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1. 发明申请

US20060147568A1 Blood pressure-lowering agent, vascular flexibility -improving agent and foods having these functions imparted thereto 审中-公开
标题翻译：血压降低剂，血管柔性改善剂和赋予其功能的食品
公开(公告)号：US20060147568A1
公开(公告)日：2006-07-06
申请号：US10542344
申请日：2004-01-16
申请人： Akihiko Takeuchi , Taku Sato , Hiroaki Yajima , Yutaka Miura , Keiji Kondo , Aruto Yoshida , Kiyoshi Yoshida , Junko Tomita
发明人： Akihiko Takeuchi , Taku Sato , Hiroaki Yajima , Yutaka Miura , Keiji Kondo , Aruto Yoshida , Kiyoshi Yoshida , Junko Tomita
IPC分类号： A61K36/185
CPC分类号： A61K36/185 , A23L33/105 , A61K31/122
摘要： According to the present invention, there is provided a blood pressure-lowering agent, a vascular flexibility-ameliorating agent and foods having these functions imparted thereto, which are comprising isohumulones or a hop extract and/or an isomerized hop extract as an active ingredient.
摘要翻译：根据本发明，提供降血压剂，血管弹性改善剂和赋予其功能的食品，其包含异葎草酮类或啤酒花提取物和/或异构化啤酒花提取物作为活性成分。

2. 发明申请

US20100080862A1 COMPOSITIONS AND FOODS FOR IMPROVING LIPID METABOLISM 审中-公开
标题翻译：用于改善脂质代谢的组合物和食品
公开(公告)号：US20100080862A1
公开(公告)日：2010-04-01
申请号：US12557365
申请日：2009-09-10
申请人： Hiroaki YAJIMA , Yutaka Miura , Daisuke Fujiwara , Hideharu Odai , Keiji Kondo , Hajime Nozawa
发明人： Hiroaki YAJIMA , Yutaka Miura , Daisuke Fujiwara , Hideharu Odai , Keiji Kondo , Hajime Nozawa
IPC分类号： A61K31/12 , C07C49/11 , C07C49/115 , C07C49/15 , A61P3/04 , A61P3/10 , A61K36/00
CPC分类号： A61K31/122 , A23L33/105 , A23V2002/00 , A61K36/185 , A23V2250/21
摘要： It is intended to provide compositions and foods for use in the treatment, prophylaxis, or amelioration of diseases or symptoms which can be treated, prevented or ameliorated by activating PPAR, in particular, insulin resistant diabetes and hyperlipidemia. Namely, medicinal compositions usable in treating, preventing or improving diseases or symptoms which can be treated, prevented or ameliorated by activation PPAR which contain humulones, isohumulones or lupulones or pharmaceutically acceptable salts or solvates thereof.
摘要翻译：旨在提供用于治疗，预防或改善可通过激活PPAR，特别是胰岛素抵抗型糖尿病和高脂血症治疗，预防或改善的疾病或症状的组合物和食品。也就是说，可用于治疗，预防或改善可通过激活含有葎草酮，异葎草酮或杜松酮的PPAR或其药学上可接受的盐或溶剂化物的治疗，预防或改善的疾病或症状的药物组合物。

3. 发明申请

US20060233902A1 Compositions and foods for improving lipid metabolism 审中-公开
标题翻译：用于改善脂质代谢的组合物和食物
公开(公告)号：US20060233902A1
公开(公告)日：2006-10-19
申请号：US10504694
申请日：2003-02-14
申请人： Hiroaki Yajima , Yutaka Miura , Daisuke Fujiwara , Hideharu Odai , Keiji Kondo , Hajime Nozawa
发明人： Hiroaki Yajima , Yutaka Miura , Daisuke Fujiwara , Hideharu Odai , Keiji Kondo , Hajime Nozawa
IPC分类号： A61K36/185 , A61K31/12
CPC分类号： A61K31/122 , A23L33/105 , A23V2002/00 , A61K36/185 , A23V2250/21
摘要： It is intended to provide compositions and foods for use in the treatment, prophylaxis, or amelioration of diseases or symptoms which can be treated, prevented or ameliorated by activating PPAR, in particular, insulin resistant diabetes and hyperlipidemia. Namely, medicinal compositions usable in treating, preventing or improving diseases or symptoms which can be treated, prevented or ameliorated by activation PPAR which contain humulones, isohumulones or lupulones or pharmaceutically acceptable salts or solvates thereof.
摘要翻译：旨在提供用于治疗，预防或改善可通过激活PPAR，特别是胰岛素抵抗型糖尿病和高脂血症治疗，预防或改善的疾病或症状的组合物和食品。也就是说，可用于治疗，预防或改善可通过激活含有葎草酮，异葎草酮或杜松酮的PPAR或其药学上可接受的盐或溶剂化物的治疗，预防或改善的疾病或症状的药物组合物。

4. 发明授权

US07195915B2 Vectors for animal cells and use thereof 有权
标题翻译：用于动物细胞的载体及其用途
公开(公告)号：US07195915B2
公开(公告)日：2007-03-27
申请号：US11284905
申请日：2005-11-23
申请人： Elisa Misawa , Hiroaki Yajima , Keiji Kondo
发明人： Elisa Misawa , Hiroaki Yajima , Keiji Kondo
IPC分类号： C12N15/00 , C12N5/10 , C12N5/16
CPC分类号： C07K14/47 , C12N15/65 , C12N15/85 , C12N2510/00 , C12N2510/02 , C12N2830/42 , C12N2840/20
摘要： Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a gene encoding a ribosome-constituting protein derived from an animal. The genes may be placed in recombinant vectors, including expression vectors containing the gene together with a foreign protein structural gene.
摘要翻译：蛋白质合成抑制剂抗性基因（以放线菌酮抗性基因为代表）能够赋予对抑制剂敏感的动物细胞对蛋白质合成抑制剂（以放线菌酮为代表）的抗性。该基因具有通过在编码来自动物的构成核糖体的蛋白质的基因中的取代突变的序列。可将基因置于重组载体中，包括含有该基因的表达载体以及外来蛋白质结构基因。

5. 发明申请

US20060078992A1 Novel vectors for animal cells and use thereof 有权
标题翻译：用于动物细胞的新载体及其用途
公开(公告)号：US20060078992A1
公开(公告)日：2006-04-13
申请号：US11284905
申请日：2005-11-23
申请人： Elisa Misawa , Hiroaki Yajima , Keiji Kondo
发明人： Elisa Misawa , Hiroaki Yajima , Keiji Kondo
IPC分类号： C07H21/04 , C12N5/06 , C12N15/87
CPC分类号： C07K14/47 , C12N15/65 , C12N15/85 , C12N2510/00 , C12N2510/02 , C12N2830/42 , C12N2840/20
摘要： Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a gene encoding a ribosome-constituting protein derived from an animal. The genes may be placed in recombinant vectors, including expression vectors containing the gene together with a foreign protein structural gene.
摘要翻译：蛋白质合成抑制剂抗性基因（以放线菌酮抗性基因为代表）能够赋予对抑制剂敏感的动物细胞对蛋白质合成抑制剂（以放线菌酮为代表）的抗性。该基因具有通过在编码来自动物的构成核糖体的蛋白质的基因中的取代突变的序列。可将基因置于重组载体中，包括含有该基因的表达载体以及外来蛋白质结构基因。

6. 发明授权

US07064194B2 Vectors for animal cells and utilization thereof 有权
标题翻译：用于动物细胞的载体及其应用
公开(公告)号：US07064194B2
公开(公告)日：2006-06-20
申请号：US10471009
申请日：2002-03-08
申请人： Elisa Misawa , Hiroaki Yajima , Keiji Kondo
发明人： Elisa Misawa , Hiroaki Yajima , Keiji Kondo
IPC分类号： C07H21/04 , A61K31/713 , C12N15/12 , C12N5/00
CPC分类号： C07K14/47 , C12N15/65 , C12N15/85 , C12N2510/00 , C12N2510/02 , C12N2830/42 , C12N2840/20
摘要： Protein synthesis inhibitor resistance genes (typified by a cycloheximide resistance gene) are capable of imparting resistance to a protein synthesis inhibitor (typified by cycloheximide) to animal cells sensitive to the inhibitor. The genes have a sequence mutated by substitution in a gene encoding a ribosome-constituting protein derived from an animal. The genes may be placed in recombinant vectors, including expression vectors containing the gene together with a foreign protein structural gene.
摘要翻译：蛋白质合成抑制剂抗性基因（以放线菌酮抗性基因为代表）能够赋予对抑制剂敏感的动物细胞对蛋白质合成抑制剂（以放线菌酮为代表）的抗性。该基因具有通过在编码来自动物的构成核糖体的蛋白质的基因中的取代突变的序列。可将基因置于重组载体中，包括含有该基因的表达载体以及外来蛋白质结构基因。

7. 发明授权

US06610514B2 Yeast vector and method of producing proteins using the same 失效
公开(公告)号：US06610514B2
公开(公告)日：2003-08-26
申请号：US09908855
申请日：2001-07-20
申请人： Keiji Kondo , Yutaka Miura
发明人： Keiji Kondo , Yutaka Miura
IPC分类号： C12P2102
CPC分类号： C12N9/2411 , C07K14/43 , C12N9/2408 , C12N15/815 , C12N15/905 , C12Y302/01001
摘要： An object of the present invention is to provide a vector which can be integrated into a yeast chromosome in a high number of copies. Another object of the present invention is to provide a modified vector which can be integrated into the yeast chromosome in a high number of copies and of which expression units stably maintain on the chromosome. The vector according to the present invention comprises a marker gene for selecting transformants, a shortened promoter sequence which is operably linked to the marker gene and a sequence homologous to the chromosomal DNA of Candida utilis, and optionally a heterologous gene or a gene derived from C. utilis, wherein the vector is linearized by cleaving within said homologous DNA sequence or at both ends of the homologous DNA sequence with restriction enzymes, and wherein the heterologous gene or the gene derived from C. utilis can be integrated into the chromosomal DNA of C. utilis by homologous recombination.

8. 发明授权

US06284534B1 Yeast vector comprising a shortened promoter sequence 失效
标题翻译：包含缩短的启动子序列的酵母载体
公开(公告)号：US06284534B1
公开(公告)日：2001-09-04
申请号：US09242690
申请日：1999-02-23
申请人： Keiji Kondo , Yutaka Miura
发明人： Keiji Kondo , Yutaka Miura
IPC分类号： C12N1581
CPC分类号： C12N9/2411 , C07K14/43 , C12N9/2408 , C12N15/815 , C12N15/905 , C12Y302/01001
摘要： An object of the present invention is to provide a vector which can be integrated into a yeast chromosome in a high number of copies. Another object of the present invention is to provide a modified vector which can be integrated into the yeast chromosome in a high number of copies and of which expression units stably maintain on the chromosome. The vector according to the present invention comprises a marker gene for selecting transformants, a shortened promoter sequence which is operably linked to the marker gene and a sequence homologous to the chromosomal DNA of Candida utilis, and optionally a heterologous gene or a gene derived from C. utilis, wherein the vector is linearized by cleaving within said homologous DNA sequence or at both ends of the homologous DNA sequence with restriction enzymes, and wherein the heterologous gene or the gene derived from C. utilis can be integrated into the chromosomal DNA of C. utilis by homologous recombination.
摘要翻译：本发明的目的是提供一种能够以大量拷贝结合到酵母染色体中的载体。本发明的另一个目的是提供一种修饰的载体，其能够以大量的拷贝整合到酵母染色体中，并且其表达单位稳定地保持在染色体上。根据本发明的载体包含用于选择转化体的标记基因，可操作地连接到标记基因的缩短的启动子序列和与产朊假丝酵母的染色体DNA同源的序列，以及任选的异源基因或衍生自C的基因其中载体通过在所述同源DNA序列内切割或用限制性内切酶在同源DNA序列的两端进行线性化，其中异源基因或源自产朊酵母的基因可以整合入C的染色体DNA中通过同源重组产生。

9. 发明申请

US20110163625A1 STATOR DESIGNED TO MINIMIZE LEAKAGE CURRENT AND ELECTRIC ROTATING MACHINE USING SAME 有权
标题翻译：定位器设计为最小化泄漏电流和电动旋转机器使用相同
公开(公告)号：US20110163625A1
公开(公告)日：2011-07-07
申请号：US12984777
申请日：2011-01-05
申请人： Akira FUKUSHIMA , Keiji Kondo , Akito Akimoto , Takeo Maekawa , Makoto Taniguchi , Shin Kusase
发明人： Akira FUKUSHIMA , Keiji Kondo , Akito Akimoto , Takeo Maekawa , Makoto Taniguchi , Shin Kusase
IPC分类号： H02K3/28
CPC分类号： H02K3/345 , H02K3/12 , H02K3/28
摘要： A stator which may be employed in an electric rotating machine. The stator includes a stator winding which includes in-slot portions disposed in slots of a stator core. The in-slot portions are arrayed in each of the slots in a form of multiple layers aligned in a radial direction of the stator core. The stator winding is made up of a first winding and a second winding which are connected together through a joint. The first winding is defined by a portion of the stator winding between the joint and an end of the stator winding which is to be connected to an external. The second winding includes the in-slot portion placed within at least one of the slots as an outermost layer that is one of the layers placed most outwardly in the radial direction of the stator core. This results in a great decrease in leakage current.
摘要翻译：可用于电动旋转机器的定子。定子包括定子绕组，其包括设置在定子芯的槽中的槽内部分。插槽部分以每个定子芯的径向对准的多个层的形式排列在每个槽中。定子绕组由通过接头连接在一起的第一绕组和第二绕组组成。第一绕组由定子绕组的一部分限定在接头与要连接到外部的定子绕组的端部之间。第二绕组包括放置在至少一个狭槽内的槽内部分，其中最外层是位于定子芯的径向方向上最外侧的层之一。这导致漏电流大大降低。

10. 发明授权

US5470971A Stress-induced proteins, genes coding therefor, transformed cells of organisms, methods and applications 失效
标题翻译：应激诱导的蛋白质，编码的基因，转化细胞的生物，方法和应用
公开(公告)号：US5470971A
公开(公告)日：1995-11-28
申请号：US667276
申请日：1991-03-11
申请人： Keiji Kondo , Masayori Inouye
发明人： Keiji Kondo , Masayori Inouye
IPC分类号： C07K14/245 , C07K14/395 , C12N15/31 , C12N15/81 , C12N15/82
CPC分类号： C12N15/81 , C07K14/245 , C07K14/395 , C12N15/8273
摘要： Genes (and portions thereof) which are stress-inducible, e.g., by cold-shock which encode useful proteins. The proteins contribute to confer thermo-tolerance and/or contribute to confer low temperature tolerance to organisms, like eucaryotes or procaryotes. Typical genes encoding such proteins and homologous genes encoding proteins with equivalent properties are discussed. Nucleotide sequences encoding such proteins, recombinant replicable expression vehicles which comprise DNA constructs which encode such proteins and competent transformed organisms like eucaryotes are discussed. The production of valuable fermentation products and of biologically active proteins under conditions outside the normal or optimum physiological growth conditions are described.
摘要翻译：基因（及其部分）是应激诱导型，例如通过编码有用蛋白质的冷休克。蛋白质有助于赋予耐热性和/或有助于赋予生物体如真核生物或原核生物低温耐受性。讨论了编码这种蛋白质的典型基因和编码具有相同性质的蛋白质的同源基因。讨论了编码这种蛋白质的核苷酸序列，重组可复制表达载体，其包含编码这种蛋白质的DNA构建体和受感染的转化生物如真核生物。描述了在正常或最佳生理生长条件之外的条件下生产有价值的发酵产物和生物活性蛋白质。

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