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1. 发明授权

US08609830B2 Methods and compositions for RNA interference 有权
标题翻译： RNA干扰的方法和组成
公开(公告)号：US08609830B2
公开(公告)日：2013-12-17
申请号：US10557219
申请日：2004-05-17
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Janell M. Schelter , Peter S. Linsley
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Janell M. Schelter , Peter S. Linsley
IPC分类号： C07H21/00
CPC分类号： C12N15/1137 , C12N15/1138 , C12N2310/14 , C12N2320/10 , C12N2320/12
摘要： The invention provides methods and compositions for gene silencing by RNA interference. In particular, the invention provides methods for gene silencing or RNA knockdown using small interfering RNAs (siRNAs) having partial sequence homology to its target gene. The invention also provides methods for identifying common and/or differential responses to a plurality of different siRNAs targeting a gene. The invention also provides methods for evaluating the relative activity of the two strands of an siRNA. The invention further provides methods of designing siRNAs for gene silencing. The invention further provides methods of using siRNAs as therapeutics for treatment of diseases.
摘要翻译：本发明提供了通过RNA干扰进行基因沉默的方法和组合物。特别地，本发明提供了使用与其靶基因具有部分序列同源性的小干扰RNA（siRNA）进行基因沉默或RNA敲低的方法。本发明还提供了鉴定针对基因的多种不同siRNA的常见和/或差异应答的方法。本发明还提供了评估siRNA两条链的相对活性的方法。本发明还提供了设计用于基因沉默的siRNA的方法。本发明还提供了使用siRNA作为治疗疾病的治疗剂的方法。

2. 发明授权

US07962316B2 Method of designing siRNAs for gene silencing 有权
标题翻译：设计siRNA用于基因沉默的方法
公开(公告)号：US07962316B2
公开(公告)日：2011-06-14
申请号：US10577696
申请日：2004-10-27
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
IPC分类号： G06F17/10 , G06F7/60
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/31 , G06F19/18 , G06F19/22
摘要： The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
摘要翻译：本发明提供使用位置特异性评分矩阵法来鉴定转录物中的siRNA靶基序的方法。本发明还提供了一种使用位置特异性评分矩阵方法鉴定siRNA的靶外基因的方法。本发明还提供了设计具有较高沉默功效和特异性的siRNA的方法。本发明还提供了包含具有高沉默功效和特异性的siRNA的siRNA文库。

3. 发明申请

US20110250591A1 METHOD OF DESIGNING siRNAS FOR GENE SILENCING 有权
标题翻译：设计用于基因沉默的siRNA的方法
公开(公告)号：US20110250591A1
公开(公告)日：2011-10-13
申请号：US13100836
申请日：2011-05-04
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Wei Ge , Guy L. Cavet
IPC分类号： C12Q1/68
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/31 , G06F19/18 , G06F19/22
摘要： The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
摘要翻译：本发明提供使用位置特异性评分矩阵法来鉴定转录物中的siRNA靶基序的方法。本发明还提供了一种使用位置特异性评分矩阵方法鉴定siRNA的靶外基因的方法。本发明还提供了设计具有较高沉默功效和特异性的siRNA的方法。本发明还提供了包含具有高沉默功效和特异性的siRNA的siRNA文库。

4. 发明授权

US08457902B2 Method for selecting SIRNAs from a plurality of SIRNAs for gene silencing 有权
标题翻译：用于从多个SIRNA中选择用于基因沉默的SIRNA的方法
公开(公告)号：US08457902B2
公开(公告)日：2013-06-04
申请号：US13100836
申请日：2011-05-04
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
IPC分类号： G06F7/00
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/31 , G06F19/18 , G06F19/22
摘要： The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
摘要翻译：本发明提供使用位置特异性评分矩阵法来鉴定转录物中的siRNA靶基序的方法。本发明还提供了一种使用位置特异性评分矩阵方法鉴定siRNA的靶外基因的方法。本发明还提供了设计具有较高沉默功效和特异性的siRNA的方法。本发明还提供了包含具有高沉默功效和特异性的siRNA的siRNA文库。

5. 发明申请

US20080234941A1 Method of Designing Sirnas for Gene Silencing 有权
标题翻译：设计Sirnas进行基因沉默的方法
公开(公告)号：US20080234941A1
公开(公告)日：2008-09-25
申请号：US10577696
申请日：2004-10-27
申请人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
发明人： Aimee L. Jackson , Steven R. Bartz , Julja Burchard , Peter S. Linsley , Ge Wei , Guy L. Cavet
IPC分类号： G01N33/48
CPC分类号： C12N15/111 , C12N2310/14 , C12N2320/11 , C12N2330/31 , G06F19/18 , G06F19/22
摘要： The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
摘要翻译：本发明提供使用位置特异性评分矩阵法来鉴定转录物中的siRNA靶基序的方法。本发明还提供了一种使用位置特异性评分矩阵方法鉴定siRNA的靶外基因的方法。本发明还提供了设计具有较高沉默功效和特异性的siRNA的方法。本发明还提供了包含具有高沉默功效和特异性的siRNA的siRNA文库。

6. 发明申请

US20100227909A1 COMPOSITIONS COMPRISING MIR34 THERAPEUTIC AGENTS FOR TREATING CANCER 有权
标题翻译：包含MIR34治疗癌症治疗剂的组合物
公开(公告)号：US20100227909A1
公开(公告)日：2010-09-09
申请号：US12598590
申请日：2008-05-05
申请人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus
发明人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus
IPC分类号： A61K31/713 , C07H21/02 , A61P35/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2320/53 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： In one aspect, the invention generally relates to compositions comprising miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer.
摘要翻译：一方面，本发明一般涉及包含miR-34和在功能上和结构上与用于治疗癌症的miR-34相关的siRNA的组合物。

7. 发明授权

US08399248B2 Methods of using MIR34 as a biomarker for TP53 functional status 有权
标题翻译：使用MIR34作为TP53功能状态的生物标志物的方法
公开(公告)号：US08399248B2
公开(公告)日：2013-03-19
申请号：US12598563
申请日：2008-05-05
申请人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
发明人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
IPC分类号： C12N15/85 , C07H21/04 , C07H21/02
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2320/53 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： In one aspect, the invention generally relates to use of miR-34 as a biomarker to estimate TP53 function in a cell. In another aspect, the invention generally relates to multiple uses of miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer.
摘要翻译：一方面，本发明一般涉及miR-34作为生物标志物估计细胞中TP53功能的用途。在另一方面，本发明一般涉及miR-34和siRNA在功能上和结构上与miR-34相关的多种用途，用于治疗癌症。

8. 发明申请

US20110105583A1 METHODS OF USING MIR34 AS A BIOMARKER FOR TP53 FUNCTIONAL STATUS 有权
标题翻译：使用MIR34作为生物标记物用于TP53功能状态的方法
公开(公告)号：US20110105583A1
公开(公告)日：2011-05-05
申请号：US12598563
申请日：2008-05-05
申请人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
发明人： Michele A. Cleary , Aimee L. Jackson , Peter S. Linsley , Julja Burchard , Lee P. Lim , Jill F. Magnus , Lin He , Xingyue He , Scott W. Lowe , Gregory J. Hannon
IPC分类号： A61K31/7052 , C12Q1/68 , C40B30/04 , C12N5/00 , A61P35/00
CPC分类号： C12N15/113 , C12N15/111 , C12N2310/14 , C12N2310/141 , C12N2320/53 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/178
摘要： In one aspect, the invention generally relates to use of miR-34 as a biomarker to estimate TP53 function in a cell. In another aspect, the invention generally relates to multiple uses of miR-34 and siRNAs functionally and structurally related to miR-34 for the treatment of cancer.
摘要翻译：一方面，本发明一般涉及miR-34作为生物标志物估计细胞中TP53功能的用途。在另一方面，本发明一般涉及miR-34和siRNA在功能上和结构上与miR-34相关的多种用途，用于治疗癌症。

9. 发明申请

US20120072124A1 GENES ASSOCIATED WITH PROGRESSION AND RESPONSE IN CHRONIC MYELOID LEUKEMIA AND USES THEREOF 审中-公开
标题翻译：与慢性粒细胞白血病有关的进展与反应的基因及其用途
公开(公告)号：US20120072124A1
公开(公告)日：2012-03-22
申请号：US13207282
申请日：2011-08-10
申请人： Jerald P. Radich , Hongyue Dai , Mao Mao , Janell M. Schelter , Peter S. Linsley
发明人： Jerald P. Radich , Hongyue Dai , Mao Mao , Janell M. Schelter , Peter S. Linsley
IPC分类号： G06F19/20 , G01N33/50
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
摘要： The invention provides molecular markers that are associated with the progression of chronic myeloid leukemia (CML), and methods and computer systems for monitoring the progression of CML in a patient based on measurements of these molecular markers. The present invention also provides CML target genes, and methods and compositions for treating CML patients by modulating the expression or activity of these CML target genes and/or their encoded proteins. The invention also provides genes that are associated with resistance to imatinib mesylate (Gleevec™) treatment in CML patients, and methods and compositions for determining the responsiveness of a CML patient to imatinib mesylate treatment based on measurements of these genes and/or their encoded proteins. The invention also provides methods and compositions for enhancing the effect of Gleevec™ by modulating the expression or activity of these genes and/or their encoded proteins.
摘要翻译：本发明提供了与慢性骨髓性白血病（CML）进展相关的分子标记，以及用于基于这些分子标记物的测量来监测患者中CML进展的方法和计算机系统。本发明还提供CML靶基因，以及通过调节这些CML靶基因和/或其编码蛋白的表达或活性来治疗CML患者的方法和组合物。本发明还提供了与CML患者中对伊马替尼甲磺酸盐（Gleevec TM）治疗有关的基因，以及基于这些基因和/或其编码蛋白质的测量来确定CML患者对甲磺酸伊马替尼治疗的反应性的方法和组合物。本发明还提供了通过调节这些基因和/或其编码的蛋白质的表达或活性来增强Gleevec TM的作用的方法和组合物。

10. 发明授权

US08014957B2 Genes associated with progression and response in chronic myeloid leukemia and uses thereof 失效
标题翻译：与慢性骨髓性白血病中进展和反应相关的基因及其用途
公开(公告)号：US08014957B2
公开(公告)日：2011-09-06
申请号：US11640517
申请日：2006-12-14
申请人： Jerald P. Radich , Hongyue Dai , Mao Mao , Janell M. Schelter , Peter S. Linsley
发明人： Jerald P. Radich , Hongyue Dai , Mao Mao , Janell M. Schelter , Peter S. Linsley
IPC分类号： G01N33/48
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
摘要： The invention provides molecular markers that are associated with the progression of chronic myeloid leukemia (CML), and methods and computer systems for monitoring the progression of CML in a patient based on measurements of these molecular markers. The present invention also provides CML target genes, and methods and compositions for treating CML patients by modulating the expression or activity of these CML target genes and/or their encoded proteins. The invention also provides genes that are associated with resistance to imatinib mesylate (Gleevec™) treatment in CML patients, and methods and compositions for determining the responsiveness of a CML patient to imatinib mesylate treatment based on measurements of these genes and/or their encoded proteins. The invention also provides methods and compositions for enhancing the effect of Gleevec™ by modulating the expression or activity of these genes and/or their encoded proteins.
摘要翻译：本发明提供了与慢性骨髓性白血病（CML）进展相关的分子标记，以及用于基于这些分子标记物的测量来监测患者中CML进展的方法和计算机系统。本发明还提供CML靶基因，以及通过调节这些CML靶基因和/或其编码蛋白的表达或活性来治疗CML患者的方法和组合物。本发明还提供了与CML患者中对伊马替尼甲磺酸盐（Gleevec TM）治疗有关的基因，以及基于这些基因和/或其编码蛋白质的测量来确定CML患者对甲磺酸伊马替尼治疗的反应性的方法和组合物。本发明还提供了通过调节这些基因和/或其编码的蛋白质的表达或活性来增强Gleevec TM的作用的方法和组合物。

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