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1. 发明授权

US09775930B2 Composition for modifying myocardial infarction expansion 有权
公开(公告)号：US09775930B2
公开(公告)日：2017-10-03
申请号：US14685474
申请日：2015-04-13
申请人： Abbott Cardiovascular Systems Inc. , Medical University of South Carolina
发明人： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
IPC分类号： C12P7/28 , A61L27/26 , A61L27/20 , A61L27/22 , A61L27/50 , A61L27/52 , A61L27/38
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.

2. 发明申请

US20170258961A9 COMPOSITION FOR MODIFYING MYOCARDIAL INFARCTION EXPANSION 审中-公开
公开(公告)号：US20170258961A9
公开(公告)日：2017-09-14
申请号：US14685474
申请日：2015-04-13
申请人： Abbott Cardiovascular Systems Inc. , Medical University of South Carolina
发明人： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
IPC分类号： A61L27/26 , A61L27/38
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.

3. 发明授权

US09408949B2 Coatings for implantable devices comprising polymers of lactic acid and methods for fabricating the same 有权
标题翻译：用于包含乳酸聚合物的可植入装置的涂层及其制造方法
公开(公告)号：US09408949B2
公开(公告)日：2016-08-09
申请号：US14476623
申请日：2014-09-03
申请人： Abbott Cardiovascular Systems Inc.
发明人： Syed F. A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
IPC分类号： A61F13/00 , A61L31/10 , A61L31/14 , A61L31/16 , A61L29/08 , A61L31/08 , A61L27/28 , A61L27/34
CPC分类号： A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译：公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。

4. 发明申请

US20150182672A1 COATINGS FOR IMPLANTABLE MEDICAL DEVICES 审中-公开
标题翻译：可植入医疗器械的涂层
公开(公告)号：US20150182672A1
公开(公告)日：2015-07-02
申请号：US14643576
申请日：2015-03-10
申请人： Abbott Cardiovascular Systems Inc.
发明人： Eugene T. Michal , Syed F.A. Hossainy , Ashok Shah
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61K31/337 , A61K31/4745 , A61K31/56 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/606 , C08F8/00 , C08F8/30 , C08F8/32 , C08F2800/10 , C08F2810/50 , C08G18/6212 , C08G18/711 , C09D151/003 , C09D151/06 , C09D151/08 , C09D175/04 , C08L2666/02 , C08L2666/04 , C08L2666/14 , C08F216/06 , C08F8/34 , C08F210/02 , C08F8/14
摘要： The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.
摘要翻译：本申请教导了具有与聚合物缀合或混合的生物相容性化合物的涂层，其中所述聚合物包括至少一种烯烃衍生单元和至少一种衍生自乙烯醇，烯丙醇或其衍生物的单元。

5. 发明授权

US09402814B2 Methods and devices for forming treatment agent carriers 有权
标题翻译：用于形成治疗剂载体的方法和装置
公开(公告)号：US09402814B2
公开(公告)日：2016-08-02
申请号：US14299764
申请日：2014-06-09
申请人： Abbott Cardiovascular Systems Inc.
发明人： Shubhayu Basu , Eugene T. Michal
IPC分类号： A61K38/18 , A61K9/48 , A61K9/14 , A61K9/50 , A61K38/30
CPC分类号： A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodible material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
摘要翻译：描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。颗粒可以沉积在包含液相的收集组件中。另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将颗粒与生物可腐蚀材料混合描述了形成凝胶的能力。具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

6. 发明申请

US20140294945A1 METHODS AND DEVICES FOR FORMING TREATMENT AGENT CARRIERS 审中-公开
标题翻译：用于形成处理剂载体的方法和装置
公开(公告)号：US20140294945A1
公开(公告)日：2014-10-02
申请号：US14299764
申请日：2014-06-09
申请人： Abbott Cardiovascular Systems Inc.
发明人： Shubhayu Basu , Eugene T. Michal
IPC分类号： A61K9/48 , A61K38/30
CPC分类号： A61K9/4833 , A61K9/145 , A61K9/5031 , A61K38/30
摘要： A method is described including passing a solution having a biodegradable polymer, a solvent and a treatment agent through an electrocharged nozzle to form particles encapsulating the treatment agent. The particles emitted from the electrocharged nozzle may be exposed to a charge opposite that of the nozzle. The particles may be deposited in a collection assembly comprising a liquid phase. A further method including combining a biodegradable polymer, a solvent and a treatment agent to form a solution, electrodepositing the solution in a particle form wherein the particles encapsulate the treatment agent in a collection assembly comprising a liquid phase and mixing the particles with a bioerodable material capable of forming a gel is described. An apparatus having an electrocharged nozzle, a grounded electrode having an opposite charge to that of the nozzle and a collection assembly comprising a liquid phase is further disclosed.
摘要翻译：描述了一种方法，包括使具有可生物降解的聚合物，溶剂和处理剂的溶液通过电荷注入喷嘴以形成包封处理剂的颗粒。从电荷喷嘴发射的颗粒可以暴露于与喷嘴相反的电荷。颗粒可以沉积在包含液相的收集组件中。另一种方法包括组合可生物降解聚合物，溶剂和处理剂以形成溶液，以颗粒形式电沉积溶液，其中颗粒将包含液相的收集组合物包封处理剂并将颗粒与可生物侵蚀的材料混合描述了形成凝胶的能力。具有电荷喷嘴的设备，具有与喷嘴相反的电荷的接地电极和包括液相的收集组件进一步被公开。

7. 发明申请

US20150209473A1 METHODS OF MODIFYING MYOCARDIAL INFARCTION EXPANSION 审中-公开
公开(公告)号：US20150209473A1
公开(公告)日：2015-07-30
申请号：US14685474
申请日：2015-04-13
申请人： Abbott Cardiovascular Systems Inc.
发明人： Eugene T. Michal , Shubhayu Basu , Alexander J. Sheehy , Francis G. Spinale , Rupak Mukherjee
IPC分类号： A61L27/26 , A61L27/38
CPC分类号： A61L27/26 , A61L27/20 , A61L27/22 , A61L27/3834 , A61L27/50 , A61L27/52 , A61L2300/418 , A61L2300/64 , A61L2400/06 , A61L2430/20 , C08L5/04 , C08L89/00
摘要： A bioscaffolding can be formed within a post-myocardial infarct region sufficient to cause attenuation of a rate of myocardial infarct expansion. A bioscaffolding may further be formed in the post-myocardial infarct region to cause an increase in posterior left ventricular wall thickness. The gel or bioscaffolding can be formed from a mixture of gel components of different gelation systems. For example, a bioscaffolding can be formed by mixing at least two different components of at least two different two-component gelation systems to form a first mixture and by mixing at least two different components (other than the components that make up the first mixture) of the at least two different two-component gelation systems to form a second mixture.

8. 发明申请

US20140377325A1 COATINGS FOR IMPLANTABLE DEVICES COMPRISING POLYMERS OF LACTIC ACID AND METHODS FOR FABRICATING THE SAME 审中-公开
标题翻译：包含乳酸聚合物的可植入装置的涂料及其制造方法
公开(公告)号：US20140377325A1
公开(公告)日：2014-12-25
申请号：US14476623
申请日：2014-09-03
申请人： Abbott Cardiovascular Systems Inc.
发明人： Syed F.A. Hossainy , Yiwen Tang , Eugene T. Michal , Thierry Glauser , Stephen D. Pacetti , Jessica DesNoyer
IPC分类号： A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61F2250/0067 , A61L27/28 , A61L27/34 , A61L29/08 , A61L29/085 , A61L31/08 , A61L31/148 , A61L31/16 , A61L2420/00 , A61L2420/02 , A61L2420/06 , C08L67/04
摘要： Coatings for an implantable medical device and a method of fabricating thereof are disclosed, the coatings comprising polymers of lactic acid.
摘要翻译：公开了用于可植入医疗装置的涂层及其制造方法，所述涂层包含乳酸聚合物。

9. 发明申请

US20140038907A1 Coatings For Implantable Medical Devices 审中-公开
标题翻译：可植入医疗器械用涂料
公开(公告)号：US20140038907A1
公开(公告)日：2014-02-06
申请号：US14044693
申请日：2013-10-02
申请人： Abbott Cardiovascular Systems Inc.
发明人： Eugene T. Michal , Syed F.A. Hossainy , Ashok Shah
IPC分类号： A61L31/10
CPC分类号： A61L31/10 , A61K31/337 , A61K31/4745 , A61K31/56 , A61L31/16 , A61L2300/416 , A61L2300/43 , A61L2300/606 , C08F8/00 , C08F8/30 , C08F8/32 , C08F2800/10 , C08F2810/50 , C08G18/6212 , C08G18/711 , C09D151/003 , C09D151/06 , C09D151/08 , C09D175/04 , C08L2666/02 , C08L2666/04 , C08L2666/14 , C08F216/06 , C08F8/34 , C08F210/02 , C08F8/14
摘要： The present application teaches a coating having a biologically compatible compound conjugated to, or blended with, a polymer, wherein the polymer includes at least one olefin-derived unit and at least one unit derived from a vinyl alcohol, an allyl alcohol, or derivatives thereof.
摘要翻译：本申请教导了具有与聚合物缀合或混合的生物相容性化合物的涂层，其中所述聚合物包括至少一种烯烃衍生单元和至少一种衍生自乙烯醇，烯丙醇或其衍生物的单元。

10. 发明申请

US20130317599A1 MICRONIZED PEPTIDE COATED STENT 审中-公开
标题翻译：微胶囊包衣
公开(公告)号：US20130317599A1
公开(公告)日：2013-11-28
申请号：US13942474
申请日：2013-07-15
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.
发明人： Eugene T. Michal , Ashok A. Shah , Ni Ding
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61L31/10 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/45
摘要： A coating for an implantable device such as a stent is provided including micronized peptides. A method of making the same is also provided.
摘要翻译：提供了用于诸如支架的可植入装置的涂层，其包括微粉化肽。还提供了制造该方法的方法。

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