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1. 发明申请

US20100269838A1 MAGNETIC PARTICLES FOR DELIVERING THERAPEUTIC AGENT TO A TARGET LOCATION 有权
标题翻译：用于将治疗药物递送至目标位置的磁性颗粒
公开(公告)号：US20100269838A1
公开(公告)日：2010-10-28
申请号：US12765369
申请日：2010-04-22
申请人： Aiden Flanagan , Kent Harrison , Liliana Atanasoska , David Sogard , Liza Davis
发明人： Aiden Flanagan , Kent Harrison , Liliana Atanasoska , David Sogard , Liza Davis
IPC分类号： A61B19/00
CPC分类号： A61K9/0009 , A61K9/1676 , A61K9/501 , A61K9/5094 , A61K9/5115
摘要： A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.
摘要翻译：提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

2. 发明授权

US08550089B2 Magnetic particles for delivering therapeutic agent to a target location 有权
标题翻译：用于将治疗剂递送至目标位置的磁性颗粒
公开(公告)号：US08550089B2
公开(公告)日：2013-10-08
申请号：US12765369
申请日：2010-04-22
申请人： Aiden Flanagan , Kent Harrison , Liliana Atanasoska , David J. Sogard , Liza J. Davis
发明人： Aiden Flanagan , Kent Harrison , Liliana Atanasoska , David J. Sogard , Liza J. Davis
IPC分类号： A61B19/00
CPC分类号： A61K9/0009 , A61K9/1676 , A61K9/501 , A61K9/5094 , A61K9/5115
摘要： A system for delivering therapeutic agent to a target location in a body in accordance with one embodiment is provided comprising a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, and a magnetic device for attracting the magnetic particles to a target location. The magnetic particles may be delivered by a catheter into a blood vessel upstream from the target location so that they travel toward the target location. A method for delivering therapeutic agent to a target location in a body in accordance with another embodiment comprises providing a plurality of magnetic particles, each magnetic particle carrying a therapeutic agent, placing a magnetic device in a position to attract the magnetic particles to a target location, and allowing the magnetic particles to infuse the target location by the attraction of the magnetic particles to the magnetic device. The therapeutic agent may comprises a therapeutic agent for preventing or treating reperfusion injury, and the step of providing the plurality of magnetic particles may comprise delivering the plurality of magnetic particles through a blood vessel.
摘要翻译：提供了根据一个实施例的用于将治疗剂递送到身体中的目标位置的系统，其包括多个磁性颗粒，每个携带治疗剂的磁性颗粒和用于将磁性颗粒吸引到目标位置的磁性装置。磁性颗粒可以通过导管输送到目标位置上游的血管中，使得它们朝向目标位置行进。根据另一实施例的用于将治疗剂递送到身体中的目标位置的方法包括提供多个磁性颗粒，每个磁性颗粒携带治疗剂，将磁性装置放置在将磁性颗粒吸引到目标位置的位置，并且允许磁性颗粒通过磁性颗粒吸引到磁性装置来注入目标位置。治疗剂可以包括用于预防或治疗再灌注损伤的治疗剂，并且提供多个磁性颗粒的步骤可以包括通过血管递送多个磁性颗粒。

3. 发明授权

US08386031B2 Implantable self-powered biodegradable medical device to treat or prevent reperfusion injury 有权
标题翻译：可植入自供电的可生物降解医疗器械，用于治疗或预防再灌注损伤
公开(公告)号：US08386031B2
公开(公告)日：2013-02-26
申请号：US12826030
申请日：2010-06-29
申请人： Liliana Atanasoska , Aiden Flanagan , Liza J. Davis , Kent Harrison , David J. Sogard
发明人： Liliana Atanasoska , Aiden Flanagan , Liza J. Davis , Kent Harrison , David J. Sogard
IPC分类号： A61N1/30 , A61M31/00
CPC分类号： A61M5/14276
摘要： In one embodiment, the present disclosure provides a biodegradable, self-powered medical device for preventing or reducing reperfusion injury, comprising a galvanic cell, the galvanic cell comprising: a first biodegradable electrode member; and a second biodegradable electrode member comprising a biodegradable conductive polymer and an electrode-releasable therapeutic agent, wherein the galvanic cell generates an electric force sufficient to cause the electrode-releasable therapeutic agent to be released from the biodegradable conductive polymer and elute to a target location. The device may further include a reservoir material containing a burst-release therapeutic agent.
摘要翻译：在一个实施方案中，本公开提供了一种用于预防或减少再灌注损伤的可生物降解的自供电医疗装置，其包括原电池，所述原电池包括：第一可生物降解的电极构件; 以及包含可生物降解的导电聚合物和电极可释放治疗剂的第二可生物降解的电极构件，其中所述原电池产生足以使所述电极可释放的治疗剂从所述可生物降解的导电聚合物释放并洗脱到目标位置的电力。该装置还可以包括含有爆发释放治疗剂的贮存器材料。

4. 发明申请

US20100222873A1 Self-Buffering Medical Implants 有权
标题翻译：自我缓冲医疗植入物
公开(公告)号：US20100222873A1
公开(公告)日：2010-09-02
申请号：US12715577
申请日：2010-03-02
申请人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
发明人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Amey , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
IPC分类号： A61F2/82 , A61F2/00 , A61K31/337 , A61F2/02 , A61F2/28 , A61N1/00 , A61F2/01 , A61B17/86
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译：医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。生物腐蚀金属在生理条件下降解形成碱性降解产物。酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。

5. 发明授权

US08267992B2 Self-buffering medical implants 有权
标题翻译：自缓冲医疗植入物
公开(公告)号：US08267992B2
公开(公告)日：2012-09-18
申请号：US12715577
申请日：2010-03-02
申请人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Arney , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
发明人： Liliana Atanasoska , James Lee Shippy, III , Tom Holman , Michael S. Arney , Victor Schoenle , Frank Genovese , James Q. Feng , Aiden Flanagan , Jan Weber
IPC分类号： A61F2/06
CPC分类号： A61L31/148 , A61L27/34 , A61L27/446 , A61L27/54 , A61L27/58 , A61L31/10 , A61L31/128 , A61L31/16 , A61L2300/416 , A61L2300/604 , A61L2400/12 , A61L2420/04 , C08L67/04
摘要： A medical implant includes a bioerodible portion that includes a bioerodible polymer and a bioerodible metal. The bioerodible polymer matrix degrades under physiological conditions to form acidic degradation products. The bioerodible metal degrades under physiological conditions to form basic degradation products. The acidic degradation products and the basic degradation products buffer at least a portion of the medical implant. In one aspect, the bioerodible portion includes a bioerodible polymer matrix and a bioerodible metal within the bioerodible polymer matrix. In another aspect, the medical implant can include a body, a plurality of discrete deposits of the bioerodible polymer on the body, and a plurality of discrete deposits of the bioerodible metal on the body.
摘要翻译：医疗植入物包括生物腐蚀性部分，其包括生物可蚀解聚合物和生物腐蚀性金属。生物可蚀解聚合物基质在生理条件下降解形成酸性降解产物。生物腐蚀金属在生理条件下降解形成碱性降解产物。酸性降解产物和碱性降解产物缓冲至少一部分医用植入物。在一个方面，生物可蚀解部分包括生物可腐蚀聚合物基质和生物可腐蚀的聚合物基质内的生物可腐蚀金属。在另一方面，医疗植入物可以包括主体，身体上的生物可蚀解聚合物的多个离散沉积物，以及身体上的生物可腐蚀金属的多个离散沉积物。

6. 发明申请

US20100008970A1 Drug-Eluting Endoprosthesis 审中-公开
标题翻译：药物洗脱内假体
公开(公告)号：US20100008970A1
公开(公告)日：2010-01-14
申请号：US12334113
申请日：2008-12-12
申请人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
发明人： Barry O'Brien , Ben Arcand , James Lee Shippy, III , Liliana Atanasoska , Aiden Flanagan , John T. Clarke , Tim O'Connor , Yixin Xu , Dave McMorrow , Jan Weber , John Kremer , Michael Kuehling , Dominique Seidel
IPC分类号： A61K31/337 , A61F2/00 , B05D1/02
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/45 , A61L2300/61
摘要： A drug-eluting endoprosthesis that includes a bioerodible metal portion and a therapeutic agent. In some aspects, the endoprosthesis includes a plurality of discrete deposits and a plurality of overlying layers each overlying one of the plurality of discrete deposits. Each discrete deposit includes one or more therapeutic agents and each overlying layer includes one or more bioerodible metals. In other aspects, the bioerodible metal portion includes at least two bioerodible metal regions having different electronegativities. The at least two bioerodible metal regions being in electrical contact with each other. The bioerodible metal erodes in a physiological environment to release the therapeutic agent.
摘要翻译：包括生物腐蚀性金属部分和治疗剂的药物洗脱内用假体。在一些方面，内假体包括多个离散沉积物和多个覆盖层，每个覆盖层覆盖多个离散沉积物之一。每个离散沉积物包括一种或多种治疗剂，并且每个上覆层包括一种或多种生物可腐蚀金属。在其他方面，生物腐蚀性金属部分包括具有不同电负性的至少两个生物可腐蚀金属区域。所述至少两个生物浸渍金属区域彼此电接触。生物腐蚀性金属在生理环境中侵蚀以释放治疗剂。

7. 发明授权

US08182859B2 Using magnetism to prepare a medical device 失效
标题翻译：用磁性制备医疗器械
公开(公告)号：US08182859B2
公开(公告)日：2012-05-22
申请号：US12057135
申请日：2008-03-27
申请人： Liliana Atanasoska , Aiden Flanagan , Timothy O'Connor , David McMorrow , Robert Nolan , Anthony Malone , Jan Weber
发明人： Liliana Atanasoska , Aiden Flanagan , Timothy O'Connor , David McMorrow , Robert Nolan , Anthony Malone , Jan Weber
IPC分类号： A61L33/00
CPC分类号： B05B5/00 , A61F2/91 , A61F2210/009 , A61L31/14 , A61L31/146 , A61L31/16 , A61L2300/60 , A61L2300/62 , B05C3/09 , B05D1/18 , B05D1/32 , B05D3/207 , B05D2401/32
摘要： The present invention is directed to methods, processes, and systems for delivering therapeutic agent to a medical device. Under some methods, processes, and systems of the invention, particles including a magnetic material and a therapeutic agent may be directed towards a medical device via magnetic attraction. In another embodiment particles including a magnetic material may force a therapeutic agent/solvent solution into porous matrix by using a magnetic attraction. In still another embodiment, a medical device having at least a portion thereof including a magnetic material is used to attract and adhere particles comprising magnetic material and therapeutic agent to a target surface of the medical device, wherein the particles are fused to the target surface.
摘要翻译：本发明涉及将治疗剂递送到医疗装置的方法，过程和系统。在一些方法下，本发明的方法和系统，包括磁性材料和治疗剂的颗粒可以通过磁吸引而引向医疗装置。在另一个实施方案中，包括磁性材料的颗粒可以通过使用磁吸引剂将治疗剂/溶剂溶液强制成多孔基质。在另一个实施例中，使用包括磁性材料的至少其一部分的医疗装置将包含磁性材料和治疗剂的颗粒吸附并附着到医疗装置的靶表面上，其中所述颗粒与目标表面融合。

8. 发明授权

US09533078B2 Medical devices containing therapeutic agents 有权
标题翻译：含有治疗剂的医疗器械
公开(公告)号：US09533078B2
公开(公告)日：2017-01-03
申请号：US13000594
申请日：2009-06-19
申请人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
发明人： John Clarke , Tim O'Connor , Barry J. O'Brien , David McMorrow , Jan Weber , Aiden Flanagan
IPC分类号： A61F2/06 , A61L31/16 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/14 , A61F2/82
CPC分类号： A61L31/16 , A61F2/82 , A61F2250/0014 , A61F2250/0025 , A61F2250/0026 , A61F2250/0037 , A61F2250/0067 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/082 , A61L31/146 , A61L2300/416 , A61L2300/63
摘要： The present invention pertains to implantable or insertable medical devices which comprise a substrate and one or more therapeutic-agent-containing regions contain one or more therapeutic agents. In various aspects of the invention, one or more characteristics of such therapeutic-agent-containing regions are controlled. Further aspects of the invention relate to methods of forming such devices and to methods of using such devices.
摘要翻译：本发明涉及可植入或可插入的医疗装置，其包括基质和含有一种或多种治疗剂的一种或多种含治疗剂的区域。在本发明的各个方面，控制这种含治疗剂的区域的一个或多个特征。本发明的其它方面涉及形成这种装置的方法以及使用这种装置的方法。

9. 发明授权

US08920491B2 Medical devices having a coating of inorganic material 有权
标题翻译：具有无机材料涂层的医疗器械
公开(公告)号：US08920491B2
公开(公告)日：2014-12-30
申请号：US12425791
申请日：2009-04-17
申请人： Aiden Flanagan , John Kilcooley , Tim O'Connor , Barry O'Brien , Dominique Seidel , Michael Kuehling , Torsten Scheuermann , Jan Weber
发明人： Aiden Flanagan , John Kilcooley , Tim O'Connor , Barry O'Brien , Dominique Seidel , Michael Kuehling , Torsten Scheuermann , Jan Weber
IPC分类号： A61F2/06 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/16
CPC分类号： A61L29/10 , A61L29/16 , A61L31/082 , A61L31/16 , A61L2300/602 , A61L2300/61
摘要： In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.
摘要翻译：在一个方面，医疗装置具有第一构造和第二构造，包含治疗剂的贮存器和设置在贮存器上方的阻挡层，其中阻挡层包括无机材料。在另一方面，医疗装置具有容纳治疗剂的储存器，设置在贮存器上方的阻挡层，其中所述阻挡层包括无机材料，以及设置在所述阻挡层和所述医疗装置的表面之间的可溶胀材料，其中可膨胀材料是暴露于含水环境时膨胀的材料。在另一方面，医疗装置具有多层涂层，其具有交替的储层和阻挡层，以及穿透多层涂层的至少部分厚度的多个挖掘区域。在另一方面，医疗装置具有包含嵌段共聚物的聚合物层，其中聚合物层含有治疗剂，以及设置在聚合物层上的阻挡层，其中阻挡层包含无机材料，其中，阻挡层具有多个不连续性。还公开了在医疗装置上形成涂层的方法和将治疗剂递送到身体部位的方法。

10. 发明授权

US08361139B2 Medical devices having metal coatings for controlled drug release 有权
标题翻译：具有用于受控药物释放的金属涂层的医疗装置
公开(公告)号：US08361139B2
公开(公告)日：2013-01-29
申请号：US12498829
申请日：2009-07-07
申请人： Aiden Flanagan , Barry O'Brien , Torsten Scheuermann
发明人： Aiden Flanagan , Barry O'Brien , Torsten Scheuermann
IPC分类号： A61F2/06 , A61F2/00
CPC分类号： A61L31/088 , A61L31/16 , A61L2300/604 , A61L2300/624
摘要： Medical devices having a plurality of nanoparticles disposed over a surface of the medical device. The nanoparticles have a core comprising a therapeutic agent and a shell surrounding the core, wherein the shell comprises a metal. A barrier layer is disposed over the nanoparticles. The barrier layer is water-permeable and comprises a metal that may be different from the metal used in the nanoparticle shells. In certain embodiments, the metal in the barrier layer undergoes galvanic corrosion. Also disclosed are medical device having a reservoir containing a therapeutic agent, with nanoparticles and a barrier layer being disposed over the reservoir; and medical devices having multiple barrier layers and multiple reservoirs containing therapeutic agents.
摘要翻译：具有设置在医疗装置的表面上的多个纳米颗粒的医疗装置。纳米颗粒具有包含治疗剂的核心和围绕核心的壳体，其中壳体包含金属。阻挡层设置在纳米粒子上。阻挡层是透水性的并且包含可以与纳米颗粒壳中使用的金属不同的金属。在某些实施例中，阻挡层中的金属经历电偶腐蚀。还公开了具有包含治疗剂的储存器的医疗装置，其中纳米颗粒和阻挡层设置在储存器上方; 以及具有多个阻隔层的医疗装置和含有治疗剂的多个储存器。

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