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1. 发明申请

US20060125647A1 Aquarium water-level detector 审中-公开
标题翻译：水族馆水位探测器
公开(公告)号：US20060125647A1
公开(公告)日：2006-06-15
申请号：US11315428
申请日：2005-12-21
申请人： Gary Oakes , Ibrahim Makhlouf , Rick Slemmer , Chris Ross , David Picco , Jeffrey Gray , Yuan-Ching Liu
发明人： Gary Oakes , Ibrahim Makhlouf , Rick Slemmer , Chris Ross , David Picco , Jeffrey Gray , Yuan-Ching Liu
IPC分类号： G08B21/00
CPC分类号： A01K63/006 , A01K63/04
摘要： An aquarium liquid security system is provided. The system includes an aquarium tank, i.e., a plurality of transparent material sheets joined at the sheet edges, and a liquid detection sensor. The sensor is at least partially wrapped around the perimeter, and is electrically responsive to liquid. An alarm interface is connected to the sensor. In one aspect, the sensor includes a pair of electrically conductive ink traces printed on the outside surfaces of the transparent material sheets. In another aspect, the sensor includes a liquid-permeable strip of material, a pair of electrically conductive traces, and a liquid-permeable adhesive attaching the sensor to the perimeter outside surface. Examples of liquid-permeable materials include cardboard, burlap, cotton cloth, synthetic cloth, paper, or cheesecloth. Alternately, the sensors can be formed on the interior surfaces of the aquarium and used for the detection of a low level of water.
摘要翻译：提供水族馆液体安全系统。该系统包括水族箱，即在片材边缘处接合的多个透明材料片和液体检测传感器。传感器至少部分地围绕周边缠绕，并且对液体是电响应的。报警接口连接到传感器。在一个方面，传感器包括印刷在透明材料片的外表面上的一对导电墨迹。在另一方面，传感器包括液体可渗透的材料条，一对导电迹线和将传感器附接到周边外表面的透液性粘合剂。液体渗透材料的实例包括纸板，麻布，棉布，合成布，纸或粗棉布。或者，传感器可以形成在水族箱的内表面上，并用于检测低水位的水。

2. 发明授权

US08425903B2 Methods of treatment by administering antibodies to notch receptors 有权
标题翻译：通过向切口受体施用抗体来治疗的方法
公开(公告)号：US08425903B2
公开(公告)日：2013-04-23
申请号：US13472305
申请日：2012-05-15
申请人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译：本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。

3. 发明授权

US08226943B2 Antibodies to notch receptors 有权
标题翻译：抗缺陷受体的抗体
公开(公告)号：US08226943B2
公开(公告)日：2012-07-24
申请号：US12499627
申请日：2009-07-08
申请人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , C07K16/28 , C07K14/705 , C12N5/00
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译：本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。

4. 发明申请

US20100111958A1 Notch-Binding Agents and Antagonists and Methods of Use Thereof 有权
标题翻译：缺口结合剂和拮抗剂及其使用方法
公开(公告)号：US20100111958A1
公开(公告)日：2010-05-06
申请号：US12499627
申请日：2009-07-08
申请人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. Gurney , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , C07K16/18 , C07K16/28 , A61P35/04 , C12N5/00 , C12N5/02 , C07K14/435 , C07H21/04
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译：本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。

5. 发明申请

US20120288496A1 Notch-Binding Agents and Antagonists and Methods of Use Thereof 有权
标题翻译：缺口结合剂和拮抗剂及其使用方法
公开(公告)号：US20120288496A1
公开(公告)日：2012-11-15
申请号：US13472305
申请日：2012-05-15
申请人： Austin L. GURNEY , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
发明人： Austin L. GURNEY , Timothy Charles Hoey , Edward Thein Htun van der Horst , Aaron Ken Sato , Yuan Ching Liu , Maureen Fitch Bruhns , John A. Lewicki
IPC分类号： A61K39/395 , A61P35/00 , A61P9/00 , C12N5/09
CPC分类号： C07K16/22 , A61K31/337 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61N5/10 , C07H21/04 , C07K14/435 , C07K14/71 , C07K16/28 , C07K16/30 , C07K16/3046 , C07K16/462 , C07K16/464 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C07K2317/76 , C07K2317/92 , C12N5/0693 , C12N5/12 , C12N15/63 , C12N15/79 , C12N2501/998
摘要： The present invention relates to Notch-binding agents and Notch antagonists and methods of using the agents and/or antagonists for treating diseases such as cancer. The present invention provides antibodies that specifically bind to a non-ligand binding region of the extracellular domain of one or more human Notch receptor, such as Notch2 and/or Notch3, and inhibit tumor growth. The present invention further provides methods of treating cancer, the methods comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth.
摘要翻译：本发明涉及Notch结合剂和Notch拮抗剂以及使用这些药剂和/或拮抗剂治疗诸如癌症的疾病的方法。本发明提供了特异性结合一种或多种人Notch受体如Notch2和/或Notch3的细胞外结构域的非配体结合区并抑制肿瘤生长的抗体。本发明还提供了治疗癌症的方法，所述方法包括施用治疗有效量的特异性结合人Notch受体蛋白的细胞外结构域的非配体结合区的抗体并抑制肿瘤生长。

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