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1. 发明授权

US5883134A Broad-spectrum antimicrobially active compounds 失效
标题翻译：广谱抗微生物活性化合物
公开(公告)号：US5883134A
公开(公告)日：1999-03-16
申请号：US701145
申请日：1996-08-21
申请人： Adam Chi-Tung Hsu , Peter Osei-Gyimah , Barry C. Lange , Rhoda W. Joseph
发明人： Adam Chi-Tung Hsu , Peter Osei-Gyimah , Barry C. Lange , Rhoda W. Joseph
IPC分类号： A01N33/20 , A01N41/10 , A01N43/28 , A01N43/32 , C07C317/08 , C07C317/10 , C07C317/12 , C07C323/65 , C07D335/02 , C07D339/06 , C07D339/08
CPC分类号： A01N43/28 , A01N41/10 , A01N43/32 , C07C317/08 , C07C317/10 , C07C317/12 , C07C323/65 , C07D335/02 , C07D339/06 , C07D339/08 , C07C2101/10 , C07C2101/16
摘要： Disclosed is a method of controlling or inhibiting the growth of microorganisms comprising introducing in, at, or on a locus an antimicrobially effective amount of an antimicrobially active nitroethene compound.
摘要翻译：公开了一种控制或抑制微生物生长的方法，包括在一个或多个位置引入抗微生物有效量的抗微生物活性硝基乙烯化合物。

2. 发明授权

US5464832A Substituted 3-thioacryloyl compounds and their use as antimicrobial agents 失效
标题翻译：取代的3-硫代丙烯酰化合物及其作为抗微生物剂的用途
公开(公告)号：US5464832A
公开(公告)日：1995-11-07
申请号：US166498
申请日：1993-12-13
申请人： Peter Osei-Gyimah , Samuel E. Sherba , Barry C. Lange , Rai J. Mehta , Rhoda W. Joseph
发明人： Peter Osei-Gyimah , Samuel E. Sherba , Barry C. Lange , Rai J. Mehta , Rhoda W. Joseph
IPC分类号： A01N37/36 , A01N41/12 , A01N43/10 , A01N43/40 , A01N43/50 , A01N43/713 , A01N43/78 , A01N47/42 , A01N47/48 , C07C323/54 , C07C323/60 , C07C331/14 , C07C335/32 , C07D213/70 , C07D213/89 , C07D233/42 , C07D257/04 , C07D277/36 , C07D277/74 , C07D333/28 , C07D211/06 , A61K31/535 , C07D263/04 , C07D265/30
CPC分类号： C07D213/70 , A01N37/36 , A01N41/12 , A01N43/10 , A01N43/40 , A01N43/50 , A01N43/713 , A01N43/78 , A01N47/42 , A01N47/48 , C07C323/54 , C07C323/60 , C07C331/14 , C07C335/32 , C07D213/89 , C07D233/42 , C07D257/04 , C07D277/36 , C07D277/74 , C07D333/28
摘要： A thioacryloyl compound of the formula ##STR1## wherein Z is selected from the group consisting of OR, R and NR.sup.1 R.sup.2 ;R is selected from the group consisting of hydrogen; (C.sub.1 -C.sub.18)alkyl; (C.sub.1 -C.sub.8)alkenyl; (C.sub.1 -C.sub.8)haloalkynyl; 2-(5-chlorothienyl)methyl; phenyl optionally substituted with one or more substituents selected from the group consisting of halo-, (C.sub.1 -C.sub.3)alkoxy-, nitro-, and (C.sub.1 -C.sub.3)alkyl; phenacyl optionally substituted with one or more substituents selected from the group consisting of ring halo-, (C.sub.1 -C.sub.3)alkoxy-, nitro-, and (C.sub.1 -C.sub.3)alkyl; arylalkyl optionally substituted with one or more substituents selected from the group consisting of ring halo-, (C.sub.1 -C.sub.3)alkoxy-, nitro-, and (C.sub.1 -C.sub.3)alkyl;R.sup.1 and R.sup.2 are independently selected from (C.sub.1 -C.sub.8)alkyl and phenyl, or R.sup.1 and R.sup.2 may be joined together with the nitrogen atom to which they are attached to form a ring containing 4 to 5 carbon atoms with or without an oxygen heteroatom;X is selected from the group consisting of hydrogen, halogen, phenyl, CO.sub.2 CH.sub.3, and (C.sub.1 -C.sub.3)alkyl; andY is selected from the group consisting of CN, CH(COCH.sub.3).sub.2, CH.sub.2 COCH.sub.3, CH.sub.2 CN, CH.sub.2 CO.sub.2 C.sub.2 H.sub.5 -propargyl, SCH.dbd.CHCO.sub.2 CH.sub.3, C(.dbd.NH)NH.sub.2 hydrochloride, and 2-(5-chlorothienyl)methyl;provided that when Z is NR.sup.1 R.sup.2, Y is CN; andprovided that when Z is R, X is hydrogen, and Y is CN, R is not phenyl.
摘要翻译：式Ⅰ的硫代丙烯酰化合物，其中Z选自OR，R和NR1R2; R选自氢; （C 1 -C 18）烷基; （C1-C8）烯基; （C1-C8）卤代炔基; 2-（5-氯噻吩基）甲基; 任选被一个或多个选自卤代，（C 1 -C 3）烷氧基 - ，硝基 - 和（C 1 -C 3）烷基的取代基取代的苯基; 任选被一个或多个选自环卤，（C1-C3）烷氧基 - ，硝基 - 和（C1-C3）烷基的取代基取代的苯乙烯酰基; 任选被一个或多个选自环卤，（C 1 -C 3）烷氧基 - ，硝基 - 和（C 1 -C 3）烷基的取代基取代的芳基烷基; R 1和R 2独立地选自（C 1 -C 8）烷基和苯基，或者R 1和R 2可以与它们所连接的氮原子一起形成含有或不含有氧杂原子的含有4至5个碳原子的环; X选自氢，卤素，苯基，CO 2 CH 3和（C 1 -C 3）烷基; 并且Y选自CN，CH（COCH 3）2，CH 2 COCH 3，CH 2 CN，CH 2 CO 2 C 2 H 5 - 炔丙基，SCH = CHCO 2 CH 3，C（= NH）NH 2盐酸盐和2-（5-氯噻吩基）甲基; 条件是当Z为NR1R2时，Y为CN; 并且条件是当Z是R时，X是氢，Y是CN，R不是苯基。

3. 发明授权

US5302592A Use of substituted 3-thioacryloyl compounds as antimicrobial agents 失效
标题翻译：取代的3-硫代丙烯酰化合物用作抗微生物剂
公开(公告)号：US5302592A
公开(公告)日：1994-04-12
申请号：US107422
申请日：1993-08-16
申请人： Peter Osei-Gyimah , Samuel E. Sherba , Raj J. Mehta , Barry C. Lange , Rhoda W. Joseph
发明人： Peter Osei-Gyimah , Samuel E. Sherba , Raj J. Mehta , Barry C. Lange , Rhoda W. Joseph
IPC分类号： A01N37/36 , A01N41/12 , A01N43/10 , A01N43/40 , A01N43/50 , A01N43/713 , A01N43/78 , A01N47/42 , A01N47/48 , C07C323/54 , C07C323/60 , C07C331/14 , C07C335/32 , C07D213/70 , C07D213/89 , C07D233/42 , C07D257/04 , C07D277/36 , C07D277/74 , C07D333/28 , A01N31/02
CPC分类号： C07D213/70 , A01N37/36 , A01N41/12 , A01N43/10 , A01N43/40 , A01N43/50 , A01N43/713 , A01N43/78 , A01N47/42 , A01N47/48 , C07C323/54 , C07C323/60 , C07C331/14 , C07C335/32 , C07D213/89 , C07D233/42 , C07D257/04 , C07D277/36 , C07D277/74 , C07D333/28
摘要： Use as microbicides of thioacryloyl compounds of the formula ##STR1## Compounds and compositions are also disclosed.
摘要翻译：用作下式的硫代丙烯酰化合物的杀微生物剂也公开了化合物和组合物。

4. 发明授权

US5384326A Girondalones 失效
标题翻译：吉他隆隆
公开(公告)号：US5384326A
公开(公告)日：1995-01-24
申请号：US794753
申请日：1991-11-12
申请人： Kevin F. Gironda , Peter Osei-Gyimah , Barry C. Lange
发明人： Kevin F. Gironda , Peter Osei-Gyimah , Barry C. Lange
IPC分类号： A01N43/80 , A61K31/425 , A61P31/04 , C07D275/02 , C07D275/03 , C07D275/04
CPC分类号： C07D275/03 , A01N43/80 , C07D275/04
摘要： Girondalones of the formula I useful as microbicides ##STR1## wherein A is a residue of a dialdehyde;R.sub.1 is independently selected from the group consisting of R.sub.2 and (C.sub.1 -C.sub.18)alkyl and;R.sub.2 is ##STR2## wherein (i) X.sub.1 and X.sub.2 can be joined to form a 5 or 6 membered fused carbocyclic ring, said ring being saturated, unsaturated, or aromatic; or(ii) X.sub.1 =Cl, H, methyl, or Br; and X.sub.2 =H, Cl, or Br.
摘要翻译：用作杀微生物剂的式I的吉他隆酮（I）其中A是二醛的残基; R1独立地选自R2和（C1-C18）烷基;和 R2被固定以形成5或6元稠合碳环，所述环是饱和的，不饱和的或芳族的; 或（ii）X1 = Cl，H，甲基或Br; X2 = H，Cl或Br。

5. 发明授权

US5508417A Broad-spectrum isothiazole antimicrobial agents 失效
标题翻译：广谱异噻唑抗菌药
公开(公告)号：US5508417A
公开(公告)日：1996-04-16
申请号：US200254
申请日：1994-02-23
申请人： Peter Osei-Gyimah , Barry C. Lange
发明人： Peter Osei-Gyimah , Barry C. Lange
IPC分类号： A01N43/80 , C07D275/02 , C07D275/03 , A61K31/425 , C07D409/12
CPC分类号： C07D275/03 , A01N43/80
摘要： This invention relates to antimicrobial compounds of formula I, II, or III ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from hydrogen, halogen, or (C.sub.1 -C.sub.4)alkyl;R.sub.1 and R.sub.2 may be taken together with the carbons to which they are attached to form a 5 to 7-membered carbocyclic ring and the ring may be aromatic;R.sub.3 is hydrogen, (C.sub.1 -C.sub.8)alkyl, (C.sub.2 -C.sub.8)alkenyl, (C.sub.5 -C.sub.8)alkynyl, (C.sub.5 -C.sub.7)cycloalkyl or cycloalkenyl, phenyl or substituted phenyl, (C.sub.7 -C.sub.10)aralkyl or substituted (C.sub.7 -C.sub.10)aralkyl, or a 5 to 8-membered heteroaryl having one or more heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen;R.sub.4 is an electron-withdrawing group selected from CN, NO.sub.2, P(O)(OR.sub.7).sub.2, P(S)(OR.sub.7).sub.2, COOR.sub.6, COR.sub.6, CONHR.sub.6, SOR.sub.6, SO.sub.2 R.sub.6, where R.sub.6 is hydrogen, (C.sub.1 -C.sub.8)alkyl, phenyl or substituted phenyl, (C.sub.7 -C.sub.10)aralkyl or substituted (C.sub.7 -C.sub.10)aralkyl, (C.sub.5 -C.sub.7)cycloalkyl, or a 5 to 8-membered heteroaryl having one or more heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen and where R.sub.7 is (C.sub.1 -C.sub.4)alkyl or phenyl;R.sub.3 and R.sub.4 may be joined to form a (C.sub.5 -C.sub.7)cycloalkenone optionally containing a heteroatom selected from the group consisting of oxygen, sulfur and nitrogen;R.sub.5 is hydrogen or (C.sub.1 to C.sub.4)alkyl; andY is oxygen, sulfur, sulfoxide, sulfone, or nitrogen substituted with (C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.5)cycloalkyl, or phenyl.
摘要翻译：本发明涉及式I，II或III的抗微生物化合物，其中R 1和R 2独立地选自氢，卤素或（C 1 -C 4）烷基; R 1和R 2可以与它们所连接的碳一起形成5至7元碳环并且该环可以是芳族的; R3是氢，（C1-C8）烷基，（C2-C8）烯基，（C5-C8）炔基，（C5-C7）环烷基或环烯基，苯基或取代的苯基，（C7-C10）芳烷基或取代的（C7- C10）芳烷基或具有一个或多个选自氧，硫和氮的杂原子的5至8元杂芳基; R4是选自CN，NO2，P（O）（OR7）2，P（S）（OR7）2，COOR6，COR6，CONHR6，SOR6，SO2R6的吸电子基团，其中R6是氢，（C1-C8 ）烷基，苯基或取代的苯基，（C 7 -C 10）芳烷基或取代的（C 7 -C 10）芳烷基，（C 5 -C 7）环烷基或具有一个或多个选自氧的杂原子的5至8元杂芳基，硫和氮，其中R 7是（C 1 -C 4）烷基或苯基; R 3和R 4可以连接形成任选地含有选自氧，硫和氮的杂原子的（C5-C7）环烯酮; R5是氢或（C1-C4）烷基; 并且Y是被（C 1 -C 4）烷基，（C 3 -C 5）环烷基或苯基取代的氧，硫，亚砜，砜或氮。

6. 发明授权

US5321141A Preparation of 2-(3-oxoalk(en)yl)-3-isothiazolones and derivatives 失效
标题翻译： 2-（3-氧代烷（烯）基）-3-异噻唑酮及其衍生物的制备
公开(公告)号：US5321141A
公开(公告)日：1994-06-14
申请号：US144263
申请日：1993-10-28
申请人： Peter Osei-Gyimah , Barry C. Lange
发明人： Peter Osei-Gyimah , Barry C. Lange
IPC分类号： A23L3/3544 , A01N43/80 , A61K8/49 , A61K31/425 , A61P31/04 , C07D275/02 , C07D275/03
CPC分类号： C07D275/03 , A01N43/80
摘要： Antimicrobial compounds of the formula ##STR1## wherein R is hydrogen, halogen, or (C.sub.1 -C.sub.4)alkyl group;R.sub.1 is hydrogen or halogen; alternatively, R and R1 may be taken together with the carbons to which they are attached to form a 5- to 7-membered carbocyclic ring, said ring optionally being aromatic;R.sub.2 is hydrogen or (C.sub.1 -C.sub.3)alkyl group; andR3 is hydrogen, substituted or unsubstituted (C.sub.1 -C.sub.18)alkyl, substituted or unsubstituted (C.sub.2 -C.sub.18)alkenyl, substituted or unsubstituted (C.sub.2 -C.sub.18)alkynyl, substituted or unsubstituted (C.sub.4 -C.sub.8)cycloalkyl or cycloalkenyl, substituted or unsubstituted (C.sub.6 -C.sub.10)aryl or arylalkyl group are disclosed.
摘要翻译：下式的抗微生物化合物其中R是氢，卤素或（C 1 -C 4）烷基; R1是氢或卤素; 或者，R和R 1可以与它们所连接的碳一起形成5-至7-元碳环，所述环任选是芳族的; R2是氢或（C1-C3）烷基; 取代或未取代的（C 2 -C 18）烯基，取代或未取代的（C 2 -C 18）炔基，取代或未取代的（C 1 -C 8）环烷基或环烯基，取代或未取代的（C6-C10）芳基或芳基烷基。

7. 发明授权

US5288693A 2-(3-oxoalk(en)yl)-3-isothiazolones and derivatives as antimicrobial agents 失效
标题翻译： 2-（3-氧代烯（烯）基）-3-异噻唑酮及其衍生物作为抗微生物剂
公开(公告)号：US5288693A
公开(公告)日：1994-02-22
申请号：US83958
申请日：1993-06-25
申请人： Peter Osei-Gyimah , Barry C. Lange
发明人： Peter Osei-Gyimah , Barry C. Lange
IPC分类号： A23L3/3544 , A01N43/80 , A61K8/49 , A61K31/425 , A61P31/04 , C07D275/02 , C07D275/03 , C07D275/04
CPC分类号： C07D275/03 , A01N43/80
摘要： Antimicrobial compounds of the formula ##STR1## wherein R is hydrogen, halogen or (C.sub.1 -C.sub.4)alkyl group;R.sub.1 is hydrogen or halogen; alternatively, R and R1 may be taken together with the carbons to which they are attached to form a 5- to 7-membered carbocyclic ring, said ring optionally being aromatic;R.sub.2 is hydrogen or (C.sub.1 -C.sub.3)alkyl group; andR3 is hydrogen, substituted or unsubstituted (C.sub.1 -C.sub.18)alkyl, substituted or unsubstituted (C.sub.2 -C.sub.18)alkenyl, substituted or unsubstituted (C.sub.2 -C.sub.18)alkynyl, substituted or unsubstituted (C.sub.4 -C.sub.8)cycloalkyl or cycloalkenyl, substituted or unsubstituted (C.sub.6 -C.sub.10)aryl or arylalkyl group are disclosed.
摘要翻译：式（I）其中R为氢，卤素或（C 1 -C 4）烷基的式I的化合物; R1是氢或卤素; 或者，R和R 1可以与它们所连接的碳一起形成5-至7-元碳环，所述环任选是芳族的; R2是氢或（C1-C3）烷基; 取代或未取代的（C 2 -C 18）烯基，取代或未取代的（C 2 -C 18）炔基，取代或未取代的（C 1 -C 8）环烷基或环烯基，取代或未取代的（C6-C10）芳基或芳基烷基。

8. 发明授权

US06207828B1 Process for making 2-(trihaloacetyl)-3-(substituted amino)-2-propenoates 失效
标题翻译：制备2-（三卤代乙酰基）-3-（取代的氨基）-2-丙烯酸酯的方法
公开(公告)号：US06207828B1
公开(公告)日：2001-03-27
申请号：US09433249
申请日：1999-11-04
申请人： Peter Osei-Gyimah
发明人： Peter Osei-Gyimah
IPC分类号： C07C22900
CPC分类号： C07C227/10 , C07C229/30
摘要： This invention provides a convenient, new, one step process for the preparation of 2-(trihaloacetyl)-3-(substituted amino)-2-propenoates and related derivatives thereof by reaction of carbonyl compounds substituted with a trihaloacetyl group with an acetal in the presence of an organic acid. The resulting propenoates are useful as intermediates for the construction of trihalomethyl substituted heterocyclic compounds for use in pharmaceutical and agricultural applications.
摘要翻译：本发明提供了一种用于制备2-（三卤代乙酰基）-3-（取代的氨基）-2-丙烯酸酯及其相关衍生物的方便的，新的一步法，其中所述方法通过在三氯乙酰基中被羰基化合物与缩醛反应存在有机酸。所得丙烯酸酯可用作构建用于制药和农业应用的三卤代甲基取代的杂环化合物的中间体。

9. 发明授权

US5688744A Antimicrobial compounds with quick speed of kill 失效
标题翻译：抗菌化合物杀死速度快
公开(公告)号：US5688744A
公开(公告)日：1997-11-18
申请号：US729991
申请日：1996-10-11
申请人： Rhoda Weber Joseph , Diane Lynn Antes , Peter Osei-Gyimah
发明人： Rhoda Weber Joseph , Diane Lynn Antes , Peter Osei-Gyimah
IPC分类号： A01N43/82 , A01N43/828 , C07D285/00 , C07D285/01 , A01N43/36
CPC分类号： C07D285/01 , A01N43/82
摘要： A method of inhibiting the growth of bacteria and algae in industrial loci using a compound of formula I or II: ##STR1## is disclosed. Antimicrobial compounds useful in inhibiting the growth of bacteria and algae in industrial loci and compositions containing the antimicrobial compounds are also disclosed.
摘要翻译：公开了使用式I或II化合物抑制工业基因座中细菌和藻类生长的方法：还公开了可用于抑制工业基因座中细菌和藻类生长的抗微生物化合物和含有抗微生物化合物的组合物。

10. 发明授权

US5910602A Method for preparing 3-amino substituted crotonates 失效
标题翻译：制备3-氨基取代的巴豆酸酯的方法
公开(公告)号：US5910602A
公开(公告)日：1999-06-08
申请号：US69395
申请日：1998-04-29
申请人： Joshua Anthony Chong , Fereydon Abdesken , Peter Osei-Gyimah
发明人： Joshua Anthony Chong , Fereydon Abdesken , Peter Osei-Gyimah
IPC分类号： C07C227/08 , C07C229/20 , C07C229/30 , C07C231/12 , C07C237/16 , C07C257/14 , C07C327/22 , C07C327/36 , C07C327/44
CPC分类号： C07C227/08
摘要： The present invention relates to methods for preparing 3-amino-4,4,4-trihalocrotonates and their derivatives from a 4,4,4-trihaloacetoacetate derivative and an amine or ammonium salt.
摘要翻译：本发明涉及由4,4,4-三卤代乙酰乙酸酯衍生物和胺或铵盐制备3-氨基-4,4,4-三氯巴豆酸酯及其衍生物的方法。

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