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1. 发明申请

US20030153901A1 Drug delivery panel 审中-公开
标题翻译：药物输送面板
公开(公告)号：US20030153901A1
公开(公告)日：2003-08-14
申请号：US10187074
申请日：2002-06-28
申请人： Atrium Medical Corporation
发明人： Steve Herweck , Paul Martakos , Theodore Karwoski , Roger Labrecque
IPC分类号： A61F002/06
CPC分类号： A61F2/86 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device having a removable polymeric drug delivery panel electrostatically coupled to a surface of a radially expandable structure is provided. The removable polymeric drug delivery panel provides a microporous structure suitable for embedding one or more bioactive agents to allow for kinetic release of the agent or agents at a desired location within a hollow fluid body organ. The removable polymeric drug delivery panel is characterized as having a relatively large and flat surface area to allow for extended or high volumes of kinetic release potential at the site.
摘要翻译：提供了一种植入式医疗装置，其具有静电耦合到径向可扩张结构的表面的可移除的聚合物药物递送面板。可移除的聚合物药物递送面板提供适于嵌入一种或多种生物活性剂的微孔结构，以允许试剂或试剂在中空流体体器官内的期望位置的动力释放。可移除的聚合物药物递送面板的特征在于具有相对较大且平坦的表面积，以允许在该部位延长或高体积的动力释放电位。

2. 发明申请

US20020183716A1 Expandable fluoropolymer device and method of making 有权
标题翻译：可膨胀氟聚合物装置及其制造方法
公开(公告)号：US20020183716A1
公开(公告)日：2002-12-05
申请号：US10131396
申请日：2002-04-22
申请人： ATRIUM MEDICAL CORPORATION
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： B29C049/00 , B29C049/04 , B29C047/00 , B29C071/02 , A61M031/00
CPC分类号： A61L29/041 , A61M25/10 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , Y10T428/1376 , C08L27/18
摘要： A radially expandable device having a body constructed of a generally inelastic, expanded fluoropolymer material is described. The body is deployable upon application of a radial expansion force from a reduced diameter, collapsed configuration to an expanded configuration having a pre-defined and fixed increased diameter. The body has a singular, unitary construction of generally homogenous material that is characterized by a seamless construction of expanded fluoropolymer material, such as expanded polytetrafluoroethylene (ePTFE), and is preferably constructed through an extrusion and expansion process. The body is further characterized by a microstructure of nodes interconnected by fibrils in which substantially all the nodes of the body are oriented generally perpendicularly to the longitudinal axis of the body. The monolithic construction of the body and the orientation of the nodes, perpendicular to the longitudinal axis of the body, yields a radially expandable device that predictably and dependably expands to a predefined, fixed maximum diameter that is generally independent of the expansion force used to radially expand the device. In addition, the microstructure of nodes interconnected by fibrils provides at least one predetermined flow rate of fluid therethrough over a range of fluid pressures.
摘要翻译：描述了具有由通常非弹性的，膨胀的含氟聚合物材料构成的主体的径向可扩张装置。当径向膨胀力从减小的直径，收缩构型施加到具有预定义和固定的增大直径的膨胀构型时，主体可展开。本体具有通常均匀的材料的单一，单一结构，其特征在于扩展的含氟聚合物材料如膨胀聚四氟乙烯（ePTFE）的无缝构造，并且优选通过挤出和膨胀方法构造。身体的特征还在于通过原纤维相互连接的节点的微结构，其中主体的基本上所有的节点大致垂直于身体的纵向轴线定向。身体的整体结构和垂直于身体的纵向轴线的节点的取向产生可预测和可靠地扩展到预定的，固定的最大直径的径向可扩张装置，其通常与用于径向的膨胀力无关展开设备。此外，通过原纤维互连的节点的微观结构在一定范围的流体压力下提供至少一个预定的流体流速。

3. 发明申请

US20030062650A1 Method for treating expandable polymer materials and products produced therefrom 有权
标题翻译：用于处理可膨胀聚合物材料和由其制备的产品的方法
公开(公告)号：US20030062650A1
公开(公告)日：2003-04-03
申请号：US10131446
申请日：2002-04-22
申请人： ATRIUM MEDICAL CORPORATION
发明人： Paul Martakos , Roger Labrecque , Geoffrey Moodie , Steve A. Herweck , Theodore Karwoski
IPC分类号： B29C047/00 , B29C047/88
CPC分类号： A61F2/06
摘要： The invention is directed to methods involving rewetting of expandable polymers with a wettable liquid to allow for enhanced expansion at or below room temperature without breakage, and in some cases, allows one to achieve a greater expansion ratio than that allowed at elevated temperatures using known methods. The wettable liquid can be formed of a drug and/or an agent, such that the resulting polymer contains and emits the drug upon positioning at a target location of a patient body. The present invention also allows one to achieve material with unique properties and handling characteristics. These properties included decreased material thickness, increased density, an altered node/fibril morphology, and a more consistent web in the case of flat material. This method is not limited to room temperature conditions and can be applied whenever the expandable polymer material is wet with a wettable liquid, and the expansion is performed at a temperature preferably below the vaporization or boiling points of that liquid.
摘要翻译：本发明涉及包括用可湿性液体再湿润可膨胀聚合物以允许在室温或低于室温下增强膨胀而不破裂的方法，并且在某些情况下允许使用已知方法获得比在升高的温度下更大的膨胀比。可湿性液体可以由药物和/或药剂形成，使得所得聚合物在定位在患者身体的目标位置时含有和释放药物。本发明还可以实现具有独特性质和处理特性的材料。这些性质包括材料厚度减小，密度增加，节点/原纤维形态改变，以及在平坦材料情况下更一致的网。该方法不限于室温条件，只要可膨胀聚合物材料用可湿性液体润湿，并且膨胀在优选低于该液体的蒸发或沸点的温度下进行。

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