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1. 发明申请

US20130266584A1 METHODS AND COMPOSITIONS FOR TREATING CELIAC DISEASE 审中-公开
标题翻译：治疗CELIAC疾病的方法和组合
公开(公告)号：US20130266584A1
公开(公告)日：2013-10-10
申请号：US13695349
申请日：2011-04-29
申请人： Detlef Schuppan , Yvonne Junker , Towia Libermann , Simon T. Dillon
发明人： Detlef Schuppan , Yvonne Junker , Towia Libermann , Simon T. Dillon
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/16 , C07K2317/76
摘要： The invention features the treatment of gastrointestinal disorders associated with an innate immune response tiggered by alpha amylase inhibitor CM3, alpha amylase inhibitor 0.19 (0.19), CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or alpha amylase inhibitor 0.53 (0.53). To this end, the invention features pharmaceutical compositions including neutralizing antibodies to CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53, food products containing reduced levels of CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53 protein, the use of oral TLR4 inhibitors to block the effect of said alpha-amylase inhibitors, assays for identifying CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53 content in food products, and assays for diagnosing subjects with a disorder related to CM3, 0.19, CM1, CM2, CMa, CMd, CM16, CMb, CMX1/CMX3, CMX2, and/or 0.53 triggered innate immune responses.
摘要翻译：本发明的特征在于治疗与由α淀粉酶抑制剂CM3，α淀粉酶抑制剂0.19（0.19），CM1，CM2，CMa，CMd，CM16，CMb，CMX1 / CMX3，CMX2和/或其衍生物相关的先天免疫应答相关的胃肠道疾病 α淀粉酶抑制剂0.53（0.53）。为此，本发明的特征在于药物组合物，包括中和CM3，0.19，CM1，CM2，CMa，CMd，CM16，CMb，CMX1 / CMX3，CMX2和/或0.53的抗体，含有CM3，0.19， CM1，CM2，CMa，CMd，CM16，CMb，CMX1 / CMX3，CMX2和/或0.53蛋白，使用口服TLR4抑制剂来阻断所述α-淀粉酶抑制剂的作用，用于鉴定CM3，0.19，CM1， CM2，CMa，CMd，CM16，CMb，CMX1 / CMX3，CMX2和/或0.53含量，以及用于诊断与CM3，0.19，CM1，CM2，CMa，CMd，CM16，CMb相关的病症的受试者的测定，CMX1 / CMX3，CMX2和/或0.53触发先天免疫应答。

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