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    • 3. 发明申请
    • METHODS AND DEVICES FOR TISSUE COLLECTION AND ANALYSIS
    • 用于组织收集和分析的方法和装置
    • US20110224576A1
    • 2011-09-15
    • US13046738
    • 2011-03-12
    • George W. JacksonCharles Houssiere
    • George W. JacksonCharles Houssiere
    • A61B10/02
    • A61B10/0233A61B10/0283
    • The present invention is directed to methods and devices for tissue collection and analysis, and particularly to methods and devices for collecting, preserving and analyzing biopsy samples. In one aspect, a method for collecting a tissue sample includes disposing a collection device proximate and/or within a tissue, such as of a body, drawing in at least a portion of the tissue into the collection device, adhering the at least a portion of the tissue to at least a portion of the collection device and separating the sample and collection device from the remainder of the tissue and/or body. In general, the method of adhering the tissue sample to the collection device may also preserve the tissue sample, such as, for example, by altering the temperature of the tissue sample. In one embodiment, the method of adhering the tissue sample to the collection device includes lowering the temperature of the collection device and thus the tissue sample such that the tissue sample may adhere to the collection device and may also be preserved against degradation.
    • 本发明涉及用于组织收集和分析的方法和装置,特别涉及用于收集,保存和分析活组织检查样品的方法和装置。 在一个方面,一种用于收集组织样本的方法包括将收集装置设置在组织(例如身体)附近和/或内部,将组织的至少一部分拉入收集装置,将至少一部分 的至少一部分收集装置,并将样品和收集装置与组织和/或身体的其余部分分离。 通常,将组织样本粘附到收集装置的方法也可以保留组织样本,例如通过改变组织样本的温度。 在一个实施例中,将组织样本粘附到收集装置的方法包括降低收集装置和因此组织样本的温度,使得组织样本可以粘附到收集装置并且还可以防止降解。
    • 4. 发明申请
    • METHODS AND DEVICES FOR MOLECULAR ASSOCIATION AND IMAGING
    • 用于分子结合和成像的方法和装置
    • US20120108459A1
    • 2012-05-03
    • US13279302
    • 2011-10-23
    • George JacksonRoger McNicholsCharles Houssiere
    • George JacksonRoger McNicholsCharles Houssiere
    • C40B30/04
    • C40B50/18C40B60/14
    • The present invention is directed to devices and methods for molecular association, particularly to devices and methods for hybridization of nucleic acids utilizing temperature gradients and imaging thereof. In one aspect, a molecular hybridization system generally includes a substrate having a plurality of molecular probes attached thereto, the plurality of probes being generally present in multiple copies arranged in localized formations on the surface of the substrate. The molecular hybridization system further generally includes a chamber that encloses the plurality of molecular probes such that a fluid containing sample may be applied and kept in contact with the substrate having the probes thereon. The molecular hybridization system also includes a temperature affecting system that generally produces at least one desired temperature on the surface of the substrate and in the adjacent fluid within the chamber.
    • 本发明涉及用于分子缔合的装置和方法,特别涉及利用温度梯度和其成像对核酸进行杂交的装置和方法。 一方面,分子杂交系统通常包括具有附着于其上的多个分子探针的基底,所述多个探针通常存在于基片的表面上以局部化形式布置的多个拷贝。 分子杂交系统还通常包括包围多个分子探针的室,使得含有流体的样品可以被施加并保持与其上具有探针的基底接触。 分子杂交系统还包括温度影响系统,其通常在衬底的表面和室内的相邻流体中产生至少一个期望的温度。
    • 5. 发明申请
    • METHODS AND DEVICES FOR MOLECULAR ASSOCIATION AND IMAGING
    • 用于分子结合和成像的方法和装置
    • US20090099045A1
    • 2009-04-16
    • US12249525
    • 2008-10-10
    • George JacksonRoger McNicholsCharles Houssiere
    • George JacksonRoger McNicholsCharles Houssiere
    • C40B50/18C40B60/14
    • C40B50/18C40B60/14
    • The present invention is directed to devices and methods for molecular association, particularly to devices and methods for hybridization of nucleic acids utilizing temperature gradients and imaging thereof. In one aspect, a molecular hybridization system generally includes a substrate having a plurality of molecular probes attached thereto, the plurality of probes being generally present in multiple copies arranged in localized formations on the surface of the substrate. The molecular hybridization system further generally includes a chamber that encloses the plurality of molecular probes such that a fluid containing sample may be applied and kept in contact with the substrate having the probes thereon. The molecular hybridization system also includes a temperature affecting system that generally produces at least one desired temperature on the surface of the substrate and in the adjacent fluid within the chamber.
    • 本发明涉及用于分子缔合的装置和方法,特别涉及利用温度梯度和其成像对核酸进行杂交的装置和方法。 一方面,分子杂交系统通常包括具有附着于其上的多个分子探针的基底,多个探针通常以多个拷贝布置在基底表面上的局部形成中。 分子杂交系统还通常包括包围多个分子探针的室,使得含有流体的样品可以被施加并保持与其上具有探针的基底接触。 分子杂交系统还包括温度影响系统,其通常在衬底的表面和室内的相邻流体中产生至少一个期望的温度。