专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20130178511A1 SILENCING OF CSN5 GENE EXPRESSION USING INTERFERING RNA 审中-公开
标题翻译：使用干扰RNA沉默CSN5基因表达
公开(公告)号：US20130178511A1
公开(公告)日：2013-07-11
申请号：US13551580
申请日：2012-07-17
申请人： Ian MacLachlan , Adam Judge , Snorri S. Thorgeirsson , Yun-Han Lee
发明人： Ian MacLachlan , Adam Judge , Snorri S. Thorgeirsson , Yun-Han Lee
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K48/00 , C12N15/1135 , C12N2310/14
摘要： The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles.
摘要翻译：本发明提供包含靶向CSN5基因表达的核酸和使用这种组合物沉默CSN5基因表达的方法的组合物。更具体地，本发明提供了沉默CSN5基因表达的未修饰和化学修饰的干扰RNA分子及其使用方法，例如用于治疗细胞增殖性疾病如癌症。本发明还提供靶向CSN5基因表达的核酸 - 脂质颗粒，其包含干扰RNA分子，阳离子脂质，非阳离子脂质和任选的抑制颗粒聚集的共轭脂质。

2. 发明授权

US08227443B2 Silencing of CSN5 gene expression using interfering RNA 有权
标题翻译：使用干扰RNA沉默CSN5基因表达
公开(公告)号：US08227443B2
公开(公告)日：2012-07-24
申请号：US12903558
申请日：2010-10-13
申请人： Ian MacLachlan , Adam Judge , Snorri S. Thorgeirsson , Yun-Han Lee
发明人： Ian MacLachlan , Adam Judge , Snorri S. Thorgeirsson , Yun-Han Lee
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12N15/113 , A61K48/00 , C12N15/1135 , C12N2310/14
摘要： The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles.
摘要翻译：本发明提供包含靶向CSN5基因表达的核酸和使用这种组合物沉默CSN5基因表达的方法的组合物。更具体地，本发明提供了沉默CSN5基因表达的未修饰和化学修饰的干扰RNA分子及其使用方法，例如用于治疗细胞增殖性疾病如癌症。本发明还提供靶向CSN5基因表达的核酸 - 脂质颗粒，其包含干扰RNA分子，阳离子脂质，非阳离子脂质和任选的抑制颗粒聚集的共轭脂质。

3. 发明授权

US09222086B2 Compositions and methods for silencing genes expressed in cancer 有权
标题翻译：沉默癌症基因表达的组成和方法
公开(公告)号：US09222086B2
公开(公告)日：2015-12-29
申请号：US13497789
申请日：2010-09-23
申请人： Adam Judge , Yun-Han Lee , Ian MacLachlan , Snorri S. Thorgeirsson
发明人： Adam Judge , Yun-Han Lee , Ian MacLachlan , Snorri S. Thorgeirsson
IPC分类号： A61K31/70 , C07H21/02 , C07H21/04 , C12N15/113 , C12Q1/68 , A61K31/713 , A61K31/7105
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2310/344 , C12N2320/31 , C12N2320/32
摘要： The present invention provides therapeutic nucleic acids such as interfering RNA (e.g., siRNA) that target the expression of genes associated with tumorigenesis and/or cell transformation, lipid particles (e.g., nucleic acid-lipid particles) comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles, e.g., for the treatment of a cell proliferative disorder such as cancer.
摘要翻译：本发明提供治疗性核酸，例如靶向与肿瘤发生和/或细胞转化相关基因表达的干扰RNA（例如siRNA），包含一种或多种（例如，一种或多种）的脂质颗粒（例如，核酸 - 脂质颗粒）治疗性核酸的混合物），制备脂质颗粒的方法，以及递送和/或施用脂质颗粒的方法，例如用于治疗细胞增殖性疾病如癌症。

4. 发明申请

US20130065939A1 COMPOSITIONS AND METHODS FOR SILENCING GENES EXPRESSED IN CANCER 有权
标题翻译：用于沉默癌症基因的组合物和方法
公开(公告)号：US20130065939A1
公开(公告)日：2013-03-14
申请号：US13497789
申请日：2010-09-23
申请人： Adam Judge , Yun-Han Lee , Ian MacLachlan , Snorri S. Thorgeirsson
发明人： Adam Judge , Yun-Han Lee , Ian MacLachlan , Snorri S. Thorgeirsson
IPC分类号： A61K31/713 , C07H21/02 , A61P35/00 , C12N5/09
CPC分类号： C12N15/113 , A61K31/7105 , A61K31/713 , C12N15/1137 , C12N2310/14 , C12N2310/344 , C12N2320/31 , C12N2320/32
摘要： The present invention provides therapeutic nucleic acids such as interfering RNA (e.g., siRNA) that target the expression of genes associated with tumorigenesis and/or cell transformation, lipid particles (e.g., nucleic acid-lipid particles) comprising one or more (e.g., a cocktail) of the therapeutic nucleic acids, methods of making the lipid particles, and methods of delivering and/or administering the lipid particles, e.g., for the treatment of a cell proliferative disorder such as cancer.
摘要翻译：本发明提供治疗性核酸，例如靶向与肿瘤发生和/或细胞转化相关基因表达的干扰RNA（例如siRNA），包含一种或多种（例如，一种或多种）的脂质颗粒（例如，核酸 - 脂质颗粒）治疗性核酸的混合物），制备脂质颗粒的方法，以及递送和/或施用脂质颗粒的方法，例如用于治疗细胞增殖性疾病如癌症。

5. 发明申请

US20110178155A1 SILENCING OF CSN5 GENE EXPRESSION USING INTERFERING RNA 有权
标题翻译：使用干扰RNA沉默CSN5基因表达
公开(公告)号：US20110178155A1
公开(公告)日：2011-07-21
申请号：US12903558
申请日：2010-10-13
申请人： Ian MacLachlan , Adam Judge , Snorri S. Thorgeirsson , Yun-Han Lee
发明人： Ian MacLachlan , Adam Judge , Snorri S. Thorgeirsson , Yun-Han Lee
IPC分类号： A61K31/7105 , C07H21/02 , C12N5/071 , A61P35/00
CPC分类号： C12N15/113 , A61K48/00 , C12N15/1135 , C12N2310/14
摘要： The present invention provides compositions comprising nucleic acids that target CSN5 gene expression and methods of using such compositions to silence CSN5 gene expression. More particularly, the present invention provides unmodified and chemically modified interfering RNA molecules which silence CSN5 gene expression and methods of use thereof, e.g., for treating cell proliferative disorders such as cancer. The present invention also provides nucleic acid-lipid particles that target CSN5 gene expression comprising an interfering RNA molecule, a cationic lipid, a non-cationic lipid, and optionally a conjugated lipid that inhibits aggregation of particles.
摘要翻译：本发明提供包含靶向CSN5基因表达的核酸和使用这种组合物沉默CSN5基因表达的方法的组合物。更具体地，本发明提供了沉默CSN5基因表达的未修饰和化学修饰的干扰RNA分子及其使用方法，例如用于治疗细胞增殖性疾病如癌症。本发明还提供靶向CSN5基因表达的核酸 - 脂质颗粒，其包含干扰RNA分子，阳离子脂质，非阳离子脂质和任选的抑制颗粒聚集的共轭脂质。

6. 发明授权

US07534565B2 DLC-1 gene deleted in cancers 失效
标题翻译： DLC-1基因在癌症中被删除
公开(公告)号：US07534565B2
公开(公告)日：2009-05-19
申请号：US10995914
申请日：2004-11-22
申请人： Bao-Zhu Yuan , Snorri S. Thorgeirsson , Nicholas Popescu
发明人： Bao-Zhu Yuan , Snorri S. Thorgeirsson , Nicholas Popescu
IPC分类号： C12Q1/68
CPC分类号： C07K14/4703 , A61K48/00
摘要： A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.
摘要翻译：公开了对应于新发现的人基因的cDNA分子。在肝癌细胞和细胞系中经常缺失的新基因被称为DLC-1基因。由于该基因经常在肝癌细胞中被缺失，而是存在于正常细胞中，所以被认为是肿瘤抑制因子。该基因在乳腺癌和结肠癌中也经常被删除，并且其表达在许多前列腺癌和结肠癌中降低或不可检测。还公开了由DLC-1基因编码的蛋白质的氨基酸序列。提出了使用这些生物材料诊断和治疗肝细胞癌，乳腺癌，结肠癌，前列腺癌和腺癌的方法。

7. 发明授权

US06897018B1 DLC-1 gene deleted in cancers 失效
公开(公告)号：US06897018B1
公开(公告)日：2005-05-24
申请号：US09644947
申请日：2000-08-23
申请人： Bao-Zhu Yuan , Snorri S. Thorgeirsson , Nicholas Popescu
发明人： Bao-Zhu Yuan , Snorri S. Thorgeirsson , Nicholas Popescu
IPC分类号： A61K48/00 , C07K14/47 , C12Q1/68
CPC分类号： C07K14/4703 , A61K48/00
摘要： A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.

8. 发明申请

US20100129791A1 cDNA Encoding a Gene Bog (B5T Over-Expressed Gene) and its Protein Product 审中-公开
标题翻译：编码基因Bog（B5T过表达基因）及其蛋白质产物的cDNA
公开(公告)号：US20100129791A1
公开(公告)日：2010-05-27
申请号：US11956680
申请日：2007-12-14
申请人： Snorri S. Thorgeirsson , Joseph T. Woitach , Minghuang Zhang
发明人： Snorri S. Thorgeirsson , Joseph T. Woitach , Minghuang Zhang
IPC分类号： C12Q1/68 , G01N33/573 , C12P21/06 , C12N15/85 , C12N9/12 , C12N5/00 , C12N5/02 , C12N15/63 , C07H21/04 , C07H21/02
CPC分类号： C07K14/4738 , C07K2317/24 , C07K2319/00 , Y10S530/828
摘要： Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-β1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
摘要翻译：提供编码本申请中称为“BOG”（B5T过表达基因）的新型多肽的核酸。 BOG与pRb结合，并且在转化大鼠肝上皮（RLE）细胞系中过表达，其对TGF-β1的生长抑制作用以及原发性肝肿瘤具有抗性。还提供了包括BOG嵌合体，编码BOG的核酸和BOG抗体的组合物。进一步提供了使用BOG调节pRb蛋白相互作用和改变细胞表型的方法。

9. 发明授权

US07342099B2 cDNA encoding a gene BOG (B5T over-expressed gene) and its protein product 失效
标题翻译：编码基因BOG（B5T过表达基因）的cDNA及其蛋白质产物
公开(公告)号：US07342099B2
公开(公告)日：2008-03-11
申请号：US10772988
申请日：2004-02-05
申请人： Snorri S. Thorgeirsson , Joseph T. Woitach , Minghuang Zhang
发明人： Snorri S. Thorgeirsson , Joseph T. Woitach , Minghuang Zhang
IPC分类号： C07K14/00
CPC分类号： C07K14/4738 , C07K2317/24 , C07K2319/00 , Y10S530/828
摘要： Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-β1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
摘要翻译：提供编码本申请中称为“BOG”（B5T过表达基因）的新型多肽的核酸。 BOG与pRb结合并且在对TGF-β1以及原发性肝肿瘤的生长抑制作用有抗性的数目转化的大鼠肝上皮（RLE）细胞系中过表达。还提供了包括BOG嵌合体，编码BOG的核酸和BOG抗体的组合物。进一步提供了使用BOG调节pRb蛋白相互作用和改变细胞表型的方法。

10. 发明授权

US06727079B1 cDNA encoding a gene BOG (B5T Over-expressed Gene) and its protein product 失效
标题翻译：编码基因BOG（B5T过表达基因）的cDNA及其蛋白质产物
公开(公告)号：US06727079B1
公开(公告)日：2004-04-27
申请号：US09637746
申请日：2000-08-11
申请人： Snorri S. Thorgeirsson , Joseph T. Woitach , Minghuang Zhang
发明人： Snorri S. Thorgeirsson , Joseph T. Woitach , Minghuang Zhang
IPC分类号： C12P2106
CPC分类号： C07K14/4738 , C07K2317/24 , C07K2319/00 , Y10S530/828
摘要： Nucleic acids that encode novel polypeptides, designated in the present application as “BOG” (B5T Over-expressed Gene) are provided. BOG binds to pRb and is over-expressed in a number transformed rat liver epithelial (RLE) cell lines resistant to the growth inhibitory effect of TGF-&bgr;1 as well as in primary liver tumors. Compositions including BOG chimeras, nucleic acids encoding BOG and antibodies to BOG are also provided. Methods of using BOG to modulate pRb-protein interactions and to alter cellular phenotype are further provided.
摘要翻译：提供编码本申请中称为“BOG”（B5T过表达基因）的新型多肽的核酸。 BOG与pRb结合并且在对TGF-β1以及原发性肝肿瘤的生长抑制作用有抗性的数目转化的大鼠肝上皮（RLE）细胞系中过表达。还提供了包括BOG嵌合体，编码BOG的核酸和BOG抗体的组合物。进一步提供了使用BOG调节pRb蛋白相互作用和改变细胞表型的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式