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1. 发明授权

US08431360B2 Methods and compositions for improving sugar transport, mixed sugar fermentation, and production of biofuels 有权
公开(公告)号：US08431360B2
公开(公告)日：2013-04-30
申请号：US12843844
申请日：2010-07-26
申请人： N. Louise Glass , Chaoguang Tian , William T. Beeson, IV , Huimin Zhao , Jing Du , Jin Ho Choi , James H. Doudna Cate , Jonathan M. Galazka , Suk-Jin Ha , Yong-Su Jin , Soo Rin Kim , Sijin Li , Xiaomin Yang
发明人： N. Louise Glass , Chaoguang Tian , William T. Beeson, IV , Huimin Zhao , Jing Du , Jin Ho Choi , James H. Doudna Cate , Jonathan M. Galazka , Suk-Jin Ha , Yong-Su Jin , Soo Rin Kim , Sijin Li , Xiaomin Yang
IPC分类号： C12N1/00 , C12P21/04 , C12P21/06
CPC分类号： C12P21/02 , C07K14/37 , C07K14/705 , C12N15/80 , C12N15/81 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell, methods of increasing transport of a pentose into a cell, methods of increasing growth of a cell on a medium containing pentose sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell.

2. 发明申请

US20110020910A1 METHODS AND COMPOSITIONS FOR IMPROVING SUGAR TRANSPORT, MIXED SUGAR FERMENTATION, AND PRODUCTION OF BIOFUELS 有权
标题翻译：改善蔗糖运输，混合糖发酵和生产生物柴油的方法和组合物
公开(公告)号：US20110020910A1
公开(公告)日：2011-01-27
申请号：US12843844
申请日：2010-07-26
申请人： N.Louise C. GLASS , Chaoguang Tian , William T. Beeson, IV , Huimin Zhao , Jing Du , Jin Ho Choi , James H. Doudna Cate , Jonathan M. Galazka , Suk Jin Ha , Yong-Su Jin , Soo Rin Kim , Sijin Li , Xiaomin Yang
发明人： N.Louise C. GLASS , Chaoguang Tian , William T. Beeson, IV , Huimin Zhao , Jing Du , Jin Ho Choi , James H. Doudna Cate , Jonathan M. Galazka , Suk Jin Ha , Yong-Su Jin , Soo Rin Kim , Sijin Li , Xiaomin Yang
IPC分类号： C12N1/21 , C12N1/15 , C12N1/19
CPC分类号： C12P21/02 , C07K14/37 , C07K14/705 , C12N15/80 , C12N15/81 , Y02E50/16 , Y02E50/17
摘要： The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure further relates to methods of increasing transport of cellodextrin into a cell, methods of increasing growth of a cell on a medium containing cellodextrin, methods of co-fermenting cellulose-derived and hemicellulose-derived sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports cellodextrin into the cell. The present disclosure relates to host cells containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell, methods of increasing transport of a pentose into a cell, methods of increasing growth of a cell on a medium containing pentose sugars, and methods of making hydrocarbons or hydrocarbon derivatives by providing a host cell containing a recombinant polynucleotide encoding a polypeptide where the polypeptide transports a pentose into the cell.
摘要翻译：本公开内容涉及含有编码多肽的重组多核苷酸的宿主细胞，其中多肽将纤维葡聚糖转运入细胞。本发明进一步涉及增加纤维素递送到细胞中的方法，增加细胞在含有纤维葡聚糖的培养基上生长的方法，共发酵纤维素衍生和半纤维素衍生的糖的方法，以及制备烃或烃的方法通过提供含有编码多肽的重组多核苷酸的宿主细胞，其中所述多肽将纤维葡聚糖转运到细胞中。本公开涉及含有编码多肽的重组多核苷酸的宿主细胞，其中多肽将戊糖转运入细胞，增加戊糖转运至细胞中的方法，在含有戊糖的培养基上增加细胞生长的方法，以及通过提供含有编码多肽的重组多核苷酸的宿主细胞来制备烃或烃衍生物的方法，其中多肽将戊糖转运到细胞中。

3. 发明申请

US20100105573A1 VECTOR AND MICROORGANISM FOR INCREASING GALACTOSE CATABOLISM AND METHODS THEREFOR 失效
标题翻译：用于增加水解酶催化剂的载体和微生物及其方法
公开(公告)号：US20100105573A1
公开(公告)日：2010-04-29
申请号：US12481193
申请日：2009-06-09
申请人： Byung Jo YU , Jae Chan PARK , Hyun Min KOO , Yong Su JIN , Ki Sung LEE
发明人： Byung Jo YU , Jae Chan PARK , Hyun Min KOO , Yong Su JIN , Ki Sung LEE
IPC分类号： C40B30/06 , C12N15/63 , C12N1/19 , C12P1/02 , C12P7/06 , C12P7/04 , C12P7/16 , C12P7/28
CPC分类号： C12N15/1034 , C07K14/395 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/28 , Y02E50/10 , Y02E50/17
摘要： Provided herein are a recombinant vector and microorganism including the isolated SNR84 gene, and a method of increasing volumetric productivity of biofuel from a galactose-containing carbon source using the isolated SNR84 gene, the recombinant vector or the recombinant microorganism. Also disclosed herein is a method of screening yeast for genes associated with increased galactose catabolism when the genes are overexpressed.
摘要翻译：本文提供了包含分离的SNR84基因的重组载体和微生物，以及使用分离的SNR84基因，重组载体或重组微生物从含半乳糖的碳源增加生物燃料的体积生产率的方法。本文还公开了当基因过表达时筛选与增加的半乳糖分解代谢相关的基因的酵母的方法。

4. 发明授权

US07226735B2 Xylose-fermenting recombinant yeast strains 有权
标题翻译：木糖发酵重组酵母菌株
公开(公告)号：US07226735B2
公开(公告)日：2007-06-05
申请号：US10348464
申请日：2003-01-21
申请人： Thomas W. Jeffries , Yong-Su Jin
发明人： Thomas W. Jeffries , Yong-Su Jin
IPC分类号： C12Q1/68 , C12Q1/54 , G01N33/53 , C12P1/00 , C12N1/00 , C12N15/63
CPC分类号： C12N9/0006 , C12N9/1205 , C12N15/81 , C12P7/06 , C12P7/12 , Y02E50/17
摘要： Disclosed are xylose-fermenting recombinant yeast strains comprising heterologous PsXYL1, Ps XYL2, and PsXYL3, as well as methods of fermenting xylose to obtain ethanol using the recombinant yeast strain.
摘要翻译：公开了包含异源PsXYL1，Ps XYL2和PsXYL3的木糖发酵重组酵母菌株，以及使用重组酵母菌株发酵木糖以获得乙醇的方法。

5. 发明申请

US20140154751A1 ENHANCED FERMENTATION OF CELLODEXTRINS AND BETA-D-GLUCOSE 审中-公开
标题翻译：增强CELLODEXTRINS和BET-D-葡萄糖的发酵
公开(公告)号：US20140154751A1
公开(公告)日：2014-06-05
申请号：US13980866
申请日：2012-01-20
申请人： James H. Doudna Cate , William T. Beeson, IV , Jonathan M. Galazka , Huimin Zhao , Sijin Li , Yong-Su Jin , Suk-Jin Ha
发明人： James H. Doudna Cate , William T. Beeson, IV , Jonathan M. Galazka , Huimin Zhao , Sijin Li , Yong-Su Jin , Suk-Jin Ha
IPC分类号： C12P19/12 , C12P7/10 , C12P19/14
CPC分类号： C12P19/12 , C07K14/195 , C07K14/37 , C12N9/2445 , C12N9/90 , C12P7/10 , C12P19/14 , C12P19/16 , C12P19/24 , Y02E50/16 , Y02E50/17
摘要： The present disclosure provides compositions and methods for the fermentation of cellodextrins and β-D-glucose. Host cells and recombinant polypeptides having glucose mutarotase activity are provided. Additionally, methods for improving cell growth, production of chemicals, and consumption of cellodextrins and β-D-glucose during fermentation of mixtures containing cellodextrins and β-D-glucose are provided.
摘要翻译：本公开提供了用于发酵纤维糊精和β-葡萄糖的组合物和方法。提供具有葡萄糖变异酶活性的宿主细胞和重组多肽。另外，提供了用于改善细胞生长，化学品生产和在含有纤维糊精和β-葡萄糖的混合物发酵过程中消耗纤维糊精和消耗D-葡萄糖的方法。

6. 发明授权

US08722388B2 Vector and microorganism for increasing galactose catabolism and methods therefor 失效
标题翻译：载体和微生物用于增加半乳糖分解代谢及其方法
公开(公告)号：US08722388B2
公开(公告)日：2014-05-13
申请号：US12481193
申请日：2009-06-09
申请人： Byung Jo Yu , Jae Chan Park , Hyun Min Koo , Yong Su Jin , Ki Sung Lee
发明人： Byung Jo Yu , Jae Chan Park , Hyun Min Koo , Yong Su Jin , Ki Sung Lee
IPC分类号： C12N1/00 , C12N1/19
CPC分类号： C12N15/1034 , C07K14/395 , C12P7/04 , C12P7/06 , C12P7/16 , C12P7/28 , Y02E50/10 , Y02E50/17
摘要： Provided herein are a recombinant vector and microorganism including the isolated SNR84 gene, and a method of increasing volumetric productivity of biofuel from a galactose-containing carbon source using the isolated SNR84 gene, the recombinant vector or the recombinant microorganism. Also disclosed herein is a method of screening yeast for genes associated with increased galactose catabolism when the genes are overexpressed.
摘要翻译：本文提供了包含分离的SNR84基因的重组载体和微生物，以及使用分离的SNR84基因，重组载体或重组微生物从含半乳糖的碳源增加生物燃料的体积生产率的方法。本文还公开了当基因过表达时筛选与增加的半乳糖分解代谢相关的基因的酵母的方法。

7. 发明申请

US20140057323A1 ENHANCED CELLODEXTRIN METABOLISM 审中-公开
标题翻译：增强细胞因子代谢
公开(公告)号：US20140057323A1
公开(公告)日：2014-02-27
申请号：US13982248
申请日：2012-02-07
申请人： James H. Doudna Cate , Yong-Su Jin , Jonathan M. Galazka , Suk-Jin Ha
发明人： James H. Doudna Cate , Yong-Su Jin , Jonathan M. Galazka , Suk-Jin Ha
IPC分类号： C12P19/18 , C12P19/02
CPC分类号： C12P19/18 , C07K14/395 , C12N9/1051 , C12N9/1205 , C12N9/2445 , C12N9/90 , C12P7/10 , C12P19/02 , C12Y204/0102 , C12Y204/01049 , C12Y302/01021 , C12Y504/02002 , Y02E50/16
摘要： The present disclosure relates to host cells containing two or more of a recombinant cellodextrin transporter, a recombinant cellodextrin phosphorylase, a recombinant β-glucosidase, a recombinant phosphoglucomutase, or a recombinant hexokinase; and to methods of using such cells for degrading cellodextrin, for producing hydrocarbons or hydrocarbon derivatives from cellodextrin, and for reducing ATP consumption during glucose utilization.
摘要翻译：本公开涉及含有两种或更多种重组纤维蛋白转运蛋白，重组纤维蛋白磷酸化酶，重组β-葡糖苷酶，重组磷酸葡萄糖变位酶或重组己糖激酶的宿主细胞; 以及使用这种细胞降解纤维素的方法，用于从纤维糊精生产烃或烃衍生物，以及降低葡萄糖利用期间的ATP消耗。

8. 发明授权

US07741070B2 Gene targets for enhanced carotenoid production 失效
标题翻译：增强类胡萝卜素生产的基因靶标
公开(公告)号：US07741070B2
公开(公告)日：2010-06-22
申请号：US11259745
申请日：2005-10-27
申请人： Gregory Stephanopoulos , Hal S. Alper , Yong-Su Jin
发明人： Gregory Stephanopoulos , Hal S. Alper , Yong-Su Jin
IPC分类号： C12P23/00 , C12N1/21 , C12N15/74
CPC分类号： C12N1/20 , C12N9/00 , C12N9/0004 , C12N9/0008 , C12N9/0016 , C12N9/0053 , C12N9/0071 , C12N9/1018 , C12N9/1022 , C12N9/1085 , C12N9/16 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/52 , C12P23/00
摘要： The present invention provides engineered cells and methods for utilizing same. Methods of enhanced carotenoid synthesis utilizing cells genetically disrupted for a yjiD, hnr or yjfP gene, or further disrupted for a gdhA, gpmB, aceE, ppc, talB or fdhF gene, or any combination thereof, or cells inhibited for their expression, activity or function are disclosed. Additionally, methods of enhanced carotenoid synthesis utilizing cells genetically disrupted for gdhA, aceE, fdhF, yjiD, hnr or yjfP gene expression or any combination thereof and ackA, appY, aspC, clp, clpP, clpXP, crcB, csdA, cyaA, evgS, fdhA, fdhD, feoB, funA, glnE, glxR, gntK, hycI, lipB, lysU, modA, moeA, nadA, nuoC, nuoK, pflB, pitA, pst, pstC, pta, p-yjiD, sohA, stpA, yagR, yaiD, ybaS, ycfZ, ydeN, yebB, yedN, yfcC, ygjP, yibD, yjfP, yjhH, or yliE gene expression, or a combination thereof or cells inhibited for their expression, activity or function are disclosed. Methods of enhanced carotenoid synthesis utilizing cells genetically engineered to overexpress dxs, idi, ispFD, yjiD, rpoS, torC, appY, ydgK, yeiA, yedR, tort, arcB, yggT, purDH, yfjN or a combination thereof, or further disrupted for the above-referenced genes are disclosed. Methods for identifying genes involved in optimized production of a carotenoid, and cells disrupted for, or inhibited for the expression, activity or function of genes thus identified are described.
摘要翻译：本发明提供工程细胞及其利用方法。使用对yjiD，hnr或yjfP基因进行遗传破坏的细胞的增强的类胡萝卜素合成方法，或进一步破坏gdhA，gpmB，aceE，ppc，talB或fdhF基因或其任何组合，或抑制其表达，活性或功能被公开。另外，利用对gdhA，aceE，fdhF，yjiD，hnr或yjfP基因表达或其任何组合和ackA，appY，aspC，clp，clpP，clpXP，crcB，csdA，cyaA，evgS遗传破坏的细胞的增强的类胡萝卜素合成的方法， fdhA，fdhD，feoB，funA，glnE，glxR，gntK，hycI，lipB，lysU，modA，moeA，nadA，nuoC，nuoK，pflB，pitA，pst，pstC，pta，p-yjiD，sohA，stpA， yaiD，ybaS，ycfZ，ydeN，yebB，yedN，yfcC，ygjP，yibD，yjfP，yjhH或yliE基因表达，或其组合或抑制其表达，活性或功能的细胞。增强类胡萝卜素合成的方法，利用遗传工程改造为过表达dxs，idi，ispFD，yjiD，rpoS，torC，appY，ydgK，yeiA，yedR，tort，arcB，yggT，purDH，yfjN或其组合的细胞的类胡萝卜素合成，或进一步破坏公开了上述参考的基因。描述了鉴定参与优化的类胡萝卜素生成的基因的方法，以及由此鉴定的基因的活化或功能的破坏或抑制其表达的活性或功能的方法。

9. 发明申请

US20100112657A1 NUCLEIC ACIDS AND CONSTRUCTS FOR INCREASING GALACTOSE CATABOLISM AND METHODS THEREFOR 审中-公开
标题翻译：核酸和增加凝胶酶催化剂的结构及其方法
公开(公告)号：US20100112657A1
公开(公告)日：2010-05-06
申请号：US12435697
申请日：2009-05-05
申请人： Byung Jo YU , Jae Chan PARK , Hyun Min KOO , Yong Su JIN , Ki Sung LEE
发明人： Byung Jo YU , Jae Chan PARK , Hyun Min KOO , Yong Su JIN , Ki Sung LEE
IPC分类号： C12P7/06 , C07H21/00 , C07K14/00 , C12N1/16 , C12N1/00 , C12N15/74
CPC分类号： C12P7/08 , C07K14/395 , Y02E50/17
摘要： Provided are a recombinant gene associated with increased galactose catabolism, and a recombinant vector and microorganism including the gene. Also disclosed are a method of producing ethanol from a galactose-containing carbon source by culturing the microorganism including the gene in a galactose-containing carbon source such that ethanol is produced, and a method of screening a gene in yeast resulting in increased galactose catabolism when overexpressed.
摘要翻译：提供与增加的半乳糖分解代谢相关的重组基因，以及包含该基因的重组载体和微生物。还公开了通过在含半乳糖的碳源中培养含有半乳糖的碳源的微生物以产生乙醇从含半乳糖的碳源生产乙醇的方法，以及在酵母中筛选基因导致增加的半乳糖分解代谢的方法，过度表达

10. 发明申请

US20060121558A1 Gene targets for enhanced carotenoid production 失效
标题翻译：增强类胡萝卜素生产的基因靶标
公开(公告)号：US20060121558A1
公开(公告)日：2006-06-08
申请号：US11259745
申请日：2005-10-27
申请人： Gregory Stephanopoulos , Hal Alper , Yong-Su Jin
发明人： Gregory Stephanopoulos , Hal Alper , Yong-Su Jin
IPC分类号： C12P23/00 , C12N1/21 , C12N15/74
CPC分类号： C12N1/20 , C12N9/00 , C12N9/0004 , C12N9/0008 , C12N9/0016 , C12N9/0053 , C12N9/0071 , C12N9/1018 , C12N9/1022 , C12N9/1085 , C12N9/16 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/52 , C12P23/00
摘要： The present invention provides engineered cells and methods for utilizing same. Methods of enhanced carotenoid synthesis utilizing cells genetically disrupted for a yjiD, hnr or yjfP gene, or further disrupted for a gdhA, gpmB, aceE, ppc, talB or fdhF gene, or any combination thereof, or cells inhibited for their expression, activity or function are disclosed. Additionally, methods of enhanced carotenoid synthesis utilizing cells genetically disrupted for gdhA, aceE, fdhF, yjiD, hnr or yjfP gene expression or any combination thereof and ackA, appY, aspC, clp, clpP, clpXP, crcB, csdA, cyaA, evgS, fdhA, fdhD, feoB, funA, glnE, glxR, gntK, hycI, lipB, lysU, modA, moeA, nadA, nuoC, nuoK, pflB, pitA, pst, pstC, pta, p-yjiD, sohA, sipA, yagR, yaiD, ybaS, ycfZ, ydeN, yebB, yedN, yfcC, ygjP, yibD, yjfP, yjhH, or yliE gene expression, or a combination thereof or cells inhibited for their expression, activity or function are disclosed. Methods of enhanced carotenoid synthesis utilizing cells genetically engineered to overexpress dxs, idi, ispFD, yjiD, rpoS, torC, appY, ydgK, yeiA, yedR, tort, arcB, yggT, purDH, yfjN or a combination thereof, or further disrupted for the above-referenced genes are disclosed. Methods for identifying genes involved in optimized production of a carotenoid, and cells disrupted for, or inhibited for the expression, activity or function of genes thus identified are described.
摘要翻译：本发明提供工程细胞及其利用方法。使用对yjiD，hnr或yjfP基因进行遗传破坏的细胞的增强的类胡萝卜素合成方法，或进一步破坏gdhA，gpmB，aceE，ppc，talB或fdhF基因或其任何组合，或抑制其表达，活性或功能被公开。另外，利用对gdhA，aceE，fdhF，yjiD，hnr或yjfP基因表达或其任何组合和ackA，appY，aspC，clp，clpP，clpXP，crcB，csdA，cyaA，evgS遗传破坏的细胞的增强的类胡萝卜素合成的方法， fdhA，fdhD，feoB，funA，glnE，glxR，gntK，hycI，lipB，lysU，modA，moeA，nadA，nuoC，nuoK，pflB，pitA，pst，pstC，pta，p-yjiD，sohA，sipA，yagR， yaiD，ybaS，ycfZ，ydeN，yebB，yedN，yfcC，ygjP，yibD，yjfP，yjhH或yliE基因表达，或其组合或抑制其表达，活性或功能的细胞。增强类胡萝卜素合成的方法，利用遗传工程改造为过表达dxs，idi，ispFD，yjiD，rpoS，torC，appY，ydgK，yeiA，yedR，tort，arcB，yggT，purDH，yfjN或其组合的细胞的类胡萝卜素合成，或进一步破坏公开了上述参考的基因。描述了鉴定参与优化的类胡萝卜素生成的基因的方法，以及由此鉴定的基因的活化或功能的破坏或抑制其表达的活性或功能的方法。

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