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    • 1. 发明授权
    • Method of preparing mixed formulation of sustained release microspheres by continuous one-step process
    • 通过连续一步法制备缓释微球混合制剂的方法
    • US07399486B2
    • 2008-07-15
    • US10562379
    • 2004-06-25
    • Hee Yong LeeSung Kyu KimJung Soo KimJi Suk LeeYoung Hwan JungJung In KimYun Mi SeoHo-Il ChoiSeung Gu ChangKee Don Park
    • Hee Yong LeeSung Kyu KimJung Soo KimJi Suk LeeYoung Hwan JungJung In KimYun Mi SeoHo-Il ChoiSeung Gu ChangKee Don Park
    • A61K9/22
    • A61K9/1694A61K9/1647A61K9/5084A61K38/24
    • Disclosed is a method for preparing a mixed formulation of sustained release microspheres with various compositions by a continuous one-step process. The present method is characterized by preparing the mixed formulation of sustained release microspheres with different compositions by a continuous one-step process by continuously introducing the mixed fluids into a dryer from the two or more different fluids for preparation of sustained release microspheres containing a biodegradable polymer, a drug, an additive and a solvent with different types of contents or both of the components, by controlling the mixing ratios of the fluids according to the time, unlike a conventional method including spray-drying a mixture of microspheres containing a biodegradable polymer, a drug, an additive and a solvent with a single composition. The present method can achieve a desired drug release, which is difficult to be obtained by conventional microspheres with a single composition, by preparing microspheres by a continuous one-step process, and can simplify the conventional complex process of separately preparing several microsphere formulations and then mixing the formulations at a proper ratio to achieve a desired drug release.
    • 公开了通过连续一步法制备具有各种组成的缓释微球混合制剂的方法。 本发明的方法的特征在于通过连续一步法制备具有不同组成的缓释微球的混合制剂,通过从两种或更多种不同的流体连续引入混合流体到干燥器中,用于制备含有可生物降解聚合物的缓释微球 ,药物,添加剂和具有不同类型含量的溶剂或两种组分的溶剂通过控制流体的混合比而不同于常规方法,包括喷雾干燥含有可生物降解的聚合物的微球体的混合物, 药物,添加剂和具有单一组成的溶剂。 本发明方法可以通过连续一步法制备微球,实现通过具有单一组成的常规微球难以获得的所需药物释放,并且可以简化分别制备几种微球制剂的常规复合方法,然后 以适当的比例混合制剂以实现期望的药物释放。
    • 3. 发明申请
    • Anti-collision method and system using optimized binary search tree
    • 防碰撞方法和系统采用优化二叉搜索树
    • US20060158312A1
    • 2006-07-20
    • US11316711
    • 2005-12-27
    • Kyung-ho ParkWoo-shik KangYoung-hwan JungSun-shin AnSeon-wook Kim
    • Kyung-ho ParkWoo-shik KangYoung-hwan JungSun-shin AnSeon-wook Kim
    • H04Q5/22
    • G06K7/0008G06K7/10049
    • Method for rapidly detecting identifier (ID) of tags, by radio frequency identification (RFID) reader in communication system that includes RFID reader and at least two tags communicating with RFID reader, is provided. RFID reader generates a prefix when IDs contained in at least two messages received collide with each other, prefix including a first colliding bit, which is set to ‘0’ or ‘1’, from high-order bits and non-colliding high-order bits. RFID reader sends a first message containing information that requests transmission of an assigned ID in a preset transmission period when the bits of the generated prefix match bits corresponding to the prefix, in the assigned ID. Tags receive a first message that contains a prefix including at least one bit, and sends a second message containing an assigned ID during a preset transmission period when the bits of the prefix match bits corresponding to the prefix, in assigned ID.
    • 提供了一种通过射频识别(RFID)阅读器快速检测标签的标识符(ID)的方法,该通信系统包括RFID读取器和至少两个与RFID读取器通信的标签。 当RFID包含在接收到的至少两个消息中的ID彼此冲突时,RFID读取器产生前缀,该前缀包括从高阶比特设置为“0”或“1”的第一冲突比特,并且不相关的高阶 位。 在所分配的ID中,当所生成的前缀的比特与前缀相对应的比特匹配时,RFID读取器发送包含请求在预设的传输周期中发送分配的ID的信息的第一消息。 标签接收包含至少一个比特的前缀的第一个消息,并且在分配的ID中,当前缀的比特与前缀相对应的比特匹配时,在预设的传输周期期间发送包含分配的ID的第二消息。
    • 9. 发明授权
    • Anti-collision method and system using optimized binary search tree
    • 防碰撞方法和系统采用优化二叉搜索树
    • US07741955B2
    • 2010-06-22
    • US11316711
    • 2005-12-27
    • Kyung-ho ParkWoo-shik KangYoung-hwan JungSun-shin AnSeon-wook Kim
    • Kyung-ho ParkWoo-shik KangYoung-hwan JungSun-shin AnSeon-wook Kim
    • H04Q5/22
    • G06K7/0008G06K7/10049
    • Method for rapidly detecting identifier (ID) of tags, by radio frequency identification (RFID) reader in communication system that includes RFID reader and at least two tags communicating with RFID reader, is provided. RFID reader generates a prefix when IDs contained in at least two messages received collide with each other, prefix including a first colliding bit, which is set to ‘0’ or ‘1’, from high-order bits and non-colliding high-order bits. RFID reader sends a first message containing information that requests transmission of an assigned ID in a preset transmission period when the bits of the generated prefix match bits corresponding to the prefix, in the assigned ID. Tags receive a first message that contains a prefix including at least one bit, and sends a second message containing an assigned ID during a preset transmission period when the bits of the prefix match bits corresponding to the prefix, in assigned ID.
    • 提供了一种通过射频识别(RFID)阅读器快速检测标签的标识符(ID)的方法,该通信系统包括RFID读取器和至少两个与RFID读取器通信的标签。 当RFID包含在接收到的至少两个消息中的ID彼此冲突时,RFID读取器产生前缀,该前缀包括从高阶比特设置为“0”或“1”的第一冲突比特,并且不相关的高阶 位。 在所分配的ID中,当所生成的前缀的比特与前缀相对应的比特匹配时,RFID读取器发送包含请求在预设的传输周期中发送分配的ID的信息的第一消息。 标签接收包含至少一个比特的前缀的第一个消息,并且在分配的ID中,当前缀的比特与前缀相对应的比特匹配时,在预设的传输周期期间发送包含分配的ID的第二消息。