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1. 发明申请

US20060067927A1 Methods and compositions related to the modulation of intercellular junctions 失效
公开(公告)号：US20060067927A1
公开(公告)日：2006-03-30
申请号：US11171490
申请日：2005-06-29
申请人： Aarthi Chandrasekaran , Shiladitya Sengupta , David Berry , Kristine Holley , Ganlin Zhao , Ram Sasisekharan
发明人： Aarthi Chandrasekaran , Shiladitya Sengupta , David Berry , Kristine Holley , Ganlin Zhao , Ram Sasisekharan
IPC分类号： A61K38/47 , A61K31/737 , A61K31/727
CPC分类号： A61K38/51 , A61K31/00 , A61K31/726 , A61K31/727 , A61K31/737 , A61K38/45 , A61K45/06 , A61K47/36 , A61K2300/00
摘要： The invention relates to compositions and methods for the modulation of the permeability of the epithelial cell barrier complex. In particular, the invention provides compositions and methods for using polysaccharides, preferably glycosaminoglycans, and agents that modify cell surface glycosaminoglycans, preferably glycosaminoglycan-degrading enzymes to modulate intercellular junctions. The compositions and methods provided can be used to facilitate the delivery of biologically active molecules.

2. 发明申请

US20070020243A1 Methods and compositions related to modulating the extracellular stem cell environment 审中-公开
标题翻译：与调节细胞外干细胞环境相关的方法和组合
公开(公告)号：US20070020243A1
公开(公告)日：2007-01-25
申请号：US11332766
申请日：2006-01-12
申请人： Shiladitya Sengupta , Ram Sasisekharan , Nishla Keiser , David Eavarone , Tanyel Kiziltepe Bilgicer , Aarthi Chandrasekaran , David Berry , Kristine Holley
发明人： Shiladitya Sengupta , Ram Sasisekharan , Nishla Keiser , David Eavarone , Tanyel Kiziltepe Bilgicer , Aarthi Chandrasekaran , David Berry , Kristine Holley
IPC分类号： A61K35/12 , C12N5/08 , C12N5/06
CPC分类号： A61K31/726 , A61K31/727 , A61K38/47 , C12N5/0606 , C12N5/0691 , C12N2501/70 , C12N2506/02
摘要： This invention relates, in part, to methods and compositions that modulate the stem cell environment. More specifically, the invention relates, in part, to methods and compositions for modulating stem cell differentiation. Such modulation, in some aspects of the invention, is accomplished by agents that modulate glycosaminoglycans in the stem cell microenvironment (i.e., at or on the cell surface and/or in the extracellular matrix). Therefore, methods and compositions are provide for modulating glycosaminoglycan moieties, e.g., heparan sulfate glycosaminoglycan (HSGAG) moieties, in the microenvironment of stem cells. Methods and compositions for promoting or inhibiting embryonic stem cell differentiation (e.g., differentiation into endothelial cells) are also provided. This invention also relates, therefore, in part, to cell populations (e.g., endothelial cell populations or impoverished endothelial cell populations) that can be produced with the methods and compositions provided. Furthermore, the invention relates, in part, to tissues, and uses thereof, formed by the methods and compositions provided. Moreover, the invention also relates, in part, to methods of treatment using the methods and compositions provided.
摘要翻译：本发明部分涉及调节干细胞环境的方法和组合物。更具体地，本发明部分涉及用于调节干细胞分化的方法和组合物。在本发明的某些方面，这种调节是通过调节干细胞微环境中的糖胺聚糖（即在细胞表面上和/或细胞外基质中）上的调节剂来完成的。因此，提供了在干细胞的微环境中调节糖胺聚糖部分，例如硫酸乙酰肝素糖胺聚糖（HSGAG）部分的方法和组合物。还提供了用于促进或抑制胚胎干细胞分化（例如分化成内皮细胞）的方法和组合物。因此，本发明还部分地涉及可以用所提供的方法和组合物产生的细胞群体（例如，内皮细胞群体或贫血的内皮细胞群体）。此外，本发明部分地涉及通过所提供的方法和组合物形成的组织及其用途。此外，本发明还部分涉及使用提供的方法和组合物的治疗方法。

3. 发明申请

US20060083711A1 Methods and products related to the intracellular delivery of polysaccharides 审中-公开
标题翻译：与多糖细胞内转运相关的方法和产品
公开(公告)号：US20060083711A1
公开(公告)日：2006-04-20
申请号：US11107360
申请日：2005-04-15
申请人： David Berry , Daniel Anderson , David Lynn , Ram Sasisekharan , Robert Langer
发明人： David Berry , Daniel Anderson , David Lynn , Ram Sasisekharan , Robert Langer
IPC分类号： A61K31/785 , A61K31/737 , A61K31/727
CPC分类号： A61K45/06 , A61K31/726 , A61K31/727 , A61K31/737 , A61K31/785 , A61K47/593 , A61K2300/00
摘要： The invention relates, in part, to methods and compositions for the intracellular delivery of polysaccharides. In particular, the methods and compositions relate to the intracellular delivery of glycosaminoglycans, such as heparin. The invention in other aspects relates to the use of glycosaminoglycans for the treatment of proliferative disorders, such as cancer. The invention is still other aspects relates to improving cell viability. The invention also relates to the delivery of polysaccharides while avoiding unwanted effects of the polysaccharides. For example, heparin can be delivered while avoiding its anticoagulant effects.
摘要翻译：本发明部分地涉及多糖的细胞内递送的方法和组合物。特别地，所述方法和组合物涉及糖胺聚糖如肝素的细胞内递送。本发明在其它方面涉及使用糖胺聚糖来治疗增殖性疾病如癌症。本发明还涉及提高细胞活力的其它方面。本发明还涉及多糖的递送，同时避免多糖的不期望的影响。例如，可以输送肝素同时避免其抗凝血作用。

4. 发明申请

US20060154894A1 Biologically active surfaces and methods of their use 审中-公开
标题翻译：生物活性表面及其使用方法
公开(公告)号：US20060154894A1
公开(公告)日：2006-07-13
申请号：US11229488
申请日：2005-09-15
申请人： David Berry , Alireza Khademhosseini , Kahp Suh , Ram Sasisekharan , Robert Langer
发明人： David Berry , Alireza Khademhosseini , Kahp Suh , Ram Sasisekharan , Robert Langer
IPC分类号： A61K31/737 , A61K31/727
CPC分类号： C08L5/08 , A61K31/726 , A61K31/727 , A61K31/737 , A61L17/10 , A61L27/20 , A61L27/38 , A61L29/043 , A61L31/042 , C08J7/047 , C08J2405/00 , C09D105/08 , C08L5/10
摘要： The invention relates to the immobilization of polysaccharides on a substrate. In particular, the invention relates to biologically active surfaces formed by the immobilization of glycosaminoglycans on a substrate. The invention also provides biologically active surfaces that contain one or more different glycosaminoglycans and, optionally, one or more other agents. These agents can be biological or therapeutic agents. The invention also relates to methods of using the surfaces of the invention, such as, methods of affecting biological processes, eliciting patterns of cellular response, screening, treatment, diagnosis and preventing food contamination and/or spoilage.
摘要翻译：本发明涉及在底物上固定多糖。特别地，本发明涉及通过在基质上固定糖胺聚糖形成的生物活性表面。本发明还提供含有一种或多种不同的糖胺聚糖和任选的一种或多种其它试剂的生物活性表面。这些试剂可以是生物或治疗剂。本发明还涉及使用本发明的表面的方法，例如影响生物过程的方法，引发细胞反应的模式，筛选，治疗，诊断和预防食物污染和/或腐败。

5. 发明申请

US20120120967A1 Universal Serial Interface 审中-公开
标题翻译：通用串行接口
公开(公告)号：US20120120967A1
公开(公告)日：2012-05-17
申请号：US13077521
申请日：2011-03-31
申请人： Ali Ghiasi , Krishna Kalidindi , David Berry
发明人： Ali Ghiasi , Krishna Kalidindi , David Berry
IPC分类号： H04J99/00 , G06F15/16
CPC分类号： H04L25/4908
摘要： A communication device may utilize a serial interface to communicate with a peer device via a serial interface link utilizing a serial interface protocol. The communication device may be operable to generate a first serial signal from a first plurality of signals associated with one or more interface protocols. The generated first serial signal may be communicated to the peer device via the serial interface link. The peer device may then regenerate the first plurality of signals from the communicated first serial signal. The communication device may be operable to receive a second serial signal from the peer device via the serial interface link. The second serial signal was generated by the peer device from a second plurality of signals associated with the one or more interface protocols. The communication device may then regenerate the second plurality of signals from the received second serial signal.
摘要翻译：通信设备可以利用串行接口通过串行接口链路与对等设备进行通信，利用串行接口协议。通信设备可以用于从与一个或多个接口协议相关联的第一多个信号中产生第一串行信号。生成的第一串行信号可以经由串行接口链路传送到对等设备。然后，对等设备可以从传送的第一串行信号中再生第一多个信号。通信设备可以用于经由串行接口链路从对等设备接收第二串行信号。第二串行信号由对等设备从与一个或多个接口协议相关联的第二多个信号生成。然后，通信设备可以从所接收的第二串行信号中再生第二多个信号。

6. 发明授权

US07744625B2 Repair of ruptured membrane by injection of naturally occurring protein in amniotic fluid sac 失效
标题翻译：通过在羊水囊中注射天然存在的蛋白质来修复破裂的膜
公开(公告)号：US07744625B2
公开(公告)日：2010-06-29
申请号：US10144472
申请日：2002-05-13
申请人： David Berry
发明人： David Berry
IPC分类号： A61B17/08 , A61K35/54
CPC分类号： A61K38/38 , A61B17/00491 , A61B17/0057 , A61B17/42 , A61K2300/00
摘要： The present invention provides compositions and methods for use in treatment of premature rupture of membrane. The compositions of the invention include a therapeutic amount of an avian thick egg white composition. Preferably, the compositions include the purified thick egg white protein, ovomucin. The methods of the invention involve injecting an effective amount of the compositions into the prematurely ruptured amniotic sac of a patient in order to seal the rupture.
摘要翻译：本发明提供了用于治疗膜过早破裂的组合物和方法。本发明的组合物包括治疗量的禽蛋白组合物。优选地，组合物包括纯化的厚蛋白蛋白质，卵蛋白质。本发明的方法包括将有效量的组合物注射到患者的过早破裂的羊膜囊中，以密封破裂。

7. 发明授权

US07666136B2 Retractor 失效
标题翻译：牵引器
公开(公告)号：US07666136B2
公开(公告)日：2010-02-23
申请号：US10511967
申请日：2003-04-22
申请人： Alistair Royse , David Berry , Brett Hamilton , Michael Kerr
发明人： Alistair Royse , David Berry , Brett Hamilton , Michael Kerr
IPC分类号： A61B1/32
CPC分类号： A61B17/0206 , A61B17/0293
摘要： A retractor for use in surgery, has arms (2, 4) pivotal into a V-shaped configuration. Blades (16) are carried by the arms via mounting portions (16a) which can slide along the arms to provide adjustment in position with the blades being locked in that position simply by skewing the mounting portions on the arms.
摘要翻译：用于手术的牵开器具有枢转成V形构型的臂（2,4）。叶片（16）通过可沿着臂滑动的安装部分（16a）由臂支撑，以通过使臂上的安装部分歪斜而将叶片锁定在该位置来提供位置调节。

8. 发明申请

US20060177857A1 Dark quenchers, probes and other conjugates incorporating the same, and their use 有权
标题翻译：暗猝灭剂，探针和其它掺合物的共轭物及其用途
公开(公告)号：US20060177857A1
公开(公告)日：2006-08-10
申请号：US11346688
申请日：2006-02-03
申请人： David Berry , William Pearson
发明人： David Berry , William Pearson
IPC分类号： C12Q1/68 , C07H19/04 , C07F9/576
CPC分类号： C07H19/073 , C07D455/04 , C07F9/6561 , C07H19/04 , C09B35/039
摘要： The specification discloses quenchers of excited state energy, probes and other conjugates comprising the same, and methods for their use. The quenchers of excited state energy have a structure comprising at least one reactive functional group for linking the quencher to a carrier molecule, and at least three radicals covalently linked via exocyclic diazo bonds, the at least three radicals including at least one comprising a julolidine of the nominal formula: and the remainder of the at least three radicals being selected from the group of substituted and unsubstituted aryls, substituted and unsubstituted heteroaryls, and combinations thereof.
摘要翻译：该说明书公开了激发态能量的猝灭剂，探针和包含其的共轭物，以及它们的使用方法。激发态能的猝灭剂具有包含至少一个用于将猝灭剂与载体分子连接的至少一个反应性官能团的结构，以及至少三个通过环外重氮键共价连接的基团，所述至少三个基团包括至少一个，所述至少三个基团的其余部分选自取代和未取代的芳基，取代和未取代的杂芳基，及其组合。

9. 发明申请

US20060129170A1 Surgical clamps 失效
标题翻译：手术钳
公开(公告)号：US20060129170A1
公开(公告)日：2006-06-15
申请号：US10521422
申请日：2002-07-26
申请人： Alistair Royce , Brett Hamilton , David Berry , Michael Kerr
发明人： Alistair Royce , Brett Hamilton , David Berry , Michael Kerr
IPC分类号： A61B17/08
CPC分类号： A61B17/122
摘要： An arterial clamp has opposed clamping posts arranged to lie at opposite sides of an artery to clamp the artery between opposed clamping faces of the posts. The posts are carried by a pair of arms pivotally movable one relative to the other to move the posts into clamping relationship with the artery. A ratchet device releasably locks the arms in a selected clamping position. The clamp including posts, arms, and ratchet device is formed as a one-piece plastics moulding.
摘要翻译：动脉夹具具有相对的夹持柱，其布置成位于动脉的相对侧以将动脉夹持在柱的相对夹紧面之间。柱由一对相对于另一个臂枢转运动的臂支撑，以将柱移动成与动脉夹紧关系。棘爪装置可释放地将臂锁定在选定的夹紧位置。包括柱，臂和棘轮装置的夹具形成为一体式塑料模制件。

10. 发明授权

US4261755A Acid formates for use as setting and early strength development accelerators in cementitious compositions 失效
标题翻译：酸性甲酸酯用作水泥组合物中的固化和早期强度开发促进剂
公开(公告)号：US4261755A
公开(公告)日：1981-04-14
申请号：US091746
申请日：1979-11-06
申请人： David Berry , Brian D. Black , Peter Kirby
发明人： David Berry , Brian D. Black , Peter Kirby
IPC分类号： C04B24/04 , C04B7/35
CPC分类号： C04B24/04
摘要： This invention relates to the use of sodium, calcium and ammonium salts of formic acid as early strength developers and setting accelerators in hydraulic cements, concretes, mortars and plasters. The salts used are acidic salts containing between 1.5 and 5 moles of the formate ion per mole of the cation. These salts have much greater solubility and are more effective than the corresponding calcium salts, particularly under low temperature conditions.
摘要翻译：本发明涉及甲酸钠，钙和铵盐作为早期强度显影剂和在水硬水泥，混凝土，砂浆和灰泥中固化加速剂的用途。使用的盐是每摩尔阳离子含有1.5至5摩尔甲酸根离子的酸性盐。这些盐具有更大的溶解度，并且比相应的钙盐更有效，特别是在低温条件下。

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