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1. 发明授权

US08663625B2 Diffusively permeable monolithic biomaterial with embedded microfluidic channels 有权
标题翻译：具有嵌入式微流体通道的可扩散的整体生物材料
公开(公告)号：US08663625B2
公开(公告)日：2014-03-04
申请号：US11251707
申请日：2005-10-17
申请人： Abraham D. Stroock , Mario Cabodi , Lawrence Bonassar
发明人： Abraham D. Stroock , Mario Cabodi , Lawrence Bonassar
IPC分类号： A61K9/00
CPC分类号： A61F13/00012 , A61F2/30756 , A61F13/00063 , A61F13/00068 , A61F13/069 , A61F15/00 , A61F2002/2817 , A61F2002/30677 , A61F2002/30766 , A61F2002/30785 , A61F2002/30957 , A61F2013/00523 , A61F2013/00536 , A61F2013/00927 , A61F2310/00365 , A61L27/20 , A61L27/3817 , A61L27/3839 , C08L5/04
摘要： The present invention relates to a monolithic biomaterial. The monolithic biomaterial has a primary network of convective flow, microfluidic channels that are embedded in a substrate, where the substrate is diffusively permeable to aqueous solutes. The present invention also relates to a method of making the monolithic biomaterial, as well as methods of using the monolithic biomaterial to facilitate healing of a cutaneous wound of a mammalian subject and of regulating cells.
摘要翻译：本发明涉及一种整体式生物材料。单片生物材料具有嵌入基底中的对流流动的主要网络，微流体通道，其中基底对水溶性溶质具有扩散的渗透性。本发明还涉及制造整体式生物材料的方法，以及使用整体生物材料促进哺乳动物受试者的皮肤伤口愈合和调节细胞的方法。

2. 发明申请

US20120079876A1 MICROTENSIOMETER SENSOR, PROBE AND METHOD OF USE 有权
标题翻译：微型计量传感器，探头和使用方法
公开(公告)号：US20120079876A1
公开(公告)日：2012-04-05
申请号：US13264964
申请日：2010-04-16
申请人： Abraham D. Stroock , Alan N. Lakso , Vinay Pagay , Bojan Llic , Meredith Metzler
发明人： Abraham D. Stroock , Alan N. Lakso , Vinay Pagay , Bojan Llic , Meredith Metzler
IPC分类号： G01N13/02
CPC分类号： G01N13/02 , G01N33/0098 , G01N2013/0275 , Y10T137/189
摘要： A microtensiometer sensor includes a substrate layer fluidly coupled to an enclosed reservoir. A porous membrane is disposed on a surface of the substrate layer. The membrane defines a liquid side fluidly coupled to the reservoir and a vapor side fluidly coupled to a vapor interface. The porous membrane includes a plurality of through holes fluidly coupling the liquid reservoir to the vapor interface, and a nanoporous filler material disposed within the plurality of through holes. The filler material includes a plurality of open pores having a maximum diameter in the range of 0.2 to 200 nanometers. In one embodiment, the microtensiometer sensor includes a molecular membrane disposed adjacent to the vapor side of the porous membrane. In one example, the molecular membrane is formed of a highly crystalline polytetrafluoroethylene polymer having a microstructure characterized by nodes interconnected by fibrils. In one application, the microtensiometer sensor may be used in a probe to measure the average water potential within a network of plant or tree xylem. In another application, the microtensiometer sensor may be useful in real-time determination of the water potential in soil.
摘要翻译：微量计传感器包括流体耦合到封闭储存器的基底层。多孔膜设置在基底层的表面上。膜限定液体侧流体耦合到储存器和蒸气侧，其流体地耦合到蒸气界面。多孔膜包括将液体储存器流体耦合到蒸汽界面的多个通孔，以及设置在多个通孔内的纳米孔填料。填充材料包括多个开孔，其最大直径在0.2至200纳米的范围内。在一个实施例中，微量计传感器包括邻近多孔膜的蒸汽侧设置的分子膜。在一个实例中，分子膜由具有微结构特征的高度结晶的聚四氟乙烯聚合物形成，其中纤维通过原纤维相互连接。在一个应用中，微量计传感器可用于探针中以测量植物或树木质部分网络内的平均水势。在另一个应用中，微量计传感器可用于实时测定土壤中的水势。

3. 发明授权

US09702636B2 High performance wick 有权
公开(公告)号：US09702636B2
公开(公告)日：2017-07-11
申请号：US12990845
申请日：2009-05-05
申请人： Abraham D. Stroock , Tobias Wheeler
发明人： Abraham D. Stroock , Tobias Wheeler
IPC分类号： F28D15/04 , F28D15/02
CPC分类号： F28D15/046 , Y10T428/24322
摘要： A wicking apparatus includes a composite condenser membrane comprising a substrate layer, a vapor inlet end, a liquid discharge end, a plurality of cavities disposed in the substrate layer fluidly coupling the vapor inlet end to the liquid discharge end, and a nanoporous filler material disposed within the plurality of cavities. The nanoporous filler material has a first plurality of open pores with a maximum diameter in the range of 0.2 to 200 nanometers. The first end of the liquid conduit is fluidly coupled to the liquid discharge end of the composite condenser membrane. The wicking apparatus further includes a wick composite evaporator membrane comprising a substrate layer, a liquid inlet end, a vapor discharge end, a plurality of cavities disposed in the substrate layer fluidly coupling the liquid inlet end to the second end of the liquid conduit, and a nanoporous filler material disposed within the plurality of cavities.

4. 发明授权

US08695407B2 Microtensiometer sensor, probe and method of use 有权
标题翻译：微量计传感器，探头和使用方法
公开(公告)号：US08695407B2
公开(公告)日：2014-04-15
申请号：US13264964
申请日：2010-04-16
申请人： Abraham D. Stroock , Alan N. Lakso , Vinay Pagay , Bojan Ilic , Meredith Metzler
发明人： Abraham D. Stroock , Alan N. Lakso , Vinay Pagay , Bojan Ilic , Meredith Metzler
IPC分类号： G01N19/10 , A01G27/00
CPC分类号： G01N13/02 , G01N33/0098 , G01N2013/0275 , Y10T137/189
摘要： A microtensiometer sensor includes a substrate layer fluidly coupled to an enclosed reservoir. A porous membrane is disposed on a surface of the substrate layer. The membrane defines a liquid side fluidly coupled to the reservoir and a vapor side fluidly coupled to a vapor interface. The porous membrane includes a plurality of through holes fluidly coupling the liquid reservoir to the vapor interface, and a nanoporous filler material disposed within the plurality of through holes. The filler material includes a plurality of open pores having a maximum diameter in the range of 0.2 to 200 nanometers. In one embodiment, the microtensiometer sensor includes a molecular membrane disposed adjacent to the vapor side of the porous membrane. In one example, the molecular membrane is formed of a highly crystalline polytetrafluoroethylene polymer having a microstructure characterized by nodes interconnected by fibrils. In one application, the microtensiometer sensor may be used in a probe to measure the average water potential within a network of plant or tree xylem. In another application, the microtensiometer sensor may be useful in real-time determination of the water potential in soil.
摘要翻译：微量计传感器包括流体耦合到封闭储存器的基底层。多孔膜设置在基底层的表面上。膜限定液体侧流体耦合到储存器和蒸气侧，其流体地耦合到蒸汽界面。多孔膜包括将液体储存器流体耦合到蒸汽界面的多个通孔，以及设置在多个通孔内的纳米孔填料。填充材料包括多个开孔，其最大直径在0.2至200纳米的范围内。在一个实施例中，微量计传感器包括邻近多孔膜的蒸汽侧设置的分子膜。在一个实例中，分子膜由具有微结构特征的高度结晶的聚四氟乙烯聚合物形成，其中纤维通过原纤维相互连接。在一个应用中，微量计传感器可用于探针中以测量植物或树木质部分网络内的平均水势。在另一个应用中，微量计传感器可用于实时测定土壤中的水势。

5. 发明申请

US20110146956A1 HIGH PERFORMANCE WICK 有权
标题翻译：高性能纸
公开(公告)号：US20110146956A1
公开(公告)日：2011-06-23
申请号：US12990845
申请日：2009-05-05
申请人： Abraham D. Stroock , Tobias Wheeler
发明人： Abraham D. Stroock , Tobias Wheeler
IPC分类号： F28D15/04 , B32B3/24 , B32B3/26
CPC分类号： F28D15/046 , Y10T428/24322
摘要： A wicking apparatus includes a composite condenser membrane comprising a substrate layer, a vapor inlet end, a liquid discharge end, a plurality of cavities disposed in the substrate layer fluidly coupling the vapor inlet end to the liquid discharge end, and a nanoporous filler material disposed within the plurality of cavities. The nanoporous filler material has a first plurality of open pores with a maximum diameter in the range of 0.2 to 200 nanometers. The first end of the liquid conduit is fluidly coupled to the liquid discharge end of the composite condenser membrane. The wicking apparatus further includes a wick composite evaporator membrane comprising a substrate layer, a liquid inlet end, a vapor discharge end, a plurality of cavities disposed in the substrate layer fluidly coupling the liquid inlet end to the second end of the liquid conduit, and a nanoporous filler material disposed within the plurality of cavities.
摘要翻译：芯吸装置包括：复合冷凝器膜，其包括基底层，蒸汽入口端，液体排出端，设置在基底层中的多个空腔，其将蒸气入口端流体连接到液体排出端;以及纳米孔填料，在多个空腔内。纳米孔填料具有第一多个开孔，最大直径在0.2-200纳米的范围内。液体导管的第一端与复合冷凝器膜的液体排出端流体耦合。芯吸装置还包括芯吸复合蒸发器膜，其包括基底层，液体入口端，蒸气放电端，设置在将液体入口端流体连接到液体导管的第二端的基底层中的多个空腔，以及设置在所述多个空腔内的纳米孔填料。

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