10T74/20329
摘要： A first arm (3) of a articulated robot has a double arm structure composed of a first arm piece (3a) and a second arm piece (3b). The first arm piece (3a) transmits a drive force, and a housing (4a) of a second arm (4) is rotatably mounted to the first arm piece (3a) at the end thereof. The second arm piece (3b) houses cables and pipes or the like, and a cover (4b) of the housing (4a) is rotatably mounted to the second arm piece at the end thereof. The cover (4b) is fixed to the housing (4a) through a fixing tool (6). The housing (4a) is permitted to be opened by separating the housing (4a) and the cover (4b) from each other by causing the second arm piece (3b) to rotate relatively to the first arm piece (3a) after the removal of the fixing tool (6).
摘要翻译：铰接机器人的第一臂（3）具有由第一臂片（3a）和第二臂片（3b）组成的双臂结构。第一臂片（3a）传递驱动力，第二臂（4）的壳体（4a）在其末端可旋转地安装到第一臂片（3a）。第二臂片（3b）容纳电缆和管子等，并且壳体（4a）的盖子（4b）在其末端可旋转地安装到第二臂片。盖（4b）通过固定工具（6）固定到壳体（4a）上。通过使第二臂片（3b）相对于第一臂片（3a）相对于第一臂片（3a）旋转，通过使壳体（4a）和盖（4b）彼此分离来允许壳体（4a）打开，固定工具（6）。

2. 发明授权

US5412096A Hydrochloride salts of heterocyclic spiro compounds 失效
标题翻译：杂环螺环化合物的盐酸盐
公开(公告)号：US5412096A
公开(公告)日：1995-05-02
申请号：US230625
申请日：1994-05-24
申请人： Shin-ichi Tsukamoto , Hitoshi Nagaoka , Shinji Usuda , Masatomi Harada , Toshinari Tamura
发明人： Shin-ichi Tsukamoto , Hitoshi Nagaoka , Shinji Usuda , Masatomi Harada , Toshinari Tamura
IPC分类号： C07D211/48 , C07D471/10 , C07D491/10 , C07D491/107 , C07D491/20 , C07D491/22 , C07D495/10 , C07D495/20 , C07D495/22 , C07D497/20 , C07D497/22 , C07D405/02
CPC分类号： C07D471/10 , C07D211/48 , C07D491/10 , C07D495/10
摘要： Hydrochloride salts of heterocyclic spiro compounds are provided and can be represented by the following general formula: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## alk in which R.sup.1 to R.sub.3,R.sub.6,R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, COOH, or ester, or --C alkyl, R.sub.5 is halo, OH,SH, O alkyl, S alkyl, O acyl or S acyl, and Z, and Z.sub.2 are O or S. The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.
摘要翻译：提供了杂环螺环化合物的盐酸盐，并且可以由以下通式表示：其中A表示哌啶或N烷基哌啶或连接于非相邻哌啶环碳的N亚烷基，X为S或O，Y为羰基，其中R 1至R 3，R 6，R 7为H或烷基，R 4为H，烷基，COOH或酯或-C烷基，R 5为卤素，OH，SH， O烷基，S烷基，O酰基或S酰基，Z和Z2是O或S.上述化合物作用于毒蕈碱性乙酰胆碱受体，从而激活中枢神经系统中的乙酰胆碱神经功能。

3. 发明授权

US5041549A Heterocyclic spiro compounds and methods for preparing the same 失效
公开(公告)号：US5041549A
公开(公告)日：1991-08-20
申请号：US470093
申请日：1990-01-25
申请人： Shin-ichi Tsukamoto , Hitoshi Nagaoka , Shinji Usuda , Masatomi Harada , Toshinari Tamura
发明人： Shin-ichi Tsukamoto , Hitoshi Nagaoka , Shinji Usuda , Masatomi Harada , Toshinari Tamura
IPC分类号： C07D491/107 , A61K31/435 , A61K31/55 , A61P25/02 , A61P25/28 , C07D211/48 , C07D405/06 , C07D453/00 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/20 , C07D491/22 , C07D495/10 , C07D495/20 , C07D495/22 , C07D497/20 , C07D497/22
CPC分类号： C07D471/10 , C07D211/48 , C07D491/10 , C07D495/10
摘要： Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## wherein A represents piperidine or N alkyl piperidine or N alkylene attached to a non adjacent piperidine ring carbon, X is S or O, Y is carbonyl, thiocarbonyl, methylene, R.sup.5 methylene, ##STR2## in which R.sup.1 to R.sub.3, R.sub.6, R.sub.7 are H or alkyl, R.sub.4 is H, alkyl, --COOH, or ester, or ##STR3## R.sub.5 is halo, OH, SH, O alkyl, S alkyl, O acyl or S acyl, and Z.sub.1 and Z.sub.2 are O or S.The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.

4. 发明授权

US4379158A Antisecretory imidazole amidine compounds, composition and method of use 失效
标题翻译：咪唑咪唑类化合物，组成及使用方法
公开(公告)号：US4379158A
公开(公告)日：1983-04-05
申请号：US193742
申请日：1980-10-03
申请人： Yasufumi Hirata , Isao Yanagisawa , Toshinari Tamura , Masaaki Takeda
发明人： Yasufumi Hirata , Isao Yanagisawa , Toshinari Tamura , Masaaki Takeda
IPC分类号： C07D213/32 , C07D213/68 , C07D213/86 , C07D233/54 , C07D233/64 , C07D277/26 , C07D277/30 , C07D307/52 , A61K31/615 , C07D401/12
CPC分类号： C07D213/86 , C07D213/32 , C07D213/68 , C07D233/64 , C07D277/26 , C07D307/52
摘要： Novel heterocyclic compounds shown by the formula ##STR1## wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen atom; X represents an oxygen atom or the unsubstituted or substituted imino group shown by N--R.sub.1 (wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a cyano group, an unsubstituted or alkyl substituted carbamoyl group, an unsubstituted or lower alkyl substituted thiocarbamoyl group, or a lower alkanoylamino group); Y represents a hydrogen atom, a lower alkyl group which may have substituent(s), a cycloalkyl group of 3-6 carbon atoms, a lower alkenyl group, a lower alkynyl group, an aryl group which may have substituent(s), an aralkyl group which may have substituent(s), a hydroxyl group, a cyano group, a carbamoyl group, an amidino group, an alkanoyl group which may have been substituted by halogen atom(s), an alkanoylamino group, an arylcarbonylamino group, an alkylamino group, an arylamino group, an arylsulfamoyl group, a lower alkoxycarbamoyl group, or an oxamoylamino group; and m and n represent an integer of 1-3; when X is N--R.sub.1, said X and Y may combine with each other to form a 5-membered or 6-membered heterocyclic ring containing 2-3 nitrogen atoms which may have substituent(s), and the pharmacologically acceptable acid addition salts thereof.The compounds of this invention are useful as gastric acid secretion inhibitors.
摘要翻译：式中，Het表示可具有取代基的5元或6元杂环基的新型杂环化合物。 Z表示硫原子或氧原子; X表示氧原子或由N-R 1表示的未取代或取代的亚氨基（其中R 1为氢原子，低级烷基，氰基，未取代或烷基取代的氨基甲酰基，未取代或低级烷基取代的硫代氨基甲酰基，或低级烷酰氨基）; Y表示氢原子，可具有取代基的低级烷基，3-6个碳原子的环烷基，低级烯基，低级炔基，可具有取代基的芳基，可以具有取代基的芳烷基，羟基，氰基，氨基甲酰基，脒基，可被卤素原子取代的烷酰基，烷酰基氨基，芳基羰基氨基，烷基氨基，芳基氨基，芳基氨磺酰基，低级烷氧基氨基甲酰基或氨甲酰基氨基; m和n表示1-3的整数; 当X是N-R1时，所述X和Y可以彼此结合形成含有2-3个可具有取代基的氮原子的5元或6元杂环，其药理学上可接受的酸加成盐。本发明的化合物可用作胃酸分泌抑制剂。

5. 发明授权

US4246280A 20-Alkoxy-16-alkyl-prostadienoic acid derivatives 失效
标题翻译： 20-烷氧基-16-烷基 - 前列腺烯酸衍生物
公开(公告)号：US4246280A
公开(公告)日：1981-01-20
申请号：US16070
申请日：1979-02-28
申请人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
发明人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
IPC分类号： C07C405/00 , C07D307/935 , C07D309/12 , A61K31/557
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12
摘要： There are disclosed 20-alkoxy-16-alkyl-prostadienoic acid derivatives of the formula: ##STR1## wherein A represents ##STR2## R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group, and the pharmaceutically acceptable non-toxic salts thereof. These compounds have excellent pharmacological effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.alpha..
摘要翻译：公开了下式的20-烷氧基-16-烷基 - 前列腺烯酸衍生物：其中A表示R和R 5可以相同或不同，各自表示氢原子或低级烷基; 和可以相同或不同的R 1和R 4各自表示低级烷基及其药学上可接受的无毒盐。这些化合物具有优异的药理作用，如前列腺素E2和前列腺素F2α。

6. 发明授权

US07673536B2 Industrial robot 有权
标题翻译：工业机器人
公开(公告)号：US07673536B2
公开(公告)日：2010-03-09
申请号：US11889476
申请日：2007-08-14
申请人： Toshinari Tamura , Hidenori Kurebayashi , Yasuyoshi Tanaka
发明人： Toshinari Tamura , Hidenori Kurebayashi , Yasuyoshi Tanaka
IPC分类号： B25J17/00
CPC分类号： B25J9/046 , B25J9/104 , Y10T74/20305
摘要： An industrial robot (10) comprising three power transmission units (21, 22, 23) arranged concentrically and three drive means for driving the three power transmission units, respectively, is disclosed. The drive means for at least one of the three power transmission units includes two motors (31, 34). Also, all of the three power transmission units and the three drive means are desirably built into the base (15) of the industrial robot. This configuration makes it possible to have high-duty operation with a comparatively compact structure.
摘要翻译：公开了一种工业机器人（10），其包括同心设置的三个电力传输单元（21,22,23）和分别驱动三个电力传输单元的三个驱动装置。用于三个动力传递单元中的至少一个的驱动装置包括两个马达（31,34）。此外，三个动力传递单元和三个驱动装置中的所有三个驱动装置都希望内置在工业机器人的基座（15）中。这种结构使得可以以比较紧凑的结构进行高功率操作。

7. 发明申请

US20080056858A1 Industrial robot 有权
标题翻译：工业机器人
公开(公告)号：US20080056858A1
公开(公告)日：2008-03-06
申请号：US11889476
申请日：2007-08-14
申请人： Toshinari Tamura , Hidenori Kurebayashi , Yasuyoshi Tanaka
发明人： Toshinari Tamura , Hidenori Kurebayashi , Yasuyoshi Tanaka
IPC分类号： B65H29/02
CPC分类号： B25J9/046 , B25J9/104 , Y10T74/20305
摘要： An industrial robot (10) comprising three power transmission units (21, 22, 23) arranged concentrically and three drive means for driving the three power transmission units, respectively, is disclosed. The drive means for at least one of the three power transmission units includes two motors (31, 34). Also, all of the three power transmission units and the three drive means are desirably built into the base (15) of the industrial robot. This configuration makes it possible to have high-duty operation with a comparatively compact structure.
摘要翻译：公开了一种工业机器人（10），其包括同心设置的三个电力传输单元（21,22,23）和分别驱动三个电力传输单元的三个驱动装置。用于三个动力传递单元中的至少一个的驱动装置包括两个马达（31,34）。此外，三个动力传递单元和三个驱动装置中的所有三个驱动装置都希望内置在工业机器人的基座（15）中。这种结构使得可以以比较紧凑的结构进行高功率操作。

8. 再颁专利

USRE34653E Heterocyclic spiro compounds and methods for preparing the same 失效
标题翻译：杂环螺环化合物及其制备方法
公开(公告)号：USRE34653E
公开(公告)日：1994-07-05
申请号：US909639
申请日：1992-07-07
申请人： Shin-ichi Tsukamoto , Hitoshi Nagaoka , Shinji Usuda , Masatomi Harada , Toshinari Tamura
发明人： Shin-ichi Tsukamoto , Hitoshi Nagaoka , Shinji Usuda , Masatomi Harada , Toshinari Tamura
IPC分类号： C07D491/107 , A61K31/435 , A61K31/55 , A61P25/02 , A61P25/28 , C07D211/48 , C07D405/06 , C07D453/00 , C07D471/10 , C07D487/10 , C07D491/10 , C07D491/20 , C07D491/22 , C07D495/10 , C07D495/20 , C07D495/22 , C07D497/20 , C07D497/22 , C07D705/02
CPC分类号： C07D471/10 , C07D211/48 , C07D491/10 , C07D495/10
摘要： Heterocyclic spiro compounds represented by the following general formula and salts thereof: ##STR1## The above compounds act upon muscarinic acetylcholine receptors, thereby activating the acetylcholine nervous functions in the central nervous system.
摘要翻译：由以下通式表示的杂环螺环化合物及其盐：上述化合物作用于毒蕈碱性乙酰胆碱受体，由此激活中枢神经系统中的乙酰胆碱神经功能。

9. 发明授权

US4610821A 4-substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds 失效
标题翻译： 4-取代-2-氮杂环丁酮化合物，制备该化合物的方法和含有这些化合物的药物
公开(公告)号：US4610821A
公开(公告)日：1986-09-09
申请号：US785168
申请日：1985-10-07
申请人： Toshinari Tamura , Hidenori Iwamoto , Makoto Yoshida , Minoru Yamamoto
发明人： Toshinari Tamura , Hidenori Iwamoto , Makoto Yoshida , Minoru Yamamoto
IPC分类号： C07D403/14 , C07D205/08 , C07D403/12 , C07K5/078 , C07K5/097 , C07D413/12
CPC分类号： C07D403/12 , C07D205/08 , C07K5/06147
摘要： A novel 4-substituted-2-azetidinone compound shown by the general formula ##STR1## and salts thereof. The compounds of this invention have a strong CNS activity and are useful for improving a disturbance of consciousness in shizophrenia, a head injury, etc., or improving hypobulia, memory loss, etc.

10. 发明授权

US4252819A Antisecretory heterocyclic amidine compounds 失效
标题翻译：防雾杂环脒化合物
公开(公告)号：US4252819A
公开(公告)日：1981-02-24
申请号：US934276
申请日：1978-08-16
申请人： Yasufumi Hirata , Isao Yanagisawa , Toshinari Tamura , Masaaki Takeda
发明人： Yasufumi Hirata , Isao Yanagisawa , Toshinari Tamura , Masaaki Takeda
IPC分类号： C07D233/64 , A61K31/40 , A61K31/4402 , A61K31/4418 , A61K31/4427 , A61K31/455 , A61P43/00 , C07D213/30 , C07D213/32 , C07D213/68 , C07D213/86 , C07D233/54 , C07D277/26 , C07D307/52 , C07D401/12 , C07D401/14 , C07D413/12 , A61K31/34 , A61K31/38 , C07D307/54 , C07D333/24
CPC分类号： C07D213/30 , C07D213/32 , C07D213/68 , C07D213/86 , C07D233/64 , C07D277/26 , C07D307/52
摘要： Novel heterocyclic compounds shown by the formula ##STR1## wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen atom; X represents an oxygen atom or the unsubstituted or substituted imino group shown by N--R.sub.1 (wherein R.sub.1 is a hydrogen atom, a lower alkyl group, a cyano group, an unsubstituted or alkyl substituted carbamoyl group, an unsubstituted or lower alkyl substituted thiocarbamoyl group, or a lower alkanoylamino group); Y represents a hydrogen atom, a lower alkyl group which may have substituent(s), a cycloalkyl group of 3-6 carbon atoms, a lower alkenyl group, a lower alkynyl group, an aryl group which may have substituent(s), an aralkyl group which may have substituent(s), a hydroxyl group, a cyano group, a carbamoyl group, an amidino group, an alkanoyl group which may have been substituted by halogen atom(s),an alkanoylamino group, an arylcarbonylamino group, an alkylamino group, an arylamino group, an arylsulfamoyl group, a lower alkoxycarbamoyl group, or an oxamoylamino group; and m and n represent an integer of 1-3; when X is N-R.sub.1, said X and Y may combine with each other to form a 5-membered or 6-membered heterocyclic ring containing 2-3 nitrogen atoms which may have substituent(s), and the pharmaceutically acceptable acid addition salts thereof.The compounds of this invention are useful as gastric acid secretion inhibitors.
摘要翻译：式中，Het表示可具有取代基的5元或6元杂环基的新型杂环化合物。 Z表示硫原子或氧原子; X表示氧原子或由N-R 1表示的未取代或取代的亚氨基（其中R 1为氢原子，低级烷基，氰基，未取代或烷基取代的氨基甲酰基，未取代或低级烷基取代的硫代氨基甲酰基，或低级烷酰氨基）; Y表示氢原子，可具有取代基的低级烷基，3-6个碳原子的环烷基，低级烯基，低级炔基，可具有取代基的芳基，可以具有取代基的芳烷基，羟基，氰基，氨基甲酰基，脒基，可被卤素原子取代的烷酰基，烷酰基氨基，芳基羰基氨基，烷基氨基，芳基氨基，芳基氨磺酰基，低级烷氧基氨基甲酰基或氨甲酰基氨基; m和n表示1-3的整数; 当X为N-R 1时，所述X和Y可以彼此结合形成含有2-3个可具有取代基的氮原子的5元或6元杂环，及其药学上可接受的酸加成盐。本发明的化合物可用作胃酸分泌抑制剂。

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