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1. 发明授权

US5518496A Deformable magnetic field aiding coils for use in controlling tissue growth 失效
标题翻译：用于控制组织生长的变形磁场辅助线圈
公开(公告)号：US5518496A
公开(公告)日：1996-05-21
申请号：US249495
申请日：1994-05-26
申请人： Bruce R. McLeod , Stephen D. Smith , Abraham R. Liboff
发明人： Bruce R. McLeod , Stephen D. Smith , Abraham R. Liboff
IPC分类号： A61N2/02 , A61N2/04 , A61N1/00
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating the growth of living tissue are provided. The apparatus includes a deformable magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The deformable magnetic field generator includes a pair of field coils embedded in a flexible material which allows the field coils to be plastically deformed to fit the contour of a body region such as a patient's limb. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, growth characteristics of the target tissue are controlled.
摘要翻译：提供了一种用于调节生物体组织生长的装置和方法。该装置包括可变形磁场发生器和用于产生平行于通过目标组织突出的预定轴线的受控的，波动的定向磁场的磁场检测器。可变形磁场发生器包括嵌入柔性材料中的一对场线圈，其允许场线圈塑性变形以适应诸如患者肢体的身体区域的轮廓。场检测器沿着预定的通路对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与平均磁通密度的预选比率。当复合磁通密度根据目标组织受到的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。通过将这些精确的预定频率比率保持为平均磁通密度，可以控制目标组织的生长特性。

2. 发明授权

US5441495A Electromagnetic treatment therapy for stroke victim 失效
标题翻译：中风患者电磁治疗
公开(公告)号：US5441495A
公开(公告)日：1995-08-15
申请号：US136474
申请日：1993-10-13
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： A method and apparatus for therapeutically treating stroke is provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the patient's cerebral tissue. In one aspect, a field detector measures the magnetic flux density along the predetermined axis. The applied magnetic field may comprise a full-wave rectified signal oscillated at predetermined frequencies to maintain a preselected ratio of frequency to the effective flux density, where the ratio maintains tissue viability and reduces edema by controlling ion electrolyte balance. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field after nulling out the local magnetic field at that region containing the target cerebral tissue.
摘要翻译：提供了一种用于治疗性卒中的方法和装置。该装置包括磁场发生器，用于产生平行于通过患者的脑组织突出的预定轴线的受控的，波动的定向取向的磁场。一方面，场检测器测量沿预定轴线的磁通密度。施加的磁场可以包括以预定频率振荡的全波整流信号，以将频率的预选比率保持到有效磁通密度，其中该比例通过控制离子电解质平衡来维持组织活力并减少水肿。通过调整波动磁场的频率和/或通过调整在包含目标脑组织的区域处的局部磁场之后施加的磁场的强度来维持该比率。

3. 发明授权

US5318561A Deformable magnetic field aiding coils for use in controlling tissue growth 失效
标题翻译：用于控制组织生长的变形磁场辅助线圈
公开(公告)号：US5318561A
公开(公告)日：1994-06-07
申请号：US837018
申请日：1992-02-18
申请人： Bruce R. McLeod , Stephen D. Smith , Abraham R. Liboff
发明人： Bruce R. McLeod , Stephen D. Smith , Abraham R. Liboff
IPC分类号： A61N2/02 , A61N2/04 , A61N1/00
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating the growth of living tissue are provided. The apparatus includes a deformable magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The deformable magnetic field generator includes a pair of field coils embedded in a flexible material which allows the field coils to be plastically deformed to fit the contour of a body region such as a patient's limb. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, growth characteristics of the target tissue are controlled.
摘要翻译：提供了一种用于调节生物体组织生长的装置和方法。该装置包括可变形磁场发生器和用于产生平行于通过目标组织突出的预定轴线的受控的，波动的定向磁场的磁场检测器。可变形磁场发生器包括嵌入柔性材料中的一对场线圈，其允许场线圈塑性变形以适应诸如患者肢体的身体区域的轮廓。场检测器沿着预定的通路对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与平均磁通密度的预选比率。当复合磁通密度根据目标组织受到的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。通过将这些精确的预定频率比率保持为平均磁通密度，可以控制目标组织的生长特性。

4. 发明授权

US5269745A Method and apparatus for controlling tissue growth with an applied fluctuating magnetic field 失效
标题翻译：用施加的波动磁场控制组织生长的方法和装置
公开(公告)号：US5269745A
公开(公告)日：1993-12-14
申请号：US861673
申请日：1992-04-01
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating tissue growth in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, growth characteristics of the target tissue are controlled.
摘要翻译：提供了一种用于调节体内组织生长的装置和方法。该装置包括磁场发生器和磁场检测器，用于产生平行于通过目标组织突出的预定轴线的受控的，波动的定向取向的磁场。场检测器沿着预定的通路对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与平均磁通密度的预选比率。当复合磁通密度根据目标组织受到的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。通过将这些精确的预定频率比率保持为平均磁通密度，可以控制目标组织的生长特性。

5. 发明授权

US5267939A Techniques for controlling osteoporosis using non-invasive magnetic fields 失效
标题翻译：使用非侵入性磁场控制骨质疏松症的技术
公开(公告)号：US5267939A
公开(公告)日：1993-12-07
申请号：US774439
申请日：1991-10-10
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/02 , A61N2/04 , A61N1/00
CPC分类号： A61N2/02
摘要： An apparatus and method for preventing and therapeutically treating osteoporosis are provided. The apparatus includes a magnetic field generator for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target bone or skeletal system. In one aspect, a field detector samples the magnetic flux density along the predetermined axis and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density which controls osteoporosis. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target bone is subjected.
摘要翻译：提供了预防和治疗骨质疏松症的装置和方法。该装置包括磁场发生器，用于产生平行于通过目标骨骼或骨骼系统突出的预定轴线的受控的，波动的定向取向的磁场。在一个方面，场检测器沿着预定轴对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与控制骨质疏松的平均磁通密度的预选比率。当复合磁通密度根据目标骨经受的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。

6. 发明授权

US5143588A Techniques for enhancing the permeability of ions through membranes 失效
标题翻译：通过膜增强离子渗透性的技术
公开(公告)号：US5143588A
公开(公告)日：1992-09-01
申请号：US561844
申请日：1990-08-02
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N1/32 , A61N2/02 , C12N13/00
CPC分类号： C12N13/00 , A61N1/325 , A61N2/02
摘要： A method is provided for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane located in a space subjected to a local magnetic field. The space defines at least one reference path passing through the membrane in opposite first and second directions. The method includes the steps of creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending in the first direction along the path. This component of the magnetic field has a magnitude that fluctuates at a predetermined rate to produce a nonzero average value. A predetermined relationship between the ratio of the selected rate to the nonzero average value and the charge-to-mass ratio of the predetermined ion is thereby created. The predetermined relationship is a function of the cyclotron resonance frequency of the ion.The present invention also provides an apparatus for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane. The apparatus includes field creating means responsive to signals for creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having flux density with at least one component representable by a component vector having a direction extending along a path through the membrane and having a magnitude that fluctuates at a predetermined rate to create a nonzero average value. The ratio of the predetermined rate to the nonzero average value has a predetermined relationship with respect to the charge-to-mass ratio of the predetermined ion which is a function of the cyclotron resonance frequency of the ion. Signal generating means is provided for generating the signals, at least some of which are generated at the predetermined rate.
摘要翻译：提供了一种通过位于经受局部磁场的空间中的生物分子膜来增强具有预定电荷质量比的选定离子的输送的方法。该空间限定了沿相反的第一和第二方向穿过膜的至少一个参考路径。该方法包括产生磁场的步骤，当与局部磁场组合时，产生具有磁通密度的磁场，该磁场具有至少一个分量，该分量矢量具有沿着该路径在第一方向上延伸的分量矢量。磁场的这个分量具有以预定速率波动以产生非零平均值的幅度。由此产生所选择的速率与非零平均值的比率与预定离子的电荷质量比之间的预定关系。预定关系是离子的回旋共振频率的函数。本发明还提供一种用于通过生物分子膜增强具有预定电荷质量比的选定离子的输送的装置。该装置包括响应于用于产生磁场的信号的场产生装置，其与局部磁场组合产生具有通量密度的磁场，该磁场具有至少一个分量，该分量矢量具有沿着穿过该磁场的路径延伸的分量矢量膜并且具有以预定速率波动以产生非零平均值的幅度。预定速率与非零平均值的比率相对于作为离子的回旋加速器共振频率的函数的预定离子的电荷质量比具有预定关系。信号发生装置被提供用于产生信号，其中至少一些以预定速率产生。

7. 发明授权

US5088976A Deformable magnetic field aiding coils for use in controlling tissue growth 失效
标题翻译：用于控制组织生长的变形磁场辅助线圈
公开(公告)号：US5088976A
公开(公告)日：1992-02-18
申请号：US280395
申请日：1988-12-05
申请人： Abraham R. Liboff , Stephen D. Smith , Bruce R. McLeod
发明人： Abraham R. Liboff , Stephen D. Smith , Bruce R. McLeod
IPC分类号： A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating the growth of living tissue are provided. The apparatus includes a deformable magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The deformable magnetic field generator includes a pair of field coils embedded in a flexible material which allows the field coils to be plastically deformed to fit the contour of a body region such as a patient's limb. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise determined ratios of frequency to average magnetic flux density, growth characteristics of the target tissue are controlled.
摘要翻译：提供了一种用于调节生物体组织生长的装置和方法。该装置包括可变形磁场发生器和用于产生平行于通过目标组织突出的预定轴线的受控的，波动的定向磁场的磁场检测器。可变形磁场发生器包括嵌入柔性材料中的一对场线圈，其允许场线圈塑性变形以适应诸如患者肢体的身体区域的轮廓。场检测器沿着预定的通路对磁通密度进行采样，并向确定通量密度的平均值的微处理器提供信号。施加的磁场以预定频率振荡，以保持频率与平均磁通密度的预选比率。当复合磁通密度根据目标组织受到的局部磁场的变化而变化时，通过调节波动磁场的频率和/或调整所施加的磁场的强度来维持该比例。通过保持这些精确确定的频率与平均磁通密度的比值，控制靶组织的生长特性。

8. 发明授权

US4932951A Method and apparatus for controlling tissue growth and an applied fluctuating magnetic field 失效
标题翻译：用于控制组织生长和施加的波动磁场的方法和装置
公开(公告)号：US4932951A
公开(公告)日：1990-06-12
申请号：US172268
申请日：1988-03-23
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N2/00 , A61N2/02 , A61N2/04
CPC分类号： A61N2/02
摘要： An apparatus and method for regulating tissue growth in vivo are provided. The apparatus includes a magnetic field generator and a magnetic field detector for producing a controlled, fluctuating, directionally oriented magnetic field parallel to a predetermined axis projecting through the target tissue. The field detector samples the magnetic flux density along the predetermined access and provides a signal to a microprocessor which determines the average value of the flux density. The applied magnetic field is oscillated at predetermined frequencies to maintain a preselected ratio of frequency to average flux density. This ratio is maintained by adjusting the frequency of the fluctuating magnetic field and/or by adjusting the intensity of the applied magnetic field as the composite magnetic flux density changes in response to changes in the local magnetic field to which the target tissue is subjected. By maintaining these precise predetermined ratios of frequency to average magnetic flux density, growth characteristics of the target tissue are controlled.

9. 发明授权

US4818697A Techniques for enhancing the permeability of ions through membranes 失效
公开(公告)号：US4818697A
公开(公告)日：1989-04-04
申请号：US923760
申请日：1986-10-27
申请人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
发明人： Abraham R. Liboff , Bruce R. McLeod , Stephen D. Smith
IPC分类号： A61N1/30 , A61N1/32 , A61N2/00 , A61N2/02 , B01D61/00 , C12N13/00 , G05D21/02 , G05F7/00
CPC分类号： C12N13/00 , A61N1/325 , A61N2/02
摘要： A method is provided for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane located in a space subjected to a local magnetic field. The space defines at least one reference path passing through the membrane in opposite first and second directions. The method includes the steps of creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending in the first direction along the path. This component of the magnetic field has a magnitude that fluctuates at a predetermined rate to produce a nonzero average value. A predetermined relationship between the ratio of the selected rate to the nonzero average value and the charge-to-mass ratio of the predetermined ion is thereby created. The predetermined relationship, is a function of the cyclotron resonance frequency of the ion.The present invention also provides an apparatus for enhancing the transport of a selected ion having a predetermined charge-to-mass ratio through a biomolecular membrane. The apparatus includes field creating means responsive to signals for creating a magnetic field which, when combined with the local magnetic field, produces a magnetic field having a flux density with at least one component representable by a component vector having a direction extending along a path through the membrane and having a magnitude that fluctuates at a predetermined rate to create a nonzero average value. The ratio of the predetermined rate to the nonzero average value has a predetermined relationship with respect to the charge-to-mass ratio of the predetermined ion which is a function of the cyclotron resonance frequency of the ion. Signal generating means is provided for generating the signals, at least some of which are generated at the predetermined rate.

10. 发明授权

US6146586A Dual current method and apparatus for sterilization of medical devices 失效
标题翻译：用于医疗器械灭菌的双电流方法和装置
公开(公告)号：US6146586A
公开(公告)日：2000-11-14
申请号：US84959
申请日：1998-05-28
申请人： Bruce R. McLeod , J. William Costerton
发明人： Bruce R. McLeod , J. William Costerton
IPC分类号： A61L2/03 , A61L2/18 , A61L2/24
CPC分类号： A61L2/035 , A61L2/18 , A61L2/24
摘要： In order to completely sterilize all of the surfaces of a medical instrument on which biofilms are apt to form, the device is immersed in a container containing an antibiotic solution in a manner wherein all of the contaminated surfaces are forced into intimate contact with the antibiotic solution. A first current is applied to a first electrode disposed at one end of the container to establish a first current flow about the exterior of the instrument between the first electrode and a second distal electrode which is either proximate or in direct contact with an end portion of the device. A second current is passed between a third electrode which is either in electrical contact with a part of the instrument that is not immersed in the antibiotic solution, or immersed in the solution has been forced into the interior of the device, and the second electrode via a second current path which extends through the interior of the instrument. The two currents are applied for a predetermined time selected to achieve the sterilization of any biofilms which have formed.
摘要翻译：为了对生物膜易于形成的医疗器具的所有表面进行完全灭菌，将该装置浸入容纳抗生素溶液的容器中，其中所有被污染的表面被迫与抗生素溶液紧密接触。将第一电流施加到设置在容器的一端处的第一电极，以在第一电极和第二远端电极之间建立围绕仪器外部的第一电流，所述第一电极与第二电极的接近或直接接触的第二远端电极装置。第二电流在与浸没在抗生素溶液中的仪器的一部分电接触的第三电极或浸入溶液中的第三电极被迫进入器件的内部，并且第二电极通过延伸穿过仪器内部的第二电流路径。施加两个电流达预定时间，以实现已经形成的任何生物膜的灭菌。

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