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1. 发明申请

US20180354925A1 NOVEL HYDROXYL PYRANONE COMPOUND, METHOD FOR PRODUCING SAME, AND COSMETICS COMPOSITION COMPRISING COMPOUND 审中-公开
公开(公告)号：US20180354925A1
公开(公告)日：2018-12-13
申请号：US15780421
申请日：2016-11-30
申请人： AMOREPACIFIC CORPORATION
发明人： Ho Sik RHO , Jae Won YOO , Yong Jin KIM
IPC分类号： C07D309/40 , A61K8/49 , A61Q19/08
CPC分类号： C07D309/40 , A61K8/498 , A61Q19/08
摘要： The present invention relates to a novel hydroxyl pyranone compound, a method for producing same, and a cosmetic composition having the compound. The hydroxyl pyranone compound according to the present invention exhibits markedly improved effectiveness compared to the conventional adipocyte differentiation-promoting material, and thus is preferably included as an active ingredient in a cosmetic composition for increasing skin volume or elasticity.

2. 发明申请

US20180078522A1 COMPOSITION FOR ACTIVATING LONGEVITY GENES, CONTAINING KOJIC ACID DERIVATIVE AS ACTIVE INGREDIENT 审中-公开
公开(公告)号：US20180078522A1
公开(公告)日：2018-03-22
申请号：US15563119
申请日：2016-03-28
申请人： AMOREPACIFIC CORPORATION
发明人： Hyun Jung KIM , Ji Hyun KIM , Jue Won KIM , Ho Sik RHO , Hyun Seo KANG
IPC分类号： A61K31/351 , A61Q19/00 , A61K8/49
CPC分类号： A61K31/351 , A61K8/498 , A61K31/35 , A61K31/36 , A61Q19/00 , A61Q19/007 , A61Q19/08
摘要： Disclosed is a composition for activating longevity genes, particularly, a Sirt-1, Klotho, XPD, ERCC8 or FoxO3a gene, containing a kojic acid derivative as an active ingredient. The composition activates longevity genes, thereby having anticancer, lifetime extension, skin moisturization or skin barrier strengthening effects.

3. 发明申请

US20180370939A1 NOVEL HYDROXYL PYRANONE COMPOUND, METHOD FOR PRODUCING SAME, AND COSMETICS COMPOSITION COMPRISING COMPOUND 审中-公开
公开(公告)号：US20180370939A1
公开(公告)日：2018-12-27
申请号：US15780412
申请日：2016-11-28
申请人： AMOREPACIFIC CORPORATION
发明人： Ho Sik RHO , Jae Won YOO , Yong Jin KIM
IPC分类号： C07D309/40 , A61K8/49 , A61Q19/08
摘要： The present invention relates to a novel hydroxyl pyranone compound, a method for producing same, and a cosmetic composition having the compound. The hydroxyl pyranone compound according to the present invention exhibits markedly improved effectiveness compared to the conventional adipocyte differentiation-promoting material, and thus is preferably included as an active ingredient in a cosmetic composition for increasing skin volume or elasticity.

4. 发明申请

US20180065922A1 NOVEL BENZOIC ACID AMIDE COMPOUND 审中-公开
公开(公告)号：US20180065922A1
公开(公告)日：2018-03-08
申请号：US15561585
申请日：2016-03-30
申请人： AMOREPACIFIC CORPORATION
发明人： Yung Hyup JOO , Soo Jeong CHOI , Heung Soo BAEK , Chang Seok LEE , Jeong Hwan KIM , Yongjin KIM , Hong-Ju SHIN , Ho Sik RHO , Song Seok SHIN , Jon Hwan LEE
IPC分类号： C07C233/70 , A61K8/42 , A61K31/166 , A61Q19/02
CPC分类号： C07C233/70 , A23L29/00 , A61K8/42 , A61K31/166 , A61Q19/02 , C07C231/12 , C07C235/48
摘要： Disclosed are a novel benzoic acid amide derivative compound, an isomer thereof, a pharmaceutically acceptable salt thereof, a prodrug thereof, a hydrate thereof, or a solvate thereof. The novel compound and the like inhibit melanin production, prevent tyrosinase activity, and have an excellent skin whitening effect.

5. 发明申请

US20190010137A1 PSEUDO-CERAMIDE COMPOUND AND PREPARATION METHOD THEREFOR 审中-公开
公开(公告)号：US20190010137A1
公开(公告)日：2019-01-10
申请号：US16064764
申请日：2016-12-15
申请人： AMOREPACIFIC CORPORATION
发明人： Yung Hyup JOO , Jae Won YOO , Yong Jin KIM , Ho Sik RHO , John Hwan LEE
IPC分类号： C07D311/72 , A61Q19/00 , A61Q17/00 , A61K8/68
摘要： The present invention relates to a pseudo-ceramide compound and a method for preparing the same. The pseudo-ceramide compound of the present invention may provide antioxidant effects, and exhibits improved properties such as high solubility compared to existing natural ceramides and pseudo-ceramide compounds, and therefore, may be included in large quantities in the formulation. Accordingly, the pseudo-ceramide compound may be used in various fields such as cosmetics, medicinal substances, external preparations and foods.

6. 发明申请

US20160324824A1 COSMETIC COMPOSITION CONTAINING HYDROXY PYRANONE DERIVATIVE COMPOUND FOR PROMOTING DIFFERENTIATION OF ADIPOCYTES 审中-公开
标题翻译：含有羟基吡咯烷酮衍生化合物的化妆品组合物用于促进ADIPOCY的分化
公开(公告)号：US20160324824A1
公开(公告)日：2016-11-10
申请号：US15107955
申请日：2015-01-20
申请人： AMOREPACIFIC CORPORATION
发明人： Ho Sik RHO , Heung Soo BAEK , Yu Jung KIM , Song Seok SHIN , John Hwan LEE
IPC分类号： A61K31/357 , A61K8/49 , A61Q19/00 , A61K31/36
CPC分类号： A61K31/357 , A61K8/498 , A61K31/36 , A61K2800/74 , A61K2800/91 , A61K2800/92 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to a cosmetic composition containing a hydroxypyranone derivative compound as an active ingredient for promoting the differentiation of adipocytes. The composition according to the present invention has an effect of promoting the differentiation of adipocytes, and thus allows the differentiation of adipocyte in a skin layer, thereby increasing the skin volume or elasticity. Therefore, the composition of the present invention can be variously used as a cosmetic composition or a pharmaceutical composition in the field, such as skin damage.
摘要翻译：本发明涉及含有羟基吡喃酮衍生物化合物作为促进脂肪细胞分化的活性成分的化妆品组合物。根据本发明的组合物具有促进脂肪细胞分化的作用，从而允许脂肪细胞在皮肤层中分化，从而增加皮肤体积或弹性。因此，本发明的组合物可以各种用作本领域的化妆品组合物或药物组合物，例如皮肤损伤。

7. 发明申请

US20190248736A1 PSEUDO-CERAMIDE COMPOUND AND PREPARATION METHOD THEREFOR 审中-公开
公开(公告)号：US20190248736A1
公开(公告)日：2019-08-15
申请号：US16336893
申请日：2017-09-14
申请人： AMOREPACIFIC CORPORATION
发明人： Yung Hyup JOO , Jae Won YOO , Yong Jin KIM , Ho Sik RHO , John Hwan LEE
IPC分类号： C07C235/06 , C07C231/02 , C07B51/00
摘要： The present invention relates to a pseudo-ceramide compound and a preparation method therefor. According to the present invention, the pseudo-ceramide compound has a molecular structure and a function similar to those of a natural ceramide, can be readily synthesized, and has excellent solubility in an organic solvent and excellent stability, and thus the pseudo-ceramide compound can be used as an alternative to a natural ceramide. Therefore, the pseudo-ceramide compound of the present invention can be widely applied to a skin preparation for external use, a cosmetic composition, and the like for reinforcing and maintaining a skin barrier function.

8. 发明申请

US20180370940A1 SALICYLIC ACID DERIVATIVE, METHOD FOR PREPARING SAME, AND COSMETIC COMPOSITION FOR WHITENING COMPRISING SAME 审中-公开
公开(公告)号：US20180370940A1
公开(公告)日：2018-12-27
申请号：US16064753
申请日：2016-12-13
申请人： AMOREPACIFIC CORPORATION
发明人： Ho Sik RHO , Jae Won YOO , Yong Jin KIM
IPC分类号： C07D309/40 , A61K8/49 , A61Q19/02
摘要： The present invention relates to a novel salicylic acid derivative, a method for preparing the same, and a cosmetic composition for whitening having the same. The compound exhibits a skin whitening effect by acting on tyrosinase, which is a melanin producing enzyme, to inhibit the production of melanin, and exhibits an improved skin whitening effect compared with kojic acid, alkyl salicylic acid, or alkoxy salicylic acid, which is previously known as a skin whitening agent. Therefore, the compound can be variously applied to cosmetics, preparations for external use, and the like.

9. 发明申请

US20130129849A1 METHOD OF EXTERNAL SKIN APPLICATION OF COMPOSITION CONTAINING RED PINE ROOT EXTRACT 有权
标题翻译：含有红皮酚提取物的组合物外用皮肤应用方法
公开(公告)号：US20130129849A1
公开(公告)日：2013-05-23
申请号：US13756227
申请日：2013-01-31
申请人： AMOREPACIFIC CORPORATION
发明人： Ho Sik RHO , Eun Joo Kim , Ga Young Cho , Hye Yoon Park , Ji Seong Kim , Duck Hee Kim , Han Kon Kim
IPC分类号： A61K8/97 , A61Q19/00 , A61Q19/08
CPC分类号： A61K8/97 , A61Q17/04 , A61Q19/00 , A61Q19/08
摘要： The present invention relates to a composition for skin external application containing a pine root extract. More specifically, the composition for skin external application according to the present invention contains, as an active ingredient, a pine root extract which shows various effects, including eliminating free radicals, protecting the cell membrane from damage by UV radiation, inhibiting the production of reactive oxygen species caused by UV radiation, inhibiting the reduction in the expression of superoxide dismutase (SOD) and catalase caused by UV radiation, stimulating the production of HSP70 to protect cells, inhibiting MMP-2 biosynthesis caused by UV radiation, inducing the expression of SIRT1 gene that restores DNA damage, and inducing the expression of LMNA1 gene that maintains the structure of the nuclear membrane. Ultimately, the composition of the present invention prevents skin aging.
摘要翻译：本发明涉及含有松根提取物的皮肤外用组合物。更具体地，根据本发明的皮肤外用组合物含有作为活性成分的松果提取物，其显示各种效果，包括消除自由基，保护细胞膜免受紫外线辐射的损伤，抑制反应性的生成由紫外线引起的氧物质，抑制由紫外线辐射引起的超氧化物歧化酶（SOD）和过氧化氢酶的表达的降低，刺激HSP70的产生以保护细胞，抑制由UV辐射引起的MMP-2生物合成，诱导SIRT1的表达基因，其恢复DNA损伤，并诱导维持核膜结构的LMNA1基因的表达。最终，本发明的组合物可防止皮肤老化。

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