专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20060205672A1 Novel peptides as NS3-serine protease inhibitors of hepatitis C virus 审中-公开
公开(公告)号：US20060205672A1
公开(公告)日：2006-09-14
申请号：US11241656
申请日：2005-09-30
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping McCormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-Wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
IPC分类号： A61K38/05 , C07K5/06
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

2. 发明授权

US06260167B1 Apparatus and method for deterministic receiver testing 失效
标题翻译：用于确定性接收机测试的装置和方法
公开(公告)号：US06260167B1
公开(公告)日：2001-07-10
申请号：US09255708
申请日：1999-02-23
申请人： William Lo , Yuhua Huang
发明人： William Lo , Yuhua Huang
IPC分类号： G01R3128
CPC分类号： H04L43/50 , H04B17/20
摘要： A physical layer (PHY) device in an Ethernet type LAN is configured to permit ease of testing of the PHY device's logic. The PHY device comprises a PHY receiver, a start frame delimiter detector (SFD), and automatic checker circuitry in which the clock position and the PHY pop-up position of received signals can be determined. The automatic checker circuitry receives a data signal having a predetermined pattern corresponding to a valid data packet from a pattern generating circuit. The automatic checker circuitry outputs a verification signal indicating whether the supplied signals are valid. This arrangement supports a one pass test, which reduces production costs and testing duration.
摘要翻译：以太网类型LAN中的物理层（PHY）设备被配置为允许容易地测试PHY设备的逻辑。 PHY设备包括PHY接收器，起始帧定界符检测器（SFD）和自动检测器电路，其中可以确定接收信号的时钟位置和PHY弹出位置。自动检查电路从模式发生电路接收具有与有效数据分组对应的预定模式的数据信号。自动检查器电路输出指示所提供的信号是否有效的验证信号。这种安排支持一次通过测试，这降低了生产成本和测试持续时间。

3. 发明授权

US09433621B2 Substituted pyridine and pyrimidine derivatives and their use in treating viral infections 有权
标题翻译：取代的吡啶和嘧啶衍生物及其在治疗病毒感染中的应用
公开(公告)号：US09433621B2
公开(公告)日：2016-09-06
申请号：US13579399
申请日：2011-02-18
申请人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Francisco Velazquez , Vinay M. Girijavallabhan , Yuhua Huang , Hollis S. Kezar, III , Joseph A. Maddry , Robert C. Reynolds , Abhijit Roychowdhury , Anita T. Fowler , John A. Secrist, III , Joseph A. Kozlowski , Bandarpalle B. Shankar , Ling Tong , Seong Heon Kim , Malcolm MacCoss , Srikanth Venkatraman , Vishal Verma
发明人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Francisco Velazquez , Vinay M. Girijavallabhan , Yuhua Huang , Hollis S. Kezar, III , Joseph A. Maddry , Robert C. Reynolds , Abhijit Roychowdhury , Anita T. Fowler , John A. Secrist, III , Joseph A. Kozlowski , Bandarpalle B. Shankar , Ling Tong , Seong Heon Kim , Malcolm MacCoss , Srikanth Venkatraman , Vishal Verma
IPC分类号： A01N43/04 , A61K31/70 , A61K48/00 , A01N37/18 , A61K38/00 , A61P1/16 , A61K51/00 , A61M36/14 , A61K31/506 , A61K45/06 , C07D403/04 , C07D413/04 , C07D417/04 , C07D491/048 , C07D513/04 , C07D417/14
CPC分类号： A61K31/506 , A61K45/06 , C07D403/04 , C07D413/04 , C07D417/04 , C07D417/14 , C07D491/048 , C07D513/04
摘要： The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.

4. 发明申请

US20150299243A1 2'-ALKYNYL SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR THE TREATMENT OF VIRAL DISEASES 有权
标题翻译： 2'-烷基取代的核苷衍生物及其用于治疗病毒性疾病的方法
公开(公告)号：US20150299243A1
公开(公告)日：2015-10-22
申请号：US14443922
申请日：2013-11-14
申请人： Frank BENNETT , Yuhua HUANG , Lingyan WANG , Stephane L. BOGEN , Angela D. KEREKES , Vinay M. GIRIJAVALLABHAN , Gabor BUTORA , Quang TRUONG , Ian DAVIES , Anne E. WEBER , MERCK SHARP & DOHME CORP.
发明人： Frank Bennett , Yuhua Huang , Lingyan Wang , Stephane L. Bogen , Angela D. Kerekes , Vinay M. Girijavallabhan M. Girijavallabhan , Gabor Butora , Quang Truong , Ian Davies , Ann E. Weber
IPC分类号： C07H19/10 , A61K31/7072 , A61K45/06 , C07H19/06
CPC分类号： C07H19/10 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K45/06 , C07H19/06 , C07H19/067 , C07H19/09 , C07H19/11
摘要： The present invention relates to 2′-Alkynyl Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2, R3 and R4 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Alkynyl Substituted Nucleoside Derivative, and methods of using the 2′-Alkynyl Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译：本发明涉及式（I）的2'-炔炔基取代的核苷衍生物及其药学上可接受的盐，其中B，X，R 1，R 2，R 3和R 4如本文所定义。本发明还涉及包含至少一种2'-炔基取代的核苷衍生物的组合物，以及使用2'-炔基取代的核苷衍生物治疗或预防患者HCV感染的方法。

5. 发明申请

US20110318305A1 SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS 有权
标题翻译：取代的吡啶和吡嗪衍生物及其在治疗病毒感染中的应用
公开(公告)号：US20110318305A1
公开(公告)日：2011-12-29
申请号：US13059193
申请日：2009-08-19
申请人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Jeremy Clark , Hollis S. Kezar, III , Vinay M. Girijavallabhan , Yuhua Huang , Regina Huelgas , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , Anita T. Fowler , Feng Geng , John A. Secrist, III , Neng-Yang Shih , Vishal Verma , Francisco Velazquez , Srikanth Venkatraman
发明人： Ashok Arasappan , F. George Njoroge , Cecil D. Kwong , Subramaniam Ananthan , Frank Bennett , Jeremy Clark , Hollis S. Kezar, III , Vinay M. Girijavallabhan , Yuhua Huang , Regina Huelgas , Joseph A. Maddry , John J. Piwinski , Robert C. Reynolds , Abhijit Roychowdhury , Anita T. Fowler , Feng Geng , John A. Secrist, III , Neng-Yang Shih , Vishal Verma , Francisco Velazquez , Srikanth Venkatraman
IPC分类号： A61K31/506 , C07D413/14 , A61P31/12 , A61K38/21 , A61K39/00 , A61K39/42 , C07D407/14 , A61K31/5377
CPC分类号： C07D239/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/04
摘要： The present invention provides compounds of Formula (I): and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R1, X, Y, Z, R2, R3, R4, R5, R6, R7, R8, R9, R18, R19 and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing diseases or disorders such as viral infections and virus-related disorders.
摘要翻译：本发明提供式（I）的化合物：所述化合物的互变异构体，异构体和酯，以及所述化合物的药学上可接受的盐，溶剂合物和前药，其中R，R 1，X，Y，Z，R 2， R3，R4，R5，R6，R7，R8，R9，R18，R19和n独立选择和如本文所定义。还提供了包含这些化合物的组合物。本发明的化合物作为HCV的抑制剂是有效的，并且单独和与其它治疗剂一起用于治疗或预防疾病或病症如病毒感染和病毒相关疾病。

6. 发明申请

US20110033417A1 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS 失效
标题翻译：用于治疗病毒感染的2,3-取代的吲哚衍生物
公开(公告)号：US20110033417A1
公开(公告)日：2011-02-10
申请号：US12675897
申请日：2008-08-27
申请人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
发明人： Gopinadhan N. Anilkumar , Frank Bennett , Tin-Yau Chan , Kevin X. Chen , Mousumi Sannigrahi , Francisco Velazquez , Srikanth Venkatraman , Qingbei Zeng , Jose S. Duca , Charles A. Lesburg , Joseph A. Kozlowski , F. George Njoroge , Stuart B. Rosenblum , Neng-Yang Shih , Stephen J. Gavalas , Yueheng Jiang , Patrick A. Pinto , Haiyan Pu , Oleg B. Selyutin , Bancha Vibulbhan , Li Wang , Wanli Wu , Weiying Yang , Yuhua Huang , Hsueh-Cheng Huang , Robert Palermo , Boris Feld
IPC分类号： A61K38/21 , C07D401/04 , C07D413/14 , C07D209/42 , C07D401/14 , C07D417/14 , C07D407/14 , C07D409/14 , A61K31/4439 , A61K31/444 , A61K31/404 , A61K31/4545 , A61K31/513 , A61K31/443 , A61K31/4709 , A61K31/4436 , A61K31/5377 , A61K31/538 , A61K31/5415 , A61K31/7088 , A61K31/7052 , A61K39/12 , A61K39/42 , A61P31/12 , A61P31/14
CPC分类号： C07D417/14 , C07D209/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention relates to 2,3-Substituted Indole Derivatives, compositions comprising at least one 2,3-Substituted Indole Derivative, and methods of using the 2,3-Substituted Indole Derivatives for treating or preventing a viral infection or a virus-related disorder in a patient.
摘要翻译：本发明涉及2,3-取代的吲哚衍生物，包含至少一种2,3-取代的吲哚衍生物的组合物和使用2,3-取代的吲哚衍生物用于治疗或预防病毒感染或病毒相关的方法病人无序。

7. 发明申请

US20070042968A1 Sulfur compounds as inhibitors of Hepatitis C virus NS3 serine protease 有权
标题翻译：硫化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂
公开(公告)号：US20070042968A1
公开(公告)日：2007-02-22
申请号：US11064673
申请日：2005-02-24
申请人： Frank Bennett , Raymond Lovey , Yuhua Huang , Siska Hendrata , Anil Saksena , Stephane Bogen , Yi-Tsung Liu , F. Njoroge , Srikanth Venkatraman , Kevin Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor Girijavallabhan , Francisco Velazquez
发明人： Frank Bennett , Raymond Lovey , Yuhua Huang , Siska Hendrata , Anil Saksena , Stephane Bogen , Yi-Tsung Liu , F. Njoroge , Srikanth Venkatraman , Kevin Chen , Mousumi Sannigrahi , Ashok Arasappan , Viyyoor Girijavallabhan , Francisco Velazquez
IPC分类号： A61K38/04 , C07K7/04 , C07D417/02 , C07D49/02
CPC分类号： C07D209/52 , A61K38/00 , C07D207/16 , C07D209/56 , C07D405/12 , C07D409/12 , C07D411/12 , C07D491/04 , C07K5/0202
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译：本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。

8. 发明授权

US07079203B1 Electrically tunable polarization-independent micro lens using polymer network twisted nematic liquid crystal 有权
标题翻译：使用聚合物网络扭曲向列液晶的电可调偏振无关微透镜
公开(公告)号：US07079203B1
公开(公告)日：2006-07-18
申请号：US10871109
申请日：2004-06-18
申请人： Yuhua Huang , Hongwen Ren , Xinyu Zhu , Shin-Tson Wu
发明人： Yuhua Huang , Hongwen Ren , Xinyu Zhu , Shin-Tson Wu
IPC分类号： G02F1/1333 , G02F1/13 , G02F1/1335
CPC分类号： G02F1/29 , G02F1/1334 , G02F1/1396 , G02F2001/13345 , G02F2001/294
摘要： Inhomogeneous concentrated polymer network with approximately 90° twisted nematic liquid crystal (TN-LC) is used for fabricating lens and prisms. For forming a positive lens, the approximately 90° TN-LC polymer network concentration can gradually decrease from the center to the side edges. For forming a negative lens, the approximately 90° TN-LC polymer network concentration can gradually increase from the center to the side edges. The lens can be created by ultra violet (UV) light exposure to patterned photo masks. The lens can be tuned by applying voltage above the threshold voltage to the polymer network. The inhomogeneous 90° TN-LC polymer network can also be used in Fresnel lens and prisms. Applications of the invention can be used for micro lens, array, optical communication, micro-optics, adaptive optics and beam steering.
摘要翻译：使用具有约90°扭曲向列型液晶（TN-LC）的不均匀浓缩聚合物网络用于制造透镜和棱镜。为了形成正透镜，大约90°TN-LC聚合物网络浓度可以从中心到边缘逐渐减小。为了形成负透镜，大约90°TN-LC聚合物网络浓度可以从中心向侧边逐渐增加。透镜可以通过紫外（UV）光照曝光到图案化的照相掩模上。可以通过将高于阈值电压的电压施加到聚合物网络来调整透镜。不均匀的90°TN-LC聚合物网络也可用于菲涅尔透镜和棱镜。本发明的应用可用于微透镜，阵列，光通信，微光学，自适应光学和光束转向。

9. 发明授权

US07012066B2 Peptides as NS3-serine protease inhibitors of hepatitis C virus 有权
公开(公告)号：US07012066B2
公开(公告)日：2006-03-14
申请号：US09908955
申请日：2001-07-19
申请人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
发明人： Anil K. Saksena , Viyyoor Moopil Girijavallabhan , Raymond G. Lovey , Edwin Jao , Frank Bennett , Jinping L. Mc Cormick , Haiyan Wang , Russell E. Pike , Stephane L. Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. George Njoroge , Ashok Arasappan , Tejal Parekh , Ashit K. Ganguly , Kevin X. Chen , Srikanth Venkatraman , Henry A. Vaccaro , Patrick A. Pinto , Bama Santhanam , Scott Jeffrey Kemp , Odile Esther Levy , Marguerita Lim-Wilby , Susan Y. Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang
IPC分类号： A61K38/07 , A61K38/06 , C07K5/08 , C07K5/10
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.

10. 发明授权

US07009670B1 Achromatic quarter-wave films 失效
标题翻译：无色四分之一波片
公开(公告)号：US07009670B1
公开(公告)日：2006-03-07
申请号：US10811261
申请日：2004-03-26
申请人： Yuhua Huang , Thomas X. Wu , Shin-Tson Wu
发明人： Yuhua Huang , Thomas X. Wu , Shin-Tson Wu
IPC分类号： G02F1/1335
CPC分类号： G02F1/133636 , G02B27/286 , G02F2001/133638 , G02F2202/40
摘要： The achromatic quarter-wave film of this invention has a laminated twisted nematic liquid crystal film sandwiched between two uniaxial polymer films to provide a optical component which converts linearly polarized light into circularly polarized radiation which upon reflection back through said optical component is blocked from outward radiation by the polarizer for the initial incident wide spectrum light thus realizing wider broadband width for full color flat panel displays.
摘要翻译：本发明的无色四分之一波长膜具有夹在两个单轴聚合物膜之间的层压扭曲向列型液晶膜，以提供将线性偏振光转换成圆偏振辐射的光学部件，该光学部件在通过所述光学部件的反射被阻挡外部辐射通过用于初始入射的宽光谱的偏振器，从而实现全色平板显示器的宽宽度宽。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式