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1. 发明授权

US09925295B2 Ceramic and/or glass materials and related methods 有权
公开(公告)号：US09925295B2
公开(公告)日：2018-03-27
申请号：US15230305
申请日：2016-08-05
申请人： Amedica Corporation
发明人： Bryan J. McEntire , Ryan M. Bock , Giuseppe Pezzotti
IPC分类号： A61L27/02 , C23C16/56 , C04B35/597 , A61L27/54 , A61L27/10 , A61L27/30 , A61L27/50 , A61L27/44
CPC分类号： A61L27/025 , A61L27/10 , A61L27/306 , A61L27/446 , A61L27/50 , A61L27/54 , A61L2400/18 , A61L2430/02 , A61L2430/12 , C04B35/597 , C04B2235/3873 , C23C16/56
摘要： Methods for improving the antibacterial, osteoconductive, and/or osteoinductive characteristics of silicon nitride and/or other ceramic materials, particularly to make them more suitable for use in manufacturing biomedical implants. In some embodiments and implementations, the surface chemistry and/or morphology of a silicon nitride bioceramic may be modulated significantly through thermal, chemical, and/or mechanical treatments to achieve such advantageous results. A portion of the resulting material, such as a glaze or upper layer of the material, may be separately produced as a powder or frit, for example, and used in manufacturing biomedical implants and/or other products, such as by using such portion of the material as a coating or filler. In other embodiments the surface material may be separately manufactured as a silicon oxynitride monolith.

2. 发明授权

US09399309B2 Methods for threading sinterable materials and related apparatus and systems 有权
标题翻译：可烧结材料和相关设备和系统的穿线方法
公开(公告)号：US09399309B2
公开(公告)日：2016-07-26
申请号：US14070061
申请日：2013-11-01
申请人： AMEDICA CORPORATION
发明人： Bryan J. McEntire , Prabhakar Thirugnanasambandam
IPC分类号： B28B11/08 , B28B17/00 , A61L27/10
CPC分类号： B28B11/0854 , A61L27/10 , A61L2430/38 , B28B17/0063
摘要： Methods for threading ceramic materials, such as ceramic materials used for spinal implants or other biomedical implants. In some implementations, an expected rate of shrinkage of the block upon undergoing a firing process may be determined. A scaling factor may then be applied using the expected rate of shrinkage to select a tap having a size larger than a desired thread size. A green block may then be tapped with the selected tap to form a threaded opening in the green block. The block may be machined in order to remove cracks caused by the tapping process and/or to form the block into a desired shape/size. The green block may then be fired, which may result in a reduction of a size of the block and a size of the threaded opening.
摘要翻译：用于穿刺陶瓷材料的方法，例如用于脊柱植入物或其它生物医学植入物的陶瓷材料。在一些实施方案中，可以确定经历烧制过程的块的预期收缩率。然后可以使用期望的收缩率来应用缩放因子，以选择具有大于所需螺纹尺寸的尺寸的丝锥。然后可以用所选的龙头敲击绿色块，以在绿色块中形成螺纹孔。可以加工块以便去除由攻丝过程引起的裂纹和/或将块形成为期望的形状/尺寸。然后可以点燃绿色块，这可能导致块的尺寸减小和螺纹开口的尺寸。

3. 发明申请

US20140265064A1 ALUMINA-ZIRCONIA CERAMIC IMPLANTS AND RELATED MATERIALS, APPARATUS, AND METHODS 有权
标题翻译： ALUMINA-ZIRCONIA陶瓷植入物及相关材料，装置和方法
公开(公告)号：US20140265064A1
公开(公告)日：2014-09-18
申请号：US14213769
申请日：2014-03-14
申请人： Amedica Corporation
发明人： Bryan J. McEntire , Ramaswamy Lakshminarayanan , Ryan Bock
IPC分类号： C04B35/10
CPC分类号： C04B35/10 , A61L27/00 , A61L27/10 , A61L2430/24 , C04B35/117 , C04B35/119 , C04B35/44 , C04B35/62625 , C04B35/62685 , C04B35/6455 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3217 , C04B2235/3222 , C04B2235/3225 , C04B2235/3229 , C04B2235/3232 , C04B2235/3244 , C04B2235/6567 , C04B2235/663 , C04B2235/96
摘要： Embodiments of apparatus, systems, and methods relating to biomedical implants and other devices made up of unique and improved alumina-zirconia ceramic materials. In an example of a method according to an implementation of the invention, a slurry is prepared, compressed, and fired to obtain a fired ceramic piece comprising at least aluminum oxide, zirconium dioxide, yttrium oxide, cerium oxide, strontium oxide, magnesium oxide, titanium dioxide, and calcium oxide. Some embodiments and implementations may comprise selected concentrations of one or more such compounds to yield certain preferred results.
摘要翻译：与生物医学植入物和由独特和改进的氧化铝 - 氧化锆陶瓷材料组成的其他装置相关的装置，系统和方法的实施例。在根据本发明的实施方案的方法的实例中，制备，压缩和烧制浆料以获得至少包含氧化铝，二氧化锆，氧化钇，氧化铈，氧化锶，氧化镁，二氧化钛和氧化钙。一些实施方案和实施方案可以包含一种或多种这样的化合物的选定浓度以产生某些优选的结果。

4. 发明申请

US20170197014A1 ANTIBACTERIAL BIOMEDICAL IMPLANTS AND ASSOCIATED MATERIALS, APPARATUS, AND METHODS 审中-公开
公开(公告)号：US20170197014A1
公开(公告)日：2017-07-13
申请号：US15470637
申请日：2017-03-27
申请人： AMEDICA CORPORATION
发明人： Bryan J. McEntire , Ramaswamy Lakshminarayanan , Kevin Davis , Nicholas Grimaldi , Giuseppe Pezzotti
IPC分类号： A61L31/02 , A61L31/12 , A61L31/08 , A61L31/16
CPC分类号： A61L31/028 , A61L27/06 , A61L27/306 , A61L27/50 , A61L31/022 , A61L31/026 , A61L31/088 , A61L31/12 , A61L31/14 , A61L31/16 , A61L2300/10 , A61L2300/406 , A61L2400/18 , A61L2430/02 , A61L2430/38
摘要： Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process.

5. 发明申请

US20160262896A1 COMPOSITE METALLIC-CERAMIC IMPLANTS AND RELATED METHODS 审中-公开
标题翻译：复合金属陶瓷植入物及相关方法
公开(公告)号：US20160262896A1
公开(公告)日：2016-09-15
申请号：US15162363
申请日：2016-05-23
申请人： Amedica Corporation
发明人： Bhajanjit Singh Bal , Bryan J. McEntire , Ramaswamy Lakshminarayanan , Prabhakar Thirugnanasambandam
IPC分类号： A61F2/36
CPC分类号： A61F2/3859 , A61F2/30942 , A61F2/3609 , A61F2/389 , A61F2002/30037 , A61F2002/30107 , A61F2002/30332 , A61F2002/30337 , A61F2002/30474 , A61F2002/3611 , A61F2002/365 , A61F2310/00011 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/00203 , A61F2310/00239 , A61F2310/00317
摘要： Embodiments of biomedical implants and other devices made up of a composite of materials comprising metal and/or metal alloys and ceramics. In some embodiments, a modular biomedical implant may comprise a first metallic member comprising at least one of a metal and a metal alloy, a second metallic member comprising at least one of a metal and a metal alloy, and a ceramic sleeve positioned in between the first metallic member and the second metallic member so as to at least substantially prevent contact between the first metallic member and the second metallic member.
摘要翻译：由包含金属和/或金属合金和陶瓷的材料的复合材料制成的生物医学植入物和其它装置的实施例。在一些实施例中，模块化生物医学植入物可以包括包括金属和金属合金中的至少一种的第一金属构件，包括金属和金属合金中的至少一种的第二金属构件和位于第一金属构件和第二金属构件，以便至少基本上防止第一金属构件和第二金属构件之间的接触。

6. 发明申请

US20140265065A1 CHARGE-COMPENSATING DOPANT STABILIZED ALUMINA-ZIRCONIA CERAMIC MATERIALS AND RELATED MATERIALS, APPARATUS, AND METHODS 有权
标题翻译：充电稳定剂稳定的氧化铝 - 锆石陶瓷材料及相关材料，装置和方法
公开(公告)号：US20140265065A1
公开(公告)日：2014-09-18
申请号：US14216952
申请日：2014-03-17
申请人： Amedica Corporation
发明人： Ryan M. Bock , Bryan J. McEntire , Ramaswamy Lakshminarayanan
IPC分类号： C04B35/505 , C04B35/64
CPC分类号： C04B35/505 , A61L27/10 , A61L27/105 , A61L2430/24 , C04B35/117 , C04B35/119 , C04B35/44 , C04B35/62685 , C04B35/64 , C04B35/6455 , C04B2235/3206 , C04B2235/3208 , C04B2235/3213 , C04B2235/3217 , C04B2235/3222 , C04B2235/3224 , C04B2235/3225 , C04B2235/3229 , C04B2235/3232 , C04B2235/3244 , C04B2235/3251 , C04B2235/96
摘要： Ceramic materials comprising charge-compensating dopants and related methods. In some embodiments, the materials may comprise dopants such as Y2O3, Gd2O3, Nb2O5, and/or Ta2O5. Some embodiments may comprise a molar concentration of Y2O3 and/or Gd2O3 that is at least approximately equal to the molar concentration of Nb2O5 and/or Ta2O5. Certain embodiments and implementations may comprise particular, unique concentrations or concentration ranges of various compounds/materials in order to improve performance for use of such ceramic materials as biomedical implants.
摘要翻译：包括电荷补偿掺杂剂和相关方法的陶瓷材料。在一些实施例中，材料可以包括掺杂剂，例如Y 2 O 3，Gd 2 O 3，Nb 2 O 5和/或Ta 2 O 5。一些实施方案可以包含至少大约等于Nb 2 O 5和/或Ta 2 O 5的摩尔浓度的Y 2 O 3和/或Gd 2 O 3的摩尔浓度。某些实施方案和实施方式可以包括各种化合物/材料的特定浓度或浓度范围，以便提高使用这种陶瓷材料与生物医学植入物的性能。

7. 发明申请

US20130302509A1 ANTIBACTERIAL BIOMEDICAL IMPLANTS AND ASSOCIATED MATERIALS, APPARATUS, AND METHODS 审中-公开
标题翻译：抗生素生物医用植入物及相关材料，装置及方法
公开(公告)号：US20130302509A1
公开(公告)日：2013-11-14
申请号：US13890876
申请日：2013-05-09
申请人： Amedica Corporation
发明人： Bryan J. McEntire , Ramaswamy Lakshminarayanan , Kevin Davis , Nicholas Grimaldi
IPC分类号： A61L27/02
CPC分类号： A61L27/025 , A61L27/10 , A61L27/306 , A61L27/50 , A61L27/54 , A61L2300/104 , A61L2300/204 , A61L2300/404 , A61L2400/18 , A61L2430/38
摘要： Methods for improving the antibacterial characteristics of biomedical implants and related implants manufactured according to such methods. In some implementations, a biomedical implant comprising a silicon nitride ceramic material may be subjected to a surface roughening treatment so as to increase a surface roughness of at least a portion of the biomedical implant to a roughness profile having an arithmetic average of at least about 500 nm Ra. In some implementations, a coating may be applied to a biomedical implant. Such a coating may comprise a silicon nitride ceramic material, and may be applied instead of, or in addition to, the surface roughening treatment process.
摘要翻译：根据这些方法制造的生物医学植入物和相关植入物的抗菌特性的改善方法。在一些实施方案中，包括氮化硅陶瓷材料的生物医学植入物可以进行表面粗糙化处理，以将生物医学植入物的至少一部分的表面粗糙度增加到具有至少约500的算术平均值的粗糙度轮廓 nm Ra。在一些实施方案中，涂层可以应用于生物医学植入物。这种涂层可以包括氮化硅陶瓷材料，并且可以代替或除了表面粗糙化处理工艺之外被应用。

8. 发明申请

US20160166388A1 COMPOSITE METALLIC-CERAMIC IMPLANTS AND RELATED METHODS 审中-公开
标题翻译：复合金属陶瓷植入物及相关方法
公开(公告)号：US20160166388A1
公开(公告)日：2016-06-16
申请号：US14570916
申请日：2014-12-15
申请人： Amedica Corporation
发明人： Bhajanjit Singh Bal , Bryan J. McEntire , Ramaswamy Lakshminarayanan
IPC分类号： A61F2/30 , A61F2/38 , A61F2/36
CPC分类号： A61F2/3859 , A61F2/30942 , A61F2/3609 , A61F2/389 , A61F2002/30037 , A61F2002/30107 , A61F2002/30332 , A61F2002/30337 , A61F2002/30474 , A61F2002/3611 , A61F2002/365 , A61F2310/00023 , A61F2310/00029 , A61F2310/00089 , A61F2310/00203 , A61F2310/00239 , A61F2310/00317
摘要： Embodiments of apparatus, systems, and methods relating to biomedical implants and other devices made up of a composite of materials comprising metal and/or metal alloys and ceramics. In some embodiments, a modular biomedical implant may comprise a first metallic member comprising at least one of a metal and a metal alloy, a second metallic member comprising at least one of a metal and a metal alloy, and a monolithic ceramic insert comprising a ceramic material positioned in between the first metallic member and the second metallic member so as to at least substantially prevent contact between the first metallic member and the second metallic member.
摘要翻译：与由金属和/或金属合金和陶瓷的材料复合材料构成的生物医学植入物和其他装置相关的装置，系统和方法的实施例。在一些实施例中，模块化生物医学植入物可以包括包括金属和金属合金中的至少一种的第一金属构件，包括金属和金属合金中的至少一种的第二金属构件，以及包括陶瓷位于第一金属构件和第二金属构件之间的材料至少基本上防止第一金属构件和第二金属构件之间的接触。

9. 发明申请

US20140124991A1 METHODS FOR THREADING SINTERABLE MATERIALS AND RELATED APPARATUS AND SYSTEMS 有权
标题翻译：烧结可燃材料及相关设备和系统的方法
公开(公告)号：US20140124991A1
公开(公告)日：2014-05-08
申请号：US14070061
申请日：2013-11-01
申请人： AMEDICA CORPORATION
发明人： Bryan J. McEntire , Prabhakar Thirugnanasambandam
IPC分类号： B28B11/08
CPC分类号： B28B11/0854 , A61L27/10 , A61L2430/38 , B28B17/0063
摘要： Methods for threading ceramic materials, such as ceramic materials used for spinal implants or other biomedical implants. In some implementations, an expected rate of shrinkage of the block upon undergoing a firing process may be determined. A scaling factor may then be applied using the expected rate of shrinkage to select a tap having a size larger than a desired thread size. A green block may then be tapped with the selected tap to form a threaded opening in the green block. The block may be machined in order to remove cracks caused by the tapping process and/or to form the block into a desired shape/size. The green block may then be fired, which may result in a reduction of a size of the block and a size of the threaded opening.
摘要翻译：用于穿刺陶瓷材料的方法，例如用于脊柱植入物或其它生物医学植入物的陶瓷材料。在一些实施方案中，可以确定经历烧制过程的块的预期收缩率。然后可以使用期望的收缩率来应用缩放因子，以选择具有大于所需螺纹尺寸的尺寸的丝锥。然后可以用所选的龙头敲击绿色块，以在绿色块中形成螺纹孔。可以加工块以便去除由攻丝过程引起的裂纹和/或将块形成为期望的形状/尺寸。然后可以点燃绿色块，这可能导致块的尺寸减小和螺纹开口的尺寸。

10. 发明申请

US20130236854A1 CERAMIC ORAL IMPLANTS AND RELATED APPARATUS, SYSTEMS, AND METHODS 审中-公开
标题翻译：陶瓷口腔植入物及相关设备，系统和方法
公开(公告)号：US20130236854A1
公开(公告)日：2013-09-12
申请号：US13789408
申请日：2013-03-07
申请人： AMEDICA CORPORATION
发明人： Bryan J. McEntire , Ramaswamy Lakshminarayanan
IPC分类号： A61C8/00
CPC分类号： A61C8/0013 , A61C8/0022 , Y10T29/49567
摘要： Oral implants and related methods, systems, and apparatus. Some embodiments may comprise a silicon nitride bone anchor configured to be integrated with and affixed to alveolar bone of a patient's oral bone cavity. The bone anchor may comprise a core and an outer layer comprising a silicon nitride ceramic material. The outer layer may have a density less than a density of the core. An anchor abutment may be coupled with the bone anchor, and may be configured to protrude above epithelial tissue of the patient's oral cavity and provide a substrate for positioning and fixation of a dental component, such as a crown or bridge.
摘要翻译：口腔种植体及相关方法，系统和装置。一些实施例可以包括构造成与患者的口腔骨腔的牙槽骨整合并固定到患者口腔骨的牙槽骨上的氮化硅骨锚。骨锚可以包括芯和包含氮化硅陶瓷材料的外层。外层可以具有小于芯的密度的密度。锚定邻接件可以与骨锚固件联接，并且可以构造成突出在患者口腔的上皮组织上方，并且提供用于定位和固定诸如牙冠或牙桥的牙科部件的基底。

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