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1. 发明授权

US4055589A 20-Alkoxy-16-alkyl prostadienoic acid derivatives 失效
标题翻译： 20-烷氧基-16-烷基前列腺素衍生物
公开(公告)号：US4055589A
公开(公告)日：1977-10-25
申请号：US640497
申请日：1975-12-15
申请人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
发明人： Noriyoshi Inukai , Masuo Murakami , Hidenori Iwamoto , Isao Yanagisawa , Toshinari Tamura , Yoshio Ishii , Kenichi Tomioka , Tetsuya Shiozaki, deceased
IPC分类号： C07C405/00 , C07D307/935 , C07D309/12 , C07C177/00
CPC分类号： C07D307/935 , C07C405/00 , C07D309/12
摘要： A 20-alkoxy-16-alkyl-prostadienoic acid derivative shown by the formula ##STR1## wherein A represents ##STR2## R and R.sup.5, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R.sup.1 and R.sup.4, which may be the same or different, each represents a lower alkyl group,And the pharmacologically acceptable nontoxic salts thereof.The compounds have excellent effects as prostaglandin E.sub.2 and prostaglandin F.sub.2.alpha..
摘要翻译：其中A表示R和R 5可以相同或不同，表示氢原子或低级烷基的式“IMAGE”所示的20-烷氧基-16-烷基 - 前列腺二烯酸衍生物。并且可以相同或不同的R 1和R 4各自表示低级烷基，并且其药理学上可接受的非共价键。

2. 发明授权

US4051126A Process for the preparation of 6-alkoxy-substituted penicillins 失效
标题翻译：制备6-烷氧基取代的青霉素的方法
公开(公告)号：US4051126A
公开(公告)日：1977-09-27
申请号：US704770
申请日：1976-07-13
申请人： Masuo Murakami , Ichiro Isaka , Teruya Kashiwagi
发明人： Masuo Murakami , Ichiro Isaka , Teruya Kashiwagi
IPC分类号： C07D499/00 , C07D499/21 , C07D499/44 , C07D499/58
CPC分类号： C07D499/00
摘要： An improved process of preparing a 6-alkoxy-substituted penicillin or penicillin sulfoxide is disclosed. This process comprises adding a halogenating agent to penicillin or penicillin sulfoxide while cooling, and then adding an alkali metal alcoholate to the hydrogenation product in the presence of an alcohol corresponding to the alcoholate.
摘要翻译：公开了制备6-烷氧基取代的青霉素或青霉素亚砜的改进方法。该方法包括在冷却的同时向青霉素或青霉素亚砜中加入卤化剂，然后在对应于醇化物的醇的存在下向加氢产物中加入碱金属醇化物。

3. 发明授权

US4036954A Stable prostaglandin E group-containing formulation 失效
标题翻译：稳定的前列腺素E组制剂
公开(公告)号：US4036954A
公开(公告)日：1977-07-19
申请号：US516217
申请日：1974-10-21
申请人： Masuo Murakami , Shigemi Kawahara , Hiroitsu Kawata , Kiyoshi Okazaki , Jun Sekino , Hidemi Shimizu
发明人： Masuo Murakami , Shigemi Kawahara , Hiroitsu Kawata , Kiyoshi Okazaki , Jun Sekino , Hidemi Shimizu
IPC分类号： A61K31/557 , C07C405/00 , A61K47/00 , A61K31/19 , A61K31/215
CPC分类号： A61K31/557 , C07C405/00 , Y10S514/97
摘要： There is provided a process of preparing a prostaglandin E group-containing formulation by adding to a prostaglandin E group at least one additive selected from the group consisting of a thiol compound, a water soluble high molecular weight compound and a water-soluble salt of deoxycholic acid and then subjecting the mixture to lyophilization.
摘要翻译：提供了一种通过向前列腺素E组中加入至少一种选自硫醇化合物，水溶性高分子量化合物和脱水胆碱的水溶性盐的添加剂来制备含前列腺素E组的制剂的方法酸，然后使混合物冷冻干燥。

4. 发明授权

US4021434A Sodium .beta.-[2,6-dimethyl-3,5-bis(ethoxycarbonyl)-4-(3-nitrophenyl)-1,4-dihyd ropyridine-1-yl]ethyl sulfate 失效
标题翻译： {62- {8,2,6-二甲基-3,5-双（乙氧基羰基）-4-（3-硝基苯基）-1,4-二氢吡啶-1-基{乙酸乙酯
公开(公告)号：US4021434A
公开(公告)日：1977-05-03
申请号：US606728
申请日：1975-08-21
申请人： Masuo Murakami , Kozo Takahashi , Teruaki Ozasa , Kazuharu Tamazawa , Ryutaro Kawai , Toichi Takenaka , Norio Sato
发明人： Masuo Murakami , Kozo Takahashi , Teruaki Ozasa , Kazuharu Tamazawa , Ryutaro Kawai , Toichi Takenaka , Norio Sato
IPC分类号： C07D211/82 , C07D211/90 , C07D219/06 , C07D401/04 , C07D405/04 , C07D213/55
CPC分类号： C07D401/04 , C07D211/82 , C07D211/90 , C07D219/06 , C07D405/04 , Y10S514/929
摘要： Novel 1-substituted-1, 4-dihydropyridine derivatives, particularly diethyl 1-ethoxymethyl-4-(3-nitrophenyl)-2, 6-dimethyl-1, 4-dihydropyridine-3,5-dicarboxylate are provided. The novel derivatives have cerebral vascular dilator activity with low toxicity.
摘要翻译：提供新的1-取代-1,4-二氢吡啶衍生物，特别是1-乙氧基甲基-4-（3-硝基苯基）-2,6-二甲基-1,4-二氢吡啶-3,5-二羧酸二乙酯。该新型衍生物具有低毒性的脑血管扩张剂活性。

5. 发明授权

US3991111A N-alkenyltetracycline derivatives 失效
标题翻译： N-烯基四环素衍生物
公开(公告)号：US3991111A
公开(公告)日：1976-11-09
申请号：US574865
申请日：1975-05-06
申请人： Masuo Murakami , Masaru Iwanami , Tadao Shibanuma , Masaharu Fujimoto , Norio Sato , Ryutaro Kawai , Kuniichiro Yano
发明人： Masuo Murakami , Masaru Iwanami , Tadao Shibanuma , Masaharu Fujimoto , Norio Sato , Ryutaro Kawai , Kuniichiro Yano
IPC分类号： C07C233/00 , C07C103/19
CPC分类号： C07C233/00
摘要： N-alkenyltetracycline derivatives, for example, N-(1-methyl-2-.alpha.-naphthylethenyl)tetracycline represented by the formula ##SPC1##The compounds have excellent antibacterial action as compared with tetracycline.
摘要翻译： N-烯基四环素衍生物，例如由式表示的N-（1-甲基-2-甲酰基 - 乙烯基）四环素与四环素相比，该化合物具有优异的抗菌作用。

6. 发明授权

US4186200A Novel fused derivatives of 2-pyridones 失效
标题翻译： 2-吡啶酮的新型融合衍生物
公开(公告)号：US4186200A
公开(公告)日：1980-01-29
申请号：US876517
申请日：1978-02-09
申请人： Kazuo Kubo , Noriki Ito , Isao Souzu , Yasuo Isomura , Hiroshige Homma , Masuo Murakami
发明人： Kazuo Kubo , Noriki Ito , Isao Souzu , Yasuo Isomura , Hiroshige Homma , Masuo Murakami
IPC分类号： A61K31/44 , C07D213/64 , C07D213/74 , C07D213/89 , C07D455/02 , C07D471/04 , C07D498/04 , C07D513/04 , A61K31/415
CPC分类号： C07C255/00 , C07D213/64 , C07D213/89 , C07D471/04 , C07D513/04
摘要： Novel nitrogen-containing heterocyclic compounds shown by the formula ##STR1## wherein one of R.sub.1 and R.sub.2 represents a lower alkyl group, a phenyl group, a halophenyl group, or a lower alkoxyphenyl group and the other of them represents a hydrogen atom, a lower alkyl group, or a phenyl lower alkyl group; said R.sub.1 and R.sub.2 may combine with each other to form a trimethylene group or a tetramethylene group; R.sub.3 represents a hydrogen atom, a lower alkyl group, a phenyl group, or a phenyl lower alkyl group; X represents an oxygen atom, a sulfur atom, an imino group, or a group shown by ##STR2## wherein m represents 1 or 2 and R.sub.4 represents a lower alkyl group, a hydroxy lower alkyl group, a cycloalkyl group or a phenyl lower alkyl group; and Y represents an ethylene group which may be substituted by lower alkyl group, a trimethylene group, a tetramethylene group, a vinylene group which may be substituted by a lower alkyl group, or ##STR3## wherein R.sub.5 represents a hydrogen atom, a lower alkyl group, a trifluoromethyl group, or a phenyl group; said X is the group shown by ##STR4##when one of said R.sub.1 and R.sub.2 is a lower alkyl group and the other is a hydrogen atom, and said Y is an ethylene group, and the pharmacologically acceptable non-toxic salts thereof. The compounds described above are strong analgesic anti-inflammatory agents.
摘要翻译：式中，R 1和R 2中的一个表示低级烷基，苯基，卤代苯基或低级烷氧基苯基，另一方表示氢原子，低级烷基或苯基低级烷基; 所述R1和R2可以相互结合形成三亚甲基或四亚甲基; R3表示氢原子，低级烷基，苯基或苯基低级烷基; X表示氧原子，硫原子，亚氨基或由下式表示的基团，其中m表示1或2，R4表示低级烷基，羟基低级烷基，环烷基或苯基低级烷基组; Y表示可以被低级烷基，三亚甲基，四亚甲基，可被低级烷基取代的亚乙烯基取代的亚乙基，或者R5表示氢原子的低级烷基基，三氟甲基或苯基; 说X是所示的组

7. 发明授权

US4165429A 7.alpha.-METHOXY-CEPHALOSPORANIC ACID DERIVATIVES 失效
标题翻译： 7 {60-月桂酰胺酸衍生物
公开(公告)号：US4165429A
公开(公告)日：1979-08-21
申请号：US806932
申请日：1977-06-15
申请人： Masaru Iwanami , Masuo Murakami , Yoshinobu Nagano , Masaharu Fujimoto , Tetsuya Maeda , Noriaki Nagano , Atsuki Yamazaki
发明人： Masaru Iwanami , Masuo Murakami , Yoshinobu Nagano , Masaharu Fujimoto , Tetsuya Maeda , Noriaki Nagano , Atsuki Yamazaki
IPC分类号： A61K31/545 , C07D20060101 , C07D501/28 , C07D501/36 , C07D501/56 , C07D501/57
CPC分类号： C07D501/57
摘要： Novel 7.alpha.-methoxy-7.beta.-heterocyclic thioacetamido-3-heterocyclic thiomethyl-.DELTA..sup.3 -cephem-4-carboxylic acid derivatives and pharmaceutically acceptable salts thereof. These compounds show high antibiotic activities against various microorganisms including gram positive and negative bacteria.
摘要翻译：新型7α-甲氧基-7β-杂环硫代乙酰氨基-3-杂环硫代甲基-DTTA 3-头孢烯-4-羧酸衍生物及其药学上可接受的盐。这些化合物对包括革兰氏阳性菌和阴性细菌在内的各种微生物显示出高抗生素活性。

8. 发明授权

US4109088A 2-(Indenyloxymethyl) morpholine derivatives 失效
标题翻译： 2-（茚基甲基）吗啉衍生物
公开(公告)号：US4109088A
公开(公告)日：1978-08-22
申请号：US772320
申请日：1977-02-25
申请人： Masuo Murakami , Kozo Takahashi , Yuji Kawashima , Tadao Kojima , Kunihiro Niigata , Takashi Fujikura , Yoshihisa Nozaki , Shiro Tachikawa , Shinji Usuda , Soichi Kagami
发明人： Masuo Murakami , Kozo Takahashi , Yuji Kawashima , Tadao Kojima , Kunihiro Niigata , Takashi Fujikura , Yoshihisa Nozaki , Shiro Tachikawa , Shinji Usuda , Soichi Kagami
IPC分类号： C07D265/30 , C07D265/32
CPC分类号： C07D265/32 , C07D265/30
摘要： 2-(Indenyloxymethyl) morpholine derivatives are disclosed. These derivatives are excellent in methamphetamine stereotyped increasing and antireserpine activities which are useful as antidepression agents.

9. 发明授权

US4045482A 4-(3-Isopropylamino-2-hydroxypropoxy indene 失效
标题翻译： 4-（3-异丙基氨基-2-羟基丙氧基茚
公开(公告)号：US4045482A
公开(公告)日：1977-08-30
申请号：US568097
申请日：1975-04-14
申请人： Masuo Murakami , Kiyoshi Murase , Kunihiro Niigata , Shiro Tachikawa , Toichi Takenaka
发明人： Masuo Murakami , Kiyoshi Murase , Kunihiro Niigata , Shiro Tachikawa , Toichi Takenaka
IPC分类号： A61K31/135 , F16B2/06 , C07C93/06
CPC分类号： A61K31/135 , F16B2/06
摘要： Novel indene derivatives represented by the general formula ##STR1## wherein R represents lower alkyl, phenylloweralkyl or lower cycloalkyl, and acid addition salts thereof useful as .beta.-receptor antagonists.
摘要翻译：由通式表示的新型茚衍生物，其中R表示低级烷基，苯基低级烷基或低级环烷基，及其作为β-受体拮抗剂的酸加成盐。

10. 发明授权

US4036834A Derivatives of 7-(.alpha.-hydroxy-substituted pyridyl carboxamido-.alpha. p h .DELTA..sup.3 -cephem-4-carboxylic acid 失效
标题翻译： 7 - （{6-羟基 - 取代的吡啶基甲酰氨基 - {60 {0苯基 - 乙酰氨基-3-取代的硫代甲基{66 {hu 3 {b-头孢烯-4-羧酸
公开(公告)号：US4036834A
公开(公告)日：1977-07-19
申请号：US620552
申请日：1975-10-08
申请人： Masuo Murakami , Masaru Iwanami , Ichiro Isaka , Yoshinobu Nagano , Masaharu Fujimoto , Tetsuya Maeda
发明人： Masuo Murakami , Masaru Iwanami , Ichiro Isaka , Yoshinobu Nagano , Masaharu Fujimoto , Tetsuya Maeda
IPC分类号： A61K20060101 , A61K31/545 , C07D20060101 , C07D501/04 , C07D501/36
CPC分类号： C07D501/36
摘要： Novel 7-(.alpha.-hydroxy-substituted pyridylcarboxamido-.alpha.-phenylacetamido)-3-substituted thiomethyl-.DELTA..sup.3 -cephem-4-carboxylic acid derivatives are disclosed. The compounds of this invention have high water solubility and show excellent antibacterial activities against various strains of Pseudomonas and Proteus.
摘要翻译：公开了新的7-（α-羟基取代的吡啶基甲酰氨基-α-苯基乙酰胺基）-3-取代的硫代甲基-D-TA-头孢烯-4-羧酸衍生物。本发明化合物具有高水溶性，对各种假单胞菌和变形菌菌株均具有优异的抗菌活性。

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