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1. 发明申请

US20090299265A1 Electrode Assembly for Iontophoresis Having Shape-Memory Separator and Iontophoresis Device Using the Same 审中-公开
标题翻译：具有形状记忆分离器和使用其的离子电渗装置的离子电渗电极组件
公开(公告)号：US20090299265A1
公开(公告)日：2009-12-03
申请号：US11992672
申请日：2006-10-02
申请人： Akihiko Tanioka , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
发明人： Akihiko Tanioka , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Akihiko Matsumura
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/044 , A61N1/0448
摘要： An electrode assembly for iontophoresis including an electrode coupled to an electric power source device having a same polarity as that of the ionic drug in the electrode assembly, an electrolyte solution holding portion holding an electrolyte solution by being impregnated with the electrolyte solution, the electrolyte solution holding portion being placed adjacent to the electrode, a first ion exchange membrane operable to substantially pass ions having a polarity that is same as a polarity of the ionic drug and substantially block ions having a polarity that is opposite the polarity of the ionic drug, the first ion exchange membrane being placed adjacent to the electrolyte solution holding portion, a drug solution holding portion holding the ionic drug by being impregnated with the ionic drug, the drug solution holding portion being placed adjacent to the first ion exchange membrane, a second ion exchange membrane operable to substantially pass ions having a polarity that is opposite the polarity of the ionic drug and substantially block ions having a polarity that is the same as the polarity of the ionic drug, the second ion exchange membrane being placed adjacent to the drug solution holding portion, and a shape-memory separator capable of being transformed between a first and a second configuration to respectively allow passage of a substance and blocking of the substance, the shape-memory separator placed adjacent to at least one surface of the first ion exchange membrane.
摘要翻译：一种用于离子电渗疗法的电极组件，其包括与电极组件中的离子药物极性相同的电源装置的电极，通过浸渍电解质溶液保持电解质溶液的电解液保持部分，保持部分被放置成与电极相邻，第一离子交换膜可操作以基本上通过具有与离子药物的极性相同的极性的离子，并且基本上阻挡具有与离子药物的极性相反的极性的离子，第一离子交换膜与电解质溶液保持部相邻配置，通过浸渍离子性药物而保持离子性药物的药液保持部，药液保持部与第一离子交换膜相邻配置，第二离子交换膜可操作以基本上通过具有相反极性的离子 e离子药物的极性，并且基本上阻挡具有与离子药物的极性相同的极性的离子，第二离子交换膜邻近药物溶液保持部分放置，以及形状记忆分离器，其能够在第一和第二构型之间转换以分别允许物质的通过和物质的阻塞，所述形状记忆隔离物与第一离子交换膜的至少一个表面相邻放置。

2. 发明申请

US20070066930A1 Iontophoresis device and method of producing the same 审中-公开
标题翻译：离子电渗疗法装置及其制造方法
公开(公告)号：US20070066930A1
公开(公告)日：2007-03-22
申请号：US11471973
申请日：2006-06-20
申请人： Akihiko Tanioka , Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
发明人： Akihiko Tanioka , Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
IPC分类号： A61N1/30 , A61L33/00 , B32B18/00
CPC分类号： A61N1/0444 , A61N1/044 , A61N1/0448
摘要： An iontophoresis device and method of producing the same may reduce material loss during the course of production of a conventional iontophoresis device, and may allow for easy automation of production processes and increases in production scale. The iontophoresis device may be used for administering drug ions of a first polarity generated by dissociation of a drug to a living body, and may comprise: a first conductive layer formed on a surface of a first substrate; a drug layer made of a drug coating containing the drug, the drug layer being laminated on the first conductive layer; and a first ion exchange layer made of an ion exchange coating containing an ion exchange resin having an exchange group introduced thereto, the ion exchange group having a counter ion to the first polarity ions, the first ion exchange layer being laminated on the drug layer.
摘要翻译：离子电渗装置及其制造方法可以在常规离子电渗装置的制造过程中减少材料损失，并且可以容易地实现生产方法的自动化和生产规模的增加。离子电渗装置可以用于施用通过将药物解离为活体而产生的第一极性的药物离子，并且可以包括：形成在第一基底的表面上的第一导电层; 由含有药物的药物涂层制成的药物层，所述药物层被层压在所述第一导电层上; 以及第一离子交换层，其由含有引入了交换基团的离子交换树脂的离子交换涂层构成，所述离子交换基团与所述第一极性离子具有抗衡离子，所述第一离子交换层层叠在所述药物层上。

3. 发明授权

US07660626B2 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US07660626B2
公开(公告)日：2010-02-09
申请号：US11195364
申请日：2005-08-02
申请人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译：本发明提供了具有药物高效给药的离子电渗疗法装置。一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

4. 发明申请

US20060173401A1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US20060173401A1
公开(公告)日：2006-08-03
申请号：US11195364
申请日：2005-08-02
申请人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minagawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译：本发明提供了具有药物高效给药的离子电渗疗法装置。一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

5. 发明授权

US07590444B2 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US07590444B2
公开(公告)日：2009-09-15
申请号：US11172372
申请日：2005-06-30
申请人： Akihiko Tanioka , Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
发明人： Akihiko Tanioka , Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： An iontophoresis device for administering drug ions via the first ion-exchange membrane, comprising a first semi-permeable film having a number of pores passing through the film from a front surface to a back surface, a first ion-exchange membrane formed of ion-exchange resin filling the pores of the first semi-permeable film and selective ions of a first polarity, and a working electrode structure having a drug holding part placed on a back surface of the first ion-exchange membrane and holding a drug solution containing drug ions charged in the first polarity, wherein a layer of a water-soluble polymer compound is chemically bonded on the surface of the first semi-permeable film.
摘要翻译： 1.一种用于经由第一离子交换膜施用药物离子的离子电渗疗法装置，其特征在于，具有从前表面到背面通过所述膜的多孔的第一半透膜，由离子交换膜形成的第一离子交换膜，填充第一半透膜的孔和第一极性的选择性离子的交换树脂，以及具有放置在第一离子交换膜的背面上的药物保持部并保持含有药物离子的药液的工作电极结构以第一极性充电，其中水溶性聚合物化合物层化学键合在第一半透膜的表面上。

6. 发明申请

US20100100031A1 IONTOPHORESIS DEVICE 审中-公开
标题翻译： IONTOPHORESIS设备
公开(公告)号：US20100100031A1
公开(公告)日：2010-04-22
申请号：US12643720
申请日：2009-12-21
申请人： Akihiko Tanioka , Mie Minegawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
发明人： Akihiko Tanioka , Mie Minegawa , Kiyoshi Kanamura , Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama
IPC分类号： A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0444
摘要： The present invention provides an iontophoresis device with high administration efficient of a drug. An iontophoresis device, including an active electrode structure including: an electrode to which a positive electrical potential is applied; a drug holding part for holding a drug solution containing positively charged drug ions, the drug holding part being placed on a front side of the electrode; a cellulose-based resin film placed on a front side of the drug holding part or a complex film composed of a cation exchange membrane and a cellulose-based resin film placed on a front side of the cation exchange membrane, the complex film being placed on a front side of the drug holding part, in which the drug ions are administered through the cellulose-based resin film.
摘要翻译：本发明提供了具有药物高效给药的离子电渗疗法装置。一种离子电渗疗法装置，包括有源电极结构，包括：施加正电位的电极; 用于保持含有带正电荷的药物离子的药液的药物保持部，药物保持部位于电极的前侧; 将放置在药物保持部的前侧的纤维素系树脂膜或配置在阳离子交换膜前侧的阳离子交换膜和纤维素系树脂膜构成的复合膜，将复合膜置于药物保持部的前侧，其中通过纤维素系树脂膜施用药物离子。

7. 发明申请

US20090216175A1 Transdermal Administration Device and Method of Controlling the Same 审中-公开
标题翻译：透皮给药装置及其控制方法
公开(公告)号：US20090216175A1
公开(公告)日：2009-08-27
申请号：US11917733
申请日：2006-08-04
申请人： Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura , Kiyoshi Kanamura , Akihiko Tanioka
发明人： Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Akihiko Matsumura , Kiyoshi Kanamura , Akihiko Tanioka
IPC分类号： A61N1/30
CPC分类号： A61N1/0444 , A61N1/0428 , A61N1/0436 , A61N1/0448
摘要： To provide a transdermal administration device capable of increasing the speed at which a drug is transferred into a skin and the amount of the drug to be transferred into the skin. A transdermal administration device is constituted by: an electrode supplied with a voltage of a first conductivity type; an electrolyte solution holding portion holding an electrolyte solution energized by the electrode; and a bipolar membrane that is placed on the front surface side of the electrolyte solution holding portion, and is composed of a first ion exchange membrane that selectively passes an ion of the first conductivity type and a second ion exchange membrane that selectively passes an ion of a second conductivity type.
摘要翻译：提供能够增加药物转移到皮肤中的速度和要转移到皮肤中的药物的量的透皮给药装置。透皮给药装置由以下部分构成：供给第一导电型电压的电极; 电解液保持部，其保持由所述电极通电的电解液; 以及放置在电解液保持部的前表面侧的双极性膜，其由选择性地通过第一导电类型的离子的第一离子交换膜和选择性地通过第一导电类型的离子的第二离子交换膜第二导电类型。

8. 发明申请

US20060235351A1 External preparation, method of applying external preparation, iontophoresis device, and percutaneous patch 审中-公开
标题翻译：外用剂，外用剂的应用方法，离子电渗疗法及经皮贴剂
公开(公告)号：US20060235351A1
公开(公告)日：2006-10-19
申请号：US11195351
申请日：2005-08-02
申请人： Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Kazuyuki Tsuji , Tsutomu Shibata , Akihiko Tanioka , Mie Minagawa
发明人： Akihiko Matsumura , Mizuo Nakayama , Takehiko Matsumura , Hidero Akiyama , Kazuyuki Tsuji , Tsutomu Shibata , Akihiko Tanioka , Mie Minagawa
IPC分类号： A61N1/30 , A61K31/785 , A61K31/717
CPC分类号： A61N1/0444 , A61K9/0009 , A61K9/7023
摘要： The administration efficiency of a drug may be improved by establishing compatibility between the suppression of the release of a biological counter ion from a living body's biological interface and the maintenance of a good state of contact between each of a working electrode structure and a nonworking electrode structure and the biological interface. Coating films each composed of an external preparation containing: a hydrophilic polymer matrix agent; and an ion-exchange resin dispersed in the hydrophilic polymer matrix agent, or coating films each composed of an external preparation containing a hydrophilic polymer having an ion-exchange function are formed on the biological interface, and iontophoresis is performed through the coating films.
摘要翻译：药物的给药效率可以通过建立抑制生物体离子从活体生物界面的释放与维持工作电极结构和非工作电极结构之间的良好接触状态之间的相容性来改善和生物界面。涂膜各自由外用制剂组成，含有：亲水性聚合物基质剂; 在亲水性聚合物基质剂中分散有离子交换树脂，或者在生物界面上形成各自由含有具有离子交换功能的亲水性聚合物的外用制剂构成的涂膜，通过涂膜进行离子电渗疗法。

9. 发明授权

US07437189B2 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US07437189B2
公开(公告)日：2008-10-14
申请号：US11196783
申请日：2005-08-02
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
IPC分类号： A61N1/30 , A61M5/32
CPC分类号： A61N1/306
摘要： An iontophoresis device includes: a first electrode; a biological interface contact member including a substrate having a front surface and a rear surface, and a plurality of needles that protrude from the front surface of the substrate and can be inserted into a biological interface, the biological interface contact member allowing selective permeation of ions of a first polarity; and a drug holding part applied with an electrical potential or voltage through the first electrode and holding a drug solution containing drug ions charged in the first polarity, the drug holding part being interposed between the first electrode and the biological interface contact member.
摘要翻译：离子电渗装置包括：第一电极; 生物界面接触构件，其包括具有前表面和后表面的基底，以及从所述基底的前表面突出并可以插入生物界面的多个针，所述生物界面接触构件允许离子的选择性渗透第一极性; 以及通过所述第一电极施加电位或电压并保持含有以所述第一极性充电的药物离子的药液的药物保持部，所述药物保持部插入在所述第一电极和所述生物界面接触部件之间。

10. 发明申请

US20060217654A1 Iontophoresis device 失效
标题翻译：离子渗透装置
公开(公告)号：US20060217654A1
公开(公告)日：2006-09-28
申请号：US11196783
申请日：2005-08-02
申请人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
发明人： Akihiko Matsumura , Takehiko Matsumura , Mizuo Nakayama , Hidero Akiyama , Tsutomu Shibata , Akihiko Tanioka
IPC分类号： A61N1/30
CPC分类号： A61N1/306
摘要： An iontophoresis device includes: a first electrode; a biological interface contact member including a substrate having a front surface and a rear surface, and a plurality of needles that protrude from the front surface of the substrate and can be inserted into a biological interface, the biological interface contact member allowing selective permeation of ions of a first polarity; and a drug holding part applied with an electrical potential or voltage through the first electrode and holding a drug solution containing drug ions charged in the first polarity, the drug holding part being interposed between the first electrode and the biological interface contact member.
摘要翻译：离子电渗装置包括：第一电极; 生物界面接触构件，其包括具有前表面和后表面的基底，以及从所述基底的前表面突出并可以插入生物界面的多个针，所述生物界面接触构件允许离子的选择性渗透第一极性; 以及通过所述第一电极施加电位或电压并保持含有以所述第一极性充电的药物离子的药液的药物保持部，所述药物保持部插入在所述第一电极和所述生物界面接触部件之间。

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