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1. 发明授权

US06645479B1 Targeted delivery of active/bioactive and perfuming compositions 失效
标题翻译：活性/生物活性和加香组合物的靶向递送
公开(公告)号：US06645479B1
公开(公告)日：2003-11-11
申请号：US09573534
申请日：2000-05-19
申请人： Adi Shefer , Shmuel David Shefer
发明人： Adi Shefer , Shmuel David Shefer
IPC分类号： A61K706
CPC分类号： A61Q13/00 , A61K8/11 , A61K2800/412 , G01N30/00
摘要： Described are controlled, time-release microparticulate active and bioactive compositions (including perfuming compositions) for targeted delivery to surfaces such as skin, hair and fabric and the environment proximate thereto, where the active and bioactive materials have a calculated log10P values of between 1 and 8 (P being the n-octanol-water partition coefficient). Such compositions include the active or bioactive material in single phase, solid solution in a wax or polymer matrix also having coated thereon and/or containing a compatible surfactant. Also described are processes and apparatus for preparing such compositions and processes for using same. Furthermore, certain component(s) of the aforementioned compositions in combination with one another are novel, and other components have novel uses in increasing fragrance substantivity, particularly in hair care preparations such as hair gels and shampoos.
摘要翻译：描述了用于靶向递送至表面如皮肤，毛发和织物以及接近其的环境的受控的时间释放微粒活性和生物活性组合物（包括加香组合物），其中活性和生物活性材料具有计算的log 10P值在1和 8（P为正辛醇 - 水分配系数）。这样的组合物包括在单相中的活性或生物活性物质，也在其上涂覆有和/或含有相容表面活性剂的蜡或聚合物基质中的固体溶液。还描述了制备这种组合物的方法和装置以及使用它们的方法。此外，上述组合物的某些组分彼此组合是新颖的，并且其它组分在增加香味的亲和性方面具有新颖的用途，特别是在头发护理制剂如发胶和洗发剂中。

2. 发明授权

US07115282B2 Multi component controlled release system for anhydrous cosmetic compositions 失效
标题翻译：用于无水化妆品组合物的多组分控释系统
公开(公告)号：US07115282B2
公开(公告)日：2006-10-03
申请号：US10124207
申请日：2002-04-17
申请人： Adi Shefer , Shmuel David Shefer
发明人： Adi Shefer , Shmuel David Shefer
IPC分类号： A61K9/16 , A61K9/14 , A61K6/00
CPC分类号： B82Y5/00 , A61K8/0287 , A61K2800/31 , A61K2800/413 , A61K2800/56 , A61Q13/00 , A61Q15/00 , A61Q19/00 , A61Q19/001
摘要： The present invention relates to an improved controlled release system that can be incorporated into anhydrous cosmetic formulations and can encapsulate different types of fragrances, flavors, active ingredients, or combinations of fragrances, flavors, and various active ingredients. The controlled delivery system of the present invention is substantially free-flowing powder formed of solid hydrophobic nano-spheres that are encapsulated in a moisture sensitive micro-spheres. The fragrances, flavors, and active ingredients encapsulated in the nano-spheres can be the same or different from those encapsulated in the micro-sphere. The encapsulation of one or more fragrances, flavors or active agents in the various components of the system, such as nano-spheres and micro-spheres, provides odor or flavor transition (change in odor character or change in flavor character) during the use of the product, in response to moisture, such as wetting the lips, perspiration, and the like. The incorporation of the controlled release system of the present invention into anhydrous cosmetic formulations was found to provide moisture triggered release, as well as prolonged release of the fragrances, flavors, and active ingredients that are encapsulated in the solid hydrophobic nano-spheres over an extended period of time.
摘要翻译：本发明涉及可以并入无水化妆品制剂中并可以包封不同类型的香料，香料，活性成分或香料，香料和各种活性成分的组合的改进的控释系统。本发明的受控递送系统是固体疏水性纳米球形成的基本自由流动的粉末，其被包封在湿气敏感的微球体中。包封在纳米球体中的香料，香料和活性成分可以与包封在微球体中的那些相同或不同。将一种或多种香料，香料或活性剂包封在系统的各种组分如纳米球体和微球体中，在使用期间提供气味或风味转变（气味特征的变化或风味特征的变化）该产品响应于湿气，例如润湿嘴唇，出汗等。发现将本发明的控制释放系统并入无水化妆品制剂中提供了水分触发释放，以及将包封在固体疏水性纳米球体中的香料，香料和活性成分的延长释放延长一段的时间。

3. 发明授权

US06491902B2 Controlled delivery system for hair care products 有权
标题翻译：护发产品的控制送货系统
公开(公告)号：US06491902B2
公开(公告)日：2002-12-10
申请号：US09771752
申请日：2001-01-29
申请人： Adi Shefer , Shmuel David Shefer
发明人： Adi Shefer , Shmuel David Shefer
IPC分类号： A61K706
CPC分类号： B82Y5/00 , A61K8/0283 , A61K8/11 , A61K8/34 , A61K8/416 , A61K8/671 , A61K8/8111 , A61K8/84 , A61K2800/244 , A61K2800/413 , A61Q5/02 , A61Q5/06 , A61Q5/12 , A61Q13/00 , C11D1/62 , C11D3/001 , C11D3/3719 , C11D3/3723 , C11D17/0039
摘要： The present invention is a controlled delivery system that can be incorporated in hair care products such as shampoos, conditioners, hair styling products, and other hair care products to effectively deliver a broad range of active agents and sensory markers, such as fragrances or cooling agents onto the hair. The system also prolongs the release rate of the active agents or sensory markers over an extended period of time, or provides heat triggered release of the active agents and yields a high impact fragrance “burst” upon blow drying the hair or other types of heat treatment. The controlled delivery system of the present invention is a nano-particle, having an average particle diameter of from about 0.01 microns to about 10 microns. The nano-particle comprises hydrophobic polymers and co-polymers, cationic charge boosters in conjunction with cationic surface-active conditioning agents that assist in adhering the particles onto hair. The invention further relates to a controlled delivery system where the release rate of the active ingredients is synchronized with that of a sensory marker to convey to the consumer the product performance.
摘要翻译：本发明是可以并入头发护理产品如洗发剂，护发素，头发定型产品和其它护发产品中的受控递送系统，以有效地递送广泛范围的活性剂和感官标记物，例如香料或冷却剂到头发上该系统还可延长活性剂或感官标记物在延长的时间内的释放速率，或提供活性剂的热触发释放，并在吹干头发或其它类型的热处理时产生高冲击性香味“爆裂” 。本发明的受控递送系统是平均粒径为约0.01微米至约10微米的纳米颗粒。纳米颗粒包括疏水性聚合物和共聚物，阳离子电荷增效剂与阳离子表面活性调节剂有助于将颗粒粘附到毛发上。本发明还涉及一种受控递送系统，其中活性成分的释放速率与感官标记物的释放速率同步，以向消费者传达产品性能。

4. 发明授权

US6051540A Method employing drum chilling and apparatus therefor for producing fragrance-containing long lasting solid particle 有权
标题翻译：使用鼓式冷藏的方法及其装置，用于生产含香料的持久固体颗粒
公开(公告)号：US6051540A
公开(公告)日：2000-04-18
申请号：US186487
申请日：1998-11-05
申请人： Adi Shefer , Shmuel David Shefer , Maureen S. Santoro
发明人： Adi Shefer , Shmuel David Shefer , Maureen S. Santoro
IPC分类号： C11D1/66 , C11D3/50 , C11D11/00 , C11D17/04
CPC分类号： C11D17/047 , C11D1/667 , C11D11/0082 , C11D3/505
摘要： A method and apparatus is disclosed for producing a fragrance-containing solid particle, capable of controllably releasing the fragrance to the environment in which the particle is contained for incorporation into laundry detergents, fabric softener compositions and drier-added fabric softener articles.
摘要翻译：公开了用于生产含香料的固体颗粒的方法和装置，其能够可控地将香料释放到其中包含颗粒的环境中以便结合到衣物洗涤剂中，织物柔软剂组合物和加入干燥剂的织物柔软剂制品中。

5. 发明授权

US6042792A Apparatus for preparing a solid phase microparticulate composition 失效
标题翻译：用于制备固相微粒组合物的装置
公开(公告)号：US6042792A
公开(公告)日：2000-03-28
申请号：US933599
申请日：1997-09-18
申请人： Adi Shefer , Keith J. McDermott , Shmuel David Shefer , Chee-Teck Tan
发明人： Adi Shefer , Keith J. McDermott , Shmuel David Shefer , Chee-Teck Tan
IPC分类号： A61K8/11 , A61Q13/00 , B01F3/08 , G01N30/00 , B01F7/16
CPC分类号： A61Q13/00 , A61K8/11 , G01N30/00
摘要： Described are controlled, time-release microparticulate active and bioactive compositions (including perfuming compositions) for targeted delivery to services such as skin, hair and fabric and the environment proximate thereto, where the active and bioactive materials have a calculated log.sub.10 P values of between 1 and 8 (P being the n-octanol-water partition coefficient). Such compositions include the active or bioactive material in single phase, solid solution in a wax or polymer matrix also having coated thereon and/or containing a compatible surfactant. Also described are processes and apparatus for preparing such compositions and processes for using same. Furthermore, certain component(s) of the aforementioned compositions in combination with one another are novel, and other components have novel uses in increasing fragrance substantivity.
摘要翻译：描述了用于靶向递送到诸如皮肤，毛发和织物以及邻近的环境的受控的时间释放微粒活性和生物活性组合物（包括加香组合物），其中活性和生物活性材料具有计算的log 10P值在1和 8（P为正辛醇 - 水分配系数）。这样的组合物包括在单相中的活性或生物活性物质，也在其上涂覆有和/或含有相容表面活性剂的蜡或聚合物基质中的固体溶液。还描述了制备这种组合物的方法和装置以及使用它们的方法。此外，上述组合物的某些组分彼此组合是新颖的，并且其它组分在增加香味直接性方面具有新颖的用途。

6. 发明授权

US6147046A Fragrance-containing long lasting solid particle for incorporation into detergent and fabric softening compositions 失效
标题翻译：含有香料的长效固体颗粒，用于掺入洗涤剂和织物软化组合物中
公开(公告)号：US6147046A
公开(公告)日：2000-11-14
申请号：US475977
申请日：1999-12-30
申请人： Adi Shefer , Shmuel David Shefer , Maureen S. Santoro
发明人： Adi Shefer , Shmuel David Shefer , Maureen S. Santoro
IPC分类号： C11D1/66 , C11D3/50 , C11D11/00 , C11D17/04 , C11D7/26 , C11D17/06
CPC分类号： C11D17/047 , C11D1/667 , C11D11/0082 , C11D3/505
摘要： A method and apparatus is disclosed for producing a fragrance-containing solid particle, capable of controllably releasing the fragrance to the environment in which the particle is contained, for incorporation into laundry detergents, fabric softener compositions and drier-added fabric softener articles.
摘要翻译：公开了一种用于生产含香料的固体颗粒的方法和装置，其能够可控地将香料释放到其中包含颗粒的环境中，以便结合到衣物洗涤剂，织物柔软剂组合物和添加有干燥剂的织物柔软剂制品中。

7. 发明授权

US6063365A Application of film forming technology to fragrance control release systems; and resultant fragrance control release systems 有权
公开(公告)号：US6063365A
公开(公告)日：2000-05-16
申请号：US150240
申请日：1998-09-10
申请人： Adi Shefer , Shmuel David Shefer , John M. Teffenhart
发明人： Adi Shefer , Shmuel David Shefer , John M. Teffenhart
IPC分类号： A61L9/04 , A61K7/32 , A61K7/46
CPC分类号： A61L9/042 , A61L9/048 , Y10S428/905 , Y10T442/2139 , Y10T442/2303 , Y10T442/3854 , Y10T442/674
摘要： Described is a fragrance control release system which is an emulsifier-free, single phase, nonporous, continuous, permeable polymeric film having a substantially uniform thickness of from about 1 up to about 150 microns, having entrapped and dissolved therein molecules of at least one fragrance substance capable of evolving from said film into the environment proximate said film by means of molecular diffusion at a permeation rate of from about 1.times.10.sup.-7 up to about 0.1 mg-mm/cm.sup.2 -min in a sustained and controlled release manner. Also described is a process for using the aforementioned system for imparting a fragrance into the environment above the unobstructed outer surface of the aforementioned polymer film which is coated on the surface of a solid or semi-solid support, e.g., a solid surface or human epidermis.

8. 发明授权

US06790460B2 Biodegradable bioadhesive controlled release system of nano-particles for oral care products 失效
标题翻译：用于口腔护理产品的纳米颗粒的可生物降解生物粘附控制释放系统
公开(公告)号：US06790460B2
公开(公告)日：2004-09-14
申请号：US10376761
申请日：2003-02-28
申请人： Adi Shefer , Shmuel David Shefer
发明人： Adi Shefer , Shmuel David Shefer
IPC分类号： A61K700
CPC分类号： A61Q11/00 , A61K8/0241 , A61K9/006 , A61K9/0063 , A61K9/5123 , A61K2800/413 , A61K2800/622 , A61K2800/652 , B82Y5/00
摘要： The present invention relates to a controlled release system useful for site specific delivery of biologically active ingredients or sensory markers, over an extended period of time, targeting biological surfaces comprising the oral cavity and mucous membranes of various tissues, as well as the controlled release of the biological active ingredients or sensory markers. The controlled release system of the present invention is a nano-particle, having an average particle diameter of from about 0.01 microns to about 10 microns, which comprises a biodegradable solid hydrophobic core and a bioadhesive/mucoadhesive positively charged surface. The invention also relates to the use of the nano-particles of the present invention in consumer oral hygiene products, such as toothpaste or mouthwash, for treatment and prevention of periodontal disease. The nano-particles of the present invention are particularly effective for targeted controlled delivery of biological active ingredients into the periodontal pocket. The present invention also provides synchronizing the release of the biologically active ingredient with that of the sensory markers to convey to the consumer the product performance and signal that a new application of the product is needed.
摘要翻译：本发明涉及一种控制释放系统，其可用于生物活性成分或感官标记物的特异性递送，其在延长的时间段内靶向包含各种组织的口腔和粘膜的生物学表面，以及受控释放生物活性成分或感官标记物。本发明的控制释放系统是平均粒径为约0.01微米至约10微米的纳米颗粒，其包含可生物降解的固体疏水性芯和生物粘附/粘膜粘附带正电的表面。本发明还涉及本发明的纳米颗粒在消费者口腔卫生产品如牙膏或漱口剂中用于治疗和预防牙周病的用途。本发明的纳米颗粒对于将生物活性成分靶向控制递送到牙周袋中是特别有效的。本发明还提供使生物活性成分与感官标记物的释放同步，以向消费者传达产品性能并且指示需要新产品的应用。

9. 发明授权

US06703011B2 Application of film forming technology to fragrance control release systems; and resultant fragrance control release systems 有权
标题翻译：成膜技术应用于香水控释系统; 并产生香味控制释放系统
公开(公告)号：US06703011B2
公开(公告)日：2004-03-09
申请号：US09893386
申请日：2001-06-27
申请人： Adi Shefer , Shmuel David Shefer , Michael John Robert White
发明人： Adi Shefer , Shmuel David Shefer , Michael John Robert White
IPC分类号： A61L904
CPC分类号： A61L9/042 , A61L9/048 , Y10S428/905 , Y10T442/2139 , Y10T442/2303 , Y10T442/3854 , Y10T442/674
摘要： Described is a fragrance control release system which is an emulsifier-free, single phase, nonporous, continuous, permeable polymeric film having a substantially uniform thickness of from about 1 up to about 150 microns, having entrapped and dissolved therein molecules of at least one fragrance substance capable of evolving from said film into the environment proximate said film by means of molecular diffusion at a permeation rate of from about 1×10−7 up to about 0.1 mg-mm/cm2-min in a sustained and controlled release manner. Also described is a process for using the aforementioned system for imparting a fragrance into the environment above the unobstructed outer surface of the aforementioned polymer film which is coated on the surface of a solid or semi-solid support, e.g., a woven or non-woven fabric substrate; or a solid surface or human epidermis.
摘要翻译：描述了一种香料控制释放系统，其是无乳化剂的单相，无孔，连续，可渗透的聚合物膜，其具有约1至约150微米的基本均匀的厚度，其截留并溶解在其中至少一种香料的分子在持续和控制释放的情况下，能够通过分子扩散以约1×10 -7至约0.1mg-mm / cm 2-min的渗透速率从所述膜释放到邻近所述膜的环境中的物质方式。还描述了一种使用上述系统来赋予香料至上述聚合物膜的无障碍外表面上方的环境中涂覆的固体或半固体载体例如编织或非织造织物织物基材; 或固体表面或人类表皮。

10. 发明授权

US6156826A Matrix composition comprising surfactant and matrix useful for targeted delivery articles 有权
标题翻译：包含用于靶向递送制品的表面活性剂和基质的基质组合
公开(公告)号：US6156826A
公开(公告)日：2000-12-05
申请号：US208461
申请日：1998-12-10
申请人： Eric P. Guenin , Karen A. Trotzinka , Leslie C. Smith , John M. Teffenhart , Keith J. McDermott , Shmuel David Shefer , Adi Shefer
发明人： Eric P. Guenin , Karen A. Trotzinka , Leslie C. Smith , John M. Teffenhart , Keith J. McDermott , Shmuel David Shefer , Adi Shefer
IPC分类号： A61K8/11 , A61Q13/00 , B01F3/08 , G01N30/00 , C08J89/00
CPC分类号： A61K8/11 , A61Q13/00 , A61K2800/412 , G01N30/00
摘要： Described are controlled, time-release microparticulate active and bioactive compositions (including perfuming compositions) for targeted delivery to surfaces such as skin, hair and fabric and the environment proximate thereto, where the active and bioactive materials have a calculated log.sub.10 P values of between 1 and 8 (P being the n-octanol-water partition coefficient). Such compositions include the active or bioactive material in single phase, solid solution in a wax or polymer matrix also having coated thereon and/or containing a compatible surfactant. Also described are processes and apparatus for preparing such compositions and processes for using same. Furthermore, certain component(s) of the aforementioned compositions in combination with one another are novel, and other components have novel uses in increasing fragrance substantivity, particularly in hair care preparations such as hair gels and shampoos.
摘要翻译：描述了用于靶向递送至表面如皮肤，毛发和织物以及接近其的环境的受控的时间释放微粒活性和生物活性组合物（包括加香组合物），其中活性和生物活性材料具有计算的log 10P值在1和 8（P为正辛醇 - 水分配系数）。这样的组合物包括在单相中的活性或生物活性物质，也在其上涂覆有和/或含有相容表面活性剂的蜡或聚合物基质中的固体溶液。还描述了制备这种组合物的方法和装置以及使用它们的方法。此外，上述组合物的某些组分彼此组合是新颖的，并且其它组分在增加香味的亲和性方面具有新颖的用途，特别是在头发护理制剂如发胶和洗发剂中。

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