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    • 10. 发明授权
    • Crystalline form of carbapenem derivative or its hydrates and preparation methods and uses thereof
    • 碳青霉烯衍生物或其水合物的结晶形式及其制备方法和用途
    • US08822445B2
    • 2014-09-02
    • US13701704
    • 2011-06-01
    • Zhenhua HuangYanyan Dong
    • Zhenhua HuangYanyan Dong
    • A61K31/397C07D477/20A61K31/407
    • C07D477/20A61K31/407
    • The present invention relates to the crystalline form of carbapenems derivative or hydrate thereof and the preparation methods thereof. Specifically, the present invention relates to the crystalline form of carbapenem derivative (4R,5S,6S)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-3-(((3S,5S)-5-((4-sulfamoylbenzyl)carbamoyl)pyrrolidin-3-yl)thio)-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid as represented by formula (I) or hydrate thereof, characterized in that the X-ray powder diffraction pattern thereof using Cu-Ka radiation represented as 2θ has characteristic peaks at 18.9±0.2, 19.4±0.2, 21.0±0.2, 21.7±0.2, and 23.4±0.2, the preparation methods thereof, and the use thereof in the preparation of medicament for treating and/or preventing infectious diseases, as well as a pharmaceutical composition comprising such compound and one or more pharmaceutical carriers and/or diluents.
    • 本发明涉及碳青霉烯衍生物或其水合物的结晶形式及其制备方法。 具体地说,本发明涉及碳青霉烯衍生物(4R,5S,6S)-6 - ((R)-1-羟乙基)-4-甲基-7-氧代-3 - (((3S,5S) -5 - ((4-氨基甲酰基苄基)氨基甲酰基)吡咯烷-3-基)硫代)-1-氮杂双环[3.2.0]庚-2-烯-2-羧酸或其水合物,其特征在于 其中使用Cu-Ka辐射的X射线粉末衍射图表示为2&thetas; 具有18.9±0.2,19.4±0.2,21.0±0.2,21.7±0.2和23.4±0.2的特征峰,其制备方法及其在制备用于治疗和/或预防传染病的药物中的应用,以及 作为包含这种化合物和一种或多种药物载体和/或稀释剂的药物组合物。