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1. 发明授权

US5518496A Deformable magnetic field aiding coils for use in controlling tissue growth 失效
标题翻译：用于控制组织生长的变形磁场辅助线圈
公开(公告)号：US5518496A
公开(公告)日：1996-05-21
申请号：US249495
申请日：1994-05-26
申请人： Bruce R. McLeod , Stephen D. Smith , Abraham R. Liboff
发明人： Bruce R. McLeod , Stephen D. Smith , Abraham R. Liboff
IPC分类号： A61N2/02 , A61N2/04 , A61N1/00
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating the growth of living tissue are provided. The apparatus includes a deformable magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The deformable magnetic field generator includes a pair of field coils embedded in a flexible material which allows the field coils to be plastically deformed to fit the contour of a body region such as a patient's limb. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, growth characteristics of the target tissue are controlled.
摘要翻译：提供了一种用于调节生物体组织生长的装置和方法。该装置包括可变形磁场发生器和用于产生平行于通过目标组织突出的预定轴线的受控的，波动的定向磁场的磁场检测器。可变形磁场发生器包括嵌入柔性材料中的一对场线圈，其允许场线圈塑性变形以适应诸如患者肢体的身体区域的轮廓。场检测器沿着预定的通路对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与平均磁通密度的预选比率。当复合磁通密度根据目标组织受到的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。通过将这些精确的预定频率比率保持为平均磁通密度，可以控制目标组织的生长特性。

2. 发明授权

US5441495A Electromagnetic treatment therapy for stroke victim 失效
标题翻译：中风患者电磁治疗
公开(公告)号：US5441495A
公开(公告)日：1995-08-15
申请号：US136474
申请日：1993-10-13
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： A method and apparatus for therapeutically treating stroke is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the patient's cerebral tissue. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio maintains tissue viability and reduces edema by controlling ion electrolyte balance. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the target cerebral tissue.
摘要翻译：提供了一种用于治疗性卒中的方法和装置。该装置包括磁场发生器，用于产生平行于通过患者的脑组织突出的预定轴线的受控的，波动的定向取向的磁场。一方面，场检测器测量沿预定轴线的磁通密度。施加的磁场可以包括以预定频率振荡的全波整流信号，以将频率的预选比率保持到有效磁通密度，其中该比例通过控制离子电解质平衡来维持组织活力并减少水肿。通过调整波动磁场的频率和/或通过调整在包含目标脑组织的区域处的局部磁场之后施加的磁场的强度来维持该比率。

3. 发明授权

US5215642A Improved method and apparatus for regulating transmembrane ion movement 失效
标题翻译：改进调节跨膜离子运动的方法和装置
公开(公告)号：US5215642A
公开(公告)日：1993-06-01
申请号：US778730
申请日：1991-10-16
申请人： Abraham R. Liboff , Stephen D. Smith , Bruce R. McLeod
发明人： Abraham R. Liboff , Stephen D. Smith , Bruce R. McLeod
IPC分类号： A61N1/32 , A61N2/00 , A61N2/02 , C12N13/00
CPC分类号： C12N13/00 , A61N1/325 , A61N2/00 , A61N2/02
摘要： An improved apparatus and method for regulating transmembrane ion movement through a biochemical membrane. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the membrane. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target membrane is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, ion transport is controlled.
摘要翻译：一种用于调节通过生物膜的跨膜离子运动的改进的装置和方法。该装置包括磁场发生器和磁场检测器，用于产生平行于通过膜突出的预定轴线的受控的，波动的定向磁场。场检测器沿着预定的通路对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。通过调整变动磁场的频率和/或通过随着复合磁通密度随着靶膜所经受的局部磁场的变化而改变而施加的磁场的强度而保持该比例。通过将这些精确的预定比例的频率保持为平均磁通密度，控制离子传输。

4. 发明授权

US5160591A Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation 失效
标题翻译：使用选择性谐波频率和同时多个离子调节来调节跨膜离子运动的方法和装置
公开(公告)号：US5160591A
公开(公告)日：1992-11-03
申请号：US764666
申请日：1991-10-25
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N1/32 , A61N2/02 , A61N2/04 , C12N13/00
CPC分类号： C12N13/00 , A61N1/325 , A61N2/02
摘要： Methods and apparatus for regulating ion movement across biological membranes are provided. In one aspect, harmonic frequencies of a fluctuating magnetic field based on cyclotron resonance principles are provided for selectively enhancing transmembrane ion movement. In another aspect, a method and apparatus are provided for simultaneously regulating the transmembrane movement of multiple distinct ionic species using a fluctuating magnetic field. Therapeutic applications of harmonic tuning and multiple tuning are also provided.
摘要翻译：提供了用于调节跨越生物膜的离子运动的方法和装置。在一个方面，提供了基于回旋加速器共振原理的波动磁场的谐波频率，用于选择性地增强跨膜离子运动。在另一方面，提供一种方法和装置，用于使用波动的磁场同时调节多个不同离子物质的跨膜运动。还提供了谐波调谐和多重调谐的治疗应用。

5. 发明授权

US5087336A Methods and apparatus for regulating transmembrane ion movement utilizing selective harmonic frequencies and simultaneous multiple ion regulation 失效
公开(公告)号：US5087336A
公开(公告)日：1992-02-11
申请号：US343017
申请日：1989-04-25
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N1/30 , A61N2/00 , A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： Methods and apparatus for regulating ion movement across biological membranes are provided. In one aspect, harmonic frequencies of a fluctuating magnetic field based on cyclotron resonance principles are provided for selectively enhancing transmembrane ion movement. In another aspect, a method and apparatus are provided for simultaneously regulating the transmembrane movement of multiple distinct ionic species using a fluctuating magnetic field. Therapeutic applications of harmonic tuning and multiple tuning are also provided.

6. 发明授权

US5045050A Method and apparatus for the treatment of cancer 失效
标题翻译：治疗癌症的方法和装置
公开(公告)号：US5045050A
公开(公告)日：1991-09-03
申请号：US437485
申请日：1989-11-15
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： A method and apparatus for therapeutically treating cancer is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through a malignant neoplasm. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio regulates the growth characteristics of cancer cells of the neoplasm. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the neoplasm. In one aspect, a synergistic therapeutic cancer treatment is obtained by exposing cancer cells to the magnetic fields of the invention in the presence of a chemotherapeutic cancer agent.
摘要翻译：提供了治疗癌症的方法和装置。该装置包括用于产生平行于通过恶性肿瘤突出的预定轴线的受控的，波动的定向取向的磁场的磁场发生器。一方面，场检测器测量沿预定轴线的磁通密度。所施加的磁场可以包括以预定频率振荡的全波整流信号，以将频率的预选比率保持到有效磁通密度，其中比率调节肿瘤的癌细胞的生长特性。通过调节波动磁场的频率和/或通过调整在包含肿瘤的区域中的局部磁场消失后施加的磁场的强度来维持该比率。在一个方面，通过在化疗癌症药物的存在下将癌细胞暴露于本发明的磁场来获得协同治疗性癌症治疗。

7. 发明授权

US5458558A Method for controlling tissue growth with an applied fluctuating magnetic field 失效
标题翻译：用施加的波动磁场控制组织生长的方法
公开(公告)号：US5458558A
公开(公告)日：1995-10-17
申请号：US136464
申请日：1993-10-13
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04 , A61N1/00
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating tissue growth in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, growth characteristics of the target tissue are controlled.
摘要翻译：提供了一种用于调节体内组织生长的装置和方法。该装置包括磁场发生器和磁场检测器，用于产生平行于通过目标组织突出的预定轴线的受控的，波动的定向取向的磁场。场检测器沿着预定的通路对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与平均磁通密度的预选比率。当复合磁通密度根据目标组织受到的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。通过将这些精确的预定频率比率保持为平均磁通密度，可以控制目标组织的生长特性。

8. 发明授权

US5437600A Method and apparatus for the treatment of cancer 失效
标题翻译：治疗癌症的方法和装置
公开(公告)号：US5437600A
公开(公告)日：1995-08-01
申请号：US268061
申请日：1994-06-27
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： A method and apparatus for therapeutically treating cancer is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through a malignant neoplasm. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio regulates the growth characteristics of cancer cells of the neoplasm. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the neoplasm. In one aspect, a synergistic therapeutic cancer treatment is obtained by exposing cancer cells to the magnetic fields of the invention in the presence of a chemotherapeutic cancer agent.
摘要翻译：提供了治疗癌症的方法和装置。该装置包括用于产生平行于通过恶性肿瘤突出的预定轴线的受控的，波动的定向取向的磁场的磁场发生器。一方面，场检测器测量沿预定轴线的磁通密度。所施加的磁场可以包括以预定频率振荡的全波整流信号，以将频率的预选比率保持到有效磁通密度，其中比率调节肿瘤的癌细胞的生长特性。通过调节波动磁场的频率和/或通过调整在包含肿瘤的区域中的局部磁场消失后施加的磁场的强度来维持该比率。在一个方面，通过在化疗癌症药物的存在下将癌细胞暴露于本发明的磁场来获得协同治疗性癌症治疗。

9. 发明授权

US5123898A Method and apparatus for controlling tissue growth with an applied fluctuating magnetic field 失效
标题翻译：用施加的波动磁场控制组织生长的方法和装置
公开(公告)号：US5123898A
公开(公告)日：1992-06-23
申请号：US496415
申请日：1990-03-20
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating tissue growth in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, growth characteristics of the target tissue are controlled.
摘要翻译：提供了一种用于调节体内组织生长的装置和方法。该装置包括磁场发生器和磁场检测器，用于产生平行于通过目标组织突出的预定轴线的受控的，波动的定向取向的磁场。场检测器沿着预定的通路对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与平均磁通密度的预选比率。当复合磁通密度根据目标组织受到的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。通过将这些精确的预定频率比率保持为平均磁通密度，可以控制目标组织的生长特性。

10. 发明授权

US5106361A Method and apparatus for controlling the growth of non-osseous non-cartilaginous solid connective tissue 失效
标题翻译：用于控制非骨性非软骨固体结缔组织生长的方法和装置
公开(公告)号：US5106361A
公开(公告)日：1992-04-21
申请号：US254438
申请日：1988-10-06
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating the growth of connective tissue proper in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, growth characteristics of the target connective tissue proper are controlled.
摘要翻译：提供了一种调节体内适当结缔组织生长的装置和方法。该装置包括磁场发生器和磁场检测器，用于产生平行于通过目标组织突出的预定轴线的受控的，波动的定向取向的磁场。场检测器沿着预定的通路对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与平均磁通密度的预选比率。当复合磁通密度根据目标组织受到的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。通过将这些精确的预定的频率比率保持为平均磁通密度，可以控制目标结缔组织的生长特性。

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