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1. 发明授权

US10231625B2 Internally-administered radiation therapy using endoscopic image guidance 有权
公开(公告)号：US10231625B2
公开(公告)日：2019-03-19
申请号：US15059176
申请日：2016-03-02
申请人： OHIO STATE INNOVATION FOUNDATION , Zhilin Hu
发明人： Lanchun Lu , Zhilin Hu
IPC分类号： A61N5/10 , A61B5/00 , A61B8/12
摘要： Systems and methods are provided for a catheter-based system of image-guided internally-administered treatment of medical conditions such as, for example, pancreatic cancer. A distal end of a catheter is positioned at a target site inside a patient's body. An imaging probe extended through the catheter collects image data of patient tissue at the target site. The image data is processed and a treatment plan is developed. A radiation source positioned at the distal end of the catheter without removing the catheter. In this way, images collected at the target tissue site can be used to develop a treatment plan and to guide the localized positioning and operation of a treatment device at the same internal tissue site—thereby providing higher resolution imaging than external-based imaging modalities and reduced exposure to radiation as compared to externally applied radiation therapies.

2. 发明申请

US20160263401A1 INTERNALLY-ADMINISTERED RADIATION THERAPY USING ENDOSCOPIC IMAGE GUIDANCE 审中-公开
标题翻译：使用内镜图像指导的内部管理辐射治疗
公开(公告)号：US20160263401A1
公开(公告)日：2016-09-15
申请号：US15059176
申请日：2016-03-02
申请人： Zhilin Hu , OHIO STATE INNOVATION FOUNDATION
发明人： Lanchun Lu , Zhilin Hu
IPC分类号： A61N5/10
CPC分类号： A61B5/0066 , A61B5/4836 , A61B8/12 , A61N5/1007 , A61N5/103 , A61N5/1049 , A61N2005/1058 , A61N2005/1076 , G06F19/00
摘要： Systems and methods are provided for a catheter-based system of image-guided internally-administered treatment of medical conditions such as, for example, pancreatic cancer. A distal end of a catheter is positioned at a target site inside a patient's body. An imaging probe extended through the catheter collects image data of patient tissue at the target site. The image data is processed and a treatment plan is developed. A radiation source positioned at the distal end of the catheter without removing the catheter. In this way, images collected at the target tissue site can be used to develop a treatment plan and to guide the localized positioning and operation of a treatment device at the same internal tissue site—thereby providing higher resolution imaging than external-based imaging modalities and reduced exposure to radiation as compared to externally applied radiation therapies.
摘要翻译：为基于导管的系统和方法提供图像引导的内部治疗医疗条件例如胰腺癌的系统。导管的远端定位在患者体内的目标部位。通过导管延伸的成像探针收集目标部位的患者组织的图像数据。处理图像数据并开发治疗计划。位于导管远端的辐射源，而不需要去除导管。以这种方式，可以使用在目标组织部位收集的图像来开发治疗计划并且引导治疗装置在相同的内部组织部位的局部定位和操作，从而提供比外部成像模式更高分辨率的成像，与外部使用的辐射疗法相比，减少了辐射暴露。

3. 发明授权

US09778107B2 Linear frequency domain grating and multiband spectrometer having same 有权
公开(公告)号：US09778107B2
公开(公告)日：2017-10-03
申请号：US15075187
申请日：2016-03-20
申请人： Zhilin Hu
发明人： Zhilin Hu
IPC分类号： G01J3/28 , G01J3/18 , G02B5/18 , G02B1/14 , G02B5/04 , G01J3/14 , G01J3/02 , G01J3/12
CPC分类号： G01J3/18 , G01J3/0208 , G01J3/0218 , G01J3/14 , G01J3/28 , G01J2003/1208 , G02B1/14 , G02B5/04 , G02B5/1814
摘要： A linear frequency domain grating and a multiband spectrometer having the same. The linear frequency domain grating includes a dispersive optical element and a diffractive optical element being substantially in contact with the dispersive optical element or being substantially integrated with the dispersive optical element, configured to receive a beam of incident light along an incident optical path, and diffract and disperse it into its constituent spectrum of frequencies of the light that is output from the dispersive optical element along an output optical path, such that the output light has a spatial distribution on a focal plane in the output optical path that is a linear function of the frequency. The linear frequency domain grating is a transmissive-type grating or a reflective-type grating, depending on whether the incident optical path and the output optical path are in different sides or the same side of the diffractive optical element.

4. 发明申请

US20160282180A1 LINEAR FREQUENCY DOMAIN GRATING AND MULTIBAND SPECTROMETER HAVING SAME 审中-公开
标题翻译：线性频域和多波束光谱仪
公开(公告)号：US20160282180A1
公开(公告)日：2016-09-29
申请号：US15075187
申请日：2016-03-20
申请人： Zhilin Hu
发明人： Zhilin Hu
IPC分类号： G01J3/18 , G02B1/14 , G01J3/28 , G01J3/14 , G01J3/02 , G02B5/18 , G02B5/04
CPC分类号： G01J3/18 , G01J3/0208 , G01J3/0218 , G01J3/14 , G01J3/28 , G01J2003/1208 , G02B1/14 , G02B5/04 , G02B5/1814
摘要： A linear frequency domain grating and a multiband spectrometer having the same. The linear frequency domain grating includes a dispersive optical element and a diffractive optical element being substantially in contact with the dispersive optical element or being substantially integrated with the dispersive optical element, configured to receive a beam of incident light along an incident optical path, and diffract and disperse it into its constituent spectrum of frequencies of the light that is output from the dispersive optical element along an output optical path, such that the output light has a spatial distribution on a focal plane in the output optical path that is a linear function of the frequency. The linear frequency domain grating is a transmissive-type grating or a reflective-type grating, depending on whether the incident optical path and the output optical path are in different sides or the same side of the diffractive optical element.
摘要翻译：线性频域光栅和具有相同光谱的多频带光谱仪。线性频域光栅包括色散光学元件和衍射光学元件，该衍射光学元件基本上与色散光学元件接触或者与分散光学元件基本上集成，被配置为沿着入射光路接收入射光束，并衍射并将其分散到其沿着输出光路从色散光学元件输出的光的频率的组成谱中，使得输出光在输出光路中的焦平面上具有作为线性函数的线性函数的空间分布频率。线性频域光栅是透射型光栅或反射型光栅，取决于入射光路和输出光路是否位于衍射光学元件的不同侧或同一侧。

5. 发明授权

US07929134B2 Even frequency spacing spectrometer and optical coherence tomography device 有权
标题翻译：偶数间隔光谱仪和光学相干断层摄影装置
公开(公告)号：US07929134B2
公开(公告)日：2011-04-19
申请号：US12154859
申请日：2008-05-27
申请人： Zhilin Hu , Andrew M. Rollins
发明人： Zhilin Hu , Andrew M. Rollins
IPC分类号： G01J3/28
CPC分类号： G01J3/14 , G01B9/02044 , G01B9/02091 , G01B2290/20 , G01J3/02 , G01J3/0208
摘要： This application describes a spectrometer that includes a set of collimating optics to collimate received EMR to produce a collimated EMR. The spectrometer also includes a first dispersive optical element for dispersing the collimated EMR and a second dispersive optical element spaced apart from the first dispersive optical element to produce further dispersed EMR. The first dispersive optical element and the second dispersive optical element cooperate to disperse received EMR into a plurality of even frequency spaced EMR spectra. The spectrometer also includes a detector positioned to receive the EMR after passing though an optical path that includes the set of collimating optics, the first dispersive optical element, the second dispersive optical element, and a set of focusing optics.
摘要翻译：该应用描述了一种光谱仪，其包括一组准直光学器件以准直所接收的EMR以产生准直的EMR。光谱仪还包括用于分散准直EMR的第一色散光学元件和与第一色散光学元件间隔开的第二色散光学元件以产生进一步分散的EMR。第一色散光学元件和第二色散光学元件协作以将接收到的EMR分散到多个均匀间隔的EMR光谱中。光谱仪还包括一个检测器，定位成在通过包括准直光学器件组，第一分散光学元件，第二分散光学元件和一组聚焦光学器件的光路之后接收EMR。

6. 发明申请

US20190216323A1 INTERNALLY-ADMINISTERED RADIATION THERAPY USING ENDOSCOPIC IMAGE GUIDANCE 审中-公开
公开(公告)号：US20190216323A1
公开(公告)日：2019-07-18
申请号：US16262422
申请日：2019-01-30
申请人： Zhilin Hu , OHIO STATE INNOVATION FOUNDATION
发明人： Lanchun Lu , Zhilin Hu
IPC分类号： A61B5/00 , A61N5/10
CPC分类号： A61B5/0066 , A61B5/4836 , A61B8/12 , A61N5/1007 , A61N5/103 , A61N5/1049 , A61N2005/1058 , A61N2005/1076
摘要： Systems and methods are provided for a catheter-based system of image-guided internally-administered treatment of medical conditions such as, for example, pancreatic cancer. A distal end of a catheter is positioned at a target site inside a patient's body. An imaging probe extended through the catheter collects image data of patient tissue at the target site. The image data is processed and a treatment plan is developed. A radiation source positioned at the distal end of the catheter without removing the catheter. In this way, images collected at the target tissue site can be used to develop a treatment plan and to guide the localized positioning and operation of a treatment device at the same internal tissue site—thereby providing higher resolution imaging than external-based imaging modalities and reduced exposure to radiation as compared to externally applied radiation therapies.

7. 发明申请

US20090040521A1 Even frequency spacing spectrometer and optical coherence tomography device 有权
标题翻译：偶数间隔光谱仪和光学相干断层摄影装置
公开(公告)号：US20090040521A1
公开(公告)日：2009-02-12
申请号：US12154859
申请日：2008-05-27
申请人： Zhilin Hu , Andrew M. Rollins
发明人： Zhilin Hu , Andrew M. Rollins
IPC分类号： G01J3/45
CPC分类号： G01J3/14 , G01B9/02044 , G01B9/02091 , G01B2290/20 , G01J3/02 , G01J3/0208
摘要： This application describes a spectrometer that includes a set of collimating optics to collimate received EMR to produce a collimated EMR. The spectrometer also includes a first dispersive optical element for dispersing the collimated EMR and a second dispersive optical element spaced apart from the first dispersive optical element to produce further dispersed EMR. The first dispersive optical element and the second dispersive optical element cooperate to disperse received EMR into a plurality of even frequency spaced EMR spectra. The spectrometer also includes a detector positioned to receive the EMR after passing though an optical path that includes the set of collimating optics, the first dispersive optical element, the second dispersive optical element, and a set of focusing optics.
摘要翻译：该应用描述了一种光谱仪，其包括一组准直光学器件以准直所接收的EMR以产生准直的EMR。光谱仪还包括用于分散准直EMR的第一色散光学元件和与第一色散光学元件间隔开的第二色散光学元件以产生进一步分散的EMR。第一色散光学元件和第二色散光学元件协作以将接收到的EMR分散到多个均匀间隔的EMR光谱中。光谱仪还包括一个检测器，定位成在通过包括准直光学器件组，第一分散光学元件，第二分散光学元件和一组聚焦光学器件的光路之后接收EMR。

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