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1. 发明申请

US20170027724A1 DEVICES AND METHODS FOR TREATMENT OF THE EUSTACHIAN TUBE AND SINUS CAVITY 审中-公开
标题翻译：用于治疗EUSTACHIAN TUBE和SINUS CAVITY的装置和方法
公开(公告)号：US20170027724A1
公开(公告)日：2017-02-02
申请号：US15290886
申请日：2016-10-11
申请人： Abbott Cardiovascular Systems Inc.
发明人： Syed Hossainy , Paul Consigny , Dariush Davalian , James Su , Michael Ngo , Adrain Gale , Jesus Magana , Mikael Trollsas , Evan Norton , Benjamyn Serna
IPC分类号： A61F2/958 , A61M29/02 , A61F2/915 , A61F11/00 , A61B1/06
CPC分类号： A61F2/958 , A61B1/06 , A61F2/915 , A61F11/002 , A61F2002/91575 , A61F2002/91583 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0046 , A61F2250/0048 , A61F2250/005 , A61F2250/0082 , A61M25/10 , A61M29/02 , A61M2025/105 , A61M2025/1059 , A61M2210/0675
摘要： A polymeric stent can be implanted for treatment of the Eustachian tube. The stent can be designed to have length-dependent radial strength to allow it to stay within the Eustachian tube and to allow normal closing and opening of the Eustachian tube. A balloon can be used to implant the stent, and the balloon can be coated with a therapeutic agent. A coated balloon can also be used to transfer therapeutic agents to the sinus cavity during a balloon sinus dilation procedure.
摘要翻译：可以植入聚合物支架以治疗咽鼓管。支架可以设计成具有长度依赖的径向强度，以允许其保持在咽鼓管内并允许正常的关闭和打开咽鼓管。可以使用气囊来植入支架，并且可以用治疗剂涂覆气囊。在气球窦扩张过程中，涂覆的气囊也可以用于将治疗剂转移到窦腔。

2. 发明申请

US20140330361A1 SEGMENTED SCAFFOLD DESIGNS 审中-公开
标题翻译： SEGMENTED SCAFFOLD设计
公开(公告)号：US20140330361A1
公开(公告)日：2014-11-06
申请号：US14333354
申请日：2014-07-16
申请人： Abbott Cardiovascular Systems Inc.
发明人： John E. Papp , Syed Faiyaz Ahmed Hossainy , Michael Ngo , Chad Abunassar , Boris Anukhin , Mikael Trollsas , Lewis B. Schwartz
IPC分类号： A61F2/86
CPC分类号： A61F2/915 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/958 , A61F2002/826 , A61F2002/9155 , A61F2002/91591 , A61F2210/00 , A61F2230/0013 , A61F2230/0054 , A61F2240/001 , B29C35/0805 , B29C65/64 , B29C66/1248 , B29C66/71 , B29C2035/0838 , B29K2067/046 , B29K2995/006 , B29L2031/7534
摘要： Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.
摘要翻译：公开了由具有重叠端环的断开的支架段组成的分段支架。还公开了具有至少一个不连续链节的支架。

3. 发明授权

US08828436B2 Methods and compositions for treating tissue using silk proteins 有权
标题翻译：使用丝蛋白处理组织的方法和组合物
公开(公告)号：US08828436B2
公开(公告)日：2014-09-09
申请号：US13888143
申请日：2013-05-06
申请人： Abbott Cardiovascular Systems Inc.
发明人： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
IPC分类号： A61K35/28 , C07K17/08 , A61F2/00 , A61K47/48 , C08L89/00 , A61K47/42 , A61L27/38 , A61K9/00 , A61L27/52 , A61K47/34 , A61L27/48
CPC分类号： A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
摘要翻译：本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。还公开了包括适合递送组合物的递送装置的试剂盒。在一些实施方案中，组合物可以包括至少三种组分。在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。

4. 发明申请

US20130251764A1 METHODS AND COMPOSITIONS FOR TREATING TISSUE USING SILK PROTEINS 有权
标题翻译：用丝素蛋白处理组织的方法和组合物
公开(公告)号：US20130251764A1
公开(公告)日：2013-09-26
申请号：US13888143
申请日：2013-05-06
申请人： Abbott Cardiovascular Systems Inc.
发明人： Syed Hossainy , Michael Ngo , Mikael Trollsas , John Stankus , Gene Michal
IPC分类号： A61K47/42 , A61K47/34
CPC分类号： A61K47/42 , A61K9/0024 , A61K47/34 , A61L27/3804 , A61L27/3839 , A61L27/3895 , A61L27/48 , A61L27/52 , Y10S530/812 , Y10S530/815 , C08L89/00 , C08L71/02
摘要： Compositions for forming a self-reinforcing composite biomatrix, methods of manufacture and use therefore are herein disclosed. Kits including delivery devices suitable for delivering the compositions are also disclosed. In some embodiments, the composition can include at least three components. In one embodiment, a first component can include a first functionalized polymer, a second component can include a second functionalized polymer and a third component can include silk protein or constituents thereof. In some embodiments, the composition can include at least one cell type and/or at least one growth factor. In some embodiments, the composition can include a biologic encapsulated, suspended, disposed within or loaded into a biodegradable carrier. In some embodiments, the composition(s) of the present invention can be delivered by a dual lumen injection device to a treatment area in situ, in vivo, as well as ex vivo applications.
摘要翻译：本文公开了用于形成自增强复合生物基质的组合物，因此制造和使用方法。还公开了包括适合递送组合物的递送装置的试剂盒。在一些实施方案中，组合物可以包括至少三种组分。在一个实施方案中，第一组分可以包括第一官能化聚合物，第二组分可以包括第二官能化聚合物，第三组分可以包括丝蛋白或其组分。在一些实施方案中，组合物可以包括至少一种细胞类型和/或至少一种生长因子。在一些实施方案中，组合物可以包括生物封装的，悬浮的，置于生物降解载体内或加载到可生物降解的载体中。在一些实施方案中，本发明的组合物可以通过双腔注射装置原位，体内和离体应用递送至治疗区域。

5. 发明授权

US09585778B2 Segmented scaffold designs 有权
标题翻译：分段脚手架设计
公开(公告)号：US09585778B2
公开(公告)日：2017-03-07
申请号：US14333344
申请日：2014-07-16
申请人： Abbott Cardiovascular Systems Inc.
发明人： John E. Papp , Syed Faiyaz Ahmed Hossainy , Michael Ngo , Chad Abunassar , Boris Anukhin , Mikael Trollsas , Lewis B. Schwartz
IPC分类号： A61F2/06 , A61F2/90 , A61F2/89 , A61F2/915 , A61F2/958 , A61F2/86 , A61F2/82
CPC分类号： A61F2/915 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/958 , A61F2002/826 , A61F2002/9155 , A61F2002/91591 , A61F2210/00 , A61F2230/0013 , A61F2230/0054 , A61F2240/001 , B29C35/0805 , B29C65/64 , B29C66/1248 , B29C66/71 , B29C2035/0838 , B29K2067/046 , B29K2995/006 , B29L2031/7534
摘要： Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.
摘要翻译：公开了由具有重叠端环的断开的支架段组成的分段支架。还公开了具有至少一个不连续链节的支架。

6. 发明授权

US09510976B2 Devices and methods for treatment of the Eustachian tube and sinus cavity 有权
标题翻译：用于治疗咽鼓管和窦腔的装置和方法
公开(公告)号：US09510976B2
公开(公告)日：2016-12-06
申请号：US14265343
申请日：2014-04-29
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.
发明人： Syed Hossainy , Paul Consigny , Dariush Davalian , James Su , Michael Ngo , Adrain Gale , Jesus Magana , Mikael Trollsas , Evan Norton , Benjamyn Serna
IPC分类号： A61F11/00 , A61M25/10 , A61F2/915 , A61F2/958 , A61M29/02
CPC分类号： A61F2/958 , A61B1/06 , A61F2/915 , A61F11/002 , A61F2002/91575 , A61F2002/91583 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0046 , A61F2250/0048 , A61F2250/005 , A61F2250/0082 , A61M25/10 , A61M29/02 , A61M2025/105 , A61M2025/1059 , A61M2210/0675
摘要： A polymeric stent can be implanted for treatment of the Eustachian tube. The stent can be designed to have length-dependent radial strength to allow it to stay within the Eustachian tube and to allow normal closing and opening of the Eustachian tube. A balloon can be used to implant the stent, and the balloon can be coated with a therapeutic agent. A coated balloon can also be used to transfer therapeutic agents to the sinus cavity during a balloon sinus dilation procedure.
摘要翻译：可以植入聚合物支架以治疗咽鼓管。支架可以设计成具有长度依赖的径向强度，以允许其保持在咽鼓管内并允许正常的关闭和打开咽鼓管。可以使用气囊来植入支架，并且可以用治疗剂涂覆气囊。在气球窦扩张过程中，涂覆的气囊也可以用于将治疗剂转移到窦腔。

7. 发明申请

US20150305943A1 Devices and Methods for Treatment of the Eustachian Tube and Sinus Cavity 有权
标题翻译：用于治疗咽鼓管和窦腔的装置和方法
公开(公告)号：US20150305943A1
公开(公告)日：2015-10-29
申请号：US14265343
申请日：2014-04-29
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.
发明人： Syed Hossainy , Paul Consigny , Dariush Davalian , James Su , Michael Ngo , Adrain Gale , Jesus Magana , Mikael Trollsas , Evan Norton , Benjamyn Serna
IPC分类号： A61F11/00 , A61M25/10
CPC分类号： A61F2/958 , A61B1/06 , A61F2/915 , A61F11/002 , A61F2002/91575 , A61F2002/91583 , A61F2230/0067 , A61F2250/0018 , A61F2250/0026 , A61F2250/0046 , A61F2250/0048 , A61F2250/005 , A61F2250/0082 , A61M25/10 , A61M29/02 , A61M2025/105 , A61M2025/1059 , A61M2210/0675
摘要： A polymeric stent can be implanted for treatment of the Eustachian tube. The stent can be designed to have length-dependent radial strength to allow it to stay within the Eustachian tube and to allow normal closing and opening of the Eustachian tube. A balloon can be used to implant the stent, and the balloon can be coated with a therapeutic agent. A coated balloon can also be used to transfer therapeutic agents to the sinus cavity during a balloon sinus dilation procedure.
摘要翻译：可以植入聚合物支架以治疗咽鼓管。支架可以被设计成具有长度依赖的径向强度，以允许其停留在咽鼓管内并允许正常的关闭和打开咽鼓管。可以使用气囊来植入支架，并且可以用治疗剂涂覆气囊。在气球窦扩张过程中，涂覆的气囊也可以用于将治疗剂转移到窦腔。

8. 发明申请

US20150196690A1 COATINGS WITH TUNABLE MOLECULAR ARCHITECTURE FOR DRUG-COATED BALLOON 审中-公开
标题翻译：用于涂覆气囊的可分子结构涂层
公开(公告)号：US20150196690A1
公开(公告)日：2015-07-16
申请号：US14599160
申请日：2015-01-16
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.
发明人： John Stankus , Mikael Trollsas , Syed Hossainy , Stephen Pacetti , Michael Ngo
IPC分类号： A61L29/08 , A61L29/16 , A61M25/10
CPC分类号： A61L29/085 , A61F2/958 , A61F2250/0067 , A61L29/16 , A61L2300/204 , A61L2300/416 , A61L2300/606 , A61L2420/02 , A61L2420/06 , A61M25/10 , A61M25/1029 , A61M2025/1031 , A61M2025/105
摘要： A drug delivery balloon is provided, the a balloon having an outer surface, and a tunable coating disposed on at least a length of the balloon surface. The tunable coating includes a first therapeutic agent and a first excipient, wherein the cytostatic therapeutic agent and the at least one excipient have a weight ratio of about 20:1 to about 1:20, and further wherein the coating provides increased efficiency of therapeutic transfer to a body lumen.
摘要翻译：提供药物递送球囊，具有外表面的气囊和设置在球囊表面的至少一段长度上的可调涂层。可调涂层包括第一治疗剂和第一赋形剂，其中细胞生长抑制治疗剂和至少一种赋形剂的重量比为约20:1至约1:20，并且其中所述涂层提供更高的治疗转移效率到体腔。

9. 发明授权

US09737361B2 System and method for a catheter 有权
公开(公告)号：US09737361B2
公开(公告)日：2017-08-22
申请号：US14574664
申请日：2014-12-18
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.
发明人： Jesus Magana , John Stankus , Benny Serna , Michael Ngo
IPC分类号： A61B18/14 , A61B18/00 , A61M25/04 , A61B17/00
CPC分类号： A61B18/1492 , A61B2017/00526 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/1435 , A61M25/04
摘要： A catheter apparatus defining a first lumen with a first internal diameter, the catheter apparatus further comprising a shaping structure having a distal end and a proximal end and a length therebetween, the shaping structure being moveable between a delivery state having a first helical shape, and a deployed state having a second helical shape. A deployment member having a second lumen with a second internal diameter, a first portion of the deployment member being positioned within the first lumen and having a third outside diameter sized to enable the deployment member to slide within the first lumen, the deployment member being operably coupled to the distal end of the shaping structure and being configured such that distal axial movement of the deployment member places the shaping structure in the delivery state, and proximal axial movement of the deployment member places the shaping structure in the deployed state.

10. 发明申请

US20170196718A1 SEGMENTED SCAFFOLD DESIGNS 审中-公开
公开(公告)号：US20170196718A1
公开(公告)日：2017-07-13
申请号：US15414528
申请日：2017-01-24
申请人： Abbott Cardiovascular Systems Inc.
发明人： John E. Papp , Syed Faiyaz Ahmed Hossainy , Michael Ngo , Chad Abunassar , Boris Anukhin , Mikael Trollsas , Lewis B. Schwartz
IPC分类号： A61F2/915 , B29C65/00 , B29C35/08 , B29C65/64 , A61F2/958 , A61F2/89
CPC分类号： A61F2/915 , A61F2/86 , A61F2/89 , A61F2/90 , A61F2/958 , A61F2002/826 , A61F2002/9155 , A61F2002/91591 , A61F2210/00 , A61F2230/0013 , A61F2230/0054 , A61F2240/001 , B29C35/0805 , B29C65/64 , B29C66/1248 , B29C66/71 , B29C2035/0838 , B29K2067/046 , B29K2995/006 , B29L2031/7534
摘要： Segmented scaffolds composed of disconnected scaffold segments with overlapping end rings are disclosed. Scaffolds with at least one discontinuous link are also disclosed.

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