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1. 发明授权

US3944579A 2-Amino-5-phenyl-4H-3,5-dihydro-1,5-benzodiazepin-4-ones and salts thereof 失效
标题翻译： 2-氨基-5-苯基-4H-3,5-二氢-1,5-苯并二氮杂-4-酮及其盐
公开(公告)号：US3944579A
公开(公告)日：1976-03-16
申请号：US487221
申请日：1974-07-10
申请人： Adolf Bauer , Karl Heinz Weber , Klaus Minck , Peter Danneberg
发明人： Adolf Bauer , Karl Heinz Weber , Klaus Minck , Peter Danneberg
IPC分类号： C07D243/12
CPC分类号： C07D243/12
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 and R.sub.2 are each hydrogen or methyl, andR.sub.3 is chlorine, bromine or nitro, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as tranquilizers.
摘要翻译：式WHEREIN R1和R2各自为氢或甲基，R3为氯，溴或硝基的化合物及其无毒的药学上可接受的酸加成盐; 化合物及其盐可用作镇定剂。

2. 发明授权

US4199588A 6-Phenyl-4H-s-triazolo-[3,4c]-thieno-[2,3e]-1,4-diazepines and salts thereof 失效
标题翻译： 6-苯基-4H-3-三唑并 - [3,4c] - 噻吩并[2,3e] -1,4-二氮杂及其盐
公开(公告)号：US4199588A
公开(公告)日：1980-04-22
申请号：US855753
申请日：1977-11-30
申请人： Karl-Heinz Weber , Adolf Bauer , Peter Danneberg , Franz J. Kuhn
发明人： Karl-Heinz Weber , Adolf Bauer , Peter Danneberg , Franz J. Kuhn
IPC分类号： A61K31/55 , A61K31/551 , A61P25/00 , C07D333/36 , C07D495/04 , C07D495/14
CPC分类号： C07D495/04 , C07D333/36 , C07D495/14 , Y10S514/906
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, chlorine, bromine or alkyl of 1 to 4 carbon atoms;R.sub.2 is hydrogen, fluorine, chlorine, bromine, nitro or trifluoromethyl; andR.sub.3 is chlorine, bromine, alkoxy of 1 to 3 carbon atoms, alkylmercapto of 1 to 3 carbon atoms, cycloalkyl of 3 to 6 carbon atoms, cycloalkenyl of 3 to 6 carbon atoms, or a saturated or unsaturated 5- to 6-membered heterocycle comprising an oxygen, sulfur or nitrogen heteroatom, where a substitutable nitrogen heteroatom may optionally have a lower akyl substituent attached thereto;and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as tranquilizers, muscle-relaxants and anticonvulsants.

3. 发明授权

US4094984A 6-Phenyl-8-bromo-4H-s-triazolo-[3,4C]-thieno-[2,3E]-1,4-diazepines and salts thereof 失效
标题翻译： 6-苯基-8-溴-4H-S-三唑并 - （3,4C） - 噻吩并（2,3E）-1,4-二氮杂萘及其盐
公开(公告)号：US4094984A
公开(公告)日：1978-06-13
申请号：US839792
申请日：1977-10-06
申请人： Karl-Heinz Weber , Adolf Bauer , Peter Danneberg , Franz Josef Kuhn
发明人： Karl-Heinz Weber , Adolf Bauer , Peter Danneberg , Franz Josef Kuhn
IPC分类号： A61K31/55 , A61K31/551 , A61P25/00 , C07D333/36 , C07D495/04 , C07D495/14
CPC分类号： C07D495/04 , C07D333/36 , C07D495/14 , Y10S514/906
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, fluorine, chlorine, bromine, nitro or trifluoromethyl; andR.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms or hydroxyalkyl of 1 to 4 carbon atoms; and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as tranquilizers, muscle-relaxants and anticonvulsants.
摘要翻译：其中R 1是氢，氯，溴或1至4个碳原子的烷基; R2是氢，氟，氯，溴，硝基或三氟甲基; R3为氯，溴，1〜3个碳原子的烷氧基，1〜3个碳原子的烷基巯基，3〜6个碳原子的环烷基，3〜6个碳原子的环烯基，或饱和或不饱和的5〜6元包含氧，硫或氮杂原子的杂环，其中可取代的氮杂原子可以任选地具有与其连接的低级烷基取代基; 和无毒的，药学上可接受的酸加成盐; 化合物及其盐可用作镇定剂，肌肉松弛剂和抗惊厥药。

4. 再颁专利

USRE28972E 5-Aryl-1H-1,5-benzodiazepine-2,4-diones 失效
标题翻译： 5-芳基-1H-1,5-苯并二氮杂卓-2,4-二酮
公开(公告)号：USRE28972E
公开(公告)日：1976-09-21
申请号：US637585
申请日：1975-12-04
申请人： Karl-Heinz Weber , Herbert Merz , Karl Zeile , Rolf Giesemann , Peter Danneberg
发明人： Karl-Heinz Weber , Herbert Merz , Karl Zeile , Rolf Giesemann , Peter Danneberg
IPC分类号： C07D243/12
CPC分类号： C07D243/12
摘要： 5-Aryl-1H-1,5-benzodiazepine-2,4-diones of a formula selected from the group consisting of ##SPC1##Wherein ##SPC2##-- A -- Xwherein R.sub.1 is allyl, methylallyl, dimethylallyl, chloroallyl, cyclohexyl, cycloalkylmethyl, cycloalkenylmethyl of 4 to 7 carbon atoms, phenyl, tolyl, xylyl, methoxyphenyl, dimethoxyphenyl, halophenyl, phenylalkyl of 7 to 8 carbon atoms, pyridyl or--A --Xwhere A is straight or branched alkylene of 1 to 4 carbon atoms, andX is hydroxyl, alkoxy, acyloxy, dialkylamino of 2 to 4 carbon atoms, or a 5- to 6-membered nitrogen-containing heterocyclic ring linked to A through a ring nitrogen atom,R.sub.2 is hydrogen or methyl,R.sub.3 is naphthyl, pyrimidyl, thienyl, pyridyl, methylpyridyl or halopyridyl,R.sub.4 is hydrogen, methyl, methoxy, trifluoromethyl, cyano, halogen, lower alkanoyl or (lower alkoxy of 1 to 2 carbon atoms)-carbonyl, R.sub.5 is hydrogen, methyl, ethyl, methoxy, trifluoromethyl, cyano, nitro, halogen, lower alkanoyl or lower alkoxy-carbonyl,R.sub.6 is hydrogen, methyl, ethyl, methoxy or halogen,R.sub.7 is cyano.[.,.]. .Iadd.or .Iaddend.lower alkanoyl .[.or lower alkoxycarbonyl.].,R.sub.8 is cyano, nitro, lower alkanoyl or lower alkoxycarbonyl,R.sub.9 is hydrogen, methyl, ethyl, methoxy or halogen, andR.sub.10 is hydrogen, methyl, methoxy, trifluoromethyl or halogen,Useful as psychosedatives and anticonvulsives in warm-blooded animals.

5. 再颁专利

USRE28935E 5-Phenyl-7-chloro-1H-1,5-benzodiazepine-2,4-(3H,5H)-diones 失效
标题翻译： 5-苯基-7-氯-1H-1,5-苯并二氮杂-2,4-（3H，5H） - 二酮
公开(公告)号：USRE28935E
公开(公告)日：1976-08-17
申请号：US587591
申请日：1975-06-17
申请人： Karl-Heinz Weber , Karl Zeile , Peter Danneberg , Karl Heinz Hauptmann, deceased , by Maria Hauptmann, heiress
发明人： Karl-Heinz Weber , Karl Zeile , Peter Danneberg , Karl Heinz Hauptmann, deceased , by Maria Hauptmann, heiress
IPC分类号： A61K31/00 , C07D20060101 , C07D243/12
CPC分类号： C07D243/12 , A61K31/00
摘要： Compounds of the formula ##SPC1##WhereinR.sub.1 is hydroxy-alkyl of 2 to 4 carbon atoms; haloalkyl of 2 to 4 carbon atoms; di(alkyl of 2 to 4 carbon atoms)amino-alkyl of 2 to 4 carbon atoms; .gamma.-piperidino-propyl; alkoxy of 1 to 2 carbon atoms - alkyl of 1 to 4 carbon atoms; (alkoxy of 1 to 2 carbon atoms)carbonyl-alkyl of 1 to 4 carbon atoms; (alkyl of 1 to 2 carbon atoms)mercaptoalkyl of 1 to 4 carbon atoms; .[.straight or branched alkenyl of 3 to 5 carbon atoms;.]. (alkoxy of 1 to 2 carbon atoms)carbonyl-alkenyl of 2 to 4 carbon atoms; or halo-alkenyl of 2 to 4 carbon atoms;The compounds are useful as psychosedatives and anticonvulsives.

6. 发明授权

US4263310A 8-Bromo-6-(o-chloro- phenyl)-4H-S-triazolo-[3,4,-c]-thieno-[2,3-e]-1,4-diazepines and salts thereof 失效
标题翻译： 8-溴-6-（邻氯 - 苯基）-4H-S-三唑并 - [3,4，-c] - 噻吩并[2,3-e] -1,4-二氮杂及其盐
公开(公告)号：US4263310A
公开(公告)日：1981-04-21
申请号：US82114
申请日：1979-10-05
申请人： Karl H. Weber , Adolf Bauer , Peter Danneberg , Franz J. Kuhn
发明人： Karl H. Weber , Adolf Bauer , Peter Danneberg , Franz J. Kuhn
IPC分类号： C07D333/36 , C07D495/04 , C07D495/14 , A61K31/55 , C07D495/12
CPC分类号： C07D495/04 , C07D333/36 , C07D495/14
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is chlorine, bromine, cyclopropyl or cyclohexyl and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as tranquilizers, muscle-relaxants and anticonvulsants.
摘要翻译：其中R 1是氯，溴，环丙基或环己基和无毒的药学上可接受的酸加成盐的式IMA化合物; 化合物及其盐可用作镇定剂，肌肉松弛剂和抗惊厥药。

7. 发明授权

US4536402A Vinylogous carboxamides 失效
标题翻译： Vinylogous甲酰胺
公开(公告)号：US4536402A
公开(公告)日：1985-08-20
申请号：US676067
申请日：1984-11-29
申请人： Wolfhard Engel , Eckhart Bauer , Gunter Trummlitz , Peter Danneberg , Joachim Kahling
发明人： Wolfhard Engel , Eckhart Bauer , Gunter Trummlitz , Peter Danneberg , Joachim Kahling
IPC分类号： A61K31/38 , A61K31/381 , A61P25/00 , A61P25/08 , C07D333/64 , C07D409/06 , A61K31/44 , C07D333/52
CPC分类号： C07D409/06 , C07D333/64
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is phenyl, halo- and/or methyl-substituted phenyl or pyridinyl;R.sub.2 is hydrogen, straight or branched alkyl of 1 to 4 carbon atoms, 2- or 3-hydroxy-(alkyl of 2 to 3 carbon atoms) or 2- or 3-dimethylamino-(alkyl of 2 to 3 carbon atoms);R.sub.3 is hydrogen or alkyl of 1 to 3 carbon atoms; andR.sub.4 is hydrogen, chlorine or methyl.The compounds are useful as anticonvulsants.
摘要翻译：其中R 1是苯基，卤代和/或甲基取代的苯基或吡啶基; R2是氢，1至4个碳原子的直链或支链烷基，2-或3-羟基 - （2-3个碳原子的烷基）或2-或3-二甲基氨基 - （2-3个碳原子的烷基）; R3是氢或1至3个碳原子的烷基; R4为氢，氯或甲基。该化合物可用作抗惊厥药。

8. 发明授权

US4100282A N-Aryl-N'-(phenyl- or phenoxy-alkyl)-piperazines and salts thereof 失效
标题翻译： N-芳基-N {40-（苯基 - 或苯氧基 - 烷基） - 哌嗪及其盐
公开(公告)号：US4100282A
公开(公告)日：1978-07-11
申请号：US793736
申请日：1977-05-04
申请人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
发明人： Ernst-Otto Renth , Anton Mentrup , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D207/26 , C07D207/27 , C07D279/02
CPC分类号： C07D207/27 , A61K31/495
摘要： Compounds of the formula ##STR1## wherein R is phenyl; phenyl having one or two substituents attached thereto, said substituents being selected from the group consisting of alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, alkylthio of 1 to 4 carbon atoms, chlorine and trifluoromethyl; naphthyl; tetrahydronaphthyl; indanyl; pyridyl; isoquinolyl; or thiazolyl;R.sub.1 is ##STR2## where R.sub.3 is hydrogen, alkyl of 1 to 4 carbon atoms,R.sub.4 and R.sub.5 are each hydrogen or alkyl of 1 to 4 carbon atoms, andQ is oxygen or two hydrogens,R.sub.2 is hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halogen,A is a single carbon-to-carbon bond or --OCH.sub.2 --,R.sub.6 is hydrogen, hydroxyl, alkoxy of 1 to 4 carbon atoms or alkanoyloxy of 1 to 4 carbon atoms, andm is 0, 1, 2, 3, 4 or 5, but other than 0 when R.sub.6 is hydroxyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, adrenolytics, antiphlogistics, analgesics, antihistaminics and anticholesteremics.
摘要翻译：其中R是苯基的式“IMAGE”的化合物; 所述取代基选自1至4个碳原子的烷基，1至4个碳原子的烷氧基，1至4个碳原子的烷硫基，氯和三氟甲基; 萘基; 四氢萘基; 茚满基吡啶基异喹啉基或噻唑基; R1是，其中R3是氢，1-4个碳原子的烷基，R4和R5分别是氢或1-4个碳原子的烷基，Q是氧或两个氢，R2是氢，1-4个碳原子数为1〜4的烷氧基或卤素，A为单碳 - 碳键或-OCH2-，R6为氢，羟基，1〜4个碳原子的烷氧基或1〜4个碳原子的烷酰氧基，并且M IS为0,1,2,3,4或5，但当R6为羟基时为0以及非毒性，药理学上可接受的酸添加量; 化合物作为它们的有效作为CNS抑制剂，肾上腺素，消炎药，镇痛药，抗组胺药和抗胆碱血症有用。

9. 发明授权

US3992537A Pharmaceutical compositions containing an N-phenyl-imidazolidine-2-one and method of use 失效
标题翻译：含有N-苯基 - 咪唑烷-2-酮的药物组合物及其使用方法
公开(公告)号：US3992537A
公开(公告)日：1976-11-16
申请号：US636738
申请日：1975-12-01
申请人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
发明人： Anton Mentrup , Ernst-Otto Renth , Kurt Schromm , Peter Danneberg
IPC分类号： A61K31/495 , C07D401/14 , C07D403/10
CPC分类号： C07D401/14 , A61K31/495 , C07D403/10
摘要： Pharmaceutical compositions containing as an active ingredient a compound of the formula ##SPC1##Wherein R' is in the m- or p-position and is selected from the group consisting of--CH.sub.2 --A, --CHR.sub.1 --CH.sub.2 --Aand ##EQU1## where R.sub.1 is hydrogen or hydroxyl, andA is ##SPC2##WhereR.sub.3 is hydrogen, chlorine, methyl, ethyl, trifluoromethyl or lower alkoxy, andR.sub.4 is hydrogen or methyl, orR.sub.3 and R.sub.4, together with each other and neighboring carbon atoms of the phenyl ring to which they are attached, are naphthyl,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as CNS-depressants, neuroleptics and anticholesteremics.
摘要翻译：含有式+ q，10的化合物作为活性成分的药物组合物在m-或p-位，并且选自-CH2-A，-CHR1-CH2-A和-CHR1 -CH-A，| CH3，其中R1是氢或羟基，A是+ q，12，其中R3是氢，氯，甲基，乙基，三氟甲基或低级烷氧基，R4是氢或甲基，或R3和R4一起与它们所连接的苯环的彼此和相邻的碳原子是萘基，或非毒性，药理学上可接受的酸加成盐; 和使用它们作为CNS抑制剂，精神安定药和抗胆固醇药的方法。

10. 发明授权

US4087531A N-(3-(p-Fluoro -benzoyl)-n-propyl)-4-(imidazolidin-2-one-1-yl)-piperidines and salts thereof 失效
标题翻译： N-（3-（对氟 - 苯甲酰基） - 正丙基）-4-（咪唑烷-2-酮-1-基） - 哌啶及其盐
公开(公告)号：US4087531A
公开(公告)日：1978-05-02
申请号：US730123
申请日：1976-10-06
申请人： Adolf Langbein , Gerhard Walther , Peter Danneberg , Franz Josef Kuhn
发明人： Adolf Langbein , Gerhard Walther , Peter Danneberg , Franz Josef Kuhn
IPC分类号： C07D211/58 , C07D401/04 , A61K31/445
CPC分类号： C07D211/58
摘要： Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, acetyl, alkyl of 1 to 3 carbon atoms or phenyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, sedatives and tranquilizers.
摘要翻译：其中R1是氢，乙酰基，1至3个碳原子的烷基或苯基的式“IMAGE”化合物及其无毒的药学上可接受的酸加成盐; 化合物及其盐可用作CNS抑制剂，镇静剂和镇定剂。

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