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1. 发明授权

US07534565B2 DLC-1 gene deleted in cancers 失效
标题翻译： DLC-1基因在癌症中被删除
公开(公告)号：US07534565B2
公开(公告)日：2009-05-19
申请号：US10995914
申请日：2004-11-22
申请人： Bao-Zhu Yuan , Snorri S. Thorgeirsson , Nicholas Popescu
发明人： Bao-Zhu Yuan , Snorri S. Thorgeirsson , Nicholas Popescu
IPC分类号： C12Q1/68
CPC分类号： C07K14/4703 , A61K48/00
摘要： A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.
摘要翻译：公开了对应于新发现的人基因的cDNA分子。在肝癌细胞和细胞系中经常缺失的新基因被称为DLC-1基因。由于该基因经常在肝癌细胞中被缺失，而是存在于正常细胞中，所以被认为是肿瘤抑制因子。该基因在乳腺癌和结肠癌中也经常被删除，并且其表达在许多前列腺癌和结肠癌中降低或不可检测。还公开了由DLC-1基因编码的蛋白质的氨基酸序列。提出了使用这些生物材料诊断和治疗肝细胞癌，乳腺癌，结肠癌，前列腺癌和腺癌的方法。

2. 发明授权

US06897018B1 DLC-1 gene deleted in cancers 失效
公开(公告)号：US06897018B1
公开(公告)日：2005-05-24
申请号：US09644947
申请日：2000-08-23
申请人： Bao-Zhu Yuan , Snorri S. Thorgeirsson , Nicholas Popescu
发明人： Bao-Zhu Yuan , Snorri S. Thorgeirsson , Nicholas Popescu
IPC分类号： A61K48/00 , C07K14/47 , C12Q1/68
CPC分类号： C07K14/4703 , A61K48/00
摘要： A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.

3. 发明申请

US20050106616A1 DLC-1 gene deleted in cancers 失效
公开(公告)号：US20050106616A1
公开(公告)日：2005-05-19
申请号：US10995914
申请日：2004-11-24
申请人： Bao-Zhu Yuan , Snorri Thorgeirsson , Nicholas Popescu
发明人： Bao-Zhu Yuan , Snorri Thorgeirsson , Nicholas Popescu
IPC分类号： A61K48/00 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/4703 , A61K48/00
摘要： A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.

4. 发明申请

US20050227255A9 DLC-1 gene deleted in cancers 失效
标题翻译： DLC-1基因在癌症中被删除
公开(公告)号：US20050227255A9
公开(公告)日：2005-10-13
申请号：US10995914
申请日：2004-11-22
申请人： Bao-Zhu Yuan , Snorri Thorgeirsson , Nicholas Popescu
发明人： Bao-Zhu Yuan , Snorri Thorgeirsson , Nicholas Popescu
IPC分类号： A61K48/00 , C07K14/47 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/4703 , A61K48/00
摘要： A cDNA molecule corresponding to a newly discovered human gene is disclosed. The new gene, which is frequently deleted in liver cancer cells and cell lines, is called the DLC-1 gene. Because the gene is frequently deleted in liver cancer cells, but present in normal cells, it is thought to act as a tumor suppressor. This gene is also frequently deleted in breast and colon cancers, and its expression is decreased or undetectable in many prostate and colon cancers. Also disclosed is the amino acid sequence of the protein encoded by the DLC-1 gene. Methods of using these biological materials in the diagnosis and treatment of hepatocellular cancer, breast cancer, colon cancer, prostate cancer, and adenocarcinomas are presented.
摘要翻译：公开了对应于新发现的人基因的cDNA分子。在肝癌细胞和细胞系中经常缺失的新基因被称为DLC-1基因。由于该基因经常在肝癌细胞中被缺失，而是存在于正常细胞中，所以被认为是肿瘤抑制因子。该基因在乳腺癌和结肠癌中也经常被删除，并且其表达在许多前列腺癌和结肠癌中降低或检测不到。还公开了由DLC-1基因编码的蛋白质的氨基酸序列。提出了使用这些生物材料诊断和治疗肝细胞癌，乳腺癌，结肠癌，前列腺癌和腺癌的方法。

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