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1. 发明授权

US4474779A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US4474779A
公开(公告)日：1984-10-02
申请号：US433247
申请日：1982-10-07
申请人： Noriaki Nagano , Kohji Nakano , Tadao Shibanuma , Yukiyasu Murakami
发明人： Noriaki Nagano , Kohji Nakano , Tadao Shibanuma , Yukiyasu Murakami
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D277/20 , C07D501/20 , C07D501/24 , C07D501/36 , C07D501/56
CPC分类号： C07D277/587 , Y02P20/55
摘要： Cephalosporin compounds represented by the general formula ##STR1## wherein R represents a group shown by formula ##STR2## wherein R.sup.1 represents a hydrogen atom or a lower alkyl group of 1-3 carbon atoms and R.sup.2 represents a hydrogen atom, a lower alkyl group of 1-3 carbon atoms, a phenyl group which may be substituted by an amino or hydroxy group, a cyano group, a carboxy group, or a carboxymethyl group; said R.sup.1 and R.sup.2 may form a cycloalkylidene group of 4-6 carbon atoms together with the carbon atom to which they are bonded) or a group shown by formula --CH.sub.2 --R.sup.3 (wherein R.sup.3 represents a hydrogen atom, a halogenomethyl group, a carbamoyl group, a carboxymethyl group, .alpha.4-carboxy-3-hydroxyisothiazol-5-yl-thiomethyl group, or .alpha.2-carboxyphenylthiomethyl group); R' represents a group shown by formula ##STR3## (wherein R.sub.a represents a carboxy group, a cyano group, or a carbamoyl group which may be substituted by a lower alkyl group of 1-3 carbon atoms and R.sub.b represents a hydrogen atom or an amino group) or a group shown by formula ##STR4## (wherein R.sub.a and R.sub.b have the same significance as above); and the waveline .about. shows an anti-form or syn-form bond and the salts thereof. They possess excellent antibacterial activities against gram positive bacteria and gram negative bacteria, in particular, pseudomonas aeruginosa and are useful as anti-bacterial agents.
摘要翻译：由通式表示的头孢菌素化合物（其中R表示由式表示的基团，其中R1表示氢原子或1-3个碳原子的低级烷基，R2表示氢原子，低级烷基 1-3个碳原子的苯基，可以被氨基或羟基，氰基，羧基或羧甲基取代的苯基;所述R 1和R 2可以一起形成4-6个碳原子的亚环烷基与其结合的碳原子）或式-CH 2 -R 3（其中R 3表示氢原子，卤代甲基，氨基甲酰基，羧甲基，α4-羧基-3-羟基异噻唑-5 - 基 - 硫代甲基或α2-羧基苯硫基甲基）; R'表示式IMA图示的基团（其中，Ra表示羧基，氰基或可被1-3个碳原子的低级烷基取代的氨基甲酰基，Rb表示氢原子或氨基）或由式IMA IMA表示的基团（其中Ra和Rb具有与上述相同的含义）; 并且波纹差异显示出抗形式或顺式键及其盐。它们对革兰氏阳性细菌和革兰氏阴性细菌，特别是铜绿假单胞菌具有优异的抗菌活性，可用作抗菌剂。

2. 发明授权

US4608373A Cephem compounds 失效
标题翻译：头孢烯化合物
公开(公告)号：US4608373A
公开(公告)日：1986-08-26
申请号：US560412
申请日：1983-12-12
申请人： Tadao Shibanuma , Kohji Nakano , Noriaki Nagano , Yukiyasu Murakami , Ryuichiro Hara
发明人： Tadao Shibanuma , Kohji Nakano , Noriaki Nagano , Yukiyasu Murakami , Ryuichiro Hara
IPC分类号： C07D277/20 , C07D277/42 , C07D417/12 , C07D501/16 , C07D501/20 , C07D501/22 , C07D501/36 , C07D501/46 , C07D501/59 , C07D501/34 , A61K31/545
CPC分类号： C07D277/587 , C07D277/42 , C07D417/12
摘要： Novel cephem compounds are provided having the formula: ##STR1## wherein R represents lower alkyl, which may be substituted with lower acyloxy, lower alkylthio or certain 5 or 6-membered heterocyclic ring-containing groups. The cephem compounds and salts thereof exhibit antibacterial activity to many pathogens. A process for producing the cephem compounds is also provided.
摘要翻译：提供具有下式的新型头孢烯化合物：其中R代表低级烷基，其可以被低级酰氧基，低级烷硫基或某些含有5或6元杂环基团取代。头孢烯化合物及其盐对许多病原体表现出抗菌活性。还提供了产生头孢烯化合物的方法。

3. 发明申请

US20140281161A1 MEMORY SYSTEMS AND METHODS INCLUDING TRAINING, DATA ORGANIZING, AND/OR SHADOWING 有权
标题翻译：包括培训，数据组织和/或阴影的记忆系统和方法
公开(公告)号：US20140281161A1
公开(公告)日：2014-09-18
申请号：US13995919
申请日：2013-03-14
申请人： Yi Chen , Yukiyasu Murakami
发明人： Yi Chen , Yukiyasu Murakami
IPC分类号： G06F12/02
CPC分类号： G06F3/0611 , G06F3/065 , G06F3/0688 , G06F12/0246 , G06F13/161 , G06F2212/7208
摘要： Described embodiments include memory systems that may shadow certain data stored in a first memory device (e.g. NAND flash device) onto a second memory device (e.g. DRAM device). Memory systems may train and/or re-organize stored data to facilitate the selection of data to be shadowed. Initial responses to memory commands may be serviced from the first memory device, which may have a lower latency than the second memory device. The remaining data may be serviced from the second memory device. A controller may begin to access the remaining data while the initial response is being provided from the first memory device, which may reduce the apparent latency associated with the second memory device.
摘要翻译：所描述的实施例包括可以将存储在第一存储器件（例如NAND闪存器件）中的某些数据影射到第二存储器件（例如DRAM器件）上的存储器系统）。存储器系统可以训练和/或重新组织存储的数据以便于选择要被镜像的数据。可以从第一存储器设备处理对存储器命令的初始响应，其可以具有比第二存储器设备更低的延迟。剩余的数据可以从第二存储器设备服务。当从第一存储设备提供初始响应时，控制器可以开始访问剩余的数据，这可以减少与第二存储器设备相关联的表观等待时间。

4. 发明授权

US4845211A Amino-3-substituted-methyl-3-cephem-4-carboxylic acid and lower alkylsilyl derivatives thereof 失效
标题翻译：氨基-3-取代甲基-3-头孢烯-4-羧酸及其低级烷基甲硅烷基衍生物
公开(公告)号：US4845211A
公开(公告)日：1989-07-04
申请号：US46661
申请日：1987-05-04
申请人： Tadao Shibanuma , Kohji Nakano , Noriaki Nagano , Yukiyasu Murakami , Ryuichiro Hara , Akio Koda , Atsuki Yamazaki
发明人： Tadao Shibanuma , Kohji Nakano , Noriaki Nagano , Yukiyasu Murakami , Ryuichiro Hara , Akio Koda , Atsuki Yamazaki
IPC分类号： C07D501/04 , A61K31/545 , C07D215/06 , C07D231/06 , C07D501/16 , C07D501/18 , C07D501/20 , C07D501/38 , C07D501/46 , C07D501/58
CPC分类号： C07D501/18 , Y02P20/55
摘要： Various 7-amino-3-substituted-methyl-3-cephem-4-carboxylic acids and lower alkylsily derivatives such as 7-amino-3-(2,3-cyclopenteno-1-pyridiniomethyl)-3-cephem-4 -carboxylic acid iodide and trimethylsilyl 7-trimethylsilylamino-3 -(5,6,7,8-tetrahydro-2-isoquinoliniomethyl)-3-cephem-4 -carboxylate iodide are valuable intermediates in the preparation of new and novel antibacterial agents. A new process for the preparation of these acids and the derivatives has been devised.

5. 发明授权

US4699980A Process for preparing 3-substituted-methyl-3-cephem derivatives 失效
标题翻译： 3-取代甲基-3-头孢烯衍生物的制备方法
公开(公告)号：US4699980A
公开(公告)日：1987-10-13
申请号：US699584
申请日：1985-02-08
申请人： Tadao Shibanuma , Kohji Nakano , Noriaki Nagano , Yukiyasu Murakami , Ryuichiro Hara , Akio Koda , Atsuki Yamazaki
发明人： Tadao Shibanuma , Kohji Nakano , Noriaki Nagano , Yukiyasu Murakami , Ryuichiro Hara , Akio Koda , Atsuki Yamazaki
IPC分类号： C07D501/04 , A61K31/545 , C07D215/06 , C07D231/06 , C07D501/16 , C07D501/18 , C07D501/20 , C07D501/38 , C07D501/46 , C07D501/58
CPC分类号： C07D501/18 , Y02P20/55
摘要： Various 7-amino-3-substituted-methyl-3-cephem-4-carboxylic acids and lower alkylsilyl derivatives such as 7-amino-3-(2,3-cyclopenteno-1-pyridiniomethyl)-3-cephem-4-carboxylic acid iodide and trimethylsilyl 7-trimethyl-silylamino-3-(5,6,7,8-tetrahydro-2-isoquinoliniomethyl)-3-cephem-4-carboxylate iodide are valuable intermediates in the preparation of new and novel antibacterial agents. A new process for the preparation of these acids and the derivatives has been devised.
摘要翻译：各种7-氨基-3-取代的甲基-3-头孢烯-4-羧酸和低级烷基甲硅烷基衍生物如7-氨基-3-（2,3-环戊烯-1-吡啶基甲基）-3-头孢烯-4-羧酸碘化三甲基甲硅烷基和三甲基甲硅烷基7-三甲基甲硅烷基氨基-3-（5,6,7,8-四氢-2-异喹啉甲基）-3-头孢烯-4-羧酸酯碘化物是制备新型和新型抗菌剂的有价值的中间体。已经设计出了制备这些酸和衍生物的新方法。

6. 发明授权

US4690921A Cephalosporin compounds and salts thereof 失效
标题翻译：头孢菌素化合物及其盐
公开(公告)号：US4690921A
公开(公告)日：1987-09-01
申请号：US656162
申请日：1984-09-28
申请人： Tadao Shibanuma , Noriaki Nagano , Ryuichiro Hara , Kohji Nakano , Akio Koda , Atsuki Yamazaki , Yukiyasu Murakami
发明人： Tadao Shibanuma , Noriaki Nagano , Ryuichiro Hara , Kohji Nakano , Akio Koda , Atsuki Yamazaki , Yukiyasu Murakami
IPC分类号： C07D277/20 , C07D277/42 , C07D417/12 , C07D501/34 , C07D501/46 , A61K31/545
CPC分类号： C07D277/587 , C07D277/42 , C07D417/12
摘要： Novel cephalosporin compounds of the formula ##STR1## wherein the wavy line means syn-form and anti-form bonds, R.sup.1 represents a cyanomethyl group, a thiocarbamoylmethyl group or an aminothiazolylmethyl group, and A represents a unsubstituted or substituted pyridinio group; and salts thereof. These compounds have excellent antibacterial activities.
摘要翻译：新颖的具有式（IMAGE）的头孢菌素化合物，其中波浪线表示顺式和反式键，R 1表示氰基甲基，硫代氨基甲酰基甲基或氨基噻唑基甲基，A表示未取代或取代的吡啶并基; 及其盐。这些化合物具有优良的抗菌活性。

7. 发明授权

US5463064A Dihydropyridine-3,5-dicarboxylic acid ester derivatives 失效
标题翻译：二氢吡啶-3,5-二羧酸酯衍生物
公开(公告)号：US5463064A
公开(公告)日：1995-10-31
申请号：US238537
申请日：1994-05-05
申请人： Kazuharu Tamazawa , Tadao Kojima , Hideki Arima , Yukiyasu Murakami , Yasuo Isomura , Minoru Okada , Kiyoshi Takanobu , Toichi Takenaka
发明人： Kazuharu Tamazawa , Tadao Kojima , Hideki Arima , Yukiyasu Murakami , Yasuo Isomura , Minoru Okada , Kiyoshi Takanobu , Toichi Takenaka
IPC分类号： C07D207/24 , C07D211/90 , C07D401/12
CPC分类号： C07D401/12 , C07D207/24 , C07D211/90
摘要： A dextro-rotatory optical isomer of diastereoisomer A of (.+-.)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-(1-benzylpyrrolidin-3-yl)ester 5-methyl ester is provided having the formula ##STR1## and wherein the melting point of the hydrochloride of the dextro-rotatory optical isomer is 223.degree. to 230.degree. C. (decomp.), or a pharmaceutically acceptable acid addition salt thereof.
摘要翻译：（+/-） - 2,6-二甲基-4-（3-硝基苯基）-1,4-二氢吡啶-3,5-二羧酸3-（1-苄基吡咯烷-3-酮）的非对映异构体A的右旋旋光异构体 - 基）酯5-甲酯，其具有式“IMAGE”，其中右旋旋光异构体的盐酸盐的熔点为223〜230℃（分解），或药学上可接受的酸加成的盐。

8. 发明授权

US4311842A Cephalosporin compounds 失效
标题翻译：头孢菌素化合物
公开(公告)号：US4311842A
公开(公告)日：1982-01-19
申请号：US53852
申请日：1979-07-02
申请人： Akio Koda , Ichiro Isaka , Yukiyasu Murakami
发明人： Akio Koda , Ichiro Isaka , Yukiyasu Murakami
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/20 , C07D501/24 , C07D501/34 , C07D501/36 , C07D501/57 , C07D501/56
CPC分类号： C07D501/20 , A61K31/545 , C07D501/24
摘要： Cephalosporin compounds shown by the general formula ##STR1## wherein R.sub.1 represents hydrogen atom or an amino group; R.sub.2 and R.sub.3, which may be the same or different, each represents hydrogen atom, a hydroxy group, an oxo group, a lower alkyl group, or a lower alkoxy group; R.sub.4 represents a hydrogen atom or a lower alkoxy group; R.sub.5 represents an acetoxy group or --S--R.sub.6 (wherein R.sub.6 represents a 5- or 6-membered nitrogen-containing heterocyclic group which can be substituted by a lower alkyl group or lower alkoxy group); and A represents a monocyclic or bicyclic heterocyclic ring containing one or two atoms selected from the group consisting of nitrogen, oxygen and a sulfur atom; and pharmaceutically acceptable nontoxic salts thereof.These compounds have excellent antimicrobial activity against various microorganisms including resistant bacteria and are used for the treatment of bacterial infections of animals including human beings.
摘要翻译：由通式表示的头孢菌素化合物，其中R1表示氢原子或氨基; R 2和R 3可以相同或不同，各自表示氢原子，羟基，氧代基，低级烷基或低级烷氧基; R4代表氢原子或低级烷氧基; R5表示乙酰氧基或-S-R6（其中R6表示可被低级烷基或低级烷氧基取代的5-或6-元含氮杂环基）。 A表示含有一个或两个选自氮，氧和硫原子的原子的单环或双环杂环; 及其药学上可接受的无毒盐。这些化合物对包括抗性细菌在内的各种微生物具有优异的抗微生物活性，并用于治疗包括人在内的动物的细菌感染。

9. 发明授权

US3953428A Ampicillin derivatives substituted by heterocyclic acyl group 失效
标题翻译：由杂环酰基取代的氨苄青霉素衍生物
公开(公告)号：US3953428A
公开(公告)日：1976-04-27
申请号：US356120
申请日：1973-05-01
申请人： Masuo Murakami , Ichiro Isaka , Akio Koda , Norio Kawahara , Teruya Ashiwagi , Yukiyasu Murakami , Kuniichiro Yano , Kohzi Nakano , Isao Souzo
发明人： Masuo Murakami , Ichiro Isaka , Akio Koda , Norio Kawahara , Teruya Ashiwagi , Yukiyasu Murakami , Kuniichiro Yano , Kohzi Nakano , Isao Souzo
IPC分类号： A61K31/43 , C07D20060101 , C07D499/12 , C07D499/44 , C07D499/68 , C07D499/70 , C07D499/72
CPC分类号： C07D499/68
摘要： The ampicillin derivatives represented by the general formula ##SPC1##Wherein R represents ##SPC2##Wherein R' represents a hydrogen atom, a methyl group, or an ethyl group and A and B each represents a hydrogen atom, a hydroxyl group, a methyl group, a methoxy group, a nitro group, or a halogen atom and further said B may combine with A on the carbon atom at the position to form ##SPC3##Group (where in Z represents --CH=N-- or --CH=CH-- and an R.sup.2 represents a hydrogen atom, a hydroxyl group, a phenyl group, a methyl group, an ethyl group, a methoxy group, an ethoxyl group, a methylthio group, a trifluoromethyl group, a halogen atom, a nitro group, an acetyl group, an acetamido group, a ethoxycarbonyloxy group, or a methylsulfonyl group and further R.sub.2 and ##SPC4##May form a thiazole, isothiazolo, pyrrolo, furo, or benzo fused ring which may be substituted by an oxo group, a methyl group, or an acetyl group) and the dotted line means an arbitrary double bond, ##SPC5##Wherein R.sup.3 and R.sup.4 each represents a hydrogen atom or a methyl group, ##SPC6##Wherein R.sup.5 represents a halogen atom, a methoxy group, a nitro group, or a hydroxyl group and R.sup.6 represents a hydrogen atom, a methoxy group, a halogen atom, a nitro group, or a hydroxyl group, or ##SPC7##Wherein R.sup.7 represents a hydrogen atom or a hydroxyl group, Y represents O or S, and the dotted line means an arbitrary double bond, said substituent group, being bonded to the ampicillin molecule through --CO-- at the 2-position, 3-position, 5-position or 6-position when the oxo group (+0) is at the 4-portion and being bonded to the ampicillin molecule through the --CO-- group at the 2-position, 4-position, or 5-position when the oxy group is at the 6-position, and salts of the ampicillin derivatives.Those compounds are valuable as antibacterial agents.
摘要翻译：由通式WHEREIN R表示的氨苄青霉素衍生物代表WHEREIN R'表示氢原子，甲基或乙基，A和B各自表示氢原子，羟基，甲基，甲氧基，硝基或卤素原子，并且所述B可以与碳原子上的A结合形成基团（其中Z表示-CH = N-或-CH = CH-，R2表示氢原子，羟基，苯基，甲基，乙基，甲氧基，乙氧基，甲硫基，三氟甲基，卤素原子，硝基，乙酰基，乙酰氨基，乙氧基羰基氧基或甲基磺酰基，并且还可以是OXO基团，甲基或乙酰基团可以取代的噻唑，异噻唑，吡咯，呋喃，或苯并呋喃环），并且被引导的线表示仲胺双 BOND，其中R 3和R 4各自表示氢原子或甲基其中，R5表示卤素原子，甲氧基，硝基或羟基，R6表示氢原子，甲氧基，卤素原子，硝基或羟基，或者WHEREIN R7表示氢原子或羟基，Y表示O或S，虚线表示任意双键，所述取代基通过2-位，3-位，5-位上的-CO-键合到氨苄青霉素分子上当氧基团（+0）为4-部分时，或6-位，当氧基团为氧基团时，2-位，4-位或5-位通过-CO-基团连接于氨苄青霉素分子在6位，和氨苄青霉素衍生物的盐。

10. 发明授权

US3939150A Penicillin derivatives 失效
标题翻译：青霉素衍生物
公开(公告)号：US3939150A
公开(公告)日：1976-02-17
申请号：US514363
申请日：1974-10-15
申请人： Masuo Murakami , Ichiro Isaka , Khozi Nakano , Isao Souzu , Akio Koda , Teruaki Ozasa , Teruya Kashiwagi , Yukiyasu Murakami
发明人： Masuo Murakami , Ichiro Isaka , Khozi Nakano , Isao Souzu , Akio Koda , Teruaki Ozasa , Teruya Kashiwagi , Yukiyasu Murakami
IPC分类号： C07D213/78 , C07D499/00 , C07D499/64 , C07D499/68
CPC分类号： C07D213/78 , C07D499/00
摘要： The penicillin derivatives represented by the formula ##SPC1##Wherein ring A represents a 5- or 6-membered single or fused ring which may contain one or more nitrogen atoms, an oxygen atom, or a sulfur atom; R.sup.1, R.sup.2, and R.sup.3, which may be the same or different, each represents a hydrogen atom, a hydroxy group, a lower alkyl group, a nitro group, a halogen atom, or an oxo group; and B represents a p-hydroxyphenyl group or a 1,4-cyclohexadien -1-yl group, and their nontoxic pharmaceutically acceptable salts.The compounds are antibiotics having excellent antibacterial activity in particular with respect to the Pseudomonas genus.
摘要翻译：由式WHEREIN RING A表示的青霉素衍生物代表可含有一个或多个氮原子，氧原子或硫原子的5-或6-元单或稠环; R 1，R 2和R 3可以相同或不同，表示氢原子，羟基，低级烷基，硝基，卤原子或氧代基; B表示对羟基苯基或1,4-环己二烯-1-基及其无毒的药学上可接受的盐。

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