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1. 发明授权

US08609830B2 Methods and compositions for RNA interference 有权
标题翻译： RNA干扰的方法和组成
公开(公告)号：US08609830B2
公开(公告)日：2013-12-17
申请号：US10557219
申请日：2004-05-17
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Janell M. Schelter , Peter S. Linsley
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Janell M. Schelter , Peter S. Linsley
IPC分类号： C07H21/00
CPC分类号： C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/12
摘要： The invention provides methods and compositions for gene silencing by RNA interference. In particular, the invention provides methods for gene silencing or RNA knockdown using small interfering RNAs (siRNAs) having partial sequence homology to its target gene. The invention also provides methods for identifying common and/or differential responses to a plurality of different siRNAs targeting a gene. The invention also provides methods for evaluating the relative activity of the two strands of an siRNA. The invention further provides methods of designing siRNAs for gene silencing. The invention further provides methods of using siRNAs as therapeutics for treatment of diseases.
摘要翻译：本发明提供了通过RNA干扰进行基因沉默的方法和组合物。特别地，本发明提供了使用与其靶基因具有部分序列同源性的小干扰RNA（siRNA）进行基因沉默或RNA敲低的方法。本发明还提供了鉴定针对基因的多种不同siRNA的常见和/或差异应答的方法。本发明还提供了评估siRNA两条链的相对活性的方法。本发明还提供了设计用于基因沉默的siRNA的方法。本发明还提供了使用siRNA作为治疗疾病的治疗剂的方法。

2. 发明申请

US20110250591A1 METHOD OF DESIGNING siRNAS FOR GENE SILENCING 有权
标题翻译：设计用于基因沉默的siRNA的方法
公开(公告)号：US20110250591A1
公开(公告)日：2011-10-13
申请号：US13100836
申请日：2011-05-04
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/31 , G06F19/18 , G06F19/22
摘要： The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
摘要翻译：本发明提供使用位置特异性评分矩阵法来鉴定转录物中的siRNA靶基序的方法。本发明还提供了一种使用位置特异性评分矩阵方法鉴定siRNA的靶外基因的方法。本发明还提供了设计具有较高沉默功效和特异性的siRNA的方法。本发明还提供了包含具有高沉默功效和特异性的siRNA的siRNA文库。

3. 发明授权

US07962316B2 Method of designing siRNAs for gene silencing 有权
标题翻译：设计siRNA用于基因沉默的方法
公开(公告)号：US07962316B2
公开(公告)日：2011-06-14
申请号：US10577696
申请日：2004-10-27
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
IPC分类号： G06F17/10 , G06F7/60
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/31 , G06F19/18 , G06F19/22
摘要： The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
摘要翻译：本发明提供使用位置特异性评分矩阵法来鉴定转录物中的siRNA靶基序的方法。本发明还提供了一种使用位置特异性评分矩阵方法鉴定siRNA的靶外基因的方法。本发明还提供了设计具有较高沉默功效和特异性的siRNA的方法。本发明还提供了包含具有高沉默功效和特异性的siRNA的siRNA文库。

4. 发明授权

US08457902B2 Method for selecting SIRNAs from a plurality of SIRNAs for gene silencing 有权
标题翻译：用于从多个SIRNA中选择用于基因沉默的SIRNA的方法
公开(公告)号：US08457902B2
公开(公告)日：2013-06-04
申请号：US13100836
申请日：2011-05-04
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
IPC分类号： G06F7/00
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/31 , G06F19/18 , G06F19/22
摘要： The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
摘要翻译：本发明提供使用位置特异性评分矩阵法来鉴定转录物中的siRNA靶基序的方法。本发明还提供了一种使用位置特异性评分矩阵方法鉴定siRNA的靶外基因的方法。本发明还提供了设计具有较高沉默功效和特异性的siRNA的方法。本发明还提供了包含具有高沉默功效和特异性的siRNA的siRNA文库。

5. 发明申请

US20080234941A1 Method of Designing Sirnas for Gene Silencing 有权
标题翻译：设计Sirnas进行基因沉默的方法
公开(公告)号：US20080234941A1
公开(公告)日：2008-09-25
申请号：US10577696
申请日：2004-10-27
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
IPC分类号： G01N33/48
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/31 , G06F19/18 , G06F19/22
摘要： The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
摘要翻译：本发明提供使用位置特异性评分矩阵法来鉴定转录物中的siRNA靶基序的方法。本发明还提供了一种使用位置特异性评分矩阵方法鉴定siRNA的靶外基因的方法。本发明还提供了设计具有较高沉默功效和特异性的siRNA的方法。本发明还提供了包含具有高沉默功效和特异性的siRNA的siRNA文库。

6. 发明申请

US20100166731A1 Methods and Compositions for Treating Cancer 审中-公开
标题翻译：治疗癌症的方法和组成
公开(公告)号：US20100166731A1
公开(公告)日：2010-07-01
申请号：US11992798
申请日：2006-09-29
申请人： Steven R. Bartz , Peter Linsley
发明人： Steven R. Bartz , Peter Linsley
IPC分类号： A61K39/395 , A61K33/24 , C12Q1/68 , C12Q1/48 , C12N5/02 , A61K38/00 , A61P35/04 , A61K31/7088
CPC分类号： C12Q1/485 , C12N15/1137 , C12N2310/11 , C12N2310/12 , C12N2310/14 , C12N2310/15
摘要： The present invention relates to methods and compositions for treating cancers by reducing the expression or activity of one or more of the genes encoding protein kinases ATR, MAST2, MAP3K6, TBK1, ADRBK2, CDKL2, LATS2, STK32B, STK11, DDR13 PSKH2, and NEK8, and/or the encoded kinases. The invention also relates to methods and compositions for determining the responsiveness of a cancer patient to anti-cancer drugs based on the status of one or more of such kinases. The invention further relates to methods and compositions for screening compounds that can be used to modulate the expression/activity of these kinases.
摘要翻译：本发明涉及通过降低编码蛋白激酶ATR，MAST2，MAP3K6，TBK1，ADRBK2，CDKL2，LATS2，STK32B，STK11，DDR13 PSKH2和NEK8的一种或多种基因的表达或活性来治疗癌症的方法和组合物，和/或编码的激酶。本发明还涉及用于基于一种或多种这样的激酶的状态确定癌症患者对抗癌药物的反应性的方法和组合物。本发明还涉及用于筛选可用于调节这些激酶的表达/活性的化合物的方法和组合物。

7. 发明授权

US08447526B2 Methods and computer systems for analyzing high-throughput assays 失效
标题翻译：用于分析高通量测定的方法和计算机系统
公开(公告)号：US08447526B2
公开(公告)日：2013-05-21
申请号：US11440195
申请日：2006-05-23
申请人： Lee Weng , Hongyue Dai , Steven R. Bartz
发明人： Lee Weng , Hongyue Dai , Steven R. Bartz
IPC分类号： G01N33/48 , G01N31/00 , G06G7/48 , G06G7/58
CPC分类号： G01N33/5008 , G01N33/5091 , G06F19/18 , G06F19/20 , G06F19/24
摘要： The present invention provides methods and computer programs for detecting variations in measurements of a biological variable, e.g., variations in cell viability, under different conditions, e.g., with or without treatment of a drug, under the treatments of different drugs, or under different environmental conditions. The methods and programs of the invention determine a metric of difference between measurements under different condition, and make use of predetermined errors of the measurements, e.g., errors determined from an error model, to estimate the errors in the metric of difference. Such an approach provides a more accurate estimate of the errors of measurements, which, in turn, provides a more accurate estimate of the error of the difference metric.
摘要翻译：本发明提供了用于检测生物变量的测量变化的方法和计算机程序，例如在不同条件下，例如，在不同药物的治疗下或在不同环境下，在不同的条件下，例如，有或没有治疗药物时，细胞活力的变化条件。本发明的方法和程序确定在不同条件下的测量之间的差异的度量，并且利用预定的测量误差，例如从误差模型确定的误差来估计差异度量中的误差。这种方法提供了对测量误差的更精确的估计，其反过来提供了差异度量的误差的更准确的估计。

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