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    • 2. 发明授权
    • Process for producing α-trifluoromethyl-α,β-unsaturated ester
    • α-三氟甲基-α,β-不饱和酯的制备方法
    • US08653295B2
    • 2014-02-18
    • US13060565
    • 2009-09-24
    • Akihiro IshiiManabu YasumotoTakako YamazakiKaori MogiKazunori MoriTakashi Masuda
    • Akihiro IshiiManabu YasumotoTakako YamazakiKaori MogiKazunori MoriTakashi Masuda
    • C07C69/76
    • C07C67/317C07C67/327C07C69/65
    • An α-trifluoromethyl-α,β-unsaturated ester can be produced by reacting an α-trifluoromethyl-α-hydroxy ester with sulfuryl fluoride (SO2F2) in the presence of an organic base. It is preferable that the raw substrate has a hydrogen atom as one β-position substituent group and either an alkyl group, a substituted alkyl group, an alkenyl group, a substituted alkenyl group, an aromatic ring group or a substituted aromatic ring group as the other β-position substituent group. It is more preferable that an ester moiety of the raw substrate is an alkyl ester. This raw substrate is readily available. Further, the desired reaction can proceed favorably with the use of this raw substrate. It is also preferable to use either 1,5-diazabicyclo[4.3.0]non-5-ene (DBN) or 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as the organic base. The desired reaction can proceed more favorably with the use of this organic base.
    • α-三氟甲基-α,β-不饱和酯可以通过在有机碱存在下使α-三氟甲基-α-羟基酯与硫酰氟(SO 2 F 2)反应来制备。 原料优选为具有作为一个β位取代基的氢原子,烷基,取代烷基,链烯基,取代烯基,芳香环基或取代芳环基作为 其他β位取代基。 原料的酯部更优选为烷基酯。 该原料基材容易获得。 此外,期望的反应可以有利地利用该原始基底进行。 还优选使用1,5-二氮杂双环[4.3.0]壬-5-烯(DBN)或1,8-二氮杂双环[5.4.0]十一碳-7-烯(DBU)作为有机碱。 使用该有机碱可以更有利地进行所需的反应。