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    • 1. 发明申请
    • Method for alleviating syndromes and conditions of discomfort of the mammalian intestinal and genito-urinary tracts
    • 减轻哺乳动物肠和泌尿道不适症状和不适症状的方法
    • US20020099037A1
    • 2002-07-25
    • US10051853
    • 2002-01-17
    • AkPharma, Inc.
    • Alan E. KligermanSarah Finnegan
    • A61K031/66
    • A61K31/66
    • Glycerophosphates, particularly calcium glycerophosphate (CGP), have been found to mitigate certain abdominal-area physical problems including irritable bowel syndrome and urinary urgency. It is believed that calcium and glycerophosphate, taken orally, are introduced into the human and other animal system such that the glycerophosphate and/or calcium exert a damping, soothing, irritant-interdictive or antispasmodic action on the intestinal, urinary bladder and other smooth muscle organs. Using glycerophosphates, a method is provided for alleviating, palliating, and reducing the syndromes and conditions of discomfort resulting from a variety of diseases, including irritable bowel syndrome, interstitial cystitis, inflammatory bowel disease, fibromyalgia, urinary urgency, benign prostatic hypertrophy, vulvodynia and external genital pain. It is also suggested that muscular energy supplied via glycolysis, the source of anaerobic energy, may be facilitated by the administration of a glycerophosphate moiety to the body's glycerophosphate shuttle.
    • 甘油磷酸盐,特别是甘油磷酸钙(CGP)已经被发现减轻某些腹部的身体问题,包括肠易激综合征和尿急。 据信,将口服的钙和甘油磷酸酯引入人和其他动物系统中,使得甘油磷酸盐和/或钙对肠,膀胱和其他平滑肌发挥阻尼,舒缓,刺激性 - 阻断或解痉作用 器官。 使用甘油磷酸盐,提供了一种减轻,缓解和减轻由各种疾病引起的不适症状的方法,包括肠易激综合征,间质性膀胱炎,炎性肠病,纤维肌痛,尿急,良性前列腺肥大,外阴和 外生殖器疼痛。 还有人提出,通过糖酵解提供的肌肉能量,即厌氧能的来源可以通过向身体的甘油磷酸盐梭子施用甘油磷酸酯部分来促进。
    • 2. 发明申请
    • Compositions and methods for treating skin conditions
    • 用于治疗皮肤病症的组合物和方法
    • US20040037766A1
    • 2004-02-26
    • US10639213
    • 2003-08-12
    • AkPharma, Inc.
    • Alan E. KligermanSarah FinneganMargaret Weis
    • C01B025/00
    • A61Q19/007A61K8/19A61K8/365A61K8/55A61Q5/006Y10S514/88
    • A skin treatment composition containing ionic calcium and a dermatologically acceptable water-soluble, water-miscible or water-based carrier is provided for treating a skin condition in a mammal, such as dry skin, dry scalp, a burn, sunburn, irritation or minor wound. The ionic calcium is preferably present as the water soluble calcium glycerophosphate salt. The composition may be present in a formulation such as bar soap, liquid soap, bath, lotion, cream, gel, or ointment, and may also be useful for stimulating more youthful skin cells and for improving the appearance of the skin. Methods for treating skin conditions and for accelerating cellular repair include topically applying to the skin an effective amount of ionic calcium, preferably as calcium glycerophosphate, and an null-hydroxy acid such as lactic acid.
    • 提供含有离子钙和皮肤病学可接受的水溶性,水混溶性或水性载体的皮肤处理组合物,用于治疗哺乳动物的皮肤状况,例如干性皮肤,干性头皮,烧伤,晒伤,刺激或次要 伤口。 离子钙优选作为水溶性甘油磷酸钙盐存在。 组合物可以存在于制剂如巴肥皂,液皂,浴液,洗剂,霜剂,凝胶或软膏中,并且还可用于刺激更年轻的皮肤细胞和改善皮肤的外观。 用于治疗皮肤病症和促进细胞修复的方法包括向皮肤局部施用有效量的离子钙,优选为甘油磷酸钙,和α-羟基酸如乳酸。