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1. 发明申请

US20130209446A1 Copy Number Variant-Dependent Genes As Diagnostic Tools, Predictive Biomarkers And Therapeutic Targets 审中-公开
标题翻译：作为诊断工具，预测生物标志物和治疗靶标的拷贝数变异依赖基因
公开(公告)号：US20130209446A1
公开(公告)日：2013-08-15
申请号：US13810705
申请日：2011-07-20
申请人： John D. Shaughnessy, JR. , Bart Barlogie , Erming Tian , Yiming Zhou
发明人： John D. Shaughnessy, JR. , Bart Barlogie , Erming Tian , Yiming Zhou
IPC分类号： C12Q1/68 , A61K45/00 , A61K45/06 , A61K31/727
CPC分类号： C12Q1/6886 , A61K31/727 , A61K45/00 , A61K45/06 , C12Q2600/112 , C12Q2600/156 , C12Q2600/158
摘要： Provided herein are methods of diagnosing and/or treating malignant or pre-malignant conditions in a subject. Overexpression of copy number variant-dependent genes, e.g., genes encoding a cell surface receptor, resulting from copy number changes compared to control is diagnostic of the condition, such as multiple myeloma or monoclonal gammopathy of undetermined significance. Also provided are methods for treating malignant conditions, such as multiple myeloma or a hyperdiploid subtype, with therapeutic agents, with or without other anti-cancer drugs, to downrregulate the overexpressed CNV genes and/or up-regulate the underexpressed genes. Furthermore, methods for lowering drug resistance in multiple myeloma cells via inhibition of platelet activation or thrombin release and for increasing survivability of a multiple myeloma subject via lithibition of PSMD4 gene to increase b-catenin protein expression are provided.
摘要翻译：本文提供了诊断和/或治疗受试者中恶性或恶性前病症的方法。拷贝数变异依赖性基因的过度表达，例如编码细胞表面受体的基因，与对照相比拷贝数变化所得到的是病症的诊断，例如具有未确定意义的多发性骨髓瘤或单克隆丙种球蛋白病。还提供了用治疗剂（含或不含其他抗癌药物）治疗恶性病症如多发性骨髓瘤或高倍体二倍体亚型的方法来下调调节过表达的CNV基因和/或上调低表达基因。此外，提供了通过抑制血小板活化或凝血酶释放降低多发性骨髓瘤细胞耐药性的方法，以及通过PSMD4基因通过增加b-连环蛋白表达增加多发性骨髓瘤受试者的生存性。

2. 发明授权

US08495680B2 System and method for behavioral model clustering in television usage, targeted advertising via model clustering, and preference programming based on behavioral model clusters 失效
公开(公告)号：US08495680B2
公开(公告)日：2013-07-23
申请号：US10043698
申请日：2002-01-09
申请人： Isaac Bentolila , Yiming Zhou , Isaac Labeeb Ismail , Richard Humpleman
发明人： Isaac Bentolila , Yiming Zhou , Isaac Labeeb Ismail , Richard Humpleman
IPC分类号： H04N5/445
CPC分类号： H04N21/2668 , G06Q30/0251 , G06Q30/0254 , G06Q30/0255 , G06Q30/0269 , G06Q30/0271 , H04N7/163 , H04N7/17309 , H04N21/252 , H04N21/44222 , H04N21/4532 , H04N21/454 , H04N21/466 , H04N21/4663 , H04N21/4667 , H04N21/4826
摘要： The method and system for TV user profile data prediction and modeling allows accurate and narrowly focused behavioral clustering. A client-side system classifies television consumers into representative user profiles. The profiles target individual user advertising and program preference category groups. A contextual behavioral profiling system determines the user's monitor behavior and content preferences, and the system may be continually updated with user information. A behavioral model database is queried by various system modules. The programming, including targeted advertising for television and interactive television is based on the profile data prediction, modeling and preference determination. The system is enabled to present a complete program sequence to the viewer based on the preference determination and stored programming. The latter is referred to as automatic program sequence (virtual channel) creation and the virtual channel can be presented as a separate channel in an electronic programming guide (EPG).

3. 发明申请

US20120011530A1 SYSTEM, METHOD, AND SOFTWARE APPLICATION FOR TARGETED ADVERTISING VIA BEHAVIORAL MODEL CLUSTERING, AND PREFERENCE PROGRAMMING BASED ON BEHAVIORAL MODEL CLUSTERS 有权
标题翻译：系统，方法和软件应用通过行为模型集群进行目标广告和基于行为模型集群的优先级编程
公开(公告)号：US20120011530A1
公开(公告)日：2012-01-12
申请号：US13238195
申请日：2011-09-21
申请人： Isaac Bentolila , Yiming Zhou , Labeeb K. Ismail , Richard Humpleman
发明人： Isaac Bentolila , Yiming Zhou , Labeeb K. Ismail , Richard Humpleman
IPC分类号： H04N21/258
CPC分类号： H04N21/2668 , G06Q30/0251 , G06Q30/0254 , G06Q30/0255 , G06Q30/0269 , G06Q30/0271 , H04N7/163 , H04N7/17309 , H04N21/252 , H04N21/44222 , H04N21/4532 , H04N21/454 , H04N21/466 , H04N21/4663 , H04N21/4667 , H04N21/4826
摘要： The method and system for TV user profile data prediction and modeling allows accurate and narrowly focused behavioral clustering. A client-side system classifies television consumers into representative user profiles. The profiles target individual user advertising and program preference category groups. A contextual behavioral profiling system determines the user's monitor behavior and content preferences, and the system may be continually updated with user information. A behavioral model database is queried by various system modules. The programming, including targeted advertising for television and interactive television is based on the profile data prediction, modeling and preference determination. The system is enabled to present a complete program sequence to the viewer based on the preference determination and stored programming. The latter is referred to as automatic program sequence (virtual channel) creation and the virtual channel can be presented as a separate channel in an electronic programming guide (EPG).
摘要翻译：电视用户简档数据预测和建模的方法和系统允许精确和狭义的行为聚类。客户端系统将电视消费者分为有代表性的用户配置文件。配置文件定位到个人用户广告和节目偏好类别组。上下文行为分析系统确定用户的监视行为和内容偏好，并且系统可以用用户信息不断更新。行为模型数据库由各种系统模块查询。编程，包括电视和互动电视的有针对性的广告是基于轮廓数据预测，建模和偏好确定。该系统能够基于偏好确定和存储的编程向观看者呈现完整的程序序列。后者被称为自动程序序列（虚拟通道）创建，并且虚拟通道可以作为电子节目指南（EPG）中的单独频道呈现。

4. 发明授权

US08046797B2 System, method, and software application for targeted advertising via behavioral model clustering, and preference programming based on behavioral model clusters 有权
标题翻译：通过行为模型聚类进行目标广告的系统，方法和软件应用，以及基于行为模型集群的偏好编程
公开(公告)号：US08046797B2
公开(公告)日：2011-10-25
申请号：US10043714
申请日：2002-01-09
申请人： Isaac Bentolila , Yiming Zhou , Labeeb K. Ismail , Richard Humpleman
发明人： Isaac Bentolila , Yiming Zhou , Labeeb K. Ismail , Richard Humpleman
IPC分类号： G06F3/00 , H04N7/10 , H04N7/025 , G06Q30/00 , G06F12/00
CPC分类号： H04N21/2668 , G06Q30/0251 , G06Q30/0254 , G06Q30/0255 , G06Q30/0269 , G06Q30/0271 , H04N7/163 , H04N7/17309 , H04N21/252 , H04N21/44222 , H04N21/4532 , H04N21/454 , H04N21/466 , H04N21/4663 , H04N21/4667 , H04N21/4826
摘要： The method and system for TV user profile data prediction and modeling allows accurate and narrowly focused behavioral clustering. A client-side system classifies television consumers into representative user profiles. The profiles target individual user advertising and program preference category groups. A contextual behavioral profiling system determines the user's monitor behavior and content preferences, and the system may be continually updated with user information. A behavioral model database is queried by various system modules. The programming, including targeted advertising for television and interactive television is based on the profile data prediction, modeling and preference determination. The system is enabled to present a complete program sequence to the viewer based on the preference determination and stored programming. The latter is referred to as automatic program sequence (virtual channel) creation and the virtual channel can be presented as a separate channel in an electronic programming guide (EPG).
摘要翻译：电视用户简档数据预测和建模的方法和系统允许精确和狭义的行为聚类。客户端系统将电视消费者分为有代表性的用户配置文件。配置文件定位到个人用户广告和节目偏好类别组。上下文行为分析系统确定用户的监视行为和内容偏好，并且系统可以用用户信息不断更新。行为模型数据库由各种系统模块查询。编程，包括电视和互动电视的有针对性的广告是基于轮廓数据预测，建模和偏好确定。该系统能够基于偏好确定和存储的编程向观看者呈现完整的程序序列。后者被称为自动程序序列（虚拟通道）创建，并且虚拟通道可以作为电子节目指南（EPG）中的单独频道呈现。

5. 发明申请

US20070037140A1 Methods and compositions for detecting sars virus 审中-公开
标题翻译：检测萨尔病毒的方法和组成
公开(公告)号：US20070037140A1
公开(公告)日：2007-02-15
申请号：US10556182
申请日：2003-05-09
申请人： Ze Li , Yiming Zhou , Shengce Tao , Jing Cheng , Jianwei Wang , Tao Hong , Yun Cheng , Quanzhong Shan
发明人： Ze Li , Yiming Zhou , Shengce Tao , Jing Cheng , Jianwei Wang , Tao Hong , Yun Cheng , Quanzhong Shan
IPC分类号： C12Q1/70 , C12Q1/68 , C12M1/34
CPC分类号： C07H21/00 , C12Q1/701
摘要： This invention relates generally to the field of virus detection. In particular, the invention provides chips, probes, primers, kits and methods for amplifying and detecting SARS-CoV nucleotide sequence. The clinical and other uses of the present chips, probes, primers, kits and methods are also contemplated.
摘要翻译：本发明一般涉及病毒检测领域。特别地，本发明提供用于扩增和检测SARS-CoV核苷酸序列的芯片，探针，引物，试剂盒和方法。还考虑了本发明芯片，探针，引物，试剂盒和方法的临床和其它用途。

6. 发明授权

US08938758B2 System and method for personalized TV 有权
公开(公告)号：US08938758B2
公开(公告)日：2015-01-20
申请号：US11370081
申请日：2006-03-06
申请人： Kenneth A. Klarfeld , Richard Humpleman , Isaac (Ariel) Bentolila , Yiming Zhou
发明人： Kenneth A. Klarfeld , Richard Humpleman , Isaac (Ariel) Bentolila , Yiming Zhou
IPC分类号： H04N7/173 , G06F13/00 , H04N21/262 , H04N21/475 , H04N21/45 , H04N21/845 , H04N5/76 , H04N21/466 , H04N21/8543 , H04N7/16 , G11B27/10 , H04N21/81 , G11B27/32 , H04N21/454 , H04N21/482 , H04N21/84 , H04N5/445 , H04N7/00
CPC分类号： H04N21/4532 , G11B27/105 , G11B27/322 , H04N5/76 , H04N7/163 , H04N21/231 , H04N21/251 , H04N21/25891 , H04N21/26283 , H04N21/4334 , H04N21/44222 , H04N21/454 , H04N21/466 , H04N21/4668 , H04N21/4751 , H04N21/4755 , H04N21/4756 , H04N21/482 , H04N21/4823 , H04N21/6587 , H04N21/812 , H04N21/84 , H04N21/8456 , H04N21/8543
摘要： A Personal TV System receives a plurality of video segments constituting a TV program and information describing each segment, and controls the display of the segments to a viewer in accordance with preferences of the viewer and with the description of each segment. Segments may be omitted or replaced with substitute segments. The viewer may review his preferences and edit or replace them. In a multi-viewer household, the system may prompt a viewer to confirm her preferences. A TV program may contain interactive segments, and when the viewer chooses to interact with a particular segment, the system automatically stores all subsequently received segments for later viewing while the viewer interacts with the selected segment. The system may present TV program choices to the viewer selected and arranged in accordance with her preferences.

7. 发明授权

US08302127B2 System and method for personalized TV 有权
标题翻译：个性化电视的系统和方法
公开(公告)号：US08302127B2
公开(公告)日：2012-10-30
申请号：US09963335
申请日：2001-09-24
申请人： Kenneth A. Klarfeld , Richard Humpleman , Isaac (Ariel) Bentolila , Yiming Zhou
发明人： Kenneth A. Klarfeld , Richard Humpleman , Isaac (Ariel) Bentolila , Yiming Zhou
IPC分类号： H04N5/445 , H04N7/16 , H01H9/30 , H04N7/173
CPC分类号： H04N21/4532 , G11B27/105 , G11B27/322 , H04N5/76 , H04N7/163 , H04N21/231 , H04N21/251 , H04N21/25891 , H04N21/26283 , H04N21/4334 , H04N21/44222 , H04N21/454 , H04N21/466 , H04N21/4668 , H04N21/4751 , H04N21/4755 , H04N21/4756 , H04N21/482 , H04N21/4823 , H04N21/6587 , H04N21/812 , H04N21/84 , H04N21/8456 , H04N21/8543
摘要： A Personal TV System receives a plurality of video segments constituting a TV program and information describing each segment, and controls the display of the segments to a viewer in accordance with preferences of the viewer and with the description of each segment. Segments may be omitted or replaced with substitute segments. The viewer may review his preferences and edit or replace them. In a multi-viewer household, the system may prompt a viewer to confirm her preferences. A TV program may contain interactive segments, and when the viewer chooses to interact with a particular segment, the system automatically stores all subsequently received segments for later viewing while the viewer interacts with the selected segment. The system may present TV program choices to the viewer selected and arranged in accordance with her preferences.
摘要翻译：个人电视系统接收构成电视节目的多个视频片段和描述每个片段的信息，并且根据观众的偏好以及每个片段的描述来控制片段对观众的显示。段可以省略或替换为替代段。观众可以查看他的偏好并编辑或替换它们。在多观众家庭中，系统可以提示观众确认她的偏好。电视节目可以包含交互式片段，并且当观众选择与特定片段进行交互时，系统自动存储所有随后接收到的片段，以供观众与所选片段交互作用以便稍后观看。该系统可以根据她的偏好向所选择和排列的观众呈现电视节目选择。

8. 发明申请

US20060206912A1 System and method for personalized TV 有权
公开(公告)号：US20060206912A1
公开(公告)日：2006-09-14
申请号：US11370156
申请日：2006-03-06
申请人： Kenneth Klarfeld , Richard Humpleman , Isaac (Ariel) Bentolila , Yiming Zhou
发明人： Kenneth Klarfeld , Richard Humpleman , Isaac (Ariel) Bentolila , Yiming Zhou
IPC分类号： H04N5/445 , G06F3/00 , G06F13/00
CPC分类号： H04N21/4532 , G11B27/105 , G11B27/322 , H04N5/76 , H04N7/163 , H04N21/231 , H04N21/251 , H04N21/25891 , H04N21/26283 , H04N21/4334 , H04N21/44222 , H04N21/454 , H04N21/466 , H04N21/4668 , H04N21/4751 , H04N21/4755 , H04N21/4756 , H04N21/482 , H04N21/4823 , H04N21/6587 , H04N21/812 , H04N21/84 , H04N21/8456 , H04N21/8543
摘要： A Personal TV System receives a plurality of video segments constituting a TV program and information describing each segment, and controls the display of the segments to a viewer in accordance with preferences of the viewer and with the description of each segment. Segments may be omitted or replaced with substitute segments. The viewer may review his preferences and edit or replace them. In a multi-viewer household, the system may prompt a viewer to confirm her preferences. A TV program may contain interactive segments, and when the viewer chooses to interact with a particular segment, the system automatically stores all subsequently received segments for later viewing while the viewer interacts with the selected segment. The system may present TV program choices to the viewer selected and arranged in accordance with her preferences.

9. 发明授权

US06654930B1 Video script editor 失效
标题翻译：视频脚本编辑器
公开(公告)号：US06654930B1
公开(公告)日：2003-11-25
申请号：US08821321
申请日：1997-03-20
申请人： Yiming Zhou , Mark John McGrath , Vincent Carl Harradine
发明人： Yiming Zhou , Mark John McGrath , Vincent Carl Harradine
IPC分类号： G06F700
CPC分类号： G11B27/031 , G11B27/28 , G11B27/34
摘要： A sequence of video frames is assembled from video clips. The frames have time codes associated therewith. It is desired to match sections of the text (T1, T2) to corresponding sections (V1, V2) of the video sequence. Time codes (TCx, TCx+1) corresponding to the time codes of the video frames are entered into the text. A rate n of reading the words of the text is defined. The extent W of the text which matches an associated section of the video is calculated as W=(TCx+1−Tcx).n. On a text display, the extent W of the text which matches the video section is indicated by highlighting or in other ways. More text than matches a video section may be provided. The excess text or overflow text is distinguished on the display by e.g. color from the active text which matches the video section.
摘要翻译：一系列视频帧由视频片段组合起来。帧具有与之相关联的时间码。期望将文本（T1，T2）的部分与视频序列的相应部分（V1，V2）进行匹配。对应于视频帧的时间码的时间码（TCx，TCx + 1）被输入到文本中。定义阅读文本单词的速率n。与视频的相关部分匹配的文本的范围W被计算为文本显示，与突出显示或以其他方式指示与视频部分匹配的文本的扩展W。可以提供比匹配视频部分更多的文本。多余的文本或溢出文本在显示器上被区分。来自与视频部分匹配的活动文本的颜色。

10. 发明授权

US08850465B2 System, method, and software application for targeted advertising via behavioral model clustering, and preference programming based on behavioral model clusters 有权
标题翻译：通过行为模型聚类进行目标广告的系统，方法和软件应用，以及基于行为模型集群的偏好编程
公开(公告)号：US08850465B2
公开(公告)日：2014-09-30
申请号：US13238195
申请日：2011-09-21
申请人： Isaac Bentolila , Yiming Zhou , Labeeb K. Ismail , Richard Humpleman
发明人： Isaac Bentolila , Yiming Zhou , Labeeb K. Ismail , Richard Humpleman
IPC分类号： H04N7/10 , H04N5/445 , H04N21/466 , H04N7/173 , G06Q30/02 , H04N7/16 , H04N21/45 , H04N21/25 , H04N21/454 , H04N21/2668 , H04N21/442 , H04N21/482
CPC分类号： H04N21/2668 , G06Q30/0251 , G06Q30/0254 , G06Q30/0255 , G06Q30/0269 , G06Q30/0271 , H04N7/163 , H04N7/17309 , H04N21/252 , H04N21/44222 , H04N21/4532 , H04N21/454 , H04N21/466 , H04N21/4663 , H04N21/4667 , H04N21/4826
摘要： The method and system for TV user profile data prediction and modeling allows accurate and narrowly focused behavioral clustering. A client-side system classifies television consumers into representative user profiles. The profiles target individual user advertising and program preference category groups. A contextual behavioral profiling system determines the user's monitor behavior and content preferences, and the system may be continually updated with user information. A behavioral model database is queried by various system modules. The programming, including targeted advertising for television and interactive television is based on the profile data prediction, modeling and preference determination. The system is enabled to present a complete program sequence to the viewer based on the preference determination and stored programming. The latter is referred to as automatic program sequence (virtual channel) creation and the virtual channel can be presented as a separate channel in an electronic programming guide (EPG).
摘要翻译：电视用户简档数据预测和建模的方法和系统允许精确和狭义的行为聚类。客户端系统将电视消费者分为有代表性的用户配置文件。配置文件定位到个人用户广告和节目偏好类别组。上下文行为分析系统确定用户的监视行为和内容偏好，并且系统可以用用户信息不断更新。行为模型数据库由各种系统模块查询。编程，包括电视和互动电视的有针对性的广告是基于轮廓数据预测，建模和偏好确定。该系统能够基于偏好确定和存储的编程向观看者呈现完整的程序序列。后者被称为自动程序序列（虚拟通道）创建，并且虚拟通道可以作为电子节目指南（EPG）中的单独频道呈现。

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